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Journal of Neuroscience, ISSN 0270-6474, 10/2011, Volume 31, Issue 42, pp. 14899 - 14909
Multiple sclerosis is a demyelinating disease that affects similar to 2,000,000 people worldwide. In the advanced stages of the disease, endogenous... 
OLIGODENDROCYTE PRECURSORS | FIBROBLAST GROWTH FACTOR-2 | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | IN-VIVO | DEMYELINATED LESIONS | MIRROR MOVEMENTS | CENTRAL-NERVOUS-SYSTEM | EXTRACELLULAR-MATRIX | BLOOD-BRAIN-BARRIER | LINKED KALLMANNS-SYNDROME | NEUROSCIENCES | Oligodendroglia - metabolism | Cricetulus | Humans | Middle Aged | Cerebral Cortex - pathology | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Male | Glial Fibrillary Acidic Protein - metabolism | Phosphoproteins - metabolism | Cerebral Cortex - metabolism | Antigens, CD - metabolism | Oligodendroglia - drug effects | Transfection - methods | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gangliosides - metabolism | Up-Regulation - physiology | Aged, 80 and over | Fibroblast Growth Factor 2 - metabolism | Adult | Female | Membrane Proteins - metabolism | HLA-DR Antigens - metabolism | Extracellular Matrix Proteins - metabolism | Adult Stem Cells - drug effects | Multiple Sclerosis - metabolism | Cricetinae | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Proteoglycans - metabolism | Antigens - metabolism | Multiple Sclerosis - classification | Nerve Tissue Proteins - metabolism | Oligodendroglia - pathology | Up-Regulation - drug effects | Adult Stem Cells - metabolism | Pyrroles - pharmacology | Animals | Zonula Occludens-1 Protein | Antigens, Differentiation, Myelomonocytic - metabolism | Multiple Sclerosis - pathology | Aged | Mice | Postmortem Changes | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 2003, Volume 40, Issue 3, pp. 485 - 499
The CNS is thought to develop from self-renewing stem cells that generate neurons, astrocytes, and oligodendrocytes. Other data, however, have suggested that... 
OLIGODENDROCYTE LINEAGE | PROGENITOR CELLS | TRANSCRIPTION FACTORS | GLIAL-RESTRICTED PRECURSORS | RAT CEREBRAL-CORTEX | SONIC HEDGEHOG | EMBRYONIC SPINAL-CORD | NEURAL-TUBE | CENTRAL-NERVOUS-SYSTEM | MAMMALIAN FOREBRAIN | NEUROSCIENCES | Immunohistochemistry | Green Fluorescent Proteins | O Antigens - metabolism | Embryo, Mammalian | Cell Count | Homeodomain Proteins - metabolism | Fibroblast Growth Factor 2 - pharmacology | Glial Fibrillary Acidic Protein - metabolism | Hedgehog Proteins | RNA, Messenger - biosynthesis | Time Factors | SOXE Transcription Factors | Neurons - metabolism | Basic Helix-Loop-Helix Transcription Factors | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Enzyme Inhibitors - pharmacology | Proteoglycans - metabolism | Rats | Oligodendrocyte Transcription Factor 2 | Mice | Astrocytes - metabolism | Oligodendroglia - metabolism | Flow Cytometry - methods | Epithelial Cells - metabolism | Epithelial Cells - drug effects | PAX7 Transcription Factor | Carbocyanines - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Tubulin - metabolism | Transfection | Reverse Transcriptase Polymerase Chain Reaction - methods | beta-Galactosidase - metabolism | Fibroblast Growth Factor 2 - physiology | Bromodeoxyuridine - metabolism | Spinal Cord - cytology | Cell Differentiation - physiology | High Mobility Group Proteins - metabolism | Cells, Cultured | Antigens - metabolism | Body Patterning - physiology | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Spinal Cord - embryology | Blotting, Northern | Animals | Cell Aggregation | Stem Cells - physiology | Trans-Activators - metabolism | Epidermal Growth Factor - pharmacology | In Vitro Techniques | Luminescent Proteins - metabolism | Spinal cord | Scholarships & fellowships | Neurosciences | Rodents | Stem cells | Experiments | Neurogenesis | Index Medicus
Journal Article
Journal of Biomedical Materials Research Part A, ISSN 1549-3296, 05/2006, Volume 77A, Issue 2, pp. 242 - 252
Development of biosynthetic conduits carrying extracellular matrix molecules and cell lines expressing neurotrophic growth factors represents a novel and... 
