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Nature Immunology, ISSN 1529-2908, 08/2010, Volume 11, Issue 8, pp. 734 - 742
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 02/2013, Volume 210, Issue 2, pp. 269 - 285
Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus weak T cell receptor binding by self-peptide-MHC complexes. We find... 
DEVELOPING THYMOCYTES | MEDICINE, RESEARCH & EXPERIMENTAL | TISSUE-RESTRICTED ANTIGENS | SELF-PEPTIDE | RECEPTOR TRANSGENIC MICE | IN-VIVO | BIM | NEGATIVE SELECTION | C-MYC | CLONAL DELETION | IMMUNOLOGY | EXPRESSION | Autoimmunity | Cell Proliferation | NF-kappa B - immunology | Proto-Oncogene Proteins c-rel - metabolism | Proto-Oncogene Proteins - biosynthesis | Proto-Oncogene Proteins c-rel - immunology | CARD Signaling Adaptor Proteins - genetics | CD4-Positive T-Lymphocytes - immunology | Membrane Proteins - deficiency | CARD Signaling Adaptor Proteins - metabolism | Bcl-2-Like Protein 11 | Receptors, CCR7 - metabolism | Apoptosis Regulatory Proteins - deficiency | Programmed Cell Death 1 Receptor - biosynthesis | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Transcription Factors - immunology | Apoptosis Regulatory Proteins - biosynthesis | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Lymphocyte Activation | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Self Tolerance | Membrane Proteins - immunology | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Transcription Factors - biosynthesis | Proto-Oncogene Proteins - deficiency | Clonal Deletion - immunology | Mice, Knockout | Membrane Proteins - biosynthesis | Animals | Apoptosis - immunology | Proto-Oncogene Proteins c-rel - genetics | NF-kappa B - biosynthesis | Mice | Mutation | Programmed Cell Death 1 Receptor - immunology | DNA-Binding Proteins - biosynthesis | Index Medicus | 309
Journal Article
Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 514 - 527
Interleukin-21 (IL-21) has broad actions on T and B cells, but its actions in innate immunity are poorly understood. Here we show that IL-21 induced apoptosis... 
NKT CELLS | HOMEOSTASIS | FOLLICULAR-HELPER-CELLS | HUMAN B-CELLS | STEADY-STATE | INTERLEUKIN-21 | DIFFERENTIATION | IMMUNOLOGY | IMMUNE TOLERANCE | T-CELLS | NEGATIVE REGULATOR | Natural Killer T-Cells - drug effects | Oligonucleotide Array Sequence Analysis | Apoptosis - drug effects | Dendritic Cells - immunology | STAT5 Transcription Factor - immunology | Receptors, Interleukin-21 - genetics | Interferon-gamma - metabolism | CD4-Positive T-Lymphocytes - immunology | Interleukins - genetics | Gene Expression - immunology | STAT3 Transcription Factor - genetics | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | DNA, Intergenic - genetics | Protein Binding - immunology | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Galactosylceramides - immunology | Mice | STAT3 Transcription Factor - immunology | Gene Expression - drug effects | Galactosylceramides - pharmacology | DNA-Binding Proteins - deficiency | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Receptors, Interleukin-21 - deficiency | Flow Cytometry | Bcl-2-Like Protein 11 | Natural Killer T-Cells - metabolism | DNA, Intergenic - metabolism | Interleukins - immunology | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Dendritic Cells - drug effects | Membrane Proteins - metabolism | Interleukins - pharmacology | Dendritic Cells - metabolism | STAT3 Transcription Factor - metabolism | Proto-Oncogene Proteins - metabolism | Receptors, Interleukin-21 - immunology | Mice, Inbred C57BL | Cells, Cultured | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Membrane Proteins - immunology | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Animals | Apoptosis - immunology | Interferon-gamma - immunology | CD4-Positive T-Lymphocytes - drug effects | DNA, Intergenic - immunology | Natural Killer T-Cells - immunology | Interleukins | Dendritic cells | Analysis | Genomics | Macrophage colony stimulating factor | Biological response modifiers | T cells | Apoptosis | Cytokines | Genes | Genomes | Kinases | Binding sites | Deoxyribonucleic acid--DNA | Index Medicus | apoptosis | dendritic cells | GM-CSF | IL-21
Journal Article
Immunity, ISSN 1074-7613, 04/2015, Volume 42, Issue 4, pp. 613 - 626
Epigenetic regulation of lineage-specific genes is important for the differentiation and function of T cells. Ten-eleven translocation (Tet) proteins catalyze... 
METHYLATION | INTERLEUKIN-27 | TRANSCRIPTION | DISEASE | POPULATIONS | PATTERNS | GENERATION | DIFFERENTIATION | SPECIFICATION | IMMUNOLOGY | PLASTICITY | Cytosine - analogs & derivatives | 5-Methylcytosine - analogs & derivatives | E1A-Associated p300 Protein - immunology | Humans | E1A-Associated p300 Protein - genetics | T-Box Domain Proteins - immunology | Th1 Cells - immunology | DNA Methylation | Cytosine - metabolism | Proto-Oncogene Proteins - immunology | Th17 Cells - cytology | Cell Differentiation | STAT4 Transcription Factor - immunology | Cytokines - immunology | Cytosine - immunology | DNA-Binding Proteins - immunology | Th17 Cells - enzymology | DNA - immunology | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | T-Box Domain Proteins - genetics | Animals | Epigenesis, Genetic - immunology | Th17 Cells - immunology | STAT4 Transcription Factor - genetics | Th1 Cells - enzymology | Mice | Th1 Cells - cytology | Genome | Cytokines - biosynthesis | Proteins | Epigenetic inheritance | Cytokines | Genes | Genomics | DNA | Genetic research | Genomes | Ophthalmology | T cells | Gene expression | Cell differentiation | Transcription factors | Lymphocytes | Rodents | DNA methylation | Epigenetics | Genetic testing | Experiments | Binding sites | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Nature immunology, ISSN 1529-2908, 2009, Volume 10, Issue 10, pp. 1081 - U58
Journal Article
Immunity, ISSN 1074-7613, 03/2012, Volume 36, Issue 3, pp. 401 - 414
Journal Article
Nature Immunology, ISSN 1529-2908, 03/2015, Volume 16, Issue 4, pp. 354 - 365
Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of the IL-1 ligand family and IL-1 receptor family, respectively. Here... 
