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1. Resistance to tyrosine kinase inhibitors
by Focosi, Daniele
2016, Resistance to Targeted Anti-Cancer Therapeutics, ISBN 9783319460901, Volume 10
Chemotherapy | Inhibitors | Protein-tyrosine kinase | Therapeutic use | Cancer
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2. Receptor tyrosine kinases
: methods and protocols
by Germano, Serena and Springer Science+Business Media
2015, Methods in molecular biology, ISBN 1493917889, Volume 1233
Protein-tyrosine kinase | Receptor Protein-Tyrosine Kinases
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3. Receptor tyrosine kinases
: methods and protocols
by Germano, Serena
2015, Methods in molecular biology, ISBN 1493917889, Volume 1233
Receptor Protein-Tyrosine Kinases
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4. Full Text Diversification of TAM receptor tyrosine kinase function
by Zagórska, Anna and Zagórska, Anna and Través, Paqui G and Lew, Erin D and Dransfield, Ian and Lemke, Greg
Nature immunology, ISSN 1529-2908, 10/2014, Volume 15, Issue 10, pp. 920 - 928
The clearance of apoptotic cells is critical for both tissue homeostasis and the resolution of inflammation. We found that the TAM receptor tyrosine kinases... 
BREAST-CANCER | IMMUNE-RESPONSE | CLEARANCE | DENDRITIC CELLS | PLASMA-CONCENTRATIONS | SOLUBLE FORM | AXL | APOPTOTIC CELLS | IN-VIVO | IMMUNOLOGY | TYRO-3 FAMILY | Gene Expression - drug effects | Dendritic Cells - immunology | Receptor Protein-Tyrosine Kinases - immunology | Immunoblotting | Lipopolysaccharides - immunology | Intercellular Signaling Peptides and Proteins - metabolism | Bone Marrow Cells - immunology | c-Mer Tyrosine Kinase | Gene Expression - immunology | Proto-Oncogene Proteins - immunology | Dendritic Cells - metabolism | Macrophages - immunology | Proto-Oncogene Proteins - metabolism | Microscopy, Electron, Scanning | Mice, Inbred C57BL | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Phagocytosis - immunology | Proto-Oncogene Proteins - genetics | Protein Binding - immunology | Receptor Protein-Tyrosine Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Microscopy, Confocal | Macrophages - metabolism | Animals | Apoptosis - immunology | Receptor Protein-Tyrosine Kinases - genetics | Dendritic Cells - ultrastructure | Lipopolysaccharides - pharmacology | Bone Marrow Cells - metabolism | Intercellular Signaling Peptides and Proteins - immunology | Cell receptors | Regulation | Genetic aspects | Immune response | Properties | Phosphotransferases
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5. Full Text Tyrosine kinase gene rearrangements in epithelial malignancies
by Shaw, Alice T and Hsu, Peggy P and Awad, Mark M and Engelman, Jeffrey A
Nature Reviews Cancer, ISSN 1474-175X, 2013, Volume 13, Issue 11, pp. 772 - 787
Chromosomal rearrangements that lead to oncogenic kinase activation are observed in many epithelial cancers. These cancers express activated fusion kinases... 
CELL LUNG-CANCER | ANAPLASTIC LYMPHOMA KINASE | RECURRENT CHROMOSOMAL TRANSLOCATIONS | GENOME INSTABILITY | PAPILLARY THYROID CARCINOMAS | ATOMIC-BOMB SURVIVORS | ONCOLOGY | EML4-ALK FUSION GENE | PAN-FGFR INHIBITOR | RET/PTC REARRANGEMENTS | RET PROTOONCOGENE | Humans | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins - genetics | Genetic Markers | Gene Expression Regulation, Enzymologic | Neoplasms, Glandular and Epithelial - enzymology | Neoplasms, Glandular and Epithelial - genetics | Neoplasms, Radiation-Induced - genetics | Protein-Tyrosine Kinases - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Gene Rearrangement | Environment | Mice | Enzyme Activation | Oncogenes | Proto-Oncogene Proteins c-ret - genetics | Antibody diversity | Epithelial tumors | Protein tyrosine kinase | Physiological aspects | Genetic aspects | Research | Risk factors
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6. Full Text Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib
by Woyach, Jennifer A and Furman, Richard R and Liu, Ta-Ming and Ozer, Hatice Gulcin and Zapatka, Marc and Ruppert, Amy S and Xue, Ling and Li, Daniel Hsieh-Hsin and Steggerda, Susanne M and Versele, Matthias and Dave, Sandeep S and Zhang, Jenny and Yilmaz, Ayse Selen and Jaglowski, Samantha M and Blum, Kristie A and Lozanski, Gerard and Lozanski, Arletta and James, Danelle F and Barrientos, Jacqueline C and Lichter, Peter and Stilgenbauer, Stephan and Buggy, Joseph J and Chang, Betty Y and Johnson, Amy J and Byrd, John C
The New England Journal of Medicine, ISSN 0028-4793, 06/2014, Volume 370, Issue 24, pp. 2286 - 2294
In some patients with CLL, resistance to the BTK inhibitor ibrutinib develops. Two classes of resistance mutations have been found: the more common involves... 
