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Journal Article
Cancer treatment reviews, ISSN 0305-7372, 2014, Volume 40, Issue 10, pp. 1153 - 1160
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2006, Volume 103, Issue 6, pp. 1888 - 1893
Journal Article
Nature medicine, ISSN 1546-170X, 2012, Volume 18, Issue 8, pp. 1239 - 1247
... (encoding tumor protein 53) is a common step in human cancer. However, in melanoma-A highly chemotherapy-resistant disease-TP53 mutations are rare, raising... 
MEDICINE, RESEARCH & EXPERIMENTAL | N-RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR ACTIVITY | STAPLED P53 | BRAF | MALIGNANT-MELANOMA | P53 PATHWAY | CELL-DEATH | CELL BIOLOGY | BREAST-CANCER | METASTATIC MELANOMA | IN-VIVO | Up-Regulation | Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Recombinant Fusion Proteins - physiology | Skin Neoplasms - chemistry | Male | Melanocytes - metabolism | Neoplasm Proteins - antagonists & inhibitors | Cell Line, Tumor - transplantation | Proto-Oncogene Proteins - biosynthesis | Tumor Suppressor Protein p53 - physiology | Cell-Penetrating Peptides - pharmacology | Nuclear Proteins - biosynthesis | Female | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Cell Line, Tumor - metabolism | Melanoma - chemistry | Proto-Oncogene Proteins c-mdm2 - biosynthesis | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Stem Cell Assay | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Melanoma, Experimental - etiology | Mice, Inbred C57BL | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Melanoma - pathology | Melanoma - secondary | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Melanoma, Experimental - genetics | GTP Phosphohydrolases - genetics | Keratinocytes - metabolism | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Signal Transduction - physiology | Mice | Nuclear Proteins - physiology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Melanoma | Diagnosis | Research | Gene expression | Identification and classification | Skin cancer | Proteins | Cell growth | Mutation | Cell cycle
Journal Article
Scientific reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 2410 - 9
...1Scientific REPORtS | (2018) 8:2410 | DOI:10.1038/s41598-018-20000-4 www.nature.com/scientificreports Small-molecule MDM2 antagonists attenuate the senescence... 
CELLS | ACTIVATION | NUTLIN-3A | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GENE-EXPRESSION | P53 PATHWAY | INDUCTION | CELLULAR SENESCENCE | CANCER | Gamma Rays | Proto-Oncogene Proteins c-mdm2 - genetics | Epithelial Cells - metabolism | Interleukin-6 - antagonists & inhibitors | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | Interleukin-1alpha - metabolism | Male | Lung - cytology | Tumor Suppressor Protein p53 - genetics | Tumor Suppressor Protein p53 - agonists | Cellular Senescence - radiation effects | Cell Cycle Checkpoints - genetics | Indoles - pharmacology | Interleukin-1alpha - genetics | Epithelial Cells - cytology | Interleukin-6 - metabolism | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Fibroblasts - metabolism | Cell Line | Cellular Senescence - genetics | Epithelial Cells - radiation effects | Interleukin-6 - genetics | Enzyme Inhibitors - pharmacology | Tumor Suppressor Protein p53 - metabolism | Interleukin-1alpha - antagonists & inhibitors | Imidazoles - pharmacology | Piperazines - pharmacology | Fibroblasts - radiation effects | Foreskin - cytology | Cell Cycle Checkpoints - drug effects | Fibroblasts - drug effects | Fibroblasts - cytology | Spiro Compounds - pharmacology | Biodegradation | MDM2 protein | Phenotypes | Senescence | p53 Protein | Genotoxicity | Breast cancer | Inflammation | Interleukin 6 | Fibroblasts | Aging | Tumor suppressor genes | Growth factors | Cancer
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2016, Volume 113, Issue 50, pp. E8051 - E8058
Protein−protein interactions play a central role in cellular function. Improving the understanding of complex formation has many practical applications... 
