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Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 9, pp. 4314 - 4325
Locating a ligand-binding site is an important first step in structure-guided drug discovery, but current methods do little to suggest which interactions... 
Proto-Oncogene Proteins c-akt - chemistry | Peptide Synthases - chemistry | Protein Binding | Ligands | Proteins - chemistry | Binding Sites | Molecular Dynamics Simulation
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7497, pp. 541 - 545
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Nature, ISSN 0028-0836, 07/2007, Volume 448, Issue 7152, pp. 439 - 444
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Journal Article
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Clinical Cancer Research, ISSN 1078-0432, 05/2014, Volume 20, Issue 9, pp. 2476 - 2484
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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2014, Volume 447, Issue 4, pp. 707 - 714
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7657, pp. 307 - 307
As key executers of biological functions, the activity and abundance of proteins are subjected to extensive regulation. Deciphering the genetic architecture... 
YEAST | UBIQUITINATION | CIRCUITS | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | COMPLEXES | VIRUS ENTRY | SCREENS | NETWORKS | BETA-GAMMA-SUBUNITS | HUMAN INTERACTOME | Proto-Oncogene Proteins c-akt - chemistry | Receptors, G-Protein-Coupled - metabolism | Histones - chemistry | Humans | Cells, Cultured | Heterotrimeric GTP-Binding Proteins - metabolism | Signal Transduction - genetics | Potassium Channels - genetics | Potassium Channels - metabolism | Haploidy | Phenotype | Phosphorylation - genetics | Mutagenesis | Proteolysis | Single-Cell Analysis - methods | Receptors, G-Protein-Coupled - antagonists & inhibitors | Interferons - metabolism | Histones - metabolism | Potassium Channels - deficiency | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Wnt Signaling Pathway | Mitogen-Activated Protein Kinases - metabolism | Cell receptors | Genetic aspects | Cellular signal transduction | G proteins | Proteins | Cells | Networks | Deregulation | G protein-coupled receptors | Wnt protein | Transcription | Genes | Gene regulation | Switching theory | AKT protein | Kinases | Guanine nucleotide-binding protein | Gene sequencing | Wiring | Signal transduction | Maps | Pathways | Cascades | Random mutagenesis | Single-cell protein | Genetics | Cues | Splicing | Architecture | MAP kinase | Abundance | Exposure | Gene expression | Suppressors | Biological activity | Protein kinase | Interferon | Mutation | Methylation | Gene mapping | Cancer | Index Medicus
Journal Article