POINT MUTATIONS | MEDICINE, GENERAL & INTERNAL | THERAPEUTIC TARGET | ACQUIRED-RESISTANCE | PCI-32765 | CHRONIC LYMPHOCYTIC-LEUKEMIA | CLINICAL RESISTANCE | GENE MUTATION | ANTIGEN RECEPTOR | CANCER | CHRONIC MYELOID-LEUKEMIA | Recurrence | Phospholipase C gamma - metabolism | Pyrazoles - therapeutic use | Humans | Middle Aged | Binding Sites - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Pyrimidines - pharmacology | Receptors, Antigen, B-Cell - metabolism | Sequence Analysis, DNA | Exome | Point Mutation | Drug Resistance, Neoplasm - genetics | Protein-Tyrosine Kinases - genetics | Pyrimidines - therapeutic use | Phospholipase C gamma - genetics | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Protein-Tyrosine Kinases - antagonists & inhibitors | Pyrazoles - pharmacology | Tyrosine | Cysteine | Chronic lymphatic leukemia | Serine | Leukemia | Genomes | Lymphatic leukemia | Kinases | Bruton's tyrosine kinase | Lymphocytes B | Mutation | Lymphocytosis | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Apoptosis
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7. Full Text Endocytosis of receptor tyrosine kinases
by Goh, Lai Kuan and Sorkin, Alexander
Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 2013, Volume 5, Issue 5, pp. a017459 - a017459
Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The canonical model of RTK endocytosis involves rapid internalization of... 
FACTOR EGF RECEPTOR | CBL-MEDIATED UBIQUITINATION | PDGF-BETA-RECEPTOR | C-CBL | NEGATIVE REGULATION | EPIDERMAL-GROWTH-FACTOR | LOW-DENSITY-LIPOPROTEIN | CLATHRIN-COATED PITS | DEPENDENT DOWN-REGULATION | FACTOR-I RECEPTOR | CELL BIOLOGY | Protein Structure, Tertiary | Endocytosis | Phosphorylation | Ubiquitination | Endosomes - physiology | Signal Transduction | Models, Biological | Receptor Protein-Tyrosine Kinases - metabolism | Endosomes - metabolism | Receptor Protein-Tyrosine Kinases - chemistry | Protein Transport | 072
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8. Full Text Clinical pharmacokinetics of tyrosine kinase inhibitors
by van Erp, Nielka P and Gelderblom, Hans and Guchelaar, Henk-Jan
Cancer Treatment Reviews, ISSN 0305-7372, 2009, Volume 35, Issue 8, pp. 692 - 706
Summary In the recent years, eight tyrosine kinase inhibitors (TKIs) have been approved for cancer treatment and numerous are under investigation. These drugs... 
Hematology, Oncology and Palliative Medicine | Excretion | Absorption | Metabolism | Tyrosine kinase inhibitors | Distribution | Drug transporters and interactions | CHRONIC MYELOGENOUS LEUKEMIA | RENAL-CELL CARCINOMA | CHRONIC MYELOID-LEUKEMIA | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | CHRONIC MYELOCYTIC-LEUKEMIA | ADVANCED SOLID MALIGNANCIES | IMATINIB MESYLATE GLEEVEC | GASTROINTESTINAL STROMAL TUMORS | CEREBROSPINAL-FLUID PHARMACOKINETICS | CANCER RESISTANCE PROTEIN | Erlotinib Hydrochloride | Niacinamide - analogs & derivatives | Pyrroles - pharmacokinetics | Humans | Cytochrome P-450 Enzyme System - metabolism | Pyridines - pharmacokinetics | Quinazolines - pharmacokinetics | Biological Availability | Phenylurea Compounds | Antineoplastic Agents - administration & dosage | Intestinal Absorption | Thiazoles - pharmacokinetics | Antineoplastic Agents - metabolism | Tissue Distribution | Benzenesulfonates - pharmacokinetics | Drug Interactions | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Piperazines - pharmacokinetics | Protein Kinase Inhibitors - pharmacokinetics | Dasatinib | Administration, Oral | Imatinib Mesylate | Protein Kinase Inhibitors - blood | Protein Kinase Inhibitors - administration & dosage | Antineoplastic Agents - blood | Pyrimidines - pharmacokinetics | Indoles - pharmacokinetics | Protein Kinase Inhibitors - pharmacology | Benzamides | Protein Kinase Inhibitors - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Care and treatment | Oncology, Experimental | Cytochrome P-450 | Physiological aspects | Phenols | Research | Phosphotransferases | Protein binding | Cancer | Index Medicus
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9. Full Text Targeting Bruton's tyrosine kinase in B cell malignancies
by Hendriks, Rudi W and Yuvaraj, Saravanan and Kil, Laurens P
Nature Reviews Cancer, ISSN 1474-175X, 2014, Volume 14, Issue 4, pp. 219 - 232
Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and functions as an important regulator of cell proliferation and cell... 
