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Journal of Clinical Oncology, ISSN 0732-183X, 07/2011, Volume 29, Issue 21, pp. 2904 - 2909
Purpose Melanomas harbor aberrations in the c-Kit gene. We tested the efficiency of the tyrosine kinase inhibitor imatinib in selected patients with metastatic... 
ACTIVATION | THERAPY | PROGNOSTIC-FACTORS | ONCOLOGY | SAFETY | TYROSINE KINASE | CUTANEOUS MELANOMA | CLINICAL-EFFICACY | MALIGNANT-MELANOMA | GASTROINTESTINAL STROMAL TUMORS | HONG-KONG | Skin Neoplasms - drug therapy | Exons | United States | Humans | Middle Aged | Melanoma - enzymology | Male | Tomography, X-Ray Computed | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Skin Neoplasms - enzymology | Time Factors | Antineoplastic Agents - adverse effects | Melanoma - genetics | Skin Neoplasms - mortality | China | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Skin Neoplasms - pathology | Risk Assessment | Risk Factors | Kaplan-Meier Estimate | Survival Rate | Treatment Outcome | Piperazines - therapeutic use | Imatinib Mesylate | Piperazines - adverse effects | Melanoma - secondary | Disease-Free Survival | Gene Amplification | Tumor Burden - drug effects | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Melanoma - drug therapy | Skin Neoplasms - genetics | Pyrimidines - adverse effects | Aged | Benzamides | Mutation | Melanoma - mortality | Imatinib | Toxicity | Melanoma | Clinical trials | Disease control | Protein-tyrosine kinase | Survival | c-Kit protein | Metastases | Tumors | Index Medicus
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2007, Volume 129, Issue 14, pp. 4386 - 4392
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2011, Volume 108, Issue 6, pp. 2450 - 2455
The full-length AML1-ETO (AE) fusion gene resulting from t(8;21) (q22;q22) in human acute myeloid leukemia (AML) is not sufficient to induce leukemia in... 
Cell growth | Receptors | 3T3 cells | NIH 3T3 cells | Myeloid leukemia | Leukemia | Mice | Transplantation | Genetic mutation | Blood | Interleukin-3 | Mouse model | Combinatorial therapy | Targeted therapy | Stem cell factor | TRANSCRIPTION FACTORS | GENE-MUTATIONS | targeted therapy | interleukin-3 | PROGNOSTIC IMPACT | stem cell factor | mouse model | MULTIDISCIPLINARY SCIENCES | FUSION GENE | MURINE MODEL | combinatorial therapy | MYELOPROLIFERATIVE DISEASE | EMBRYONIC LETHALITY | STI-571 INHIBITION | GASTROINTESTINAL STROMAL TUMORS | RECEPTOR TYROSINE KINASE | Chromosomes, Human, Pair 8 - genetics | NIH 3T3 Cells | Chromosomes, Human, Pair 21 - metabolism | Oncogene Proteins, Fusion - metabolism | Cytarabine - pharmacology | Humans | Leukemia, Myeloid, Acute - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Cell Transformation, Neoplastic - genetics | Leukemia, Lymphoid - metabolism | Antimetabolites, Antineoplastic - pharmacology | Proto-Oncogene Proteins c-kit - genetics | Leukemia, Lymphoid - genetics | Protein Structure, Tertiary | Core Binding Factor Alpha 2 Subunit - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Transgenic | Leukemia, Lymphoid - pathology | Chromosomes, Human, Pair 21 - genetics | Cell Transformation, Neoplastic - metabolism | RUNX1 Translocation Partner 1 Protein | Chromosomes, Human, Pair 8 - metabolism | Animals | Oncogene Proteins, Fusion - genetics | Mutation | Cell Transformation, Neoplastic - pathology | Core Binding Factor Alpha 2 Subunit - genetics | Leukemia, Myeloid, Acute - genetics | Translocation, Genetic - genetics | Gene mutations | Health aspects | Molecules | Signal transduction | Genes | Rodents | Kinases | Cells | Index Medicus | Cell proliferation | cytarabine | Animal models | Hybrids | Transcription factors | Data processing | Intracellular signalling | Lymphatic leukemia | c-Kit protein | Myeloproliferative diseases | Molecular modelling | Life span | Leukemogenesis | Transmembrane domains | Fusion protein | Acute myeloid leukemia | Protein-tyrosine kinase | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1398 - 1403
Journal Article
Oncogene, ISSN 0950-9232, 02/2012, Volume 31, Issue 7, pp. 869 - 883
BRCA1 mutation-associated breast cancer originates in oestrogen receptor-alpha-negative (ER-) progenitors in the mammary luminal epithelium. These cells also... 
progenitor | Brca1 | c-Kit | mammary | LINEAGE-COMMITMENT | PROGENITOR CELLS | STEM-CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE KINASE | CELL BIOLOGY | SIGNAL-TRANSDUCTION | FUNCTIONAL MAMMARY-GLAND | 2 SPLICE FORMS | ONCOLOGY | ESTROGEN-RECEPTOR-ALPHA | GENETICS & HEREDITY | NIH 3T3 Cells | Cell Proliferation | Epithelial Cells - metabolism | Humans | Gene Expression Regulation, Neoplastic | Cell Survival - genetics | Apoptosis - genetics | Gene Expression Profiling | Mammary Neoplasms, Experimental - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Stem Cells - metabolism | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - metabolism | Cell Differentiation - genetics | RNA Interference | BRCA1 Protein - metabolism | Mammary Neoplasms, Experimental - pathology | Estrogen Receptor alpha - metabolism | Female | Proto-Oncogene Proteins c-kit - genetics | Cells, Cultured | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mammary Glands, Animal - cytology | BRCA1 Protein - genetics | Animals | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Mammary Glands, Animal - metabolism | Breast Neoplasms - pathology | Mice | Mutation | Signal transduction | Cell growth | Breast cancer | Gene expression | Flow cytometry | Cell survival | BRCA1 protein | Colonies | Estrogens | Epithelium | c-Kit protein | Overexpression | Stem cells | KIT protein | Lyn protein | Mammary gland | Differentiation | Apoptosis | Tumors | Index Medicus
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 1, pp. 314 - 318
Journal Article
Journal Article