Druggable surface | Direct coupling analysis | Drug design | Protein-protein interface | Hot spots | drug design | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | DIMERIZATION | protein-protein interface | INHIBITION | CONSERVATION | hot spots | CDK1 | HOT-SPOTS | direct coupling analysis | HIV-1 PROTEASE | BINDING-SITES | WEB SERVER | druggable surface | COMPUTATIONAL PREDICTION | Histone Deacetylase 1 - chemistry | Molecular Probes | HIV Protease - drug effects | Humans | Proto-Oncogene Proteins c-mdm2 - chemistry | CDC2-CDC28 Kinases - antagonists & inhibitors | Repressor Proteins - antagonists & inhibitors | HIV Protease Inhibitors - pharmacology | Proto-Oncogene Proteins c-mdm2 - drug effects | CDC2 Protein Kinase - drug effects | Drug Design | Histone Deacetylase 1 - drug effects | CDC2 Protein Kinase - chemistry | Histone Deacetylase 1 - antagonists & inhibitors | Binding Sites | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Molecular Docking Simulation - methods | Repressor Proteins - chemistry | Protein Interaction Domains and Motifs - drug effects | CDC2 Protein Kinase - antagonists & inhibitors | HIV-1 - drug effects | CDC2-CDC28 Kinases - chemistry | CDC2-CDC28 Kinases - drug effects | Histone Deacetylases - chemistry | HIV Protease Inhibitors - chemistry | Tumor Necrosis Factor-alpha - chemistry | Tumor Necrosis Factor-alpha - drug effects | HIV-1 - enzymology | Histone Deacetylases - drug effects | Repressor Proteins - drug effects | HIV Protease - chemistry | Protein Multimerization - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Evolution, Molecular | Observations | Protein-protein interactions | Biological Sciences | PNAS Plus | protein−protein interface
Journal Article
Journal Article
Journal of hematology and oncology, ISSN 1756-8722, 2017, Volume 10, Issue 1, pp. 133 - 17
.... Indeed, the two proteins act as regulators of P53, a well-known key controller of the cell cycle regulation and cell proliferation that, when altered, plays a direct role on cancer development and progression... 
MDM2 | Pediatric tumors | Clinical studies | Leukemia | MDMX | Pharmacological inhibitor | MULTIPLE-MYELOMA | GENE-MUTATIONS | ACUTE MYELOID-LEUKEMIA | P53 PATHWAY | TP53 MUTATIONS | B-CELL LYMPHOMA | ONCOLOGY | PHASE-I TRIAL | CHRONIC LYMPHOCYTIC-LEUKEMIA | HIGHLY POTENT | HEMATOLOGY | CHROMOSOMAL-ABERRATIONS | Proto-Oncogene Proteins c-mdm2 - genetics | Protein Interaction Maps - drug effects | para-Aminobenzoates - pharmacology | Humans | Spiro Compounds - therapeutic use | Antineoplastic Agents - therapeutic use | Hematologic Neoplasms - pathology | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Imidazolines - therapeutic use | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Child | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Hematologic Neoplasms - metabolism | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Animals | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | para-Aminobenzoates - therapeutic use | Hematologic Neoplasms - drug therapy | Indoles - therapeutic use | Hematologic Neoplasms - genetics | Spiro Compounds - pharmacology | Pediatrics | Medical research | Clinical trials | Medicine, Experimental | Development and progression | Tumor proteins | Cancer | Cell proliferation | MDM2 protein | Animal models | Hematology | Medical innovations | p53 Protein | Genomics | Multiple myeloma | Genomes | Proteins | Side effects | Chemotherapy | Cell cycle | Lymphomas | Mutation | Chromosomes | Regulatory proteins | Tumors
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2013, Volume 135, Issue 31, pp. 11623 - 11633
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2019, Volume 116, Issue 3, pp. 1027 - 1032
Merkel cell polyomavirus (MCV) contributes to approximately 80% of all Merkel cell carcinomas (MCCs), a highly aggressive neuroendocrine carcinoma of the skin.... 
MDM2–MDM4 | Lenalidomide | Merkel cell carcinoma | Casein kinase 1 alpha | P53 | UBIQUITINATION | casein kinase 1 alpha | POLYOMAVIRUS | MULTIDISCIPLINARY SCIENCES | GROWTH | DEGRADATION | MDM2-MDM4 | lenalidomide | p53 | T-ANTIGEN | Tumor Virus Infections - genetics | Proto-Oncogene Proteins c-mdm2 - genetics | Humans | Polyomavirus Infections - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Retinoblastoma Binding Proteins - genetics | Nuclear Proteins - genetics | Retinoblastoma Binding Proteins - metabolism | DNA Helicases - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Tumor Virus Infections - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Virus Infections - metabolism | Carcinoma, Merkel Cell - genetics | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Merkel cell polyomavirus - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Polyomavirus Infections - pathology | DNA Helicases - metabolism | Nuclear Proteins - antagonists & inhibitors | Polyomavirus Infections - genetics | Carcinoma, Merkel Cell - metabolism | Merkel cell polyomavirus - genetics | Carcinoma, Merkel Cell - virology | Ubiquitin-Protein Ligases - genetics | Cell Cycle Proteins | Carcinoma, Merkel Cell - pathology | Physiological aspects | Care and treatment | Tumor proteins | Oncogenes | Chromatin | MDM2 protein | Carcinoma | p53 Protein | Antigen T (large) | Genes | Xenotransplantation | Viruses | Homology | Activation | Myc protein | Ribonucleic acid--RNA | Gene expression | Gene sequencing | Proteins | Depletion | Inhibitors | Rodents | Xenografts | Skin | Mutation | Cancer | Tumors | Apoptosis | Biological Sciences
Journal Article