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Glia, ISSN 0894-1491, 04/2016, Volume 64, Issue 4, pp. 507 - 523
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 31, pp. 12591 - 12598
Hedgehog (Hh) moves from the producing cells to regulate the growth and development of distant cells in a variety of tissues. Here, we have investigated the... 
Dextrans | Drosophila | Internalization | Antibodies | Lipids | Cell membranes | Recycling | Epithelium | Plasma interactions | Cholesterols | LIPID MODIFICATIONS | CELLS | PROTEIN | IMAGINAL DISCS | SONIC HEDGEHOG | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | CHOLESTEROL MODIFICATION | HEPARAN-SULFATE PROTEOGLYCANS | GLYPICAN DALLY-LIKE | LATERAL INHIBITION | Immunohistochemistry | Membrane Glycoproteins - metabolism | Wings, Animal - ultrastructure | Hedgehog Proteins - metabolism | Epithelium - ultrastructure | Green Fluorescent Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Microscopy, Immunoelectron | Drosophila melanogaster - metabolism | Morphogenesis | Wings, Animal - growth & development | Hedgehog Proteins - genetics | RNA Interference | Cytoplasmic Vesicles - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Green Fluorescent Proteins - metabolism | Epithelium - growth & development | Epithelium - metabolism | Animals, Genetically Modified | Membrane Proteins - genetics | Proteoglycans - metabolism | Receptors, Cell Surface - metabolism | Membrane Glycoproteins - genetics | Protein Transport | Microscopy, Confocal | Wings, Animal - metabolism | Animals | Drosophila melanogaster - growth & development | Drosophila Proteins - genetics | Mutation | Proteoglycans - genetics | Receptors, Cell Surface - genetics | Cellular proteins | Physiological aspects | Wings (Animal) | Research | Hedgehog proteins | Proteins | Genetics | Membranes | Insects | Cells | Index Medicus | Biological Sciences
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2017, Volume 76, Issue 4, pp. 748 - 755
ObjectiveTo investigate the impact of systemic inhibition of interleukin 6 (IL-6) or signal transducer and activator of transcription (Stat3) in an... 
IN-VITRO | ACTIVATED RECEPTOR 2 | ONCOSTATIN-M | SYNOVIAL-FLUID | GENE-EXPRESSION | ARTICULAR CHONDROCYTES | NECROSIS-FACTOR-ALPHA | RHEUMATOLOGY | INTERLEUKIN-6 | RADIOGRAPHIC KNEE OSTEOARTHRITIS | CARTILAGE DEGRADATION | Synovitis - prevention & control | Interleukin-6 - antagonists & inhibitors | Apoptosis - drug effects | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Osteophyte - prevention & control | ADAMTS5 Protein - metabolism | Receptors, Interleukin-6 - immunology | Cyclic S-Oxides - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | STAT3 Transcription Factor - metabolism | Disease Models, Animal | Osteoarthritis - prevention & control | Mice, Inbred C57BL | Cells, Cultured | Osteoarthritis - metabolism | Proteoglycans - metabolism | Matrix Metalloproteinase 3 - metabolism | ADAMTS4 Protein - metabolism | Cartilage - metabolism | Matrix Metalloproteinase 13 - metabolism | Antibodies - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Interleukin-6 - pharmacology | Chondrocytes | Mice | STAT3 Transcription Factor - antagonists & inhibitors | Cellular signal transduction | Research | Osteoarthritis | Health aspects | Analysis | Interleukin-6 | Arthritis | Cytokines | Kinases | Pathogenesis | Experiments | Rodents | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2006, Volume 12, Issue 2, pp. 634 - 642
Purpose: Angiogenesis is required for tumor progression and represents a rational target for therapeutic intervention. Histone deacetylase (HDAC) inhibitors... 
Histone deacetylase inhibitor | prostate cancer | gene regulation | tumor angiogenesis | CELLS | APOPTOSIS | ONCOLOGY | ACETYLATION | PHOSPHATIDYLINOSITOL 3-KINASE | IN-VIVO | CXCR4 | COMBINATION | EXPRESSION | CANCER | ENDOTHELIAL GROWTH-FACTOR | Endothelium, Vascular - cytology | Prostatic Neoplasms - metabolism | Humans | Endothelium, Vascular - drug effects | Male | Transplantation, Heterologous | Vascular Endothelial Growth Factor A - metabolism | G2 Phase - drug effects | Tubulin - metabolism | Umbilical Veins - drug effects | Indoles | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Umbilical Veins - cytology | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Neoplasm Invasiveness | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Proteoglycans - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Cell Division - drug effects | Receptors, CXCR4 - metabolism | Collagen - metabolism | Acetylation - drug effects | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Mice, Nude | Neovascularization, Pathologic - drug therapy | Hydroxamic Acids - therapeutic use | Cell Proliferation - drug effects | Mice | Histones - metabolism | Laminin - metabolism | Drug Combinations | Mitogen-Activated Protein Kinase 1 - metabolism | Umbilical Veins - metabolism | Index Medicus
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 09/2011, Volume 194, Issue 5, pp. 721 - 735
Although pericentromeric heterochromatin is essential for chromosome segregation, its role in humans remains controversial. Dissecting the function of... 
