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The Lancet Oncology, ISSN 1470-2045, 12/2017, Volume 18, Issue 12, pp. 1590 - 1599
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 11/2008, Volume 4, Issue 11, pp. 691 - 699
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 2014, Volume 106, Issue 2, pp. djt378 - djt378
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 350 - 359
Based on genetic studies that establish the role of spleen tyrosine kinase (Syk) in immune function, inhibitors of this kinase are being investigated as... 
ANTIBODIES | SURVIVAL | B-CELL LYMPHOMA | COLLAGEN | SYK | PLATELETS | DISEASE | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | MICE | INDUCTION | Edema - complications | Synovitis - prevention & control | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - drug effects | Precursor Cells, B-Lymphoid - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Precursor Cells, B-Lymphoid - drug effects | Receptors, Antigen, B-Cell - metabolism | Blood - metabolism | Cyclohexylamines - administration & dosage | Lymphocyte Activation - immunology | Synovitis - etiology | Phosphorylation - drug effects | Syk Kinase | B-Lymphocytes - metabolism | Disease Models, Animal | Edema - prevention & control | Protein Kinase Inhibitors - pharmacokinetics | Rats | Pyrimidines - pharmacology | Cyclohexylamines - therapeutic use | Synovitis - pathology | Protein Kinase Inhibitors - administration & dosage | B-Lymphocytes - immunology | Signal Transduction - drug effects | Cell Line, Tumor | Pyrimidines - pharmacokinetics | Leukocytes - drug effects | Mice | Mice, Inbred BALB C | Edema - pathology | Leukocytes - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Blood - immunology | Rats, Inbred Lew | Precursor Cells, B-Lymphoid - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Cyclohexylamines - pharmacokinetics | Arthritis, Experimental - pathology | Leukocytes - immunology | Signal Transduction - immunology | Biocatalysis - drug effects | Cyclohexylamines - pharmacology | Arthritis, Experimental - prevention & control | Basophils - immunology | Protein-Tyrosine Kinases - drug effects | Inhibitory Concentration 50 | Female | Receptors, Antigen, B-Cell - agonists | Molecular Structure | Foot - pathology | Basophils - drug effects | Cell Line | Pyrimidines - administration & dosage | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Blood - drug effects | Arthritis, Experimental - complications | B-Lymphocytes - drug effects | Animals | Lymphocyte Activation - drug effects | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Cell Degranulation - drug effects | Index Medicus
Journal Article
Nature medicine, ISSN 1078-8956, 2014, Volume 20, Issue 9, pp. 1027 - 1034
Journal Article
Nature Neuroscience, ISSN 1097-6256, 08/2017, Volume 20, Issue 8, pp. 1074 - 1084
Aberrant epidermal growth factor receptor (EGFR) signaling is widespread in cancer, making the EGFR an important target for therapy. EGFR gene amplification... 
CANCER-CELLS | GROWTH-FACTOR RECEPTOR | LUNG-CANCER | PHASE-II TRIAL | TARGETED THERAPIES | FEEDBACK ACTIVATION | NEWLY-DIAGNOSED GLIOBLASTOMA | RECURRENT GLIOBLASTOMA | KINASE INHIBITORS | TYROSINE KINASES | NEUROSCIENCES | Cell Survival - drug effects | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Extracellular Signal-Regulated MAP Kinases - drug effects | Humans | ErbB Receptors - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Brain Neoplasms - drug therapy | Brain Neoplasms - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Glioblastoma - drug therapy | Epidermal growth factor | Tumor necrosis factor | Extracellular signal-regulated kinases | Cellular signal transduction | Genetic aspects | Research | Gene expression | Glioblastoma multiforme | Tyrosine | Therapy | Transcription factors | Cell survival | Epidermal growth factor receptors | Secretion | Brain tumors | Glioblastoma | c-Jun protein | Extracellular signal-regulated kinase | Kinases | Axl protein | Gene amplification | Glioma cells | Protein-tyrosine kinase receptors | Tumor necrosis factor-TNF | Inhibition | Aberration | Protein-tyrosine kinase | Cancer | Index Medicus
Journal Article
Journal Article
Antiviral Research, ISSN 0166-3542, 07/2017, Volume 143, pp. 113 - 121
Infection with human cytomegalovirus (HCMV) is a serious medical problem, particularly in immunocompromised individuals and neonates. The success of... 
