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Nature (London), ISSN 1476-4687, 2010, Volume 468, Issue 7326, pp. 973 - 977
Journal Article
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 5, pp. 652 - 663
.... Ablation of B-Raf had no significant effect on tumor development. However, c-Raf expression was absolutely essential for the onset of NSCLC... 
C-RAF-1 GENE | APOPTOSIS | TUMOR PROGRESSION | ONCOLOGY | MAP KINASE | GROWTH | ORAL MEK INHIBITOR | PHASE-II | MICE | BRAF | CANCER | CELL BIOLOGY | Fibroblasts - enzymology | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Mitogen-Activated Protein Kinase 1 - deficiency | Lung Neoplasms - pathology | MAP Kinase Kinase 1 - genetics | Transfection | RNA Interference | Time Factors | Cellular Senescence | Mitogen-Activated Protein Kinase 1 - genetics | MAP Kinase Kinase 2 - genetics | Proto-Oncogene Proteins B-raf - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Proto-Oncogene Proteins B-raf - deficiency | Lung Neoplasms - enzymology | MAP Kinase Kinase 2 - deficiency | Mitogen-Activated Protein Kinase 3 - genetics | Proto-Oncogene Proteins c-raf - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Tumor Burden | Proto-Oncogene Proteins c-raf - metabolism | Mice, Knockout | Gene Expression Regulation, Enzymologic | Animals | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Line, Tumor | Mice | Mitogen-Activated Protein Kinase 3 - deficiency | Carcinoma, Non-Small-Cell Lung - enzymology | Genes, ras | Apoptosis | MAP Kinase Kinase 1 - deficiency | Development and progression | Carcinoma | Lung cancer, Non-small cell | Phosphotransferases | Cancer
Journal Article
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 480, Issue 7377, pp. 387 - 390
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 464, Issue 7287, pp. 427 - 430
.... Here we demonstrate the mechanistic basis for these findings. We used chemical genetic methods to show that drug-mediated transactivation of RAF dimers is responsible for paradoxical activation of the enzyme by inhibitors... 
SELECTIVE INHIBITOR | ACTIVATION | MELANOMA | MECHANISM | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | HETERODIMERIZATION | KINASE INHIBITOR | B-RAF | CRAF | ONCOGENIC BRAF | Neoplasms - metabolism | ras Proteins - genetics | Phosphorylation | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | Transcriptional Activation - drug effects | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Adenosine Triphosphate - metabolism | Indoles - pharmacology | raf Kinases - genetics | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Cell Line | raf Kinases - chemistry | Catalytic Domain | Neoplasms - enzymology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Models, Biological | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein Kinase Inhibitors - metabolism | Care and treatment | Enzyme inhibitors | Gene mutations | Cellular signal transduction | Genetic aspects | Research | Health aspects | Cancer | Proteins | Competition | Drugs | Mutation | Kinases | Tumors | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 15, pp. 13096 - 13105
.... A screen of protein kinases that bind to NHE1 revealed that B-Raf bound to the cytosolic regulatory tail of NHE1 Immunoprecipitation of NHE1 from He La and HEK cells confirmed the association of B-Raf with NHE1 in vivo... 
AMINO-ACIDS SER | PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | GROWTH | FUNCTIONAL-ANALYSIS | BRAF | MELANOMA-CELLS | INHIBITORS | Niacinamide - analogs & derivatives | Humans | Phenylurea Compounds | Extracellular Signal-Regulated MAP Kinases - metabolism | Mutation, Missense | Extracellular Signal-Regulated MAP Kinases - genetics | Cell Movement - genetics | Sodium-Hydrogen Exchangers - metabolism | Benzenesulfonates - pharmacology | Phosphorylation - genetics | Protein Isoforms - metabolism | Cation Transport Proteins - metabolism | Melanoma - genetics | HEK293 Cells | Cation Transport Proteins - genetics | Indoles - pharmacology | Sodium-Hydrogen Exchangers - genetics | Phosphorylation - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Protein Structure, Tertiary | Rabbits | Cell Size | Melanoma - pathology | Sulfonamides - pharmacology | Cell Movement - drug effects | Animals | Proto-Oncogene Proteins B-raf - genetics | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | HeLa Cells | Sodium-Hydrogen Exchanger 1 | Amino Acid Substitution | Hydrogen-Ion Concentration | Protein Isoforms - genetics | Membrane Proteins | Membrane Enzymes | Membrane Biology | Sodium Proton Exchange | Melanoma | Cell pH | Membrane
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 8, pp. 3041 - 3046
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 468, Issue 7326, pp. 968 - 972
...(1). Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK... 
TRANSFORMATION | CELLS | ACTIVATION | TUMOR PROGRESSION | GENE | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | BRAF | MUTATIONS | CANCER | Allosteric Regulation | Humans | Gene Expression Regulation, Neoplastic | Melanoma - enzymology | Gene Expression Profiling | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Indoles - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Gene Library | Proto-Oncogene Proteins c-raf - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Open Reading Frames - genetics | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein research | Research | Properties | Protein kinases | Cancer cells | Cell lines | Biochemistry | Mutation | Kinases | Genes | Cancer
Journal Article