X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
proteolysis-inducing factor (71) 71
animals (41) 41
cachexia (39) 39
humans (39) 39
oncology (34) 34
weight-loss (31) 31
index medicus (27) 27
mice (25) 25
skeletal-muscle (25) 25
nf-kappa-b (23) 23
cancer cachexia (21) 21
eicosapentaenoic acid (19) 19
cancer (17) 17
cancer cachectic factor (16) 16
proteoglycans (16) 16
cachexia - etiology (15) 15
cachexia - metabolism (15) 15
muscle protein-degradation (15) 15
muscle, skeletal - metabolism (14) 14
expression (12) 12
lipid-mobilizing factor (12) 12
male (12) 12
neoplasms - complications (12) 12
cell biology (11) 11
cell line (11) 11
activation (10) 10
cachexia - physiopathology (10) 10
proteins (10) 10
weight loss (10) 10
biochemistry & molecular biology (9) 9
cells, cultured (9) 9
factor pif (9) 9
induction (9) 9
protein-degradation (9) 9
proteolysis (9) 9
ubiquitin-proteasome pathway (9) 9
blotting, western (8) 8
dermcidin (8) 8
female (8) 8
messenger-rna (8) 8
muscle proteins - metabolism (8) 8
neoplasms - metabolism (8) 8
oxidative stress (8) 8
pancreatic-cancer (8) 8
survival (8) 8
tumor-necrosis-factor (8) 8
acute-phase response (7) 7
inflammation (7) 7
muscle fibers, skeletal - metabolism (7) 7
muscle, skeletal - drug effects (7) 7
muscle, skeletal - pathology (7) 7
musculoskeletal system (7) 7
proteoglycans - metabolism (7) 7
review (7) 7
signal transduction (7) 7
skeletal muscle (7) 7
tumors (7) 7
ubiquitin-dependent proteolysis (7) 7
analysis (6) 6
anorexia (6) 6
blood proteins - pharmacology (6) 6
care and treatment (6) 6
cell lung-cancer (6) 6
cytokines (6) 6
disease models, animal (6) 6
in-vitro (6) 6
mechanism (6) 6
medicine & public health (6) 6
nf-kappa b - metabolism (6) 6
peptides (6) 6
proteasome endopeptidase complex (6) 6
protein degradation (6) 6
research (6) 6
tumor-bearing rats (6) 6
ubiquitin - metabolism (6) 6
atrophy (5) 5
cachectic factor (5) 5
cachexia - pathology (5) 5
cell line, tumor (5) 5
cells (5) 5
endocrinology & metabolism (5) 5
exercise (5) 5
experimental therapeutics (5) 5
gene expression regulation (5) 5
growth-factor-i (5) 5
identification (5) 5
immunohistochemistry (5) 5
murine myotubes (5) 5
muscular atrophy - metabolism (5) 5
necrosis-factor-alpha (5) 5
neoplasms - pathology (5) 5
nf-κb (5) 5
nutrition & dietetics (5) 5
peptide (5) 5
physiology (5) 5
proteasome (5) 5
quality-of-life (5) 5
reverse transcriptase polymerase chain reaction (5) 5
signal transduction - physiology (5) 5
tumor (5) 5
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


British Journal of Cancer, ISSN 0007-0920, 02/2005, Volume 92, Issue 4, pp. 711 - 721
.... The role of nuclear factor-kappaB (NF-kappaB) in regulating muscle protein degradation and expression of the ubiquitin - proteasome proteolytic pathway in response to a tumour cachectic factor, proteolysis-inducing factor (PIF... 
NF-κB | Protein degradation | Proteasome proteolysis | Proteolysis-inducing factor (PIF) | ACTIVATION | CANCER CACHECTIC FACTOR | MECHANISM | TRANSCRIPTION | KINASE | FACTOR PIF | proteolysis-inducing factor (PIF) | MURINE MYOTUBES | DEPENDENT PROTEOLYSIS | NF-kappa B | ONCOLOGY | PATHWAY | TNF-ALPHA | proteasome proteolysis | protein degradation | Translational Therapeutics
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2007, Volume 407, Issue 1, pp. 113 - 120
... (eukaryotic initiation factor 2 alpha) in skeletal muscle of mice bearing the MAC 16 tumour, due to an increased expression of PP1... 
