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1. Full Text Interferon-γ Excess Leads to Pathogenic Accumulation of Follicular Helper T Cells and Germinal Centers
by Lee, Sau K and Silva, Diego G and Martin, Jaime L and Pratama, Alvin and Hu, Xin and Chang, Pheh-Ping and Walters, Giles and Vinuesa, Carola G
Immunity (Cambridge, Mass.), ISSN 1074-7613, 11/2012, Volume 37, Issue 5, pp. 880 - 892
Life Sciences & Biomedicine | Immunology | Science & Technology | RNA, Messenger - immunology | Nephritis - genetics | Germinal Center - immunology | Autoimmunity - genetics | Interferon-gamma - metabolism | CD4-Positive T-Lymphocytes - immunology | Nephritis - immunology | Autoimmunity - immunology | T-Lymphocytes, Helper-Inducer - immunology | Proto-Oncogene Proteins c-bcl-6 - metabolism | Female | T-Lymphocytes, Helper-Inducer - pathology | Interferon-gamma - genetics | Receptors, Interferon - genetics | B-Lymphocytes - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | CD4-Positive T-Lymphocytes - metabolism | Germinal Center - pathology | Receptors, Interferon - metabolism | Proto-Oncogene Proteins c-bcl-6 - genetics | Autoantibodies - immunology | Animals | B-Lymphocytes - immunology | Germinal Center - metabolism | Receptors, Interferon - immunology | Interferon-gamma - immunology | Nephritis - metabolism | Mice | Proto-Oncogene Proteins c-bcl-6 - immunology | Index Medicus
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2. Full Text The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells
by Ise, Wataru and Kohyama, Masako and Schraml, Barbara U and Zhang, Tingting and Schwer, Bjoern and Basu, Uttiya and Alt, Frederick W and Tang, Jun and Oltz, Eugene M and Murphy, Theresa L and Murphy, Kenneth M
Nature immunology, ISSN 1529-2908, 06/2011, Volume 12, Issue 6, pp. 536 - 543
Life Sciences & Biomedicine | Immunology | Science & Technology | Basic-Leucine Zipper Transcription Factors - metabolism | Oligonucleotide Array Sequence Analysis | Germinal Center - immunology | Immunoglobulin Class Switching - immunology | Basic-Leucine Zipper Transcription Factors - immunology | Male | Gene Expression Profiling | Mice, 129 Strain | CD40 Ligand - immunology | Lymphocyte Activation - immunology | CD40 Ligand - metabolism | Flow Cytometry | T-Lymphocytes - metabolism | Recombination, Genetic | Proto-Oncogene Proteins c-bcl-6 - metabolism | Female | B-Lymphocytes - metabolism | Carrier Proteins - immunology | Cytidine Deaminase - genetics | Mice, Inbred C57BL | Cells, Cultured | Basic-Leucine Zipper Transcription Factors - genetics | Mice, Inbred Strains | Mice, Knockout | Proto-Oncogene Proteins c-bcl-6 - genetics | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Animals | B-Lymphocytes - immunology | Carrier Proteins - metabolism | Germinal Center - metabolism | CD40 Ligand - genetics | Cytidine Deaminase - metabolism | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Immunoglobulin Class Switching - genetics | Proto-Oncogene Proteins c-bcl-6 - immunology | Physiological aspects | Transcription factors | B cells | Research | Gene expression | T cells | Index Medicus
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3. Full Text Development of a Novel B‑Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6
by McCoull, William and Cheung, Tony and Anderson, Erica and Barton, Peter and Burgess, Jonathan and Byth, Kate and Cao, Qing and Castaldi, M. Paola and Chen, Huawei and Chiarparin, Elisabetta and Carbajo, Rodrigo J and Code, Erin and Cowan, Suzanna and Davey, Paul R and Ferguson, Andrew D and Fillery, Shaun and Fuller, Nathan O and Gao, Ning and Hargreaves, David and Howard, Martin R and Hu, Jun and Kawatkar, Aarti and Kemmitt, Paul D and Leo, Elisabetta and Molina, Daniel M and O’Connell, Nichole and Petteruti, Philip and Rasmusson, Timothy and Raubo, Piotr and Rawlins, Philip B and Ricchiuto, Piero and Robb, Graeme R and Schenone, Monica and Waring, Michael J and Zinda, Michael and Fawell, Stephen and Wilson, David M
ACS chemical biology, ISSN 1554-8929, 11/2018, Volume 13, Issue 11, pp. 3131 - 3141
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Proto-Oncogene Proteins c-bcl-6 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-6 - chemistry | Lymphoma, Large B-Cell, Diffuse - drug therapy | Thalidomide - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Quinolones - metabolism | Ubiquitin-Protein Ligases - metabolism | Quinolones - pharmacology | Thalidomide - pharmacology | Antineoplastic Agents - metabolism | Thalidomide - analogs & derivatives | Thalidomide - chemical synthesis | Quinolones - chemical synthesis | Proteolysis | Proto-Oncogene Proteins c-bcl-6 - metabolism | HEK293 Cells | Cell Line, Tumor | Protein Binding | Ligands | Antineoplastic Agents - pharmacology | Peptide Hydrolases - metabolism | Index Medicus
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4. Full Text Discovery of a B‑Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach
