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Methods, ISSN 1046-2023, 02/2017, Volume 115, pp. 80 - 90
We present TrackMate, an open source Fiji plugin for the automated, semi-automated, and manual tracking of single-particles. It offers a versatile and modular... 
Phototoxicity | Open-source software | Image analysis | Single-particle tracking | Microscopy | Clathin-mediated endocytosis | SYSTEM | CLATHRIN-MEDIATED ENDOCYTOSIS | TPLATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | TRANSPORT | DYNAMICS | ARABIDOPSIS | CELL | EMBRYOGENESIS | Image Processing, Computer-Assisted - statistics & numerical data | Plant Cells - metabolism | Adaptor Proteins, Vesicular Transport - genetics | Cell Tracking - methods | Embryo, Nonmammalian - metabolism | Arabidopsis - ultrastructure | Clathrin - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Fibroblasts - ultrastructure | Cell Tracking - statistics & numerical data | Clathrin - metabolism | Arabidopsis - metabolism | Caenorhabditis elegans | Endocytosis | Algorithms | Animals | Light Signal Transduction | Single-Cell Analysis - statistics & numerical data | Single-Cell Analysis - methods | Embryo, Nonmammalian - ultrastructure | Plant Cells - ultrastructure | Gene Expression Regulation, Plant | Software | Fibroblasts - metabolism | Single-Cell Analysis/methods | Arabidopsis/metabolism | Embryo, Nonmammalian/ultrastructure | Cellular Biology | Life Sciences | Clathrin/genetics | Fibroblasts/metabolism | Cell Tracking/methods | Plant Cells/metabolism | Cell Tracking/statistics & numerical data | Arabidopsis/ultrastructure | Image Processing, Computer-Assisted/statistics & numerical data | Embryo, Nonmammalian/metabolism | Adaptor Proteins, Vesicular Transport/genetics | Clathrin/metabolism | Plant Cells/ultrastructure | Single-Cell Analysis/statistics & numerical data | Fibroblasts/ultrastructure | Adaptor Proteins, Vesicular Transport/metabolism
Journal Article
Cell Reports, ISSN 2211-1247, 09/2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2011, Volume 108, Issue 19, pp. 8003 - 8008
Dengue virus (DENV) causes the major arboviral disease of the tropics, characterized in its severe forms by signs of hemorrhage and plasma leakage. DENV... 
Molecules | Lipoproteins | Secretion | Dengue | HDL lipoproteins | Lipids | Triglycerides | Dengue virus | Detergents | Fatty acids | Amphiphilic proteins | Dengue hemorrhagic fever | Arbovirus | amphiphilic proteins | CELLS | COMPLEMENT | INFECTIONS | RNA REPLICATION | FORM | GLYCOPROTEIN NS1 | MULTIDISCIPLINARY SCIENCES | arbovirus | dengue hemorrhagic fever | secretion | LIPID PROFILE | HEMORRHAGIC-FEVER | WEST-NILE | REVEALS | Cell Line | Protein Subunits | Recombinant Proteins - ultrastructure | Drosophila | Humans | Protein Multimerization | Dengue Virus - ultrastructure | Cercopithecus aethiops | Models, Molecular | Recombinant Proteins - chemistry | Dengue Virus - chemistry | Cryoelectron Microscopy | Lipoproteins, HDL - ultrastructure | Viral Nonstructural Proteins - chemistry | Animals | Computer Simulation | HEK293 Cells | Protein Structure, Quaternary | Lipoproteins, HDL - chemistry | Nuclear Magnetic Resonance, Biomolecular | Imaging, Three-Dimensional | Viral Nonstructural Proteins - ultrastructure | Vero Cells | Dengue viruses | Genetic aspects | Lipid metabolism | Viral Nonstructural Proteins/ultrastructure | Lipoproteins, HDL/ultrastructure | Life Sciences | Recombinant Proteins/chemistry | Lipoproteins, HDL/chemistry | Viral Nonstructural Proteins/chemistry | Dengue Virus/ultrastructure | Dengue Virus/chemistry | Recombinant Proteins/ultrastructure | Microbiology and Parasitology | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7641, pp. 377 - 380
The spliceosome excises introns from pre-mRNAs in two sequential transesterifications-branching and exon ligation(1)-catalysed at a single catalytic metal site... 
