X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (23644) 23644
Publication (4328) 4328
Book Review (62) 62
Book Chapter (34) 34
Dissertation (23) 23
Conference Proceeding (20) 20
Magazine Article (5) 5
Data Set (3) 3
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
proto-oncogene proteins c-akt - metabolism (17577) 17577
humans (16302) 16302
index medicus (16090) 16090
animals (14295) 14295
mice (9092) 9092
phosphorylation (8068) 8068
signal transduction (7958) 7958
phosphatidylinositol 3-kinases - metabolism (6909) 6909
cell line, tumor (6582) 6582
male (5976) 5976
apoptosis (5938) 5938
cell biology (5851) 5851
proto-oncogene proteins c-akt - genetics (5823) 5823
female (5655) 5655
oncology (5418) 5418
signal transduction - drug effects (4911) 4911
biochemistry & molecular biology (4775) 4775
expression (4738) 4738
activation (4715) 4715
akt (4503) 4503
cancer (3841) 3841
rats (3284) 3284
proto-oncogene proteins c-akt (3282) 3282
apoptosis - drug effects (3251) 3251
cells, cultured (3213) 3213
proteins (3201) 3201
cell proliferation (3077) 3077
kinases (2988) 2988
cell line (2792) 2792
akt protein (2713) 2713
gene expression (2624) 2624
proto-oncogene proteins - metabolism (2600) 2600
cell proliferation - drug effects (2509) 2509
article (2484) 2484
research (2418) 2418
phosphorylation - drug effects (2371) 2371
growth (2159) 2159
pathway (2127) 2127
research article (2116) 2116
phosphatidylinositol 3-kinases - genetics (2110) 2110
proto-oncogene proteins c-akt - antagonists & inhibitors (2105) 2105
blotting, western (2087) 2087
signal transduction - physiology (2069) 2069
mice, inbred c57bl (1978) 1978
inhibition (1968) 1968
tor serine-threonine kinases - metabolism (1951) 1951
transfection (1945) 1945
analysis (1908) 1908
gene expression regulation, neoplastic (1894) 1894
multidisciplinary sciences (1879) 1879
protein-serine-threonine kinases - metabolism (1864) 1864
mutation (1852) 1852
enzyme activation (1841) 1841
mice, knockout (1809) 1809
medicine (1798) 1798
rna interference (1775) 1775
phosphatidylinositol 3-kinases - antagonists & inhibitors (1772) 1772
genetic aspects (1740) 1740
proliferation (1739) 1739
cells (1738) 1738
middle aged (1684) 1684
physiological aspects (1647) 1647
survival (1638) 1638
cell survival - drug effects (1581) 1581
antineoplastic agents - pharmacology (1577) 1577
extracellular signal-regulated map kinases - metabolism (1570) 1570
protein-serine-threonine kinases (1558) 1558
down-regulation (1548) 1548
metastasis (1535) 1535
rna, messenger - metabolism (1502) 1502
health aspects (1493) 1493
science (1486) 1486
rodents (1474) 1474
up-regulation (1472) 1472
gene-expression (1436) 1436
tumors (1436) 1436
disease models, animal (1422) 1422
oxidative stress (1409) 1409
insulin (1404) 1404
phosphatidylinositol 3-kinase (1399) 1399
cell cycle (1397) 1397
mice, nude (1381) 1381
physiology (1378) 1378
rna, messenger - genetics (1377) 1377
biology (1367) 1367
adult (1316) 1316
protein kinase inhibitors - pharmacology (1312) 1312
time factors (1305) 1305
signal transduction - genetics (1289) 1289
in-vivo (1282) 1282
enzyme inhibitors - pharmacology (1276) 1276
1-phosphatidylinositol 3-kinase (1275) 1275
in-vitro (1264) 1264
cell survival (1239) 1239
nf-kappa b - metabolism (1236) 1236
cell growth (1213) 1213
nf-kappa-b (1213) 1213
breast cancer (1200) 1200
signaling (1196) 1196
reverse transcriptase polymerase chain reaction (1195) 1195
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (23444) 23444
Chinese (151) 151
Japanese (19) 19
Russian (16) 16
French (12) 12
German (3) 3
Spanish (2) 2
Italian (1) 1
Korean (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Nature Communications, ISSN 2041-1723, 07/2015, Volume 6, Issue 1, p. 7557
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number... 
WIDE DNA METHYLATION | AMPLIFICATION | PIK3CA GENE | EMBRYONAL RHABDOMYOSARCOMA | PATHWAY MUTATIONS | ADOLESCENTS | MULTIDISCIPLINARY SCIENCES | PTEN | ALVEOLAR RHABDOMYOSARCOMA | HUMAN CANCER | BREAST | Paired Box Transcription Factors - genetics | F-Box-WD Repeat-Containing Protein 7 | ras Proteins - genetics | Prognosis | Rhabdomyosarcoma, Embryonal - classification | Humans | Transcriptome | Child, Preschool | PAX7 Transcription Factor - genetics | Infant | Male | Rhabdomyosarcoma, Alveolar - classification | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Exome | Rhabdomyosarcoma, Embryonal - genetics | Young Adult | Cell Cycle Proteins - genetics | Female | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Child | Gene Expression Regulation, Neoplastic - genetics | PTEN Phosphohydrolase - genetics | PAX3 Transcription Factor | Rhabdomyosarcoma, Alveolar - genetics | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | DNA Methylation - genetics | Forkhead Transcription Factors - genetics | beta Catenin - genetics | Epigenesis, Genetic - genetics | Adolescent | Rhabdomyosarcoma - classification | Forkhead Box Protein O1 | Rhabdomyosarcoma - genetics | Mutation | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics
Journal Article
Journal Article
Journal Article
Annual Review of Medicine, ISSN 0066-4219, 1/2016, Volume 67, Issue 1, pp. 11 - 28
Anticancer targeted therapies are designed to exploit a particular vulnerability in the tumor, which in most cases results from its dependence on an oncogene... 
lymphoproliferative disorders | mammalian target of rapamycin (mTOR) | mutation | breast cancer | phosphoinositide 3-kinase (PI3K) AKT | pathway inhibitors | Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K)/AKT | Breast cancer | Lymphoproliferative disorders | Mutation | Pathway inhibitors | MEDICINE, RESEARCH & EXPERIMENTAL | PIK3CA MUTATIONS | PHOSPHATIDYLINOSITOL 3-KINASE | TYROSINE KINASE | ESTROGEN DEPRIVATION | phosphoinositide 3-kinase (PI3K)/AKT | PHOSPHOINOSITIDE 3-KINASE | RENAL-CELL CARCINOMA | POSITIVE BREAST-CANCER | MAMMARY-TUMORS | CHRONIC LYMPHOCYTIC-LEUKEMIA | UP-REGULATION | TOR Serine-Threonine Kinases - metabolism | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Antineoplastic Agents - therapeutic use | Receptors, Estrogen - analysis | Receptor Protein-Tyrosine Kinases - metabolism | Breast Neoplasms - drug therapy | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Breast Neoplasms - chemistry | Phosphatidylinositol 3-Kinase - genetics | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Female | Lymphoproliferative Disorders - drug therapy | Receptor, ErbB-2 - analysis | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Care and treatment | Protein kinases | Health aspects | Methods | Cancer
Journal Article
Science Signaling, ISSN 1945-0877, 06/2012, Volume 5, Issue 230, pp. ra46 - ra46
Journal Article