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Cancer Research, ISSN 0008-5472, 2010, Volume 70, Issue 11, pp. 4528 - 4538
MicroRNA-21 (miR-21) was reported to be overexpressed and contributes to invasion and gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC). The... 
SURVIVAL | CELLS | INVASION | METASTASIS | INHIBITION | ONCOLOGY | PHOSPHORYLATION | POOR-PROGNOSIS | ADENOCARCINOMA | EXPRESSION PROFILES | CHEMOTHERAPY | Vascular Endothelial Growth Factor A - biosynthesis | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Middle Aged | Carcinoma, Pancreatic Ductal - metabolism | Apoptosis - genetics | Carcinoma, Pancreatic Ductal - genetics | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | RNA, Messenger - biosynthesis | Deoxycytidine - therapeutic use | Matrix Metalloproteinase 9 - genetics | Aged, 80 and over | Adult | Retrospective Studies | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Matrix Metalloproteinase 2 - biosynthesis | Matrix Metalloproteinase 9 - biosynthesis | Cell Growth Processes - drug effects | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | PTEN Phosphohydrolase - biosynthesis | MicroRNAs - biosynthesis | Pancreatic Neoplasms - genetics | Treatment Outcome | Carcinoma, Pancreatic Ductal - pathology | Proto-Oncogene Proteins c-akt - biosynthesis | Carcinoma, Pancreatic Ductal - drug therapy | Matrix Metalloproteinase 2 - genetics | Antimetabolites, Antineoplastic - therapeutic use | Cell Line, Tumor | Aged | MicroRNAs - genetics | Deoxycytidine - analogs & derivatives | Index Medicus
Journal Article
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 11/2014, Volume 41, Issue 5, pp. 802 - 814
Protein kinase B (also known as AKT) and the mechanistic target of rapamycin (mTOR) are central regulators of T cell differentiation, proliferation,... 
PATHWAYS | RESPONSES | EFFECTOR FUNCTIONS | ACTIVATION | MEMORY | METABOLISM | TOLERANCE | DIFFERENTIATION | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | EXHAUSTION | Forkhead Transcription Factors - immunology | Lymphocytic choriomeningitis virus - immunology | Humans | Antibodies, Blocking - pharmacology | Lymphocytic Choriomeningitis - immunology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Lymphocyte Activation - immunology | Programmed Cell Death 1 Receptor - biosynthesis | Receptors, Antigen, T-Cell - immunology | Granzymes - biosynthesis | TOR Serine-Threonine Kinases - biosynthesis | T-Lymphocytes, Cytotoxic - immunology | Forkhead Transcription Factors - biosynthesis | Lymphocytic Choriomeningitis - virology | Jurkat Cells | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Mice, Transgenic | CD28 Antigens - immunology | Forkhead Transcription Factors - genetics | Sirolimus - pharmacology | Proto-Oncogene Proteins c-akt - biosynthesis | Cell Differentiation - immunology | Animals | Cell Line, Tumor | Forkhead Box Protein O1 | Mice | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Chronic Disease | T-Lymphocytes, Cytotoxic - cytology | Interferon-gamma - biosynthesis | T cell receptors | Kinases | Plasmids | Viral infections | Immune system | Index Medicus
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2010, Volume 430, Issue 1, pp. 141 - 149
A paradoxical but common finding in the obesity clinic is the identification of individuals who can be considered 'inappropriately' healthy for their degree of... 