Eukaryotic-initiation factor 4E-binding protein 1 (4E-BP1) | Eukaryotic-initiation factor 4E (eIF4E) | Branched-chain amino acid (BCAA) | Double-stranded-RNA-dependent protein kinase (PKR) | Eukaryotic elongation factor 2 (eEF2) | Cachexia | Leucine | double-stranded-RNA-dependent protein kinase (PKR) | leucine | PROTEOLYSIS-INDUCING FACTOR | INCREASED EXPRESSION | PHOSPHORYLATION | eukaryotic-initiation factor 4E (eIF4E) | BIOCHEMISTRY & MOLECULAR BIOLOGY | cachexia | eukaryotic elongation factor 2 (eEF2) | branched-chain amino acid (BCAA) | TRANSLATION INITIATION | PROTEIN-SYNTHESIS | POSTABSORPTIVE RATS | eukaryotic-initiation factor 4E-binding protein 1 (4E-BP1) | MURINE MYOTUBES | INSULIN | SKELETAL-MUSCLE | DEGRADATION | Neoplasms - metabolism | Protein Kinases - metabolism | Leucine - pharmacology | Phosphorylation | Muscular Atrophy - metabolism | Cells, Cultured | Eukaryotic Initiation Factor-4E - metabolism | Eukaryotic Initiation Factor-4G - metabolism | Mice, Inbred Strains | Phosphoproteins - metabolism | Myoblasts - metabolism | Animals | Carrier Proteins - metabolism | Proteoglycans - pharmacology | Time Factors | Amino Acids, Branched-Chain - pharmacology | Mice | Valine - pharmacology | Cachexia - metabolism | eIF, eukaryotic initiation factor | PKR, double-stranded-RNA-dependent protein kinase | PIF, proteolysis-inducing factor | NF-κB, nuclear factor κB | Ang II, angiotensin II | PP1, protein phosphatase 1 | DMEM, Dulbecco's modified Eagle's medium | eEF, eukaryotic elongation factor | 4E-BP1, eIF4E-binding protein | m7GTP, 7-methyl-GTP | HS, horse serum | mTOR, mammalian target of rapamycin | BCAA, branched-chain amino acid | p70S6k, 70 kDa ribosomal protein S6 kinase | FCS, fetal calf serum
Journal Article
Journal of the American College of Nutrition, ISSN 0731-5724, 08/2004, Volume 23, Issue 4, pp. 281 - 302
.... Cell specific lipid metabolism, as well as the expression of fatty acid-regulated transcription factors, likely play an important role in determining how cells respond to changes in PUFA composition... 
EPA = eicosapentaenoic acid | TGF = transforming growth factor | polyunsaturated fatty acids | DHA = docosahexaenoic acid | EFA = essential fatty acids | SREBP = sterol regulatory element-binding protein | TX = thromboxane | HETE = hydroxyeicosatetraenoic acid | LXR = liver X receptors | LNA = alpha-linolenic acid | PBMC = peripheral blood mononuclear cells | EGF = epithelial growth factor | LT = leukotriene | IL = interleukin | LOX = lipooxygenase | PUFA = polyunsaturated fatty acids | DGLA = di-homo-gamma-linolenic acid | PIF = proteolysis-inducing factor | PLA2 = phospholipase A | chronic diseases | TR = thyroid hormone receptor | PPAR = peroxisome proliferator-activated receptor | RXR = retinoid X receptors | NF-kB = nuclear factor kB | COX = cyclooxigenase | LA = linoleic acid | PGI = prostacyclin | TNF = tumor necrosis factor | BMD = bone mineral density | nutrition | HPETE = hydroperoxyeicosatetraenoic acid | IGF = insulin-like growth factor | PGE = prostaglandin | IFN = interferon | carnitine | NSAIDs = nonsteroidal antiinflammatory drugs | AA = arachidonic acid | HNF = hepatic nuclear factor | gene expression | eicosanoid metabolism | Chronic diseases | Nutrition | Gene expression | Polyunsaturated fatty acids | Eicosanoid metabolism | Carnitine | DIETARY LINOLEIC-ACID | CARNITINE PALMITOYLTRANSFERASE I | SKELETAL-MUSCLE PHOSPHOLIPIDS | ARACHIDONIC-ACID | NUTRITION & DIETETICS | BREAST-CANCER RISK | DOCOSAHEXAENOIC ACID | GENE-EXPRESSION | FISH-OIL | RETINOID-X-RECEPTOR | SREBP-1C MESSENGER-RNA | Animals | Humans | Dietary Fats - administration & dosage | Gene Expression Regulation | Dietary Fats, Unsaturated - administration & dosage | Fatty Acids, Unsaturated - physiology | Transcription, Genetic | Nutritional Status | Fatty Acids, Unsaturated - metabolism | Chronic Disease
Journal Article
Cellular Signalling, ISSN 0898-6568, 11/2012, Volume 24, Issue 11, pp. 2118 - 2122
Proteolysis-inducing factor (PIF) induces muscle loss in cancer cachexia through a high affinity membrane bound receptor... 
Cancer cachexia | Proteolysis-inducing factor (PIF) | PIF-receptor | signalling
Journal Article
Journal of Innate Immunity, ISSN 1662-811X, 06/2012, Volume 4, Issue 4, pp. 349 - 360
Journal Article
British Journal of Cancer, ISSN 0007-0920, 05/2004, Volume 90, Issue 9, pp. 1850 - 1857
Proteolysis-inducing factor (PIF) is a sulphated glycoprotein produced by cachexia-inducing tumours, which initiates muscle protein degradation through an increased expression of the ubiquitin - proteasome proteolytic pathway... 
Protein kinase C | Proteolysis-inducing factor | Nuclear factor-κB | Proteasome expression | ACTIVATION | CANCER CACHECTIC FACTOR | PHOSPHORYLATION | WEIGHT-LOSS | nuclear factor-kappa B | proteolysis-inducing factor | MAMMALIAN-CELLS | FACTOR PIF | proteasome expression | MURINE MYOTUBES | SKELETAL-MUSCLE | ONCOLOGY | PATHWAY | EICOSAPENTAENOIC ACID | protein kinase C | nuclear factor-κB | Experimental Therapeutics
Journal Article
British Journal of Cancer, ISSN 0007-0920, 06/2006, Volume 94, Issue 11, pp. 1663 - 1671
Journal Article