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Nature Medicine, ISSN 1078-8956, 09/2017, Volume 23, Issue 9, pp. 1055 - 1062
Bromodomain and extraterminal domain (BET) protein inhibitors are emerging as promising anticancer therapies. The gene encoding the E3 ubiquitin ligase... 
SELECTIVE-INHIBITION | TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | ANDROGEN RECEPTOR | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | ENHANCERS | CELL BIOLOGY | RNA-SEQ | BROMODOMAIN INHIBITION | MUTATIONS | BRD4 | Prostatic Neoplasms - metabolism | Immunoprecipitation | TOR Serine-Threonine Kinases - metabolism | Humans | Drug Resistance, Neoplasm | Male | Gene Expression Profiling | Molecular Targeted Therapy | Mechanistic Target of Rapamycin Complex 1 | Transcription Factors - drug effects | Multiprotein Complexes - metabolism | Prostatic Neoplasms - genetics | Proteasome Endopeptidase Complex - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Nuclear Proteins - drug effects | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | TOR Serine-Threonine Kinases - drug effects | Multiprotein Complexes - drug effects | Prostatic Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Triazoles - therapeutic use | Cell Survival | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Azepines - therapeutic use | RNA-Binding Proteins - drug effects | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Nuclear Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mutation | RNA-Binding Proteins - metabolism | rac1 GTP-Binding Protein - metabolism | Proto-Oncogene Proteins c-akt - drug effects | rac1 GTP-Binding Protein - genetics | Gene mutations | Physiological aspects | Genetic aspects | Research | Drug resistance | Drug therapy | Prostate cancer | Ubiquitin | Inhibitor drugs | Stabilization | AKT protein | Activation | Biosynthesis | Degradation | Proteins | Ubiquitination | Transcription activation | Bioindicators | Ubiquitin-protein ligase | Binding | Rac1 protein | Tumor cell lines | Gene expression | Cholesterol | Mutants | Inhibitors | Proteasomes | Biomarkers | Bet protein | Prostate | Cancer | Guanosinetriphosphatase
Journal Article
Nature Medicine, ISSN 1078-8956, 2015, Volume 21, Issue 3, pp. 231 - 238
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2011, Volume 121, Issue 6, pp. 2242 - 2253
Probiotic bacteria can potentially have beneficial effects on the clinical course of several intestinal disorders, but our understanding of probiotic action is... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR RECEPTOR | EPITHELIAL-CELLS | CROHNS-DISEASE | INDUCED APOPTOSIS | SULFATE-INDUCED COLITIS | IMMUNE-RESPONSES | LACTOBACILLUS-GG | ACTIVE ULCERATIVE-COLITIS | PLACEBO-CONTROLLED TRIAL | OXAZOLONE COLITIS | Recombinant Proteins - therapeutic use | Hydrogels | Apoptosis - drug effects | Epithelial Cells - drug effects | Oxazolone - toxicity | Receptor, Epidermal Growth Factor - drug effects | Administration, Rectal | Quinazolines | Probiotics - chemistry | Bacterial Proteins - therapeutic use | Intestinal Mucosa - drug effects | Microspheres | Lactobacillus rhamnosus - chemistry | Colitis - chemically induced | Colitis - drug therapy | Drug Evaluation, Preclinical | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Epidermal Growth Factor - physiology | Permeability - drug effects | Mice, Inbred C57BL | Epithelial Cells - pathology | Tyrphostins - pharmacology | Lactobacillus rhamnosus - physiology | Recombinant Proteins - pharmacology | Enzyme Activation - drug effects | Bacterial Proteins - administration & dosage | Recombinant Proteins - administration & dosage | Dextran Sulfate - toxicity | Bacterial Proteins - pharmacology | Animals | Colitis - enzymology | Signal Transduction - drug effects | Epithelial Cells - enzymology | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Bacterial Proteins - isolation & purification | Colitis - prevention & control | Intestinal Mucosa - pathology | Proto-Oncogene Proteins c-akt - drug effects | Inflammation | Gastrointestinal diseases | Analysis | Apoptosis
Journal Article
Cancer Treatment Reviews, ISSN 0305-7372, 2014, Volume 40, Issue 6, pp. 750 - 759
Abstract The hedgehog (Hh) pathway is aberrantly activated in a number of tumors. In medulloblastoma, basal cell carcinoma, and rhabdomyosarcoma, mutations in... 
Hematology, Oncology and Palliative Medicine | Hedgehog | Smoothened | Combination chemotherapy | Targeted therapy | Novel antitumor agents | Cell signaling | STEM-CELLS | ACTIVATED PROTEIN-KINASE | SELF-RENEWAL | CHRONIC MYELOID-LEUKEMIA | EPITHELIAL-MESENCHYMAL TRANSITION | GLI TRANSCRIPTION FACTORS | ONCOLOGY | BASAL-CELL CARCINOMA | PROSTATE-CANCER | TARGETING HEDGEHOG | SONIC-HEDGEHOG | Hedgehog Proteins - drug effects | Neoplasms - metabolism | TOR Serine-Threonine Kinases - metabolism | Receptors, Notch - metabolism | Humans | Hedgehog Proteins - metabolism | Receptor, Epidermal Growth Factor - drug effects | Phosphatidylinositol 3-Kinases - metabolism | raf Kinases - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Receptor, Epidermal Growth Factor - metabolism | Phosphatidylinositol 3-Kinases - drug effects | Proto-Oncogene Proteins c-akt - metabolism | TOR Serine-Threonine Kinases - drug effects | Janus Kinase 2 - antagonists & inhibitors | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins p21(ras) - metabolism | Receptors, Notch - drug effects | Fusion Proteins, bcr-abl - drug effects | Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - drug effects | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | raf Kinases - drug effects | Fusion Proteins, bcr-abl - metabolism | Proto-Oncogene Proteins c-akt - drug effects | Receptor Cross-Talk - drug effects | Care and treatment | Health aspects | Leukemia | Analysis | Cancer
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2011, Volume 31, Issue 11, pp. 2616 - 2623
OBJECTIVE—Reduced plasma adiponectin (APN) in diabetic patients is associated with endothelial dysfunction. However, APN knockout animals manifest modest... 
endothelial function | nitric oxide | diabetes mellitus | signal transduction | T-CADHERIN | REGULATED KINASE | INSULIN-RESISTANCE | ENDOTHELIAL-CELLS | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | MICE | HYPOADIPONECTINEMIA | RECEPTORS | HEMATOLOGY | SYNTHASE ACTIVATION | ADIPOSE-TISSUE | Endothelium, Vascular - cytology | AMP-Activated Protein Kinases - metabolism | Humans | Receptors, Adiponectin - metabolism | Endothelium, Vascular - drug effects | Aorta - metabolism | Glycoproteins - pharmacology | AMP-Activated Protein Kinases - drug effects | Receptors, Adiponectin - antagonists & inhibitors | Nitric Oxide Synthase Type III - metabolism | Phosphorylation - drug effects | Vasodilation - physiology | Proto-Oncogene Proteins c-akt - metabolism | Adiponectin - pharmacology | AMP-Activated Protein Kinases - antagonists & inhibitors | Aorta - drug effects | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Enzyme Inhibitors - pharmacology | Mice, Knockout | Animals | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Signal Transduction - physiology | Mice | Vasodilation - drug effects | Nitric Oxide - metabolism | Receptors, Adiponectin - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - drug effects | Endothelial Function | Nitric Oxide | Diabetes | Signal Transduction
Journal Article
Cancer Research, ISSN 0008-5472, 06/2007, Volume 67, Issue 12, pp. 5840 - 5850
Journal Article