Obesity | Signal transduction | Insulin resistance | Inflammation | 3T3-L1 ADIPOCYTES | SER | PROINFLAMMATORY STATE | signal transduction | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONONUCLEAR-CELLS | ALPHA | inflammation | RESISTANCE | insulin resistance | INSULIN-RECEPTOR SUBSTRATE-1 | obesity | Insulin - physiology | Humans | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Obesity, Morbid - immunology | Male | Interleukin-1beta - genetics | I-kappa B Proteins - biosynthesis | I-kappa B Proteins - genetics | Proto-Oncogene Proteins c-akt - genetics | RNA, Messenger - biosynthesis | Inflammation - metabolism | Insulin Receptor Substrate Proteins - biosynthesis | Adult | Female | Interleukin-1beta - biosynthesis | Insulin Receptor Substrate Proteins - genetics | Obesity, Morbid - metabolism | Macrophages - immunology | Biomarkers - metabolism | Intra-Abdominal Fat - immunology | NF-KappaB Inhibitor alpha | Interleukin-6 - genetics | Insulin Resistance | Mitogen-Activated Protein Kinases - biosynthesis | Inflammation - immunology | Intra-Abdominal Fat - metabolism | Proto-Oncogene Proteins c-akt - biosynthesis | NF-kappa B - genetics | NF-kappa B - biosynthesis | Interleukin-6 - biosynthesis | Mitogen-Activated Protein Kinases - genetics | Tumor Necrosis Factor-alpha - biosynthesis | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 01/2009, Volume 104, Issue 1, pp. 15 - 18
Ischemic postconditioning (IPoC) reduces infarct size following ischemia/reperfusion. Whether or not phosphorylation of RISK (reperfusion injury salvage... 
PERMEABILITY TRANSITION PORE | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTECTION | REPERFUSION | reperfusion injury | NECROSIS-FACTOR-ALPHA | ADENOSINE RECEPTORS | infarct size | INHIBITION | MYOCARDIAL INFARCT SIZE | cardioprotection | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | MOUSE HEARTS | SIGNAL TRANSDUCER | Glycogen Synthase Kinase 3 - physiology | MAP Kinase Kinase 2 - physiology | Nitriles - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Glycogen Synthase Kinase 3 beta | Ribosomal Protein S6 Kinases, 70-kDa - physiology | MAP Kinase Kinase 1 - physiology | Myocardial Reperfusion Injury - enzymology | Ribosomal Protein S6 Kinases, 70-kDa - biosynthesis | Protein Processing, Post-Translational - drug effects | Swine | Mitogen-Activated Protein Kinase 3 - biosynthesis | Myocardial Infarction - pathology | Swine, Miniature | Phosphorylation - drug effects | Myocardial Infarction - enzymology | MAP Kinase Kinase 1 - antagonists & inhibitors | Butadienes - pharmacology | Glycogen Synthase Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 1 - physiology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Coronary Occlusion - enzymology | Enzyme Induction | Proto-Oncogene Proteins c-akt - physiology | Enzyme Activation - drug effects | Mitogen-Activated Protein Kinase 3 - physiology | Mitogen-Activated Protein Kinase 1 - biosynthesis | Proto-Oncogene Proteins c-akt - biosynthesis | Animals | Androstadienes - pharmacology | Myocardial Reperfusion | MAP Kinase Kinase 2 - antagonists & inhibitors | Coronary Occlusion - pathology | Phosphatidylinositol 3-Kinases - physiology | Protein Kinase Inhibitors - pharmacology | Myocardial Reperfusion Injury - prevention & control | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 03/2010, Volume 70, Issue 6, pp. 2264 - 2273
Journal Article
Oncogene, ISSN 0950-9232, 03/2008, Volume 27, Issue 12, pp. 1749 - 1758
Journal Article
Cancer Research, ISSN 0008-5472, 04/2008, Volume 68, Issue 7, pp. 2391 - 2399
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 07/2011, Volume 71, Issue 13, pp. 4720 - 4731
Journal Article
STEM CELLS, ISSN 1066-5099, 01/2013, Volume 31, Issue 1, pp. 146 - 155
Tumor tropism of human bone marrow‐derived mesenchymal stem cells (MSC) has been exploited for the delivery of therapeutic genes for anticancer therapy.... 