by Kamada, Yusuke and Sakai, Nozomu and Sogabe, Satoshi and Ida, Koh and Oki, Hideyuki and Sakamoto, Kotaro and Lane, Weston and Snell, Gyorgy and Iida, Motoo and Imaeda, Yasuhiro and Sakamoto, Junichi and Matsui, Junji
Journal of medicinal chemistry, ISSN 0022-2623, 05/2017, Volume 60, Issue 10, pp. 4358 - 4368
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Surface Plasmon Resonance | Proto-Oncogene Proteins c-bcl-6 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-6 - chemistry | Small Molecule Libraries - chemistry | Small Molecule Libraries - pharmacology | Protein Interaction Maps - drug effects | Humans | Proto-Oncogene Proteins c-bcl-6 - metabolism | Ligands | Molecular Docking Simulation | Drug Discovery | Index Medicus
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5. Full Text The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns
by Oestreich, Kenneth J and Huang, Albert C and Weinmann, Amy S
The Journal of experimental medicine, ISSN 0022-1007, 05/2011, Volume 208, Issue 5, pp. 1001 - 1013
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Genetic Loci - genetics | Suppressor of Cytokine Signaling 1 Protein | T-Box Domain Proteins - immunology | Th1 Cells - immunology | Genetic Loci - immunology | Th1 Cells - metabolism | Cell Differentiation - genetics | Proto-Oncogene Proteins c-bcl-6 - metabolism | Response Elements - genetics | T Cell Transcription Factor 1 - metabolism | Repressor Proteins - metabolism | Cell Line | Suppressor of Cytokine Signaling Proteins - immunology | Hepatocyte Nuclear Factor 1-alpha | Repressor Proteins - genetics | Suppressor of Cytokine Signaling Proteins - genetics | T-Box Domain Proteins - genetics | Down-Regulation - genetics | Response Elements - immunology | T-Box Domain Proteins - metabolism | Mice, Knockout | T Cell Transcription Factor 1 - genetics | Proto-Oncogene Proteins c-bcl-6 - genetics | Autoimmunity - physiology | Cell Differentiation - immunology | Suppressor of Cytokine Signaling 3 Protein | Animals | Down-Regulation - immunology | Repressor Proteins - immunology | T Cell Transcription Factor 1 - immunology | Transcription, Genetic - immunology | Mice | Th1 Cells - cytology | Suppressor of Cytokine Signaling Proteins - metabolism | Transcription, Genetic - genetics | Proto-Oncogene Proteins c-bcl-6 - immunology | Index Medicus
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6. Full Text Structure of a BCOR Corepressor Peptide in Complex with the BCL6 BTB Domain Dimer
by Ghetu, Alexandru F and Corcoran, Connie M and Cerchietti, Leandro and Bardwell, Vivian J and Melnick, Ari and Privé, Gilbert G
Molecular cell, ISSN 1097-2765, 2008, Volume 29, Issue 3, pp. 384 - 391
DNA | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Models, Chemical | Molecular Sequence Data | Crystallography, X-Ray | Proto-Oncogene Proteins - chemistry | Recombinant Fusion Proteins - metabolism | Peptides - metabolism | Proto-Oncogene Proteins c-bcl-6 - metabolism | Thioredoxins - metabolism | Binding Sites | Dimerization | Repressor Proteins - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Proto-Oncogene Proteins c-bcl-6 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-6 - chemistry | Repressor Proteins - chemistry | Protein Structure, Secondary | Models, Molecular | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Recombinant Fusion Proteins - chemistry | Amino Acid Motifs | Peptides - isolation & purification | Sequence Alignment | Proto-Oncogene Proteins c-bcl-6 - isolation & purification | Protein Binding | Protein Conformation | Mutation | Histidine - chemistry | Peptides | Lymphomas | Cells | Index Medicus
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7. Full Text Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms
by Huang, Chuanxin and Hatzi, Katerina and Melnick, Ari
Nature immunology, ISSN 1529-2908, 04/2013, Volume 14, Issue 4, pp. 380 - 388
Life Sciences & Biomedicine | Immunology | Science & Technology | T-Lymphocyte Subsets - immunology | Immunoglobulins - immunology | T-Lymphocyte Subsets - cytology | Germinal Center - immunology | Cell Survival - genetics | Antibody Affinity - immunology | Immunoglobulins - metabolism | Lymphocyte Activation - immunology | T-Lymphocytes, Helper-Inducer - immunology | Proto-Oncogene Proteins c-bcl-6 - metabolism | T-Lymphocytes, Helper-Inducer - cytology | Female | Germinal Center - cytology | Cell Lineage - genetics | Macrophages - immunology | Chemokines - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Inflammation - immunology | Cell Survival - immunology | Mice, Knockout | Proto-Oncogene Proteins c-bcl-6 - genetics | Macrophages - metabolism | Phenotype | Animals | B-Lymphocytes - immunology | Germinal Center - metabolism | Inflammation - genetics | Chemokines - metabolism | Mice | Proto-Oncogene Proteins c-bcl-6 - immunology | Cell Lineage - immunology | Transcription factors | Immune response | Genetic aspects | Zinc finger proteins | Research | Macrophages | Properties | Index Medicus