MULTIPLE-MYELOMA | SIGNALING PATHWAYS | INDUCED PHOSPHORYLATION | ONCOLOGY | PRE-B | X-LINKED AGAMMAGLOBULINEMIA | CHRONIC LYMPHOCYTIC-LEUKEMIA | TUMOR-SUPPRESSOR | PH DOMAIN | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Protein Structure, Tertiary | Signal Transduction | Protein-Tyrosine Kinases - metabolism | Humans | Leukemia, B-Cell - enzymology | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Molecular Targeted Therapy | Animals | Protein Kinase Inhibitors - therapeutic use | Protein-Tyrosine Kinases - chemistry | Leukemia, B-Cell - drug therapy | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Protein-Tyrosine Kinases - antagonists & inhibitors | Cell receptors | Cellular control mechanisms | Physiological aspects | Physiological research | B cells | Research | Properties | Phosphotransferases
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10. Full Text Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma
by Snuderl, Matija and Fazlollahi, Ladan and Le, Long P and Nitta, Mai and Zhelyazkova, Boryana H and Davidson, Christian J and Akhavanfard, Sara and Cahill, Daniel P and Aldape, Kenneth D and Betensky, Rebecca A and Louis, David N and Iafrate, A. John
Cancer Cell, ISSN 1535-6108, 2011, Volume 20, Issue 6, pp. 810 - 817
Tumor heterogeneity has been implicated in tumor growth and progression as well as resistance to therapy. We present an example of genetic heterogeneity in... 
HETEROGENEITY | VEGFR2 | EVOLUTION | ONCOLOGY | KIT | CANCER | CELL BIOLOGY | Proto-Oncogene Proteins c-met - metabolism | Receptor, Epidermal Growth Factor - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Humans | Middle Aged | Brain Neoplasms - pathology | Brain Neoplasms - genetics | Male | Brain Neoplasms - metabolism | Genetic Heterogeneity | DNA Copy Number Variations | Proto-Oncogene Proteins c-met - genetics | Receptor, Epidermal Growth Factor - metabolism | Comparative Genomic Hybridization | Glioblastoma - genetics | Receptor, Platelet-Derived Growth Factor alpha - genetics | Base Sequence | Glioblastoma - pathology | Adult | Female | Glioblastoma - metabolism | Mosaicism | Aged | Tyrosine | Medical colleges | Platelet-derived growth factor | Gene mutations | Brain tumors | Genes | Phenols | Development and progression | Phosphotransferases
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11. Full Text Microbial protein-tyrosine kinases
by Chao, Joseph D and Wong, Dennis and Av-Gay, Yossef
Journal of Biological Chemistry, ISSN 0021-9258, 04/2014, Volume 289, Issue 14, pp. 9463 - 9472
Microbial ester kinases identified in the past 3 decades came as a surprise, as protein phosphorylation on Ser, Thr, and Tyr amino acids was thought to be... 
Protein-tyrosine Kinase (Tyrosine Kinase) | MYCOBACTERIUM-TUBERCULOSIS | Tyr Kinase | Signal Transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | BY-kinases | Signaling | Mycobacterium tuberculosis PtkA | MYXOCOCCUS-XANTHUS | STREPTOCOCCUS-PNEUMONIAE | Bacterial Signal Transduction | BACILLUS-SUBTILIS | GROUP-1 CAPSULAR POLYSACCHARIDES | PSEUDOMONAS-AERUGINOSA | ESCHERICHIA-COLI K-12 | STAPHYLOCOCCUS-AUREUS | Bacterial Protein Kinases | BIOFILM FORMATION | PHOSPHOTYROSINE PHOSPHATASE | Protein Structure, Tertiary | Protein-Tyrosine Kinases - genetics | Protein-Tyrosine Kinases - metabolism | Mycobacterium tuberculosis - enzymology | Bacterial Proteins - genetics | Bacterial Proteins - metabolism | Phylogeny | Mycobacterium tuberculosis - genetics | Minireviews
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