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Oncogene, ISSN 1476-5594, 2012, Volume 32, Issue 22, pp. 2767 - 2781
.... Here, we show that c-Kit is not just a marker of OTICs, but also a critical mediator of the phenotype that can be a viable target for the treatment of ovarian cancer... 
b-catenin | chemoresistance | c-Kit | ovarian cancer | ABCG2 | beta-catenin | SURFACE EPITHELIUM | ONCOLOGY-GROUP | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLATINUM-RESISTANT | CHRONIC MYELOID-LEUKEMIA | CELL BIOLOGY | PHASE-II TRIAL | ONCOLOGY | SEROUS CARCINOMA | GENETICS & HEREDITY | IMATINIB MESYLATE | EPITHELIAL OVARIAN | CLINICOPATHOLOGICAL FEATURES | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Paclitaxel - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Tumor Microenvironment | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Wnt Proteins - metabolism | Cell Hypoxia | Neoplastic Stem Cells - metabolism | RNA Interference | Cell Transformation, Neoplastic - genetics | ATP-Binding Cassette Transporters - metabolism | Female | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - drug therapy | Cell Survival - drug effects | Cisplatin - pharmacology | Pyrimidines - pharmacology | Cell Transformation, Neoplastic - metabolism | Imatinib Mesylate | Piperazines - pharmacology | beta Catenin - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Wnt Signaling Pathway - drug effects | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering
Journal Article
Blood, ISSN 0006-4971, 12/2008, Volume 112, Issue 12, pp. 4646 - 4654
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 6, pp. 2450 - 2455
.... We and others have identified activating mutations of C-KIT in nearly half of patients with t (8;21) AML. To test the hypothesis that activating C-KIT mutations cooperate... 
Cell growth | Receptors | 3T3 cells | NIH 3T3 cells | Myeloid leukemia | Leukemia | Mice | Transplantation | Genetic mutation | Blood | Interleukin-3 | Mouse model | Combinatorial therapy | Targeted therapy | Stem cell factor | TRANSCRIPTION FACTORS | GENE-MUTATIONS | targeted therapy | interleukin-3 | PROGNOSTIC IMPACT | stem cell factor | mouse model | MULTIDISCIPLINARY SCIENCES | FUSION GENE | MURINE MODEL | combinatorial therapy | MYELOPROLIFERATIVE DISEASE | EMBRYONIC LETHALITY | STI-571 INHIBITION | GASTROINTESTINAL STROMAL TUMORS | RECEPTOR TYROSINE KINASE | Chromosomes, Human, Pair 8 - genetics | NIH 3T3 Cells | Chromosomes, Human, Pair 21 - metabolism | Oncogene Proteins, Fusion - metabolism | Cytarabine - pharmacology | Humans | Leukemia, Myeloid, Acute - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Cell Transformation, Neoplastic - genetics | Leukemia, Lymphoid - metabolism | Antimetabolites, Antineoplastic - pharmacology | Proto-Oncogene Proteins c-kit - genetics | Leukemia, Lymphoid - genetics | Protein Structure, Tertiary | Core Binding Factor Alpha 2 Subunit - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Transgenic | Leukemia, Lymphoid - pathology | Chromosomes, Human, Pair 21 - genetics | Cell Transformation, Neoplastic - metabolism | RUNX1 Translocation Partner 1 Protein | Chromosomes, Human, Pair 8 - metabolism | Animals | Oncogene Proteins, Fusion - genetics | Mutation | Cell Transformation, Neoplastic - pathology | Core Binding Factor Alpha 2 Subunit - genetics | Leukemia, Myeloid, Acute - genetics | Translocation, Genetic - genetics | Gene mutations | Health aspects | Biological Sciences
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2010, Volume 70, Issue 13, pp. 5438 - 5447
Journal Article
Oncogene, ISSN 0950-9232, 02/2012, Volume 31, Issue 7, pp. 869 - 883
.... However, the functional significance of c-Kit expression in the mammary gland is unknown... 
