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Cancer cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, Lkb1 deletion and activation of Kras G12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these... 
CELLCYCLE | SIGNALING | INACTIVATION | SUPPRESSOR | SIGNATURES | ONCOLOGY | SRC | ADENOCARCINOMA | SENSITIVITY | MUTATIONS | LKB1/STK11 | EXPRESSION | TUMORIGENESIS | CELL BIOLOGY | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer
Journal Article
Cancer discovery, ISSN 2159-8290, 2017, Volume 7, Issue 4, pp. 400 - 409
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two phase I studies in patients with advanced or metastatic solid tumors, including patients... 
REARRANGEMENT | ONCOGENE | ONCOLOGY | ANALOG SECRETORY CARCINOMA | LANDSCAPE | KINASE FUSIONS | SARCOMAS | ETV6-NTRK3 GENE FUSION | CRIZOTINIB | GENOMIC ALTERATIONS | CLINICAL-RESPONSE | Benzamides - pharmacokinetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Receptor, trkA - antagonists & inhibitors | Male | Receptor, trkB - genetics | Indazoles - administration & dosage | Protein Kinase Inhibitors - adverse effects | Mammary Analogue Secretory Carcinoma - genetics | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Anaplastic Lymphoma Kinase | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Receptor, trkB - antagonists & inhibitors | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Benzamides - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Crizotinib | Protein Kinase Inhibitors - pharmacokinetics | Proto-Oncogene Proteins - antagonists & inhibitors | Pyridines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Receptor, trkC - antagonists & inhibitors | Melanoma - pathology | Mammary Analogue Secretory Carcinoma - drug therapy | Membrane Glycoproteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sequestosome-1 Protein - genetics | Pyrazoles - administration & dosage | Indazoles - pharmacokinetics | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Melanoma - drug therapy | Adolescent | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Indazoles - adverse effects | Colorectal Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Cancer cell, ISSN 1535-6108, 2012, Volume 22, Issue 2, pp. 153 - 166
... ALL). The genetic alterations that activate kinase signaling in Ph-like ALL are poorly understood... 
GROWTH-FACTOR RECEPTOR | BCR-JAK2 FUSION GENE | ONCOLOGY | NUCLEAR-PORE | MYELOPROLIFERATIVE NEOPLASMS | ACUTE MYELOID-LEUKEMIA | OF-FUNCTION MUTATIONS | FLT3 MUTATIONS | CHILDHOOD | B-PROGENITOR | CHRONIC MYELOMONOCYTIC LEUKEMIA | CELL BIOLOGY | Recurrence | Humans | Molecular Sequence Data | RNA, Messenger - metabolism | Receptor, Platelet-Derived Growth Factor beta - genetics | Protein-Tyrosine Kinases - genetics | DNA Mutational Analysis | Base Sequence | Trans-Activators - genetics | Phosphorylation - drug effects | Philadelphia Chromosome | Receptors, Cytokine - genetics | Genetic Predisposition to Disease | RNA, Messenger - genetics | Risk Factors | Gene Expression Regulation, Leukemic - drug effects | Signal Transduction - genetics | Enzyme Activation - drug effects | Mutation - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Signal Transduction - drug effects | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Mice | Protein Kinase Inhibitors - pharmacology | Gene Rearrangement - genetics | Sequence Deletion - genetics | Tyrosine | Platelet-derived growth factor | Cytokines | Genes | Oncology, Experimental | Genomes | Research | Gene expression | Population genetics | Hunger | Medical genetics | Genetic research | Nucleotide sequencing | Acute lymphocytic leukemia | Cancer | DNA sequencing
Journal Article
Biochemical journal, ISSN 1470-8728, 2009, Volume 420, Issue 3, pp. 345 - 361
RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and differentiation... 
