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Haematologica, ISSN 0390-6078, 03/2011, Volume 96, Issue 3, pp. 472 - 476
Mutations in the IL-2-inducible T-cell kinase gene have recently been shown to cause an autosomal recessive fatal Epstein Barr virus (EBV) associated... 
Hereditary childhood EBV-positive B-cell lymphoma | Bone marrow transplantation | IL-2-inducible T-cell kinase (ITK) deficiency | ITK | SAP | hereditary childhood EBV-positive B-cell lymphoma | DISORDERS | BARR-VIRUS INFECTION | bone marrow transplantation | LINKED LYMPHOPROLIFERATIVE-DISEASE | BROTHERS | PATHOGENESIS | NON-HODGKINS-LYMPHOMA | HEMATOLOGY | GENE-PRODUCT | Lymphohistiocytosis, Hemophagocytic - pathology | Hodgkin Disease - genetics | Hodgkin Disease - pathology | Herpesvirus 4, Human - growth & development | Humans | Child, Preschool | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Lymphohistiocytosis, Hemophagocytic - mortality | Protein-Tyrosine Kinases - immunology | Hodgkin Disease - etiology | Bone Marrow Transplantation - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Protein-Tyrosine Kinases - genetics | Epstein-Barr Virus Infections - therapy | Epstein-Barr Virus Infections - genetics | Female | B-Lymphocytes - pathology | Epstein-Barr Virus Infections - immunology | Codon, Nonsense | Remission Induction | Transplantation, Homologous - immunology | Epstein-Barr Virus Infections - pathology | Disease-Free Survival | Homozygote | B-Lymphocytes - immunology | Pedigree | Hodgkin Disease - therapy | Death | Epstein-Barr Virus Infections - complications | Hodgkin Disease - immunology | Index Medicus | Brief Report
Journal Article
International Archives of Allergy and Immunology, ISSN 1018-2438, 06/2012, Volume 158, Issue 4, pp. 418 - 422
IL-2-inducible T-cell kinase (ITK) deficiency is a rare inherited immunodeficiency disease characterized by homozygous mutations in the ITK gene and the... 
Novel Insights from Clinical Practice | Epstein-Barr virus-positive lymphoproliferative disorder | Rituximab | Lung involvement | IL-2-inducible T-cell kinase deficiency | LINKED LYMPHOPROLIFERATIVE SYNDROME | ITK | CYTOKINE PRODUCTION | ALLERGY | IMMUNOLOGY | MATURATION | Cough - drug therapy | Humans | Pneumonia, Viral - drug therapy | Cough - diagnosis | DNA, Viral - analysis | Tomography, X-Ray Computed | Lung - diagnostic imaging | Cough - enzymology | Lymphoproliferative Disorders - diagnostic imaging | Lung - enzymology | Lung - virology | Lymphocyte Activation - genetics | Protein-Tyrosine Kinases - genetics | Lymphoproliferative Disorders - enzymology | B-Lymphocytes - virology | Female | B-Lymphocytes - pathology | Fever - pathology | Lung - pathology | Cough - virology | Bronchoalveolar Lavage Fluid - virology | Epstein-Barr Virus Infections - enzymology | Lymphoproliferative Disorders - virology | Pneumonia, Viral - pathology | Fever - diagnosis | Epstein-Barr Virus Infections - drug therapy | Fever - virology | Lymphoproliferative Disorders - pathology | Epstein-Barr Virus Infections - pathology | B-Lymphocytes - drug effects | Point Mutation | Fever - enzymology | Cough - pathology | Lymphocyte Activation - drug effects | Lung - drug effects | Adolescent | Pneumonia, Viral - enzymology | Lymphoproliferative Disorders - drug therapy | Fever - drug therapy | Antibodies, Monoclonal, Murine-Derived - therapeutic use | Immunologic Factors - therapeutic use | Monoclonal antibodies | Viruses | Mutation | Drug therapy | Genes | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2009, Volume 119, Issue 5, pp. 1350 - 1358
The fatal immune dysregulation that sometimes follows EBV infection in boys has been linked to mutations in two X chromosome-encoded genes, SLAM-associated... 
SH2 DOMAIN | MEDICINE, RESEARCH & EXPERIMENTAL | NKT CELLS | ITK | NATURAL-KILLER | VIRUS | TYROSINE KINASE | ENCODING GENE | LINKAGE ANALYSIS | INFECTION | TEC-FAMILY KINASES | Lymph Nodes - pathology | Gene Expression - genetics | Cell Count | Humans | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Male | Antineoplastic Agents - therapeutic use | Lymphoproliferative Disorders - immunology | Protein-Tyrosine Kinases - deficiency | Protein-Tyrosine Kinases - genetics | Protein-Tyrosine Kinases - chemistry | Antibodies - immunology | Female | Epstein-Barr Virus Infections - blood | B-Lymphocytes - pathology | Protein Stability | Child | B-Lymphocytes - metabolism | Antibodies, Monoclonal, Murine-Derived | Epstein-Barr Virus Infections - immunology | Lymphoproliferative Disorders - virology | Models, Molecular | Natural Killer T-Cells - cytology | Rituximab | Lymphoproliferative Disorders - genetics | Lymphoproliferative Disorders - pathology | T-Box Domain Proteins - genetics | Homozygote | Pedigree | Antibodies - blood | Epstein-Barr Virus Infections - complications | Mutation, Missense - immunology | Consanguinity | Care and treatment | Interleukin-2 | Lymphoproliferative disorders | Epstein-Barr virus | Genetic aspects | Research | Protein deficiency | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7480, pp. 394 - 400
Journal Article
Immunity, ISSN 1074-7613, 03/2015, Volume 42, Issue 3, pp. 443 - 456
The mechanisms underlying human natural killer (NK) cell phenotypic and functional heterogeneity are unknown. Here, we describe the emergence of diverse... 