cell proliferation | fibronectin | cell culture | nerve tissue engineering | bioprosthesis | Cell proliferation | Cell culture | Bioprosthesis | Fibronectin | Nerve tissue engineering | PERIPHERAL-NERVE REGENERATION | STEM-CELLS | MATERIALS SCIENCE, BIOMATERIALS | RAT SCHWANN-CELLS | INJURED SPINAL-CORD | ADULT RATS | ENGINEERING, BIOMEDICAL | OLFACTORY ENSHEATHING GLIA | HUMAN BONE-MARROW | GROWTH-FACTORS | MARROW STROMAL CELLS | BASEMENT-MEMBRANE | Biocompatible Materials - metabolism | Stromal Cells - transplantation | Biocompatible Materials - chemistry | Nerve Regeneration - physiology | Collagen - chemistry | Ganglia, Spinal - cytology | Alginates - metabolism | Proteoglycans - chemistry | Schwann Cells - cytology | Neurites - ultrastructure | Cell Shape | Female | Hydrogels - metabolism | Olfactory Bulb - cytology | Animals, Newborn | Bone Marrow Cells - cytology | Stromal Cells - metabolism | Cells, Cultured | Proteoglycans - metabolism | Rats | Schwann Cells - transplantation | Materials Testing | Neurites - metabolism | Schwann Cells - metabolism | Rats, Sprague-Dawley | Fibronectins - metabolism | Collagen - metabolism | Animals | Alginates - chemistry | Laminin - chemistry | Laminin - metabolism | Bone Marrow Cells - metabolism | Drug Combinations | Hydrogels - chemistry | Stromal Cells - cytology | Cell Transplantation - methods | Index Medicus | Proteoglycans/chemistry/metabolism | Cell Transplantation/methods | Collagen/chemistry/metabolism | Nerve Regeneration/physiology | Cells; Cultured | Bone Marrow Cells/cytology/metabolism | Rats; Sprague-Dawley | Animals; Newborn | Hydrogels/chemistry/metabolism | Biocompatible Materials/chemistry/metabolism | Stromal Cells/cytology/metabolism/transplantation | Alginates/chemistry/metabolism | Ganglia; Spinal/cytology | Olfactory Bulb/cytology | Neurites/metabolism/ultrastructure | Fibronectins/metabolism | Schwann Cells/cytology/metabolism/transplantation | Laminin/chemistry/metabolism
Journal Article
Genes and Development, ISSN 0890-9369, 08/2003, Volume 17, Issue 15, pp. 1835 - 1840
Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer... 
Pericyte | Cell retention | Retina | Mesangial cell | PDGF | Heparan sulphate proteoglycan | DIABETIC-RETINOPATHY | VEGF ISOFORMS | pericyte | ANGIOGENESIS | A-CHAIN | DEVELOPMENTAL BIOLOGY | mesangial cell | CELL BIOLOGY | cell retention | retina | IN-VIVO | GENETICS & HEREDITY | MICE | heparan sulphate proteoglycan | HEPARAN-SULFATE PROTEOGLYCANS | GROWTH-FACTOR | BINDING | SMOOTH-MUSCLE CELLS | Kidney - physiology | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Microcirculation - metabolism | Retina - metabolism | Vascular Endothelial Growth Factors | Glomerulosclerosis, Focal Segmental - genetics | Molecular Sequence Data | Intercellular Signaling Peptides and Proteins - metabolism | Lymphokines - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Retinal Degeneration - genetics | Pericytes - metabolism | Proteinuria - genetics | Amino Acid Motifs | Retina - physiology | Phenotype | Platelet-Derived Growth Factor - metabolism | Animals | Endothelium, Vascular - metabolism | Alleles | Mice | Models, Genetic | Mutation | Microscopy, Fluorescence | Cell Movement | Proteins | Blood platelets | Secretion | Analysis | Genetic research | Genetic aspects | Growth factors | Endothelium | Index Medicus | Research Communications | Glomerulosclerosis; Focal Segmental/genetics | Intercellular Signaling Peptides and Proteins/metabolism | Platelet-Derived Growth Factor/metabolism | Proto-Oncogene Proteins c-sis/genetics/metabolism | Proteinuria/genetics | Models; Genetic | Microcirculation/metabolism | Lymphokines/metabolism | Microscopy; Fluorescence | Pericytes/metabolism | Kidney/physiology | Protein Structure; Tertiary | Retinal Degeneration/genetics | Endothelial Growth Factors/metabolism | Endothelium; Vascular/metabolism | Retina/metabolism/physiology
