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British journal of clinical pharmacology, ISSN 0306-5251, 2016, Volume 82, Issue 4, pp. 943 - 956
Journal Article
The FASEB journal, ISSN 1530-6860, 2010, Volume 25, Issue 3, pp. 1028 - 1039
Journal Article
PLoS biology, ISSN 1545-7885, 2009, Volume 7, Issue 6, p. e1000121
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 48, pp. 18782 - 18787
Journal Article
Cell Cycle, ISSN 1551-4005, 2014, Volume 8, Issue 16, pp. 2502 - 2508
The Akt (PKB) protein kinases are critical regulators of human physiology that control an impressive array of diverse cellular functions, including the modulation of growth, survival, proliferation and metabolism... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Glucose homeostasis | Akt2 | Isoforms | Akt1 | Akt | GLUT4 | Metabolism | Cellular growth | Signaling specificity | signaling specificity | GLUT4-CONTAINING VESICLES | STIMULATED GLUT4 TRANSLOCATION | GTPASE-ACTIVATING-PROTEIN | isoforms | PLASMA-MEMBRANE | MICE LACKING | CELL BIOLOGY | cellular growth | glucose homeostasis | SKELETAL-MUSCLE | GLUCOSE-HOMEOSTASIS | SIGNALING PATHWAY | CELL-MIGRATION | INSULIN-RESISTANCE | metabolism | cancer
Journal Article
Cancer cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 58 - 71
Activation of the PI3K-AKT pathway in tumors is modulated by negative feedback, including mTORC1-mediated inhibition of upstream signaling. We now show that... 
RAPAMYCIN | TARGET | FORKHEAD TRANSCRIPTION FACTOR | CELLS | INSULIN-RECEPTOR | ACTIVATION | ONCOLOGY | SIGNALING PATHWAY | PHOSPHORYLATION | UPSTREAM | HUMAN CANCER | CELL BIOLOGY | RNA, Small Interfering - genetics | Receptor, IGF Type 1 - metabolism | Protein Binding - genetics | Receptor, ErbB-3 - metabolism | Humans | Forkhead Transcription Factors - metabolism | Protein Binding - drug effects | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Receptor, ErbB-2 - antagonists & inhibitors | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Quinoxalines - therapeutic use | Carcinoma, Non-Small-Cell Lung - metabolism | Receptor, ErbB-3 - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Breast Neoplasms - drug therapy | Receptor, IGF Type 1 - genetics | Signal Transduction - drug effects | Mice, Nude | Models, Biological | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | Feedback, Physiological - physiology | Quinazolines - pharmacology | Proteins - antagonists & inhibitors | Neoplasms - metabolism | Gene Expression - drug effects | Multiprotein Complexes | Receptor, ErbB-2 - metabolism | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Mechanistic Target of Rapamycin Complex 1 | Quinoxalines - pharmacology | Receptor, Insulin - genetics | Female | Forkhead Transcription Factors - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Drug Therapy, Combination | Gene Expression Regulation, Neoplastic - physiology | Carcinoma, Non-Small-Cell Lung - pathology | Up-Regulation - genetics | Forkhead Transcription Factors - genetics | Xenograft Model Antitumor Assays | Animals | Receptor Protein-Tyrosine Kinases - genetics | Breast Neoplasms - pathology | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Feedback, Physiological - drug effects | Receptor, Insulin - metabolism | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Benzylamines - pharmacology | Benzylamines - therapeutic use | Proto-Oncogene Proteins c-akt - antagonists & inhibitors
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e83080
Aberrant proliferation of nucleus pulposus cell is implicated in the pathogenesis of intervertebral disc degeneration. Recent findings revealed that microRNAs,... 
OVARIAN-CANCER CELLS | BREAST-CANCER | TRANSFORMATION | INVASION | METASTASIS | SIGNALING PATHWAY | MIR-B-10 | MULTIDISCIPLINARY SCIENCES | GROWTH | UP-REGULATION | EXPRESSION | RNA, Small Interfering - genetics | Phosphorylation | Cell Proliferation | rho GTP-Binding Proteins - antagonists & inhibitors | Homeodomain Proteins - metabolism | Humans | Middle Aged | Spine - metabolism | Male | MicroRNAs - metabolism | Proto-Oncogene Proteins c-akt - genetics | Intervertebral Disc Degeneration - metabolism | Intervertebral Disc Degeneration - pathology | Adult | Female | Proto-Oncogene Proteins c-akt - metabolism | Spine - pathology | Chondrocytes - metabolism | Intervertebral Disc Degeneration - genetics | Chondrocytes - pathology | Signal Transduction | rho GTP-Binding Proteins - genetics | Gene Expression Regulation | rhoC GTP-Binding Protein | Transcription Factors - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | rho GTP-Binding Proteins - metabolism | MicroRNAs - genetics | Primary Cell Culture | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | RNA, Small Interfering - metabolism | Physiological aspects | Development and progression | MicroRNA | Comparative analysis | Scoliosis | Cell proliferation | Disease | Laboratories | Pathogenesis | AKT protein | Nucleus pulposus | Intervertebral discs | Tissues | Nuclei | Stomach cancer | Ovarian cancer | Cell growth | Rodents | Surgery | miRNA | Degeneration | Inhibition | Ribonucleic acid--RNA | Hospitals | MicroRNAs | Medical prognosis | Nuclei (cytology) | Aberration | Apoptosis | RNA | Ribonucleic acid
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 5, p. e0127942
Myocardial ischemia reperfusion injury (IRI) adversely affects cardiac performance and the prognosis of patients with acute myocardial infarction. Although... 
HEART | OVEREXPRESSION | HYPERTROPHY | JAK-STAT PATHWAY | MULTIDISCIPLINARY SCIENCES | KINASE | TRANSDUCER | INDUCIBLE GENE | TRANSCRIPTION-3 | AKT | CONFERS RESISTANCE | Mitogen-Activated Protein Kinase 3 - genetics | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Suppressor of Cytokine Signaling Proteins - genetics | Myocardium - pathology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Signaling System | Mice, Knockout | Muscle Proteins - genetics | Myocardial Reperfusion Injury - metabolism | Suppressor of Cytokine Signaling 3 Protein | Phosphorylation - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Gene Deletion | Myocardium - metabolism | Muscle Proteins - metabolism | Mice | Suppressor of Cytokine Signaling Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Myocardial Reperfusion Injury - genetics | Myocardial Reperfusion Injury - prevention & control | Prevention | Physiological aspects | Cellular signal transduction | Research | Cytokines | Reperfusion injury | Heart | Myocardial infarction | Phosphorylation | Bcl-2 protein | Transcription | Physicians | Leukemia | Myocardial ischemia | AKT protein | Activation | Kinases | Proteins | Signal transduction | Mitochondria | Negative feedback | Reperfusion | Ischemia | Clonal deletion | Rodents | Janus kinase | Heart diseases | Internal medicine | Coronary artery | Stat3 protein | Extracellular signal-regulated kinase | Cardiomyocytes | Mcl-1 protein | Medicine | Signaling | Injury prevention | Coronary vessels | Infarction | Apoptosis
Journal Article