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Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7326, pp. 973 - 977
Journal Article
Journal Article
Nature, ISSN 0028-0836, 07/2011, Volume 475, Issue 7354, pp. 106 - 110
Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer(1). Normally, ROS levels are tightly controlled by an inducible antioxidant program... 
TRANSFORMATION | OXIDATIVE STRESS | ACTIVATION | INHIBITION | K-RAS | PATHWAY | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | HEME OXYGENASE-1 | MUTATIONS | EXPRESSION | NIH 3T3 Cells | Cell Proliferation | Pancreatic Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Antioxidants - metabolism | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Cell Transformation, Neoplastic - genetics | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Proto-Oncogene Proteins B-raf - metabolism | Fibroblasts - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Oncogenes - genetics | Oxidation-Reduction | Pancreatic Neoplasms - pathology | Cells, Cultured | Pancreatic Neoplasms - genetics | NF-E2-Related Factor 2 - deficiency | Cell Transformation, Neoplastic - metabolism | Animals | Proto-Oncogene Proteins B-raf - genetics | Genes, myc - genetics | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Alleles | Cell Line, Tumor | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Polymerase chain reaction | Usage | Reactive oxygen species | Physiological aspects | Research | Gene expression | Oncogenes | Studies | Mass spectrometry | Rodents | Evacuations & rescues | Cancer | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 431 - 435
Activating mutations in KRAS and BRAF are found in more than 30% of all human tumours and 40% of melanoma, respectively, thus targeting this pathway could have... 
SELECTIVE INHIBITOR | POTENT | EFFICACY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | C-RAF | HETERODIMERIZATION | B-RAF | PROTEIN-KINASE KINASE | CANCER | Neoplasms - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | ras Proteins - metabolism | Protein Transport - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Benzamides - pharmacology | Cell Membrane - metabolism | raf Kinases - genetics | Cell Membrane - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Pyrazoles - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Indenes - pharmacology | raf Kinases - chemistry | Proto-Oncogene Proteins c-raf - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Ras genes | Growth | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Mitogen-activated protein kinases | Competition | Clinical trials | Enzymes | Kinases | Index Medicus | Proteins | Cellular | Inhibitors | Pathways | Tumours | Signalling | Dimerization
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 06/2010, Volume 107, Issue 23, pp. 10649 - 10654
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e33891 - e33891
Background: Langerhans cell histiocytosis (LCH) features inflammatory granuloma characterised by the presence of CD1a+ dendritic cells or 'LCH cells'.... 
ACTIVATION | MELANOMA | MULTIDISCIPLINARY SCIENCES | DYNAMICS | BRAF | PROLIFERATION | MUTATIONS | MULTIPLE SEQUENCE ALIGNMENT | EXPRESSION | CHILDHOOD | LESIONS | Granuloma - metabolism | Histiocytosis, Langerhans-Cell - genetics | Humans | Transcriptional Activation | Child, Preschool | Molecular Sequence Data | Infant | Male | Monocytes - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Histiocytosis, Langerhans-Cell - metabolism | Young Adult | Phosphorylation - genetics | HEK293 Cells | Female | Child | Proto-Oncogene Proteins B-raf - metabolism | Lymphocytes - metabolism | Amino Acid Sequence | Genetic Predisposition to Disease | Granuloma - genetics | Proto-Oncogene Proteins c-raf - genetics | Proto-Oncogene Proteins c-raf - metabolism | Polymorphism, Genetic | Sequence Homology, Amino Acid | Proto-Oncogene Proteins B-raf - genetics | Alleles | Histiocytosis, Langerhans-Cell - enzymology | Mutation | Pediatrics | RNA | Gene mutations | Dendritic cells | Genetic aspects | Children | Histiocytosis | T cells | Diseases | Granuloma | Phosphorylation | Senescence | Identification methods | Lymphocytes T | mRNA | Metastasis | Kinases | Paraffin | Blood | Cell activation | Cell growth | Lymphocytes | Cell cycle | Deoxyribonucleic acid--DNA | Hematology | Melanoma | Extracellular signal-regulated kinase | Abundance | Inflammation | Biophysics | Patients | Mutants | Medicine | Monocytes | Cellular biology | Diabetes | Conformation | Tumors | Cancer | Structure-function relationships | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article