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2013, Volume 19, Issue 8, pp. 1047 - 1053
Journal Article
by Iglesias, Adriana I and Mishra, Aniket and Vitart, Veronique and Bykhovskaya, Yelena and Höhn, René and Springelkamp, Henriët and Cuellar-Partida, Gabriel and Gharahkhani, Puya and Bailey, Jessica N. Cooke and Willoughby, Colin E and Li, Xiaohui and Yazar, Seyhan and Nag, Abhishek and Khawaja, Anthony P and Polašek, Ozren and Siscovick, David and Mitchell, Paul and Tham, Yih Chung and Haines, Jonathan L and Kearns, Lisa S and Hayward, Caroline and Shi, Yuan and Van Leeuwen, Elisabeth M and Taylor, Kent D and Wang, Jie Jin and Rochtchina, Elena and Attia, John and Scott, Rodney and Holliday, Elizabeth G and Baird, Paul N and Xie, Jing and Inouye, Michael and Viswanathan, Ananth and Sim, Xueling and Bonnemaijer, Pieter and Rotter, Jerome I and Martin, Nicholas G and Zeller, Tanja and Mills, Richard A and Staffieri, Sandra E and Jonas, Jost B and Schmidtmann, Irene and Boutin, Thibaud and Kang, Jae H and Lucas, Sionne E. M and Wong, Tien Yin and Beutel, Manfred E and Wilson, James F and Allingham, R. Rand and Brilliant, Murray H and Budenz, Donald L and Christen, William G and Fingert, John and Friedman, David S and Gaasterland, Douglas and Gaasterland, Terry and Hauser, Michael A and Kraft, Peter and Lee, Richard K and Lichter, Paul R and Liu, Yutao and Loomis, Stephanie J and Moroi, Sayoko E and Pericak-Vance, Margaret A and Realini, Anthony and Richards, Julia E and Schuman, Joel S and Scott, William K and Singh, Kuldev and Sit, Arthur J and Vollrath, Douglas and Weinreb, Robert N and Wollstein, Gadi and Zack, Donald J and Zhang, Kang and Donnelly, Peter and Barroso, Ines and Blackwell, Jenefer M and Bramon, Elvira and Brown, Matthew A and Casas, Juan P and Corvin, Aiden and Deloukas, Panos and Duncanson, Audrey and Jankowski, Janusz and Markus, Hugh S and Mathew, Christopher G and Palmer, Colin N. A and Plomin, Robert and Rautanen, Anna and Sawcer, Stephen J and Trembath, Richard C and Wood, Nicholas W and Spencer, Chris C. A and Band, Gavin and Bellenguez, Céline and Freeman, Colin and Hellenthal, Garrett and Giannoulatou, Eleni and Pirinen, Matti and ... and Blue Mountains Eye Study-GWAS Grp and NEIGHBORHOOD Consortium and Wellcome Trust Case Control Consor and Blue Mountains Eye Study—GWAS group and Wellcome Trust Case Control Consortium 2 (WTCCC2)
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
DECORIN | CHROMATIN STATES | POLYMORPHISMS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | HERITABILITY | LUMICAN | KERATOCONUS | Glaucoma | Cornea | Genes | Myopia | Association analysis | Genomes | Gene expression | Tissues | Connective tissues | Keratoconus | Collagen | Eye diseases | Extracellular matrix | Index Medicus
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 12/2010, Volume 70, Issue 23, pp. 9621 - 9630
Journal Article
Developmental Cell, ISSN 1534-5807, 2005, Volume 8, Issue 6, pp. 949 - 961
REC8 is a key component of the meiotic cohesin complex. During meiosis, cohesin is required for the establishment and maintenance of sister-chromatid cohesion,... 
