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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 04/2016, Volume 113, Issue 16, pp. 4482 - 4487
The cell of origin for prostate cancer remains a subject of debate. Genetically engineered mouse models have demonstrated that both basal and luminal cells can... 
Oragnoid culture | Luminal cell | Cancer differentiation | Cells of origin | Human prostate cancer | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Epithelial Cells - metabolism | Kallikreins - biosynthesis | Humans | Male | Prostate - metabolism | Proto-Oncogene Proteins c-akt - genetics | Prostate - pathology | Prostate-Specific Antigen - biosynthesis | Proto-Oncogene Proteins c-myc - biosynthesis | Heterografts | Prostatic Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Receptors, Androgen - biosynthesis | Organoids - metabolism | Cell Differentiation | Prostate-Specific Antigen - genetics | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Organoids - pathology | Transduction, Genetic | Kallikreins - genetics | PTEN Phosphohydrolase - biosynthesis | Epithelial Cells - pathology | Mice, SCID | Cell Transformation, Neoplastic - metabolism | Lentivirus | Proto-Oncogene Proteins c-akt - biosynthesis | Animals | Receptors, Androgen - genetics | Cell Line, Tumor | Mice | Proto-Oncogene Proteins c-myc - genetics | Causes of | Cell differentiation | Epithelial cells | Prostate cancer | Health aspects | Index Medicus | Biological Sciences | cells of origin | cancer differentiation | human prostate cancer | luminal cell | oragnoid culture
Journal Article
Journal of cell science, ISSN 1477-9137, 09/2011, Volume 124, Issue 17, pp. 2997 - 3005
Journal Article
Cell cycle (Georgetown, Tex.), ISSN 1538-4101, 10/2014, Volume 11, Issue 15, pp. 2911 - 2921
Journal Article
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 08/2016, Volume 304, pp. 59 - 69
Honokiol, an active constituent extracted from the bark of Magnolia officinalis, possesses anticancer effects. Apoptosis is classified as type I programmed... 
Honokiol | Malignant glioma | Autophagy | ROS | p53/PI3K/Akt/mTOR | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Reactive Oxygen Species - metabolism | Tumor Suppressor Protein p53 - biosynthesis | Apoptosis - drug effects | Microtubule-Associated Proteins - drug effects | Autophagy - drug effects | Biphenyl Compounds - toxicity | Dose-Response Relationship, Drug | Lignans - toxicity | Time Factors | Phosphatidylinositol 3-Kinases - drug effects | RNA, Small Interfering - biosynthesis | Caspase 3 - drug effects | Caspase 3 - biosynthesis | TOR Serine-Threonine Kinases - biosynthesis | Phosphatidylinositol 3-Kinases - biosynthesis | TOR Serine-Threonine Kinases - drug effects | Adenine - analogs & derivatives | Signal Transduction | Down-Regulation | Adenine - pharmacology | Microtubule-Associated Proteins - biosynthesis | Sirolimus - pharmacology | Tumor Suppressor Protein p53 - drug effects | Proto-Oncogene Proteins c-akt - biosynthesis | Animals | Ascorbic Acid - pharmacology | Cell Line, Tumor | Mice | Glioma - drug therapy | Proto-Oncogene Proteins c-akt - drug effects | Biochemistry | Tumor proteins | Gliomas | Cell death | Index Medicus | GLIOMAS | APOPTOSIS | ANTIOXIDANTS | RNA | IN VIVO | 60 APPLIED LIFE SCIENCES | ASCORBIC ACID | CONCENTRATION RATIO | ABUNDANCE | IN VITRO | CELL CYCLE | MICE | PROTEINS | TIME DEPENDENCE
Journal Article
PloS one, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e40967 - e40967
MicroRNAs (miRNAs) are endogenous small non-coding RNAs that play central roles in diverse pathological processes. In this study, we investigated the effect of... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cyclin D2 - genetics | Humans | Gene Expression Regulation, Neoplastic | 3' Untranslated Regions - genetics | Male | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | MAP Kinase Signaling System - genetics | Melanoma - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Female | Uveal Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Genes, Tumor Suppressor | Microphthalmia-Associated Transcription Factor - biosynthesis | Melanoma - metabolism | Uveal Neoplasms - genetics | Uveal Neoplasms - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Down-Regulation | Tumor Suppressor Protein p53 - metabolism | MicroRNAs - biosynthesis | Melanoma - pathology | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | RNA, Neoplasm - biosynthesis | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Line, Tumor | RNA, Neoplasm - genetics | MicroRNAs - genetics | Cyclin D2 - biosynthesis | Microphthalmia-Associated Transcription Factor - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | MicroRNA | Analysis | Melanoma | Research | Tumor proteins | Tumors | Apoptosis | Transcription factors | Target recognition | Leukocyte migration | Laboratories | p53 Protein | Science | AKT protein | Metastasis | D2 protein | Cyclin D2 | Skin cancer | c-Met protein | Transfection | Cell cycle | miRNA | Tumorigenesis | Bioinformatics | Microphthalmia-associated transcription factor | Invasiveness | Extracellular signal-regulated kinase | Optometry | Gene expression | Ribonucleic acid--RNA | Hospitals | MicroRNAs | Tumor suppressor genes | Mutation | Cell migration | Index Medicus | RNA | Ribonucleic acid
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 07/2011, Volume 71, Issue 13, pp. 4720 - 4731
Journal Article
Leukemia, ISSN 0887-6924, 07/2011, Volume 25, Issue 7, pp. 1064 - 1079
It has become apparent that regulation of protein translation is an important determinant in controlling cell growth and leukemic transformation... 
mTOR | translation | sensitivity | PI3K | therapy | resistance | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Neoplasm Proteins - physiology | PTEN Phosphohydrolase - physiology | Apoptosis - genetics | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Gene Expression Regulation, Leukemic - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Transcription Factors - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | PTEN Phosphohydrolase - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Protein Processing, Post-Translational - drug effects | Drug Design | TOR Serine-Threonine Kinases - physiology | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Leukemia - genetics | Multiprotein Complexes - drug effects | PTEN Phosphohydrolase - genetics | Proteins - physiology | Transcription Factors - physiology | RNA, Messenger - genetics | Gene Expression Regulation, Leukemic - drug effects | Leukemia - drug therapy | Transcription Factors - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - physiology | Multiprotein Complexes - physiology | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Pseudogenes | Signal Transduction - drug effects | Phosphatidylinositol 3-Kinases - physiology | Proteins - drug effects | RNA, Neoplasm - genetics | Protein Biosynthesis - drug effects | MicroRNAs - genetics | Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Genes | Leukemia | Physiological aspects | Development and progression | Genetic aspects | Research | Antineoplastic agents | Drug therapy | Health aspects | Index Medicus
Journal Article