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8. Full Text Small-molecule-induced polymerization triggers degradation of BCL6
by Słabicki, Mikołaj and Yoon, Hojong and Koeppel, Jonas and Nitsch, Lena and Roy Burman, Shourya S and Di Genua, Cristina and Donovan, Katherine A and Sperling, Adam S and Hunkeler, Moritz and Tsai, Jonathan M and Sharma, Rohan and Guirguis, Andrew and Zou, Charles and Chudasama, Priya and Gasser, Jessica A and Miller, Peter G and Scholl, Claudia and Fröhling, Stefan and Nowak, Radosław P and Fischer, Eric S and Ebert, Benjamin L
Nature (London), ISSN 0028-0836, 12/2020, Volume 588, Issue 7836, pp. 164 - 168
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Proto-Oncogene Proteins c-bcl-6 - ultrastructure | Proto-Oncogene Proteins c-bcl-6 - chemistry | Solvents | Humans | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Cryoelectron Microscopy | Polymerization - drug effects | Proteolysis - drug effects | Synthetic Biology | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | Proto-Oncogene Proteins c-bcl-6 - metabolism | Ligands | Proteasome Endopeptidase Complex - metabolism | In Vitro Techniques | Ubiquitin | Transcription factors | Polymerization | Pharmacology | Electron microscopy | Lymphoma | Chemical compounds | Proteins | Degradation | Ubiquitination | Filaments | Proteasomes | Thalidomide | Ubiquitin-protein ligase | Bcl-6 protein | Index Medicus
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9. Full Text CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles
by Leong, Yew Ann and Chen, Yaping and Ong, Hong Sheng and Wu, Di and Man, Kevin and Deleage, Claire and Minnich, Martina and Meckiff, Benjamin J and Wei, Yunbo and Hou, Zhaohua and Zotos, Dimitra and Fenix, Kevin A and Atnerkar, Anurag and Preston, Simon and Chipman, Jeffrey G and Beilman, Greg J and Allison, Cody C and Sun, Lei and Wang, Peng and Xu, Jiawei and Toe, Jesse G and Lu, Hao K and Tao, Yong and Palendira, Umaimainthan and Dent, Alexander L and Landay, Alan L and Pellegrini, Marc and Comerford, Iain and McColl, Shaun R and Schacker, Timothy W and Long, Heather M and Estes, Jacob D and Busslinger, Meinrad and Belz, Gabrielle T and Lewin, Sharon R and Kallies, Axel and Yu, Di
Nature immunology, ISSN 1529-2908, 09/2016, Volume 17, Issue 10, pp. 1187 - 1196
Life Sciences & Biomedicine | Immunology | Science & Technology | Lymphocytic choriomeningitis virus - immunology | Hepatocyte Nuclear Factor 1-alpha - genetics | Humans | Male | HIV - immunology | Hepatocyte Nuclear Factor 1-alpha - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Proto-Oncogene Proteins c-bcl-6 - metabolism | Cell Differentiation | Arenaviridae Infections - immunology | T-Lymphocytes, Cytotoxic - immunology | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptors, CXCR5 - metabolism | Receptors, CXCR5 - genetics | Epstein-Barr Virus Infections - immunology | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Mice, Transgenic | Germinal Center - pathology | Transcription Factors - genetics | Proto-Oncogene Proteins c-bcl-6 - genetics | Transcription Factors - metabolism | Animals | B-Lymphocytes - immunology | Germinal Center - virology | Mice | Positive Regulatory Domain I-Binding Factor 1 | Cell receptors | Innovations | Genetic aspects | Properties | Gene expression | T cells | Health aspects | Chemokines | Infection control | Index Medicus
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10. Full Text An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8 + T Cells
by Cui, Weiguo and Liu, Ying and Weinstein, Jason S and Craft, Joseph and Kaech, Susan M
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2011, Volume 35, Issue 5, pp. 792 - 805
Life Sciences & Biomedicine | Immunology | Science & Technology | CD8-Positive T-Lymphocytes - cytology | Signal Transduction | Suppressor of Cytokine Signaling Proteins - immunology | Transcription Factors - genetics | T-Box Domain Proteins - genetics | Interleukins - metabolism | T-Box Domain Proteins - metabolism | Mice, Knockout | Proto-Oncogene Proteins c-bcl-6 - genetics | Transcription Factors - metabolism | Suppressor of Cytokine Signaling 3 Protein | Animals | CD8-Positive T-Lymphocytes - virology | Gene Expression Regulation, Developmental | Proto-Oncogene Proteins c-bcl-6 - metabolism | CD8-Positive T-Lymphocytes - metabolism | Interleukin-10 - metabolism | Cell Differentiation | Mice | CD8-Positive T-Lymphocytes - immunology | Immunologic Memory - immunology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Positive Regulatory Domain I-Binding Factor 1 | Transcription factors | Cytokines | Kinases | Rodents | Viral infections | Stem cells | Index Medicus
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