MALE-FERTILITY | RECOMBINATION | FISSION YEAST | MEIOTIC PROPHASE | SMC PROTEINS | CHROMOSOME SYNAPSIS | DEVELOPMENTAL BIOLOGY | AXIAL ELEMENTS | SACCHAROMYCES-CEREVISIAE | SYNAPTONEMAL COMPLEXES | SCHIZOSACCHAROMYCES-POMBE | CELL BIOLOGY | Meiosis - physiology | Acetaminophen - metabolism | Testis - metabolism | Pachytene Stage - physiology | Spermatogenesis - genetics | Microscopy, Electron, Transmission - methods | Humans | Male | Phosphoproteins - metabolism | Chromatids - metabolism | DNA-Binding Proteins - metabolism | Chromosome Pairing - physiology | Indoles - metabolism | Nuclear Proteins - deficiency | Cloning, Molecular - methods | Chromosomes - metabolism | Chromatids - ultrastructure | Female | Phosphoproteins - physiology | Nuclear Proteins - genetics | Saccharin - metabolism | Ovary - metabolism | Saccharin - analogs & derivatives | Acetaminophen - analogs & derivatives | Rad51 Recombinase | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Chondroitin Sulfate Proteoglycans - metabolism | Nuclear Proteins - metabolism | Testis - ultrastructure | In Situ Nick-End Labeling - methods | Meiotic Prophase I - physiology | Phosphoproteins - genetics | Electroporation - methods | Chromosome Painting - methods | Mice, Knockout | Immunohistochemistry - methods | Chromosomes - ultrastructure | Animals | Cell Death - physiology | Models, Biological | Phosphoproteins - deficiency | Oncorhynchus kisutch - metabolism | Trans-Activators - metabolism | Mice | Nuclear Proteins - physiology | Chromosomes, Human, Pair 10 - metabolism | Proliferating Cell Nuclear Antigen - metabolism | Cell research | Research | Oncology, Experimental | Cancer | Index Medicus
Journal Article
Journal Article
Nature Neuroscience, ISSN 1097-6256, 03/2012, Volume 15, Issue 3, pp. 414 - 422
Cortical plasticity is most evident during a critical period in early life, but the mechanisms that restrict plasticity after the critical period are poorly... 
ADULT VISUAL-CORTEX | PARVALBUMIN | EXPERIENCE-DEPENDENT PLASTICITY | INHIBITORY NEURONS | RAT FRONTAL-CORTEX | SULFATE | CRITICAL PERIOD | CENTRAL-NERVOUS-SYSTEM | PERINEURONAL NETS | NEUROSCIENCES | OCULAR DOMINANCE PLASTICITY | Action Potentials - genetics | Chondroitin Sulfates - genetics | Chondroitin Sulfates - metabolism | Age Factors | Amphetamines - pharmacology | Humans | Visual Pathways - metabolism | Cercopithecus aethiops | Gene Expression Regulation, Developmental - genetics | Otx Transcription Factors - metabolism | Parvalbumins - metabolism | Receptors, N-Acetylglucosamine - metabolism | Visual Cortex - physiology | Neuronal Plasticity - genetics | Neuronal Plasticity - physiology | Time Factors | Up-Regulation - physiology | Functional Laterality - physiology | Action Potentials - drug effects | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | Sulfotransferases - genetics | Visual Cortex - cytology | Vesicular Glutamate Transport Protein 2 - metabolism | Bacterial Proteins - genetics | Cells, Cultured | Chondroitin Sulfate Proteoglycans - metabolism | Mice, Transgenic | Up-Regulation - genetics | Aggrecans - metabolism | Electroporation - methods | Nerve Tissue Proteins - metabolism | Sensory Deprivation - physiology | Patch-Clamp Techniques | Animals | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Visual Cortex - drug effects | In Vitro Techniques | Plant Lectins - metabolism | Astrocytes - metabolism | Luminescent Proteins - metabolism | Physiological aspects | Cerebral cortex | Research | Sulfates | Chondroitin | Index Medicus
Journal Article