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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2012, Volume 109, Issue 33, pp. 13380 - 13385
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 4044 - 4054
Targeting kinases is central to drug-based cancer therapy but remains challenging because the drugs often lack specificity, which may cause toxic side effects.... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | GASTROINTESTINAL STROMAL TUMOR | ACTIVATION | PROTEIN-TYROSINE KINASES | STI571 | PHOSPHORYLATION | IMATINIB | STI-571 INHIBITION | PROLIFERATION | CANCER-THERAPY | Gastrointestinal Stromal Tumors - enzymology | Protein-Tyrosine Kinases - metabolism | Humans | Neoplasms, Experimental - enzymology | Piperazines - chemistry | Protein Kinase Inhibitors - adverse effects | Proto-Oncogene Proteins c-kit - metabolism | Pyrimidines - chemistry | Protein Kinase Inhibitors - chemistry | MAP Kinase Kinase 4 - metabolism | Fusion Proteins, bcr-abl | MAP Kinase Kinase 4 - antagonists & inhibitors | Heart Diseases - chemically induced | Cardiotoxins - pharmacology | Rats | Pyrimidines - pharmacology | Heart Diseases - enzymology | Imatinib Mesylate | Piperazines - adverse effects | Piperazines - pharmacology | Rats, Sprague-Dawley | Animals | Gastrointestinal Stromal Tumors - drug therapy | K562 Cells | Pyrimidines - adverse effects | Protein Kinase Inhibitors - pharmacology | Benzamides | Cardiotoxins - chemistry | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Protein-Tyrosine Kinases - antagonists & inhibitors | Care and treatment | Research | Protein kinases | Health aspects | Methods | Cancer | Index Medicus | Abridged Index Medicus | Technical Advance
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2011, Volume 184, Issue 1, pp. 116 - 123
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2011, Volume 108, Issue 6, pp. 2450 - 2455
The full-length AML1-ETO (AE) fusion gene resulting from t(8;21) (q22;q22) in human acute myeloid leukemia (AML) is not sufficient to induce leukemia in... 
Cell growth | Receptors | 3T3 cells | NIH 3T3 cells | Myeloid leukemia | Leukemia | Mice | Transplantation | Genetic mutation | Blood | Interleukin-3 | Mouse model | Combinatorial therapy | Targeted therapy | Stem cell factor | TRANSCRIPTION FACTORS | GENE-MUTATIONS | targeted therapy | interleukin-3 | PROGNOSTIC IMPACT | stem cell factor | mouse model | MULTIDISCIPLINARY SCIENCES | FUSION GENE | MURINE MODEL | combinatorial therapy | MYELOPROLIFERATIVE DISEASE | EMBRYONIC LETHALITY | STI-571 INHIBITION | GASTROINTESTINAL STROMAL TUMORS | RECEPTOR TYROSINE KINASE | Chromosomes, Human, Pair 8 - genetics | NIH 3T3 Cells | Chromosomes, Human, Pair 21 - metabolism | Oncogene Proteins, Fusion - metabolism | Cytarabine - pharmacology | Humans | Leukemia, Myeloid, Acute - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Cell Transformation, Neoplastic - genetics | Leukemia, Lymphoid - metabolism | Antimetabolites, Antineoplastic - pharmacology | Proto-Oncogene Proteins c-kit - genetics | Leukemia, Lymphoid - genetics | Protein Structure, Tertiary | Core Binding Factor Alpha 2 Subunit - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Transgenic | Leukemia, Lymphoid - pathology | Chromosomes, Human, Pair 21 - genetics | Cell Transformation, Neoplastic - metabolism | RUNX1 Translocation Partner 1 Protein | Chromosomes, Human, Pair 8 - metabolism | Animals | Oncogene Proteins, Fusion - genetics | Mutation | Cell Transformation, Neoplastic - pathology | Core Binding Factor Alpha 2 Subunit - genetics | Leukemia, Myeloid, Acute - genetics | Translocation, Genetic - genetics | Gene mutations | Health aspects | Molecules | Signal transduction | Genes | Rodents | Kinases | Cells | Index Medicus | Cell proliferation | cytarabine | Animal models | Hybrids | Transcription factors | Data processing | Intracellular signalling | Lymphatic leukemia | c-Kit protein | Myeloproliferative diseases | Molecular modelling | Life span | Leukemogenesis | Transmembrane domains | Fusion protein | Acute myeloid leukemia | Protein-tyrosine kinase | Biological Sciences
Journal Article
Oncogene, ISSN 0950-9232, 02/2012, Volume 31, Issue 7, pp. 869 - 883
BRCA1 mutation-associated breast cancer originates in oestrogen receptor-alpha-negative (ER-) progenitors in the mammary luminal epithelium. These cells also... 
progenitor | Brca1 | c-Kit | mammary | LINEAGE-COMMITMENT | PROGENITOR CELLS | STEM-CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE KINASE | CELL BIOLOGY | SIGNAL-TRANSDUCTION | FUNCTIONAL MAMMARY-GLAND | 2 SPLICE FORMS | ONCOLOGY | ESTROGEN-RECEPTOR-ALPHA | GENETICS & HEREDITY | NIH 3T3 Cells | Cell Proliferation | Epithelial Cells - metabolism | Humans | Gene Expression Regulation, Neoplastic | Cell Survival - genetics | Apoptosis - genetics | Gene Expression Profiling | Mammary Neoplasms, Experimental - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Stem Cells - metabolism | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - metabolism | Cell Differentiation - genetics | RNA Interference | BRCA1 Protein - metabolism | Mammary Neoplasms, Experimental - pathology | Estrogen Receptor alpha - metabolism | Female | Proto-Oncogene Proteins c-kit - genetics | Cells, Cultured | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mammary Glands, Animal - cytology | BRCA1 Protein - genetics | Animals | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Mammary Glands, Animal - metabolism | Breast Neoplasms - pathology | Mice | Mutation | Signal transduction | Cell growth | Breast cancer | Gene expression | Flow cytometry | Cell survival | BRCA1 protein | Colonies | Estrogens | Epithelium | c-Kit protein | Overexpression | Stem cells | KIT protein | Lyn protein | Mammary gland | Differentiation | Apoptosis | Tumors | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 05/2013, Volume 32, Issue 22, pp. 2767 - 2781
Cisplatin and paclitaxel are standard chemotherapy for metastatic ovarian cancer, but with limited efficacy. Cancer stem/progenitor cells (or tumor-initiating... 
b-catenin | chemoresistance | c-Kit | ovarian cancer | ABCG2 | beta-catenin | SURFACE EPITHELIUM | ONCOLOGY-GROUP | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLATINUM-RESISTANT | CHRONIC MYELOID-LEUKEMIA | CELL BIOLOGY | PHASE-II TRIAL | ONCOLOGY | SEROUS CARCINOMA | GENETICS & HEREDITY | IMATINIB MESYLATE | EPITHELIAL OVARIAN | CLINICOPATHOLOGICAL FEATURES | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Paclitaxel - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Tumor Microenvironment | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Wnt Proteins - metabolism | Cell Hypoxia | Neoplastic Stem Cells - metabolism | RNA Interference | Cell Transformation, Neoplastic - genetics | ATP-Binding Cassette Transporters - metabolism | Female | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - drug therapy | Cell Survival - drug effects | Cisplatin - pharmacology | Pyrimidines - pharmacology | Cell Transformation, Neoplastic - metabolism | Imatinib Mesylate | Piperazines - pharmacology | beta Catenin - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Wnt Signaling Pathway - drug effects | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7476, pp. 397 - 401
Journal Article