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Journal Article
Leukemia, ISSN 0887-6924, 07/2011, Volume 25, Issue 7, pp. 1064 - 1079
It has become apparent that regulation of protein translation is an important determinant in controlling cell growth and leukemic transformation... 
mTOR | translation | sensitivity | PI3K | therapy | resistance | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Neoplasm Proteins - physiology | PTEN Phosphohydrolase - physiology | Apoptosis - genetics | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Gene Expression Regulation, Leukemic - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Transcription Factors - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | PTEN Phosphohydrolase - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Protein Processing, Post-Translational - drug effects | Drug Design | TOR Serine-Threonine Kinases - physiology | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Leukemia - genetics | Multiprotein Complexes - drug effects | PTEN Phosphohydrolase - genetics | Proteins - physiology | Transcription Factors - physiology | RNA, Messenger - genetics | Gene Expression Regulation, Leukemic - drug effects | Leukemia - drug therapy | Transcription Factors - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - physiology | Multiprotein Complexes - physiology | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Pseudogenes | Signal Transduction - drug effects | Phosphatidylinositol 3-Kinases - physiology | Proteins - drug effects | RNA, Neoplasm - genetics | Protein Biosynthesis - drug effects | MicroRNAs - genetics | Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Genes | Leukemia | Physiological aspects | Development and progression | Genetic aspects | Research | Antineoplastic agents | Drug therapy | Health aspects | Index Medicus
Journal Article
Cell death & disease, ISSN 2041-4889, 09/2017, Volume 8, Issue 9, pp. e3037 - e3037
.... Ribosomal protein s5 (RPS5) has been identified as a target of M19 and regulates PI3K/Akt, NF-kappa B and MAPKs pathways in osteoclastogenesis... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Mesenchymal Stromal Cells - cytology | RANK Ligand - pharmacology | Macrophage Colony-Stimulating Factor - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Mesenchymal Stromal Cells - drug effects | NF-kappa B - antagonists & inhibitors | Osteoclasts - pathology | Signal Transduction | Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Mesenchymal Stromal Cells - metabolism | Osteoporosis, Postmenopausal - genetics | Bone Density Conservation Agents - chemical synthesis | Ribosomal Proteins - agonists | Osteoporosis, Postmenopausal - drug therapy | Bone Density Conservation Agents - pharmacology | Mitogen-Activated Protein Kinases - genetics | Mice | Ovariectomy - adverse effects | Alkaloids - chemical synthesis | Osteoporosis, Postmenopausal - pathology | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Ribosomal Proteins - metabolism | Bone Marrow Cells - drug effects | Female | Benzopyrans - pharmacology | Osteogenesis - genetics | Osteoporosis, Postmenopausal - etiology | Alkaloids - pharmacology | Bone Marrow Cells - cytology | Ribosomal Proteins - genetics | Osteogenesis - drug effects | Gene Expression Regulation | Osteoclasts - metabolism | Phosphatidylinositol 3-Kinases - genetics | Bone Density - drug effects | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | NF-kappa B - genetics | RANK Ligand - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - agonists | Acetates - pharmacology | Primary Cell Culture | Bone Marrow Cells - metabolism | Osteoclasts - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mitogen-Activated Protein Kinases - metabolism | Mesenchyme | Ovariectomy | Ribosomal protein S5 | Menopause | Macrophage colony-stimulating factor | Stem cell transplantation | AKT protein | Post-menopause | 1-Phosphatidylinositol 3-kinase | Osteoclastogenesis | Osteoporosis | Allografts | Cellular biology | Bioactive compounds | Stem cells | Bone marrow | Hormone replacement therapy | Bone density | TRANCE protein | Bone loss | Public health | Osteogenesis | Adipogenesis | Index Medicus | Original
Journal Article
Scientific reports, ISSN 2045-2322, 05/2016, Volume 6, Issue 1, pp. 27071 - 27071
Until now, there is not yet antitumor drug with dramatically improved efficacy on non-small cell lung cancer (NSCLC). Marine organisms are rich source of novel... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cyclin D1 - metabolism | RNA-Binding Proteins - genetics | Reactive Oxygen Species | Triterpenes - pharmacology | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Humans | Cyclin-Dependent Kinase Inhibitor p27 - agonists | Gene Expression Regulation, Neoplastic | Autophagy-Related Protein 5 - genetics | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cyclin D1 - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Antineoplastic Agents - isolation & purification | Antineoplastic Agents - pharmacology | Porifera - chemistry | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | A549 Cells | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | G1 Phase Cell Cycle Checkpoints - genetics | Phosphatidylinositol 3-Kinases - genetics | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Cyclin D1 - genetics | Autophagy-Related Protein 5 - metabolism | Triterpenes - isolation & purification | Cell Proliferation - drug effects | G1 Phase Cell Cycle Checkpoints - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | RNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Index Medicus
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e85116 - e85116
...]. One important pathway that is frequently dysregulated is phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB or Akt)/mammalian target of rapamycin (mTOR... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cyclin D1 - metabolism | Microtubule-Associated Proteins - genetics | Nitriles - pharmacology | TOR Serine-Threonine Kinases - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Microtubule-Associated Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Gastric Mucosa - pathology | Gastric Mucosa - metabolism | Autophagy - drug effects | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Chloroquine - pharmacology | PTEN Phosphohydrolase - antagonists & inhibitors | Cyclin D1 - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Gastric Mucosa - drug effects | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Everolimus | Beclin-1 | PTEN Phosphohydrolase - genetics | Butadienes - pharmacology | Sirolimus - analogs & derivatives | Adenine - analogs & derivatives | Signal Transduction | Membrane Proteins - genetics | PTEN Phosphohydrolase - metabolism | Adenine - pharmacology | Microtubule-Associated Proteins - antagonists & inhibitors | Sirolimus - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Cyclin D1 - genetics | Membrane Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Apoptosis | Mitogen-Activated Protein Kinases - metabolism | Biochemistry | Phosphatases | Stomach cancer | Cancer cells | Cancer | TOR protein | Toxicity | Chloroquine | Cytotoxicity | Oncology | Homology | AKT protein | Cyclin D1 | Kinases | Cancer therapies | Autophagy | Proteins | Cell growth | Cell cycle | Inhibition | Growth factors | Gastric cancer | Tensin | Mortality | Extracellular signal-regulated kinase | MAP kinase | Rapamycin | Inhibitors | Cell death | PTEN protein | Phagocytosis | Index Medicus
Journal Article