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Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5797
Systemic sclerosis (SSc) is manifested by fibrosis, vasculopathy and immune dysregulation. So far, a unifying hypothesis underpinning these pathological events... 
GROWTH-FACTOR-BETA | DNA-BINDING | PULMONARY ARTERIAL-HYPERTENSION | MULTIDISCIPLINARY SCIENCES | COLLAGEN FIBRILLOGENESIS | TISSUE FIBROSIS | GENE-EXPRESSION | PROTEIN-ASSOCIATED FACTOR | DISEASE SCLERODERMA | TRANSCRIPTION FACTOR FLI1 | AUTOIMMUNE-DISEASE | Autoimmunity | RNA, Small Interfering - genetics | Skin - metabolism | Blood Vessels - metabolism | Blood Vessels - pathology | Connective Tissue Growth Factor - immunology | Epigenesis, Genetic | Humans | Scleroderma, Systemic - pathology | Autoantibodies - biosynthesis | Case-Control Studies | Blood Vessels - immunology | Collagen - genetics | Lung - metabolism | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Skin - pathology | Disease Models, Animal | Fibroblasts - metabolism | Skin - immunology | Lung - pathology | Proto-Oncogene Protein c-fli-1 - genetics | Signal Transduction | Lymphocyte Activation | Collagen - immunology | Scleroderma, Systemic - metabolism | Scleroderma, Systemic - genetics | Mice, Transgenic | Connective Tissue Growth Factor - agonists | Scleroderma, Systemic - immunology | Fibroblasts - pathology | Proto-Oncogene Protein c-fli-1 - antagonists & inhibitors | Animals | B-Lymphocytes - immunology | Fibrosis | Fibroblasts - immunology | Collagen - agonists | Connective Tissue Growth Factor - genetics | Mice | Kruppel-Like Transcription Factors - antagonists & inhibitors | Kruppel-Like Transcription Factors - genetics | Kruppel-Like Transcription Factors - immunology | Lung - immunology | Proto-Oncogene Protein c-fli-1 - immunology | RNA, Small Interfering - metabolism
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 10/2015, Volume 67, pp. 86 - 91
Systemic sclerosis (SSc) is a multisystem connective tissue disease featured by immune abnormalities, vasculopathy and tissue fibrosis with unknown etiology. A... 
Fibroblasts | Macrophages | Systemic sclerosis | Endothelial cells | Fli1 | DNA-BINDING ABILITY | SCLERODERMA FIBROBLASTS | COLLAGEN EXPRESSION | LEUKEMIA-VIRUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | TRANSCRIPTION FACTOR FLI1 | CELL BIOLOGY | GROWTH-FACTOR-BETA | DERMAL FIBROBLASTS | PROTEIN-ASSOCIATED FACTOR | T-CELLS | Bleomycin - antagonists & inhibitors | Epigenesis, Genetic | Humans | Scleroderma, Systemic - pathology | Th2 Cells - immunology | Th2 Cells - drug effects | Th17 Cells - drug effects | Proto-Oncogene Protein c-fli-1 - agonists | Macrophages - immunology | Th2 Cells - pathology | Disease Models, Animal | Th17 Cells - pathology | Genetic Predisposition to Disease | Macrophages - pathology | Proto-Oncogene Protein c-fli-1 - genetics | Scleroderma, Systemic - genetics | Mice, Transgenic | Scleroderma, Systemic - immunology | Fibroblasts - pathology | Sulfonamides - pharmacology | Endothelial Cells - immunology | Proto-Oncogene Protein c-fli-1 - antagonists & inhibitors | Animals | Fibroblasts - drug effects | Th17 Cells - immunology | Bleomycin - pharmacology | Fibroblasts - immunology | Macrophages - drug effects | Mice | Endothelial Cells - pathology | Proto-Oncogene Protein c-fli-1 - immunology | Scleroderma, Systemic - drug therapy | Endothelial Cells - drug effects | Autoimmunity | Epigenetic inheritance | Medical colleges | Endothelin | Systemic scleroderma | Leukemia | Scleroderma (Disease) | Development and progression | Health aspects | Risk factors
Journal Article
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 10/2015, Volume 67, pp. 92 - 100
Systemic sclerosis (SSc) is a heterogeneous and life-threatening autoimmune disease characterized by damage to small blood vessels, interruption of immune... 