NATURAL-KILLER-CELLS | ACTIVATION | CMV REACTIVATION | INNATE | RECEPTOR | FCR-GAMMA | DIFFERENTIATION | IMMUNOLOGY | PLZF CONTROLS | EXPRESSION | T-CELLS | Cell Proliferation | Humans | Transcription Factors - deficiency | NK Cell Lectin-Like Receptor Subfamily C - genetics | Receptors, IgG - deficiency | Intracellular Signaling Peptides and Proteins - immunology | Cytomegalovirus Infections - immunology | Gene Expression Profiling | Killer Cells, Natural - pathology | Cytomegalovirus Infections - genetics | Protein-Tyrosine Kinases - deficiency | Protein-Tyrosine Kinases - immunology | T-Lymphocytes, Cytotoxic - pathology | Intracellular Signaling Peptides and Proteins - deficiency | NK Cell Lectin-Like Receptor Subfamily C - immunology | DNA Methylation | Protein-Tyrosine Kinases - genetics | Receptors, IgG - genetics | Microarray Analysis | Antibodies - immunology | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Cytomegalovirus Infections - pathology | Kruppel-Like Transcription Factors - deficiency | Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Adaptive Immunity | T-Lymphocytes, Cytotoxic - immunology | Promoter Regions, Genetic | GPI-Linked Proteins - immunology | Signal Transduction | Killer Cells, Natural - virology | T-Lymphocytes, Cytotoxic - virology | NK Cell Lectin-Like Receptor Subfamily C - deficiency | Immunophenotyping | Receptors, IgG - immunology | Transcription Factors - genetics | Killer Cells, Natural - classification | Promyelocytic Leukemia Zinc Finger Protein | Cytomegalovirus - immunology | Epigenesis, Genetic - immunology | Kruppel-Like Transcription Factors - genetics | Kruppel-Like Transcription Factors - immunology | GPI-Linked Proteins - genetics | Virus diseases | Proteins | Epigenetic inheritance | Killer cells | Immunotherapy | Genomics | Medical genetics | Cytomegalovirus infections | T cells | Methylation | Health aspects | Antigens | Flow cytometry | Cytomegalovirus | Data analysis | Biomedical research | Transplants & implants | Cytokines | Leukemia | Cytotoxicity | Infections | Kinases | Diversification | Gene expression | Experiments | Scholarships & fellowships | Lymphocytes | DNA methylation | Epigenetics | Viral infections | Immune system | Cancer | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 2006, Volume 25, Issue 5, pp. 745 - 755
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, deletion and activation of results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and... 
CELLCYCLE | SIGNALING | EPITHELIAL-MESENCHYMAL TRANSITION | ONCOGENIC K-RAS | CANCER-CELLS | SUPPRESSOR | GENE | ONCOLOGY | SRC | KINASE INHIBITOR | EXPRESSION PROFILES | MUTATIONS | TUMORIGENESIS | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 03/2015, Volume 42, Issue 3, pp. 431 - 442
Long-lived “memory-like” NK cells have been identified in individuals infected by human cytomegalovirus (HCMV), but little is known about how the memory-like... 
ADAPTIVE IMMUNITY | CD94/NKG2C RECEPTOR | REPERTOIRE | NATURAL-KILLER-CELLS | ACTIVATION | TYROSINE KINASE | FCR-GAMMA | UMBILICAL-CORD BLOOD | DIFFERENTIATION | IMMUNOLOGY | CHILDREN | Cell Proliferation | Humans | NK Cell Lectin-Like Receptor Subfamily C - genetics | Receptors, IgG - deficiency | Intracellular Signaling Peptides and Proteins - immunology | Cytomegalovirus Infections - immunology | Gene Expression Profiling | Killer Cells, Natural - pathology | Cytomegalovirus Infections - genetics | Protein-Tyrosine Kinases - deficiency | Protein-Tyrosine Kinases - immunology | Intracellular Signaling Peptides and Proteins - deficiency | NK Cell Lectin-Like Receptor Subfamily C - immunology | DNA Methylation | Protein-Tyrosine Kinases - genetics | Receptors, IgG - genetics | Microarray Analysis | Antibodies - immunology | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Cytomegalovirus Infections - pathology | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Promoter Regions, Genetic | GPI-Linked Proteins - immunology | Signal Transduction | Killer Cells, Natural - virology | NK Cell Lectin-Like Receptor Subfamily C - deficiency | Immunophenotyping | Receptors, IgG - immunology | Killer Cells, Natural - classification | Cytomegalovirus - immunology | Epigenesis, Genetic - immunology | Immunologic Memory | GPI-Linked Proteins - genetics | Proteins | Viral antibodies | Epigenetic inheritance | Killer cells | Molecular genetics | Antibodies | Gene expression | Antigens | Cytomegalovirus | Cloning | Colleges & universities | Infections | Experiments | Long term | DNA methylation | Epigenetics | Expansion | Viral infections | Deoxyribonucleic acid--DNA | Immune system | Index Medicus
Journal Article