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Neuroscience, ISSN 0306-4522, 2011, Volume 193, pp. 440 - 451
Abstract Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that... 
Neurology | mast cell tryptase | paclitaxel-induced pain | TRPV1 | TRPA1 | proteinase-activated receptor 2 | TRPV4 | Proteinase-activated receptor 2 | Mast cell tryptase | Paclitaxel-induced pain | NEUROSCIENCES | SENSORY NEURONS | CAPSAICIN RECEPTOR | MECHANICAL HYPERALGESIA | IN-VIVO | KINASE-C-EPSILON | ION-CHANNEL | PERIPHERAL NEUROPATHY | INFLAMMATORY PAIN | PROTEASE-ACTIVATED-RECEPTOR-2 SENSITIZES | IRRITABLE-BOWEL-SYNDROME | Tryptases - metabolism | Central Nervous System - metabolism | Capsaicin - pharmacology | Receptor, PAR-2 - metabolism | Type C Phospholipases - metabolism | Male | Neuralgia - pathology | Dose-Response Relationship, Drug | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Drug Interactions | Paclitaxel - toxicity | Time Factors | Protein Kinase C - metabolism | TRPV Cation Channels - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Neuralgia - chemically induced | Neuralgia - physiopathology | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mice, Inbred ICR | Hyperalgesia - physiopathology | Antineoplastic Agents, Phytogenic - toxicity | Gene Expression Regulation - drug effects | Pain Measurement - methods | Pyrroles - pharmacology | Animals | Analysis of Variance | Ankyrins - antagonists & inhibitors | Anilides - pharmacology | Ankyrins - metabolism | Central Nervous System - drug effects | Mice | Physical Stimulation - adverse effects | Carbazoles - pharmacology | Oligopeptides - pharmacology | Protein Kinase C - pharmacology | Enzymes | Care and treatment | Neurosciences | Paclitaxel | Phospholipases | Protein kinases | Cancer
Journal Article
Pigment Cell & Melanoma Research, ISSN 1755-1471, 05/2014, Volume 27, Issue 3, pp. 431 - 441
Summary The proteinase‐activated receptor 1 (PAR‐1) plays a central role in melanoma progression and its expression level is believed to correlate with the... 
gene expression regulation | microRNAs | melanoma | proteinase‐activated receptor‐1 | metastasis | Proteinase-activated receptor-1 | Gene expression regulation | Metastasis | MicroRNAs | Melanoma | TARGET | TUMOR-CELLS | IDENTIFICATION | CANCER | MICRORNA CLUSTER | CELL BIOLOGY | DERMATOLOGY | MESSENGER-RNA | GENE | ONCOLOGY | COAGULATION | proteinase-activated receptor-1 | TISSUE FACTOR | MicroRNAs - antagonists & inhibitors | Humans | 3' Untranslated Regions - genetics | RNA, Neoplasm - isolation & purification | RNA, Messenger - metabolism | MicroRNAs - isolation & purification | Thrombin - biosynthesis | Melanoma - genetics | Neoplasm Proteins - genetics | Calcium Signaling | Gene Expression Regulation, Neoplastic - genetics | Genes, Reporter | Melanoma - metabolism | RNA Processing, Post-Transcriptional | Neoplasm Proteins - biosynthesis | RNA, Messenger - genetics | Gene Silencing | Melanoma - secondary | Receptor, PAR-1 - genetics | Receptor, PAR-1 - biosynthesis | Cell Line, Tumor | RNA, Neoplasm - genetics | MicroRNAs - genetics | MicroRNAs - physiology | Neoplasm Invasiveness - genetics | Thrombin | MicroRNA | Gene expression | Antigen presentation | melanoma; metastasis; proteinase-activated receptor-1; gene expression regulation; microRNAs | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 04/2017, Volume 15, Issue 4, pp. 597 - 607
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2004, Volume 24, Issue 18, pp. 4293 - 4299
Proteinase-activated receptor (PAR) 2 is expressed on a subset of primary afferent neurons and involved in inflammatory nociception. Transient receptor... 