FISSION YEAST | ACCESSORY PROTEIN | P300 | GENE-EXPRESSION | COHESIN | KINETOCHORE PROTEIN | CHROMOSOME SEGREGATION | HUMAN-IMMUNODEFICIENCY-VIRUS | CENTROMERE | MAMMALIAN-CELLS | CELL BIOLOGY | Chromatin - metabolism | RNA, Small Interfering - genetics | Autoantigens - metabolism | p300-CBP Transcription Factors - antagonists & inhibitors | Interphase - physiology | Microtubule-Associated Proteins - metabolism | Epigenesis, Genetic | Humans | Aneuploidy | Centromere - metabolism | Phosphoproteins - metabolism | Chromatids - metabolism | Centromere Protein A | Heterochromatin - metabolism | Lymphocytes - virology | p300-CBP Transcription Factors - genetics | Gene Deletion | Chromosome Segregation - physiology | vpr Gene Products, Human Immunodeficiency Virus - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Chondroitin Sulfate Proteoglycans - metabolism | Nuclear Proteins - metabolism | Lymphocytes - cytology | Aurora Kinases | HIV-1 - genetics | Chromosomal Proteins, Non-Histone - genetics | Proteins - genetics | p300-CBP Transcription Factors - metabolism | Proteins - metabolism | Mitosis - physiology | Chromatids - drug effects | HeLa Cells | Anacardic Acids - pharmacology | vpr Gene Products, Human Immunodeficiency Virus - genetics | Proteins | Epigenetic inheritance | Chromatin | Physiological aspects | Genetic aspects | Research | HIV (Viruses) | Health aspects | Epigenetics | Heterochromatin | Enzyme kinetics | Chromosomes | Index Medicus
Journal Article
Cell Biochemistry and Function, ISSN 0263-6484, 08/2008, Volume 26, Issue 6, pp. 664 - 675
To further study the proliferation and multi‐differentiation potentials of adipose‐derived stem cells (ADSCs), the cells were isolated with improved methods... 
adipose tissue | doubling time | multipotential | proliferation | mesenchymal stem cells | Multipotential | Adipose tissue | Proliferation | Doubling time | Mesenchymal stem cells | multipoential | YIELD | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE | CELL BIOLOGY | HUMAN BONE-MARROW | SURFACE | THERAPIES | STROMAL CELLS | EXPRESSION | AGE | Chondrocytes - cytology | Gene Expression - drug effects | Humans | Adipose Tissue, White - metabolism | Adipocytes - cytology | Antigens, CD - metabolism | Mesenchymal Stromal Cells - cytology | Adipose Tissue, White - cytology | Bone Marrow Cells - drug effects | Osteoblasts - cytology | HLA-DR Antigens - metabolism | Chondrocytes - metabolism | Adult Stem Cells - drug effects | Cell Survival - drug effects | Mesenchymal Stromal Cells - drug effects | Adult Stem Cells - cytology | Connexin 43 - metabolism | Myocytes, Cardiac - cytology | Bone Marrow Cells - cytology | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Proteoglycans - metabolism | Cell Separation - methods | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Transcription Factors - metabolism | Cell Lineage | Adult Stem Cells - metabolism | Calcification, Physiologic | Cell Differentiation - drug effects | Culture Media - pharmacology | Myocytes, Cardiac - metabolism | Cell Proliferation - drug effects | Osteoblasts - metabolism | Adipose Tissue, White - drug effects | Bone Marrow Cells - metabolism | Index Medicus
Journal Article
Experimental Neurology, ISSN 0014-4886, 2005, Volume 195, Issue 2, pp. 293 - 304
Bone morphogenetic proteins (BMPs) are a large class of secreted factors, which serve as modulators of development in multiple organ systems, including the... 