Therapy | Biomarker | Epigenetic mechanisms | Systemic sclerosis | HISTONE MODIFICATION | CD4+ T-CELLS | DIFFERENTIAL EXPRESSION | DNA METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCLERODERMA DERMAL FIBROBLASTS | DOWN-REGULATION | SKIN FIBROSIS | CELL BIOLOGY | I COLLAGEN EXPRESSION | ENDOTHELIAL-CELLS | DECREASED EXPRESSION | MicroRNAs - antagonists & inhibitors | Epigenesis, Genetic | Humans | Extracellular Matrix - immunology | Scleroderma, Systemic - pathology | DNA Methylation | CD40 Antigens - genetics | Biomarkers - metabolism | CD27 Ligand - immunology | Histones - immunology | Proto-Oncogene Protein c-fli-1 - genetics | Signal Transduction | Extracellular Matrix - drug effects | Scleroderma, Systemic - genetics | CD27 Ligand - genetics | Azacitidine - analogs & derivatives | Scleroderma, Systemic - immunology | MicroRNAs - immunology | Antimetabolites, Antineoplastic - therapeutic use | Histones - genetics | Fibrosis | Histone Deacetylase Inhibitors - therapeutic use | MicroRNAs - genetics | Protein Processing, Post-Translational | Extracellular Matrix - pathology | CD40 Antigens - immunology | Proto-Oncogene Protein c-fli-1 - immunology | Scleroderma, Systemic - drug therapy | Azacitidine - therapeutic use | Epigenetic inheritance | Development and progression | B cells | Systemic scleroderma | Health aspects | Scleroderma (Disease)
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2014, Volume 193, Issue 6, pp. 2661 - 2668
Journal Article
Journal Article
Infection, Genetics and Evolution, ISSN 1567-1348, 04/2017, Volume 49, pp. 212 - 220
Journal Article
Experimental Hematology, ISSN 0301-472X, 2015, Volume 43, Issue 2, pp. 125 - 136
Platelets are produced from megakaryocytes (MKs) in the bone marrow. In contrast, most nonmammalian vertebrates have nucleated and spindle-shaped thrombocytes... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | PLATELET-RELEASE | MEDICINE, RESEARCH & EXPERIMENTAL | RAINBOW-TROUT | CHICKEN THROMBOCYTES | CONNECTED CANALICULAR SYSTEM | MEGAKARYOCYTES | RECEPTOR | C-MPL | THROMBOPOIETIN | HEMATOLOGY | LOW-TEMPERATURE | CFU-MK | Thrombopoiesis | Blood Platelets - immunology | Spleen - immunology | Antibodies, Monoclonal - biosynthesis | Male | Spleen - drug effects | Liver - immunology | Lymphocytes - immunology | Thrombin - pharmacology | Liver - drug effects | Blood Platelets - cytology | Platelet Membrane Glycoprotein IIb - immunology | Collagen - pharmacology | Xenopus laevis - genetics | Blood Platelets - drug effects | Biomarkers - metabolism | Gene Expression | Xenopus laevis - immunology | Proto-Oncogene Protein c-fli-1 - genetics | Antibodies, Monoclonal - pharmacology | Thrombocytopenia - immunology | Cells, Cultured | Lymphocytes - cytology | Spleen - cytology | Thrombocytopenia - chemically induced | Organ Specificity | Thrombocytopenia - pathology | Adenosine Diphosphate - pharmacology | Platelet Aggregation | Calcium Chloride - pharmacology | Animals | Lymphocytes - drug effects | Ploidies | Liver - cytology | Mice | Mice, Inbred BALB C | Platelet Membrane Glycoprotein IIb - genetics | Proto-Oncogene Protein c-fli-1 - immunology | Frogs | Analysis | Monoclonal antibodies | Thrombin | Amphibians | Adenosine triphosphatase | Biomedical engineering
Journal Article