PKC | Proteinase-activated receptor | TRPV1 | Thermal hyperalgesia | Inflammatory pain | Mechanical allodynia | thermal hyperalgesia | proteinase-activated receptor | INVOLVEMENT | KINASE-C | CAPSAICIN-RECEPTOR | NEUROSCIENCES | RAT PAW | PATHWAY | PROTECTIVE ROLE | NEURONS | inflammatory pain | mechanical allodynia | MOLECULAR-CLONING | GROWTH-FACTOR | THROMBIN RECEPTOR | Neurons - pathology | Temperature | Spinal Cord - metabolism | Receptor, PAR-1 - metabolism | Receptors, Drug - genetics | Humans | Receptor, PAR-2 - metabolism | Male | Transfection | Pain - enzymology | Protein Kinase C - metabolism | Spinal Cord - pathology | Receptors, Drug - deficiency | Neurons - metabolism | Neurons - drug effects | Receptor, PAR-2 - genetics | Endopeptidases - metabolism | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Proto-Oncogene Proteins c-fos - metabolism | Protein Kinase C - antagonists & inhibitors | Receptor, PAR-1 - genetics | Receptors, Drug - metabolism | Hyperalgesia - physiopathology | Mice, Knockout | Patch-Clamp Techniques | Animals | Receptors, Thrombin - genetics | Hyperalgesia - genetics | Pain - physiopathology | Ganglia, Spinal - pathology | Receptor, PAR-2 - agonists | Receptors, Thrombin - metabolism | Signal Transduction - physiology | Mice | Inflammation - enzymology | Ganglia, Spinal - metabolism | Inflammation - physiopathology | Cellular | Molecular
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2012, Volume 366, Issue 1, pp. 20 - 33
In this trial, vorapaxar, a protease-activated–receptor 1 antagonist that inhibits thrombin-induced platelet activation, was not effective in reducing the... 
MEDICINE, GENERAL & INTERNAL | PLACEBO | GLYCOPROTEIN IIB/IIIA INHIBITORS | CLOPIDOGREL | TASK-FORCE | SAFETY | DOUBLE-BLIND | ANTIPLATELET THERAPY | Follow-Up Studies | Angioplasty | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Pyridines - adverse effects | Cardiovascular Diseases - mortality | Female | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Pyridines - therapeutic use | Double-Blind Method | Receptor, PAR-1 - antagonists & inhibitors | Kaplan-Meier Estimate | Combined Modality Therapy | Lactones - adverse effects | Lactones - therapeutic use | Acute Coronary Syndrome - drug therapy | Intracranial Hemorrhages - chemically induced | Coronary Artery Bypass | Acute Coronary Syndrome - therapy | Aged | Hemorrhage - chemically induced | Antagonists (Biochemistry) | Drugs | Dose-response relationship (Biochemistry) | Dosage and administration | Product/Service Evaluations | Drug therapy | Coronary heart disease | Myocardial infarction | Cerebral infarction | Stroke | Heart attacks | Proteinase-activated receptor 1 | Thrombin | Cardiovascular disease | Hemorrhage | Bleeding | Investigations | Manuscripts | Ischemia | Blood platelets | Acute coronary syndromes | Research centers | Malalties cardiovasculars | Bypass cardiopulmonar | Medicaments | Bypass cardiopulmonary | Plaquetes sanguínies | Cardiovascular diseases | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
CNS Neuroscience & Therapeutics, ISSN 1755-5930, 12/2011, Volume 17, Issue 6, pp. 742 - 749
SUMMARY Targets for antipruritic therapies are now expanding from the skin to the central nervous system. Recent studies demonstrate that various neuronal... 
Histamine | Itch | Spinal cord | Neurokinin‐1 receptor | Gastrin‐releasing peptide | Opioid | Skin | Pruritus | Neurokinin-1 receptor | Gastrin-releasing peptide | DORSAL-HORN NEURONS | PROTEINASE-ACTIVATED RECEPTOR-2 | GENE-RELATED PEPTIDE | KAPPA-OPIOID RECEPTORS | VASOACTIVE-INTESTINAL-PEPTIDE | INTRATHECAL MORPHINE | HISTAMINE H-1 RECEPTORS | NEUROSCIENCES | PHARMACOLOGY & PHARMACY | MORPHINE-INDUCED ITCH | INDUCED SCRATCHING BEHAVIOR | SUBSTANCE-P RECEPTOR | Receptors, Histamine - physiology | Receptors, Serotonin - physiology | Gastrin-Secreting Cells - physiology | Receptors, Bradykinin - physiology | Humans | Receptors, Serotonin - drug effects | Receptors, Histamine - drug effects | Receptors, Bradykinin - drug effects | Receptors, Neurokinin-1 - physiology | Receptors, Glutamate - drug effects | Pruritus - physiopathology | Receptors, Opioid - physiology | Receptors, Neurokinin-1 - drug effects | Animals | Pruritus - drug therapy | Spinal Cord - physiology | Drug Design | Neurotransmitter Agents - physiology | Receptors, Opioid - drug effects | Receptors, Glutamate - physiology | Gastrin-Secreting Cells - drug effects | Antihistamines | Methyl aspartate | Gabapentin | Dermatology | Sulfonamides | Bradykinin | Formulae, receipts, prescriptions | Gastrin | Dermatologic agents | Glutamate | Drugs | pruritus | Opioid receptors | Glutamic acid receptors (ionotropic) | Substance P | Central nervous system | Opioid receptors (type mu) | N-Methyl-D-aspartic acid receptors | Antagonists | Glutamic acid receptors | Drug development | Side effects | gabapentin | Neurotransmission | Dorsal horn
Journal Article