Virus-induced upregulation of DYRK1A and DYRK1B | Antiviral therapy | Broad anti-herpesviral activity | Antiviral drug target | DYRK inhibitors | Human cytomegalovirus | RNA-POLYMERASE-II | LOCALIZATION | ACTIVATION | DYRK1B | NUCLEAR EGRESS COMPLEX | Virus-induced upregulation of DYRK1A and | GREEN FLUORESCENT PROTEIN | REPLICATION | VIROLOGY | CARBOXYL-TERMINAL DOMAIN | PHARMACOLOGY & PHARMACY | INFECTION | REVEALS | Phosphorylation | Humans | Cercopithecus aethiops | Antiviral Agents - antagonists & inhibitors | Drug Delivery Systems | Gene Knockdown Techniques | Harmine - antagonists & inhibitors | Microbial Sensitivity Tests | Macaca mulatta - virology | Herpesvirus 3, Human - drug effects | Protein-Tyrosine Kinases - genetics | Sensitivity and Specificity | Protein-Tyrosine Kinases - drug effects | Vero Cells | Fibroblasts - virology | Cell Line | Cell Survival - drug effects | Virus Replication - drug effects | Ganciclovir - antagonists & inhibitors | Herpesviridae - drug effects | Protein-Serine-Threonine Kinases - genetics | Drug Discovery | Herpesvirus 1, Human - drug effects | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Protein-Serine-Threonine Kinases - drug effects | Cell Proliferation - drug effects | Cell Cycle - drug effects | Cytomegalovirus - drug effects | Tyrosine | Phenols | Antiviral agents | Gene expression | Health aspects | Analysis | Index Medicus
Journal Article
Journal Article
British Journal of Cancer, ISSN 0007-0920, 09/2012, Volume 107, Issue 6, pp. 967 - 976
BACKGROUND: Neuroblastoma remains a major cause of cancer-linked mortality in children. miR-204 has been used in microRNA expression signatures predictive of... 
BCL2 | neuroblastoma | NTRK2 | miR-204 | cisplatin | tumour suppressor | CANCER-CELLS | SURVIVAL | CHEMOTHERAPY-INDUCED APOPTOSIS | MODULATES MULTIDRUG-RESISTANCE | MIRNA EXPRESSION | TARGETING BCL2 | AMPLIFICATION | ONCOLOGY | PATHWAY | NEUROTROPHIC FACTOR ACTIVATION | DIFFERENTIATION | Predictive Value of Tests | Up-Regulation | Membrane Glycoproteins - metabolism | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Gene Expression Regulation, Neoplastic | Cell Survival - genetics | Apoptosis - genetics | Neuroblastoma - mortality | MicroRNAs - pharmacology | Protein-Tyrosine Kinases - genetics | Protein-Tyrosine Kinases - drug effects | Antineoplastic Agents - pharmacology | Receptor, trkB - drug effects | Real-Time Polymerase Chain Reaction | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - drug effects | Neuroblastoma - genetics | Kaplan-Meier Estimate | Proportional Hazards Models | Etoposide - pharmacology | Proto-Oncogene Proteins - genetics | Cisplatin - pharmacology | Down-Regulation - drug effects | Mice, Inbred Strains | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | Animals | Analysis of Variance | Neuroblastoma - drug therapy | Cell Line, Tumor | Membrane Glycoproteins - drug effects | Mice | Proto-Oncogene Proteins c-bcl-2 | Receptor, trkB - metabolism | Drug Resistance, Neoplasm - drug effects | Index Medicus | Translational Therapeutics
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2004, Volume 114, Issue 3, pp. 379 - 388
  Mutant isoforms of the KIT or PDGF receptors expressed by gastrointestinal stromal tumors (GISTs) are considered the therapeutic targets for STI571 (imatinib... 
Index Medicus | Abridged Index Medicus
Journal Article