Angiogenesis | Interleukin‐1β | Glioma | Platelet derived growth factor | Mesenchymal stem cells | Interleukin-1β | MIGRATION | ENDOTHELIAL PROGENITOR-CELL | PERICYTE RECRUITMENT | BLOOD-VESSEL FORMATION | CATHEPSIN-B EXPRESSION | TUMOR ANGIOGENESIS | Interleukin-1 beta | CELL & TISSUE ENGINEERING | CELL BIOLOGY | PDGFR-BETA | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROSTATE TUMOR | SMOOTH-MUSCLE-CELLS | STROMAL CELLS | HEMATOLOGY | Human Umbilical Vein Endothelial Cells | Coculture Techniques | Humans | Neovascularization, Pathologic | Bone Marrow Cells - physiology | Tumor Microenvironment | RNA, Messenger - metabolism | Brain Neoplasms - metabolism | Glioma - pathology | Glioma - therapy | Cathepsin B - biosynthesis | Interleukin-1beta - biosynthesis | Mesenchymal Stromal Cells - physiology | Proto-Oncogene Proteins c-sis - biosynthesis | Proto-Oncogene Proteins c-sis - genetics | Astrocytes | Down-Regulation | RNA, Messenger - genetics | Receptors, Platelet-Derived Growth Factor - genetics | Proto-Oncogene Proteins c-akt - biosynthesis | Animals | Mice, Nude | Brain Neoplasms - therapy | Receptors, Platelet-Derived Growth Factor - biosynthesis | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Mesenchymal Stem Cell Transplantation | Neurosciences | Platelet-derived growth factor | Growth | Oncology, Experimental | Genes | College graduates | Antibodies | Cathepsins | Information management | Research | Financial disclosure | Endothelium | Viral antibodies | Stem cell research | Anopheles | Messenger RNA | Interleukins | Gliomas | Analysis | Stem cells | Physiological aspects | Research institutes | Protein binding | Cancer | Bone marrow | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2016, Volume 304, pp. 59 - 69
Honokiol, an active constituent extracted from the bark of , possesses anticancer effects. Apoptosis is classified as type I programmed cell death, while... 
Honokiol | Malignant glioma | Autophagy | ROS | p53/PI3K/Akt/mTOR | APOPTOSIS | GLIOBLASTOMA-MULTIFORME | PROTEIN-KINASE | DNA-DAMAGE | CYCLE ARREST | P53 | BREAST-CANCER | IN-VITRO | INHIBITION | GROWTH | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Reactive Oxygen Species - metabolism | Tumor Suppressor Protein p53 - biosynthesis | Apoptosis - drug effects | Microtubule-Associated Proteins - drug effects | Autophagy - drug effects | Biphenyl Compounds - toxicity | Dose-Response Relationship, Drug | Lignans - toxicity | Time Factors | Phosphatidylinositol 3-Kinases - drug effects | RNA, Small Interfering - biosynthesis | Caspase 3 - drug effects | Caspase 3 - biosynthesis | TOR Serine-Threonine Kinases - biosynthesis | Phosphatidylinositol 3-Kinases - biosynthesis | TOR Serine-Threonine Kinases - drug effects | Adenine - analogs & derivatives | Signal Transduction | Down-Regulation | Adenine - pharmacology | Microtubule-Associated Proteins - biosynthesis | Sirolimus - pharmacology | Tumor Suppressor Protein p53 - drug effects | Proto-Oncogene Proteins c-akt - biosynthesis | Animals | Ascorbic Acid - pharmacology | Cell Line, Tumor | Mice | Glioma - drug therapy | Proto-Oncogene Proteins c-akt - drug effects | Biochemistry | Tumor proteins | Gliomas | Cell death | Index Medicus | GLIOMAS | ANTIOXIDANTS | RNA | IN VIVO | 60 APPLIED LIFE SCIENCES | ASCORBIC ACID | CONCENTRATION RATIO | ABUNDANCE | IN VITRO | CELL CYCLE | MICE | PROTEINS | TIME DEPENDENCE
Journal Article