Noggin | Spinal cord | Endothelin | OPC | BMP | Injury | Neural stem cell | Transplantation | Differentiation | neural stem cell | differentiation | noggin | BMP SIGNALING INHIBITION | BONE MORPHOGENETIC PROTEINS | NEUROSCIENCES | endothelin | CONTUSION INJURIES | ADULT-RAT | STRUCTURAL BASIS | transplantation | GROWTH | GENE-EXPRESSION | spinal cord | injury | CYSTINE KNOT PROTEIN | LINEAGE | Nestin | O Antigens - metabolism | Embryo, Mammalian | Microtubule-Associated Proteins - metabolism | Vimentin - metabolism | Rats, Inbred F344 | Phosphopyruvate Hydratase - metabolism | Glial Fibrillary Acidic Protein - metabolism | RNA, Messenger - metabolism | Stem Cells - metabolism | Bone Morphogenetic Proteins - metabolism | Transfection - methods | Time Factors | Reverse Transcriptase Polymerase Chain Reaction - methods | Female | Membrane Proteins - metabolism | Neurons - metabolism | Bone Morphogenetic Proteins - genetics | Cell Differentiation - physiology | Green Fluorescent Proteins - metabolism | Spinal Cord Injuries - metabolism | Bone Morphogenetic Protein 2 | Ectodysplasins | Cells, Cultured | Spinal Cord Injuries - surgery | Gene Expression Regulation - physiology | Proteoglycans - metabolism | Rats | Antigens - metabolism | Oligopeptides - metabolism | Immunohistochemistry - methods | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Electrophoretic Mobility Shift Assay - methods | Stem Cell Transplantation - methods | Animals | Carrier Proteins - metabolism | Cell Count - methods | Transforming Growth Factor beta - genetics | Neuroglia - metabolism | Blotting, Northern - methods | Intermediate Filament Proteins - metabolism | Transforming Growth Factor beta - metabolism | Neurons | Stem cells | Bone morphogenetic proteins | Spinal cord injuries | Universities and colleges | Index Medicus
Journal Article
Journal Article
Science, ISSN 0036-8075, 11/2014, Volume 346, Issue 6212, pp. 968 - 972
Chromosome segregation depends on sister chromatid cohesion mediated by cohesin. The cohesin subunits Smc1, Smc3, and Scc1 form tripartite rings that are... 
ATP HYDROLYSIS | COMPLEX | REPLICATION | CHROMATIN | ACETYLATION | MULTIDISCIPLINARY SCIENCES | SCC2 | CHROMOSOMES | BINDING | ASSOCIATION | WAPL | Chromatin - metabolism | Chondroitin Sulfate Proteoglycans - genetics | Chondroitin Sulfate Proteoglycans - chemistry | Humans | Protein Multimerization | Molecular Sequence Data | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Cell Cycle Proteins - chemistry | Mass Spectrometry | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Chromosome Segregation | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Chondroitin Sulfate Proteoglycans - metabolism | DNA Replication | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | DNA - metabolism | Phosphoproteins - genetics | Microscopy, Electron | Nuclear Proteins - chemistry | Chromosomal Proteins, Non-Histone - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Separase - metabolism | Chromosomal Proteins, Non-Histone - chemistry | Genetic research | Research | Nucleotide sequencing | DNA sequencing | Mutation | Chromosomes | Deoxyribonucleic acid--DNA | Cell adhesion & migration | Index Medicus | Mutations | Cohesion | Deoxyribonucleic acid | Strands | Cleavage | Gates | Rings (mathematics)
Journal Article
Nature Neuroscience, ISSN 1097-6256, 12/2008, Volume 11, Issue 12, pp. 1392 - 1401
Platelet-derived growth factor a receptor (PDGFRA)/NG2-expressing glia are distributed throughout the adult CNS. They are descended from oligodendrocyte... 
PROGENITOR CELLS | STEM-CELLS | CORPUS-CALLOSUM | PDGF-ALPHA-RECEPTOR | SPINAL-CORD | SUBVENTRICULAR ZONE | RAT OPTIC-NERVE | CNS WHITE-MATTER | NG2-EXPRESSING CELLS | PRECURSOR CELLS | NEUROSCIENCES | Adult Stem Cells - physiology | Humans | Estrogen Antagonists - pharmacology | Phosphopyruvate Hydratase - metabolism | Cerebral Cortex - cytology | Neural Pathways - physiology | Luminescent Proteins - biosynthesis | Oligodendroglia - physiology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neurons - physiology | Bromodeoxyuridine - metabolism | Cell Differentiation - physiology | Adult Stem Cells - drug effects | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Myelin Basic Protein - metabolism | Gene Expression Regulation - genetics | SOXE Transcription Factors - metabolism | RNA, Untranslated | Proteoglycans - metabolism | Mice, Transgenic | Antigens - metabolism | Oligodendrocyte Transcription Factor 2 | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Proteins - genetics | Receptor, Platelet-Derived Growth Factor alpha - physiology | Animals | Proteins - metabolism | Cell Differentiation - drug effects | Receptor, Platelet-Derived Growth Factor alpha - genetics | Tamoxifen - pharmacology | Cerebral Cortex - physiology | Luminescent Proteins - genetics | Mice | Physiological aspects | Oligodendroglia | Myelination | Receptors | Research | Blood platelets | Index Medicus
Journal Article