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Nature reviews. Cancer, ISSN 1474-1768, 2017, Volume 17, Issue 2, pp. 93 - 115
Journal Article
Cancer discovery, ISSN 2159-8290, 2017, Volume 7, Issue 4, pp. 400 - 409
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two phase I studies in patients with advanced or... 
REARRANGEMENT | ONCOGENE | ONCOLOGY | ANALOG SECRETORY CARCINOMA | LANDSCAPE | KINASE FUSIONS | SARCOMAS | ETV6-NTRK3 GENE FUSION | CRIZOTINIB | GENOMIC ALTERATIONS | CLINICAL-RESPONSE | Benzamides - pharmacokinetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Receptor, trkA - antagonists & inhibitors | Male | Receptor, trkB - genetics | Indazoles - administration & dosage | Protein Kinase Inhibitors - adverse effects | Mammary Analogue Secretory Carcinoma - genetics | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Anaplastic Lymphoma Kinase | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Receptor, trkB - antagonists & inhibitors | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Benzamides - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Crizotinib | Protein Kinase Inhibitors - pharmacokinetics | Proto-Oncogene Proteins - antagonists & inhibitors | Pyridines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Receptor, trkC - antagonists & inhibitors | Melanoma - pathology | Mammary Analogue Secretory Carcinoma - drug therapy | Membrane Glycoproteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sequestosome-1 Protein - genetics | Pyrazoles - administration & dosage | Indazoles - pharmacokinetics | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Melanoma - drug therapy | Adolescent | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Indazoles - adverse effects | Colorectal Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Apoptosis, ISSN 1360-8185, 3/2008, Volume 13, Issue 3, pp. 343 - 353
... (mitogen-activated protein kinases) pathways, which modulate the activity of transcription factors by phosphorylation... 
Biochemistry, general | Kinases inhibitors | Retinal pigment epithelium cells | Biomedicine | MAP kinases | Oncology | Cancer Research | Ultra violet | AP-1 | Virology | Cell Biology | Apoptosis | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | PHOSPHORYLATION | JNK | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | retinal pigment epithelium cells | apoptosis | FOS | kinases inhibitors | ultra violet | CELL BIOLOGY | GENE-EXPRESSION | INHIBITORS | C-JUN | Retina - radiation effects | Cell Line | MAP Kinase Signaling System - physiology | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Apoptosis - radiation effects | Mitogen-Activated Protein Kinase 9 - metabolism | Humans | Mitogen-Activated Protein Kinase 8 - metabolism | Mitogen-Activated Protein Kinase 9 - radiation effects | Pigment Epithelium of Eye - physiopathology | Proto-Oncogene Proteins c-fos - metabolism | p38 Mitogen-Activated Protein Kinases - radiation effects | Transcription Factor AP-1 - metabolism | MAP Kinase Kinase 4 - metabolism | Ultraviolet Rays | Retina - enzymology | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - radiation effects | p38 Mitogen-Activated Protein Kinases - metabolism | Apoptosis - physiology | Pigment Epithelium of Eye - cytology | Mitogen-Activated Protein Kinase 1 - metabolism | Epithelium | Protein kinases
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 3, pp. 493 - 506
.... However, pharmacological strategies that directly target N-Myc, the protein encoded by MYCN, remain elusive... 
BI6727 | targeted therapy | ubiquitination | Myc | PLK1 | neuroblastoma | Fbw7 | small cell lung carcinoma | ABT199 | TARGETED THERAPY | INHIBITOR VOLASERTIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-MYC | C-MYC | F-BOX PROTEINS | AMPLIFIED NEUROBLASTOMA | AURORA KINASE | FBW7 UBIQUITIN LIGASE | CANCER-THERAPY | HUMAN NEUROBLASTOMA | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Neuroblastoma - mortality | N-Myc Proto-Oncogene Protein - antagonists & inhibitors | Transcription, Genetic | Neurons - metabolism | Brain Neoplasms - mortality | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Drug Synergism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Feedback, Physiological | Mice, Nude | Survival Analysis | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism | F-Box-WD Repeat-Containing Protein 7 | Neurons - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | N-Myc Proto-Oncogene Protein - genetics | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Neurons - drug effects | Neuroblastoma - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | F-Box Proteins - metabolism | Neuroblastoma - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Ubiquitin | Polo | Ligases | Lung cancer | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer
Journal Article
Nature, ISSN 0028-0836, 04/2003, Volume 422, Issue 6934, pp. 905 - 909
.... Here we report a conserved nuclear protein, named Chibby, which was identified in a screen for proteins that directly interact with the C-terminal region of β-catenin... 