Extracellular-signal-regulated kinase (ERK) | Pleiotrophin | Anaplastic large cell lymphoma (ALCL) | Neuroblastoma | Non-small cell lung cancer (NSLCL) | Midkine | Anaplastic lymphoma kinase (ALK) | Inflammatory myofibroblastic tumour (IMT) | ALK PROTEIN EXPRESSION | inflammatory myofibroblastic tumour (IMT) | NPM-ALK | HEPARIN-BINDING | GROWTH-FACTOR PLEIOTROPHIN | non-small cell lung cancer (NSLCL) | BIOCHEMISTRY & MOLECULAR BIOLOGY | anaplastic lymphoma kinase (ALK) | EML4-ALK FUSION GENE | neuroblastoma | LARGE-CELL LYMPHOMA | extracellular-signal-regulated kinase (ERK) | pleiotrophin | NEUROTROPHIC FACTOR HBNF | INFLAMMATORY MYOFIBROBLASTIC TUMOR | NON-HODGKINS-LYMPHOMA | midkine | anaplastic large cell lymphoma (ALCL) | RECEPTOR TYROSINE KINASE | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Oncogene Proteins, Fusion - metabolism | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Neuroblastoma - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Lung Neoplasms - pathology | Nuclear Proteins - metabolism | Receptor Protein-Tyrosine Kinases | Protein-Tyrosine Kinases - genetics | Models, Biological | Oncogene Proteins, Fusion - genetics | Lymphoma, Large-Cell, Anaplastic - pathology | Neuroblastoma - metabolism | Nuclear Proteins - genetics | Lymphoma, Large-Cell, Anaplastic - metabolism | Neuroblastoma - pathology | Lymphoma, Large-Cell, Anaplastic - genetics | ALK, anaplastic lymphoma kinase | LTK, leucocyte tyrosine kinase | MUC-1, mucin-1 | IRS-1, IR substrate-1 | PTN, pleiotrophin | TGFβ, transforming growth factor β | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | Shc, Src homology and collagen homology | TPM, tropomyosin | IMP cyclohydrolase | MK, midkine | MYH9, non-muscle myosin heavy chain | MAM, meprin, A5 protein and receptor protein tyrosine phosphatase mu | NPM, nucleophosmin | mTOR, mammalian target of rapamycin | NIPA, nuclear interacting partner of ALK | RPTP, receptor protein tyrosine phosphatase | DLBCL, diffuse large B-cell lymphoma | FOXO3a, forkhead box O 3a | NF-κB, nuclear factor κB | Shp1, SH2 domain-containing phosphatase 1 | RANBP2, Ran-binding protein 2 | ALCL, anaplastic large cell lymphoma | Dpp, decapentaplegic | FRS2, fibroblast growth factor receptor substrate 2 | LDLa, low-density lipoprotein class A | EGFR, epidermal growth factor receptor | SEC31L1, SEC31 homologue A | GIST, gastrointestinal stromal tumour | RTK, receptor tyrosine kinase | SH2, Src homology 2 | TFG, TRK-fused gene | ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase | CLTC, clathrin heavy chain | MAPK, mitogen-activated protein kinase | Hen-1, hesitation-1 | MEK, MAPK | PI3K, phosphoinositide 3-kinase | HEK, human embryonic kidney | SCD-2, suppressor of constitutive dauer 2 | Review | EBPβ, CCAAT | CARS, cysteinyl-tRNA synthetase | JNK, c-Jun N-terminal kinase | ERK kinase | Grb2, growthfactor-receptor-bound protein 2 | SCC, squamous cell carcinoma | EML4, echinoderm microtubule-associated protein like 4 | SHH, sonic hedghog | BCR-Abl, breakpoint cluster region-Abl | IR, insulin receptor | ALO17, ALK lymphoma oligomerization partner on chromosome 17 | enhancer-binding protein β | PLCγ, phospholipase Cγ | NSCLC, non-small cell lung cancer | UCN-01, unco-ordinated 1 | Cdc42, cell division cycle 42 | STAT, signal transducer and activator of transcription | DRG, dorsal root ganglia | MSN, moesin | dALK, Drosophila ALK | IL-3, interleukin-3 | CNS, central nervous system | JAK, Janus kinase | CML, chronic myeloid leukaemia | Jeb, jelly belly | IMT, inflammatory myofibroblastic tumour
Journal Article
Oncogene, ISSN 1476-5594, 2007, Volume 26, Issue 38, pp. 5606 - 5614
The mechanisms of cell transformation mediated by the nucleophosmin (NPM)/anaplastic lymphoma kinase (ALK... 
