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Cancer cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, Lkb1 deletion and activation of Kras G12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these... 
CELLCYCLE | SIGNALING | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer | Index Medicus
Journal Article
Haematologica (Roma), ISSN 1592-8721, 11/2010, Volume 96, Issue 3, pp. 472 - 476
Journal Article
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 03/2015, Volume 42, Issue 3, pp. 431 - 442
... tyrosine kinase SYK, for which the reduced expression was stable over time and correlated with epigenetic modification of the gene promoter... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Cell Proliferation | Humans | NK Cell Lectin-Like Receptor Subfamily C - genetics | Receptors, IgG - deficiency | Intracellular Signaling Peptides and Proteins - immunology | Cytomegalovirus Infections - immunology | Gene Expression Profiling | Killer Cells, Natural - pathology | Cytomegalovirus Infections - genetics | Protein-Tyrosine Kinases - deficiency | Protein-Tyrosine Kinases - immunology | Intracellular Signaling Peptides and Proteins - deficiency | NK Cell Lectin-Like Receptor Subfamily C - immunology | DNA Methylation | Protein-Tyrosine Kinases - genetics | Receptors, IgG - genetics | Microarray Analysis | Antibodies - immunology | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Cytomegalovirus Infections - pathology | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Promoter Regions, Genetic | GPI-Linked Proteins - immunology | Signal Transduction | Killer Cells, Natural - virology | NK Cell Lectin-Like Receptor Subfamily C - deficiency | Immunophenotyping | Receptors, IgG - immunology | Killer Cells, Natural - classification | Cytomegalovirus - immunology | Epigenesis, Genetic - immunology | Immunologic Memory | GPI-Linked Proteins - genetics | Proteins | Viral antibodies | Epigenetic inheritance | Killer cells | Molecular genetics | Antibodies | Gene expression | Antigens | Cytomegalovirus | Cloning | Colleges & universities | Infections | Experiments | Long term | DNA methylation | Epigenetics | Expansion | Viral infections | Deoxyribonucleic acid--DNA | Immune system | Index Medicus
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 11/2012, Volume 130, Issue 5, pp. 1144 - 1152.e11
...–specific protein tyrosine kinase (Lck) is a key component of the TCR signaling machinery... 
Allergy and Immunology | LCK, SRC tyrosine kinase | recurrent infections | CD4 | T-cell receptor signaling | autoinflammation | immunodeficiency | genetic defect | lymphopenia | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Genetic Predisposition to Disease | T-Lymphocytopenia, Idiopathic CD4-Positive - diagnosis | Receptors, Antigen, T-Cell - metabolism | Genes, Recessive - genetics | Humans | Cells, Cultured | Child, Preschool | T-Lymphocytopenia, Idiopathic CD4-Positive - genetics | Mutation, Missense - genetics | Polymorphism, Genetic | CD4-Positive T-Lymphocytes - immunology | DNA Mutational Analysis | Pedigree | Immunologic Deficiency Syndromes - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - chemistry | Female | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Calcium Signaling - genetics | France | Immunologic Deficiency Syndromes - diagnosis | Tyrosine | Antigens | T cells | Genes | Immunodeficiency | T cell receptors | Infections | Kinases | Viral infections | Immune system | Index Medicus | Abridged Index Medicus | Autoimmunity | Calcium mobilization | Phosphorylation | CD8 antigen | Recurrent infection | Inflammation | Lymphocytes T | Risk factors | CD4 antigen | Calcium signalling | T-cell receptor | Missense mutation | Lymphopenia | Lck protein | Respiratory tract diseases | Differentiation | Protein-tyrosine kinase | Age | uniparental disomy | Life Sciences | Biochemistry, Molecular Biology
Journal Article
Nature (London), ISSN 1476-4687, 03/2014, Volume 508, Issue 7494, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably... 
Antineoplastic Agents/administration & dosage | Transforming Growth Factor beta/metabolism | Humans | Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors | Indoles/administration & dosage | Flow Cytometry | Receptor, Platelet-Derived Growth Factor beta/biosynthesis | Proto-Oncogene Proteins B-raf/antagonists & inhibitors | ErbB Receptors/biosynthesis | Melanoma/drug therapy | Female | Cell Proliferation/drug effects | Sulfonamides/administration & dosage | Gene Library | Cellular Senescence/drug effects | Receptor Protein-Tyrosine Kinases/biosynthesis | Drug Resistance, Neoplasm/drug effects | Gene Expression Regulation, Neoplastic/drug effects | SOXE Transcription Factors/deficiency | Signal Transduction/drug effects | Protein Kinase Inhibitors/administration & dosage | Vemurafenib | Animals | Mice | RNA, Small Interfering | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Receptor, Epidermal Growth Factor - genetics | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Melanoma - genetics | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 10/2003, Volume 40, Issue 3, pp. 501 - 514
Targeted deletion of focal adhesion kinase ( fak) in the developing dorsal forebrain resulted in local disruptions of the cortical basement membrane located between the neuroepithelium and pia-meninges... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Immunohistochemistry | Membrane Glycoproteins - metabolism | Embryo, Mammalian | Protein-Tyrosine Kinases - metabolism | Homeodomain Proteins - metabolism | Astrocytes - pathology | Cerebral Cortex - pathology | Glial Fibrillary Acidic Protein - metabolism | Muscular Dystrophies - genetics | Protein-Tyrosine Kinases - deficiency | Focal Adhesion Kinase 1 | Calbindins | Neurons - metabolism | Serine Endopeptidases | Disease Models, Animal | Fibroblasts - metabolism | Muscular Dystrophies - metabolism | Muscular Dystrophies - congenital | Silver Staining | Nerve Tissue Proteins | Basement Membrane - metabolism | Blotting, Western | Precipitin Tests | Mice, Knockout | Infection | Staining and Labeling | Mice | Mutation | Dura Mater | Astrocytes - metabolism | Neurons - pathology | Microtubule-Associated Proteins - metabolism | Otx Transcription Factors | Phosphopyruvate Hydratase - metabolism | Basement Membrane - pathology | Dystroglycans | Cerebral Cortex - metabolism | Cerebral Cortex - ultrastructure | Phosphotyrosine - metabolism | DNA-Binding Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Lamins - metabolism | src-Family Kinases - metabolism | Cytoskeletal Proteins - metabolism | Cell Adhesion Molecules, Neuronal - metabolism | Cerebral Cortex - abnormalities | Extracellular Matrix Proteins - metabolism | Fibroblasts - virology | Cells, Cultured | Focal Adhesion Protein-Tyrosine Kinases | Microscopy, Electron | Muscular Dystrophies - pathology | S100 Calcium Binding Protein G - metabolism | Transcription Factors - metabolism | Animals | Carrier Proteins - metabolism | Calbindin 2 | Bacterial Proteins - metabolism | Heterozygote | Proteins | Neurons | Rodents | Protein expression | Kinases | Embryos | Muscular dystrophy | Deoxyribonucleic acid--DNA | Cell adhesion & migration | Index Medicus
Journal Article