PROTEIN | GENE | WINGLESS SIGNAL | MULTIDISCIPLINARY SCIENCES | XENOPUS EMBRYOS | INTERFERENCE | MAMMALIAN-CELLS | EXPRESSION | DROSOPHILA | ARMADILLO | LEF-1 | Wnt1 Protein | Cytoskeletal Proteins - antagonists & inhibitors | Humans | Transcriptional Activation | Molecular Sequence Data | Wnt Proteins | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Trans-Activators - chemistry | Drosophila melanogaster - genetics | DNA-Binding Proteins - metabolism | Lymphoid Enhancer-Binding Factor 1 | Armadillo Domain Proteins | RNA Interference | Trans-Activators - genetics | Conserved Sequence | Carrier Proteins - chemistry | Cytoskeletal Proteins - metabolism | Nuclear Proteins - genetics | Binding Sites | Proto-Oncogene Proteins - metabolism | Cell Line | Proto-Oncogene Proteins - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | beta Catenin | RNA, Messenger - genetics | Zebrafish Proteins | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | Cytoskeletal Proteins - chemistry | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Phenotype | Animals | Carrier Proteins - metabolism | Epistasis, Genetic | Protein Binding | Trans-Activators - metabolism | Drosophila Proteins - genetics | Trans-Activators - antagonists & inhibitors | COS Cells | Proteins | Genetics | Genes | Cells
Journal Article
Cancer cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, Lkb1 deletion and activation of Kras G12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these... 
CELLCYCLE | SIGNALING | INACTIVATION | SUPPRESSOR | SIGNATURES | ONCOLOGY | SRC | ADENOCARCINOMA | SENSITIVITY | MUTATIONS | LKB1/STK11 | EXPRESSION | TUMORIGENESIS | CELL BIOLOGY | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer
Journal Article
Leukemia, ISSN 0887-6924, 08/2007, Volume 21, Issue 8, pp. 1773 - 1782
...) and different leukemic cell lines was mediated by the Bcl-2 regulated intrinsic pathway and demonstrated a requirement for de novo protein synthesis... 
CLL | SUBEROYLANILIDE HYDROXAMIC ACID | bim | apoptosis | DEPENDENT APOPTOSIS | DEPSIPEPTIDE FR901228 | LYMPHOID MALIGNANCIES | Mcl-1 | ONCOLOGY | noxa | CHRONIC LYMPHOCYTIC-LEUKEMIA | TRAIL-INDUCED APOPTOSIS | FRAMESHIFT MUTATIONS | MELANOMA-CELLS | HEMATOLOGY | UP-REGULATION | BH3-ONLY PROTEINS | histone deacetylase inhibitors | Immunoprecipitation | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Transcriptional Activation | bcl-2 Homologous Antagonist-Killer Protein - genetics | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cell Nucleus - metabolism | Bcl-2-Like Protein 11 | RNA Interference | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Tumor Cells, Cultured | Proto-Oncogene Proteins - metabolism | Cell Line | Proto-Oncogene Proteins - antagonists & inhibitors | Membrane Proteins - genetics | RNA, Messenger - genetics | bcl-2 Homologous Antagonist-Killer Protein - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Tumor Suppressor Protein p53 - metabolism | Proto-Oncogene Proteins - genetics | Blotting, Western | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Apoptosis Regulatory Proteins - metabolism | Membrane Proteins - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Myeloid Cell Leukemia Sequence 1 Protein | Adaptor Proteins, Signal Transducing - genetics | Apoptosis Regulatory Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Histone Deacetylase Inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Usage | Care and treatment | Cancer cells | Histones | Research | Properties | Health aspects | Apoptosis | Cancer
Journal Article