Mammalian target of rapamycin (mTOR) | Protein kinase B (PKB/Akt) | Mitogen-activated protein kinase pathway (MAPK) | Anaplastic lymphoma kinase (ALK) | MAMMALIAN TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | anaplastic lymphoma kinase (ALK) | mammalian target of rapamycin (mTOR) | T-CELL LYMPHOMA | ANAPLASTIC LYMPHOMA | CELL BIOLOGY | mitogen-activated protein kinase pathway (MAPK) | IN-VITRO | ONCOLOGY | AMINO-ACIDS | GENETICS & HEREDITY | TRANSFORMED B-LYMPHOCYTES | NON-HODGKINS-LYMPHOMA | TUBEROUS SCLEROSIS | S6 KINASE | protein kinase B (PKB/Akt) | MEDIATED LYMPHOMAGENESIS | Immunohistochemistry | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Protein Kinases - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Lymphoma, T-Cell - metabolism | Protein-Tyrosine Kinases - genetics | Transfection | Phosphatidylinositol 3-Kinases - pharmacology | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Cell Line | Cell Survival - drug effects | Nuclear Proteins - metabolism | Lymphoma, T-Cell - genetics | Receptor Protein-Tyrosine Kinases | Sirolimus - pharmacology | Blotting, Western | Phosphatidylinositol 3-Kinases - genetics | Protein Kinase Inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - drug effects | Models, Biological | Lymphoma, T-Cell - pathology | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Cell Proliferation - drug effects | TOR Serine-Threonine Kinases | Quinazolines - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mitogen-Activated Protein Kinases - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Physiological aspects | Cellular signal transduction | Genetic aspects | Rapamycin | Dosage and administration | Research | Protein kinases | Proteins | Signal transduction | Genetics | Lymphomas | Inhibitor drugs | Cancer
Journal Article
Nature immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
.... Here we found that signaling pathways dependent on the kinases Syk and Jnk were required for the activation of caspase-1 via the ASC-dependent inflammasomes NLRP3 and AIM2... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases
Journal Article
Nature genetics, ISSN 1546-1718, 2012, Volume 44, Issue 8, pp. 852 - 860
Human non-small cell lung cancers (NSCLCs) with activating mutations in EGFR frequently respond to treatment with EGFRtargeted tyrosine kinase inhibitors (TKIs... 
GEFITINIB | RECEPTOR TYROSINE KINASES | MET AMPLIFICATION | GROWTH | GENETICS & HEREDITY | ACQUIRED-RESISTANCE | MUTATIONS | NF-KAPPA-B | TUMORS | MUTANT EGFR | ERLOTINIB | Erlotinib Hydrochloride | Proto-Oncogene Proteins c-met - metabolism | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Humans | Lung Neoplasms - metabolism | Middle Aged | Lung Neoplasms - pathology | Male | Intercellular Signaling Peptides and Proteins - metabolism | Epithelial-Mesenchymal Transition | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins c-met - genetics | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Enzyme Activation | Mutation | Quinazolines - pharmacology | Erlotinib | Physiological aspects | Genetic aspects | Research | Lung cancer, Non-small cell | Drug therapy | Health aspects | Protein kinases | Studies | Medical research | Rodents | Lung cancer | Genomics | Kinases | Gene expression | Acquisitions & mergers | Tumors
Journal Article
PloS one, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35826
Receptor tyrosine kinase signaling cooperates with WNT/beta-catenin signaling in regulating many biological processes, but the mechanisms of their interaction remain poorly defined... 
INSULIN | MUTATIONS | MECHANISM | WNT | FGFR3 | MULTIDISCIPLINARY SCIENCES | Phosphorylation | Humans | Gene Expression Regulation | Phosphatidylinositol 3-Kinases - metabolism | Glycogen Synthase Kinase 3 - metabolism | Wnt Proteins - metabolism | Receptor Protein-Tyrosine Kinases | beta Catenin - metabolism | Proto-Oncogene Proteins c-akt - genetics | beta Catenin - genetics | Phosphatidylinositol 3-Kinases - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | MAP Kinase Signaling System - genetics | Wnt Proteins - genetics | Glycogen Synthase Kinase 3 - genetics | Wnt Signaling Pathway - genetics | HEK293 Cells | Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinases - metabolism | Wnt protein | AKT protein | Biology | Kinases | Throat cancer | Proteins | Signal transduction | β-catenin | Immunology | TrkA protein | Protein-tyrosine kinase receptors | Physiology | Standard deviation | Protein-tyrosine kinase | Fibroblast growth factor receptor 2 | Tyrosine | Epidermal growth factor receptors | Extracellular signal-regulated kinase | MAP kinase | Biophysics | Cadherin | Biological activity | 1-Phosphatidylinositol 3-kinase | Golgi apparatus | Medicine | Signaling | Low density lipoprotein receptors | Mutation | Prostate cancer | Fibroblast growth factor receptors | Tumors
Journal Article