CELLS | FAMILY-MEMBER | INFLAMMATION | TIR8/SIGIRR | INFECTION | IMMUNOLOGY | TOLL | INHIBITOR | EXPRESSION | NEGATIVE REGULATOR | MOLECULES | Inflammation - pathology | Interleukin-1 - genetics | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Humans | Receptors, Interleukin-1 - genetics | NF-kappa B - immunology | Receptor Protein-Tyrosine Kinases - immunology | Proto-Oncogene Proteins c-fyn - genetics | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | PTEN Phosphohydrolase - immunology | RNA, Small Interfering - immunology | Receptors, Interleukin-1 - deficiency | Leukocytes, Mononuclear - immunology | c-Mer Tyrosine Kinase | Interleukin-1 - immunology | Interleukin-18 Receptor alpha Subunit - genetics | Proto-Oncogene Proteins - immunology | Proto-Oncogene Proteins c-fyn - immunology | STAT3 Transcription Factor - genetics | Cell Line | PTEN Phosphohydrolase - genetics | Interleukin-18 Receptor alpha Subunit - immunology | Leukocytes, Mononuclear - drug effects | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | RNA-Binding Proteins - immunology | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Inflammation - immunology | Immunity, Innate | MAP Kinase Kinase Kinases - immunology | Interleukin-18 Receptor alpha Subunit - antagonists & inhibitors | Leukocytes, Mononuclear - pathology | TOR Serine-Threonine Kinases - immunology | Animals | NF-kappa B - genetics | Receptor Protein-Tyrosine Kinases - genetics | Lipopolysaccharides - pharmacology | Inflammation - genetics | Protein Binding | Mice | STAT3 Transcription Factor - immunology | Receptors, Interleukin-1 - antagonists & inhibitors | Index Medicus
Journal Article
Science, ISSN 0036-8075, 12/2015, Volume 350, Issue 6266, pp. 1387 - 1390
Journal Article
Immunity, ISSN 1074-7613, 09/2012, Volume 37, Issue 3, pp. 463 - 474
Natural helper (NH) cells are innate lymphoid cells (ILCs) that produce T helper-2 (Th2)-cell-type cytokines in the lung- and gut-associated lymphoid tissues.... 
PROGENITORS | CYTOKINES | ROR-GAMMA-T | BONE-MARROW | TYPE-2 IMMUNITY | MICE | INNATE LYMPHOID-CELLS | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | Antigens, Ly - genetics | Male | Th2 Cells - immunology | Proto-Oncogene Proteins c-kit - immunology | Interleukin Receptor Common gamma Subunit - immunology | Flow Cytometry | Lymphocytes - immunology | Allergens - immunology | T-Lymphocytes, Helper-Inducer - immunology | Bone Marrow Cells - immunology | Bone Marrow Transplantation | Pneumonia - immunology | Female | Papain - immunology | Proto-Oncogene Proteins c-kit - genetics | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Pneumonia - genetics | Lymphocytes - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | Nuclear Receptor Subfamily 1, Group F, Member 1 - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Membrane Proteins - immunology | Mice, SCID | Interleukin Receptor Common gamma Subunit - genetics | Th2 Cells - metabolism | Mice, Knockout | Animals | Antigens, Ly - immunology | Mice, Inbred NOD | Mice | Nuclear Receptor Subfamily 1, Group F, Member 1 - genetics | Bone Marrow Cells - metabolism | Cell Lineage - immunology | Allergens | Proteases | Lymphocytes | Oncology, Experimental | Bone marrow | Transplantation | Inflammation | Research | Cancer | Medical research | Lungs | Cytokines | Rodents | Gene expression | Small intestine | Experiments | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 12/2017, Volume 47, Issue 6, pp. 1083 - 1099.e6
The immunosuppressive protein PD-L1 is upregulated in many cancers and contributes to evasion of the host immune system. The relative importance of the tumor... 
PD-L1 | TTP | KRAS | RAS | tristetraprolin | immunotherapy | CELL LUNG-CANCER | ACTIVATED PROTEIN-KINASE | EPITHELIAL-CELLS | TRISTETRAPROLIN | MELANOMA-CELLS | TNF-ALPHA | IMMUNOLOGY | EXPRESSION | CHECKPOINT BLOCKADE | Proto-Oncogene Proteins p21(ras) - immunology | Neoplasm Transplantation | RNA, Messenger - immunology | Tumor Escape | Proto-Oncogene Proteins p21(ras) - genetics | Tristetraprolin - immunology | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - immunology | Lung Neoplasms - pathology | Male | Female | Intracellular Signaling Peptides and Proteins - genetics | Lung Neoplasms - genetics | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Epithelial Cells - pathology | RNA Cleavage | RNA Stability | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | MAP Kinase Kinase Kinases - immunology | Lung Neoplasms - immunology | Animals | Colorectal Neoplasms - immunology | Tristetraprolin - genetics | Epithelial Cells - immunology | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - immunology | Mice | Mice, Inbred BALB C | Colorectal Neoplasms - pathology | Messenger RNA | Gastrointestinal diseases |