progenitor | Brca1 | c-Kit | mammary | LINEAGE-COMMITMENT | STEM-CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | PROTEIN-TYROSINE KINASE | CELL BIOLOGY | SIGNAL-TRANSDUCTION | FUNCTIONAL MAMMARY-GLAND | 2 SPLICE FORMS | ONCOLOGY | ESTROGEN-RECEPTOR-ALPHA | GENETICS & HEREDITY | NIH 3T3 Cells | Cell Proliferation | Epithelial Cells - metabolism | Humans | Gene Expression Regulation, Neoplastic | Cell Survival - genetics | Apoptosis - genetics | Gene Expression Profiling | Mammary Neoplasms, Experimental - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Stem Cells - metabolism | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - metabolism | Cell Differentiation - genetics | RNA Interference | BRCA1 Protein - metabolism | Mammary Neoplasms, Experimental - pathology | Estrogen Receptor alpha - metabolism | Female | Proto-Oncogene Proteins c-kit - genetics | Cells, Cultured | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mammary Glands, Animal - cytology | BRCA1 Protein - genetics | Animals | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Mammary Glands, Animal - metabolism | Breast Neoplasms - pathology | Mice | Mutation | Signal transduction | Cell growth | Breast cancer | Gene expression | Flow cytometry | Cell survival | BRCA1 protein | Colonies | Estrogens | Epithelium | c-Kit protein | Overexpression | Stem cells | KIT protein | Lyn protein | Mammary gland | Differentiation | Apoptosis | Tumors
Journal Article
PloS one, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e43952
textabstractActivating c-KIT mutations (exons 11 and 17) are found in 10-40% of testicular seminomas, the majority being missense point mutations (codon 816... 
Y-CHROMOSOME | GENE | MULTIDISCIPLINARY SCIENCES | TESTICULAR SEMINOMA | GERM-CELL TUMORS | RECEPTOR | GASTROINTESTINAL STROMAL TUMORS | EXPRESSION | GENOME-WIDE ASSOCIATION | INTERSTITIAL-CELLS | FEMALE | Humans | Ovarian Neoplasms - pathology | Child, Preschool | Infant | Male | Dysgerminoma - complications | Ovarian Neoplasms - complications | Proto-Oncogene Proteins c-kit - metabolism | Testicular Neoplasms - pathology | Testicular Neoplasms - complications | Octamer Transcription Factor-3 - genetics | Ovarian Neoplasms - genetics | DNA Mutational Analysis | Disorders of Sex Development - pathology | Biomarkers, Tumor - metabolism | Cell Cycle Proteins - genetics | Disorders of Sex Development - complications | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Child | Dysgerminoma - pathology | Testicular Neoplasms - genetics | Gonadoblastoma - complications | Cell Cycle Proteins - metabolism | Dysgerminoma - genetics | Disorders of Sex Development - genetics | Gonadoblastoma - genetics | Octamer Transcription Factor-3 - metabolism | Adolescent | Gonadoblastoma - pathology | Biomarkers, Tumor - genetics | Mutation | Gene mutations | Germ cell tumors | Physiological aspects | Genetic aspects | Research | Risk factors | Prevalence studies (Epidemiology) | Sequences | Exons | Oct-4 protein | Health risks | Melting curve | Kinases | c-Kit protein | Patients | Aberration | Lesions | Testes | Chromosomes | Chromosome aberrations | Cancer | Tumors
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 2011, Volume 29, Issue 21, pp. 2904 - 2909
Journal Article
Annals of oncology, ISSN 0923-7534, 09/2012, Volume 23, Issue 9, pp. 2409 - 2414
...), focusing on the expression and mutations of c-KIT. Immunohistochemical expression of c-KIT/CD117, p63, CD5 and neuroendocrine markers, as well as mutational analysis of c-KIT exons 9, 11, 13, 14, 17 by direct sequencing of 48 cases of TCs... 
mutation | CD117 | thymus | immunohistochemistry | c-KIT | carcinoma | Immunohistochemistry | C-KIT |