2ND STEP | ANGSTROM RESOLUTION | ELECTRON CRYOMICROSCOPY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL INTERACTIONS | CATALYTIC CENTER | CRYO-EM STRUCTURE | SPLICING FACTOR | SITE CHOICE | PRE-MESSENGER-RNA | RNA Helicases - metabolism | Spliceosomes - chemistry | Saccharomyces cerevisiae - genetics | Cell Cycle Proteins - ultrastructure | Ribonucleoprotein, U5 Small Nuclear - metabolism | RNA Splicing Factors - chemistry | Saccharomyces cerevisiae - ultrastructure | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | Ribonucleoprotein, U4-U6 Small Nuclear - ultrastructure | RNA Helicases - ultrastructure | RNA Splicing Factors - metabolism | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Spliceosomes - metabolism | RNA Splicing | Ribonucleoproteins, Small Nuclear - ultrastructure | RNA, Small Nuclear - genetics | Protein Domains | Ribonucleoprotein, U5 Small Nuclear - ultrastructure | Adenosine Triphosphatases - ultrastructure | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Biocatalysis | RNA Splice Sites - genetics | Cell Cycle Proteins - metabolism | Adenosine Triphosphatases - metabolism | Exons - genetics | Spliceosomes - ultrastructure | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | DNA-Binding Proteins - ultrastructure | RNA-Binding Proteins - ultrastructure | RNA Splicing Factors - ultrastructure | Ribonuclease H - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Adenosine - metabolism | Protein Binding | DEAD-box RNA Helicases - ultrastructure | RNA-Binding Proteins - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | RNA sequencing | Methods | Mutation | Catalysis | Ribonucleic acid--RNA | Binding sites | Crystal structure
Journal Article
Science, ISSN 0036-8075, 1/2013, Volume 339, Issue 6118, pp. 452 - 456
Journal Article
Advances in Experimental Medicine and Biology, ISSN 0065-2598, 2018, Volume 1054, pp. 3 - 13
Mammalian hair fibres can be structurally divided into three main components: a cuticle, cortex and sometimes a medulla. The cuticle consists of a thin layer... 
Cytoplasmic/nuclear remnant | Endocuticle | Cortex | Medulla | Fibre surface cuticle lipids | Exocuticle | Cell membrane complex | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | A-LAYER | WOOL FIBERS | KERATIN FIBERS | DERMATOLOGY | GENES | MAMMALIAN HAIR FIBERS | CUTICLE | FOLLICLE | PROTEINS | EXPRESSION | MORPHOLOGY
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7605, pp. 133 - 137
Ribosome biogenesis is a highly complex process in eukaryotes, involving temporally and spatially regulated ribosomal protein (r-protein) binding and ribosomal... 
REFINEMENT | COMPLEX | RNA | BIOGENESIS | INITIATION | MULTIDISCIPLINARY SCIENCES | RESOLUTION | MATURATION | IDENTIFICATION | ASSOCIATION | SUBUNIT | RNA, Fungal - ultrastructure | GTP Phosphohydrolases - ultrastructure | Saccharomyces cerevisiae - ultrastructure | DNA, Ribosomal Spacer - metabolism | RNA, Ribosomal - genetics | GTP Phosphohydrolases - chemistry | Saccharomyces cerevisiae - metabolism | Cell Nucleus - metabolism | Ribosome Subunits, Large, Eukaryotic - metabolism | DNA, Ribosomal Spacer - genetics | Base Sequence | DNA, Ribosomal Spacer - ultrastructure | Ribosome Subunits, Large, Eukaryotic - chemistry | Models, Molecular | Ribonucleoproteins - metabolism | Nuclear Proteins - chemistry | Saccharomyces cerevisiae - chemistry | RNA, Ribosomal - ultrastructure | Saccharomyces cerevisiae - cytology | Ribosomal Proteins - isolation & purification | GTP Phosphohydrolases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Ribosomal Proteins - chemistry | Ribosome Subunits, Large, Eukaryotic - ultrastructure | Nuclear Proteins - ultrastructure | Molecular Sequence Data | Cytoplasm - metabolism | Ribosomal Proteins - metabolism | Ribosomal Proteins - ultrastructure | Saccharomyces cerevisiae Proteins - isolation & purification | RNA, Fungal - genetics | Active Transport, Cell Nucleus | Ribonucleoproteins - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | GTP-Binding Proteins - chemistry | RNA, Ribosomal - metabolism | Nuclear Proteins - metabolism | GTP-Binding Proteins - ultrastructure | DNA, Ribosomal Spacer - chemistry | Cell Nucleus - ultrastructure | Rotation | RNA, Fungal - metabolism | Cryoelectron Microscopy | Protein Binding | Cell Nucleus - chemistry | Ribonucleoproteins - ultrastructure | Nucleolus organizer region | Protein research | Research | Ribosomes | Protein binding | Genetic research | Proteins | Polypeptides | Molecular structure | Ribonucleic acid--RNA
Journal Article
New Phytologist, ISSN 0028-646X, 07/2019, Volume 223, Issue 2, pp. 565 - 574
Summary The chloroplast organelle in mesophyll cells of higher plants represents a sunlight‐driven metabolic factory that eventually fuels life on our planet.... 
electron microscopy | chloroplast | thylakoid membrane | ultrastructure | photosynthesis | plastoglobuli | PHOTOSYNTHETIC APPARATUS | QUALITY-CONTROL | PLANT SCIENCES | THYLAKOID MEMBRANES | MOLECULAR SOCIOLOGY | SPINACH | PHOTOSYSTEM-II | STATE TRANSITIONS | DYNAMICS | ENERGY-DISSIPATION | PROTEIN-PHOSPHORYLATION | Photosynthesis
Journal Article
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 2009, Volume 1793, Issue 1, pp. 5 - 19
Journal Article