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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2019, Volume 116, Issue 3, pp. 1027 - 1032
Merkel cell polyomavirus (MCV) contributes to approximately 80% of all Merkel cell carcinomas (MCCs), a highly aggressive neuroendocrine carcinoma of the skin.... 
MDM2–MDM4 | Lenalidomide | Merkel cell carcinoma | Casein kinase 1 alpha | P53 | UBIQUITINATION | casein kinase 1 alpha | POLYOMAVIRUS | MULTIDISCIPLINARY SCIENCES | GROWTH | DEGRADATION | MDM2-MDM4 | lenalidomide | p53 | T-ANTIGEN | Tumor Virus Infections - genetics | Proto-Oncogene Proteins c-mdm2 - genetics | Humans | Polyomavirus Infections - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Retinoblastoma Binding Proteins - genetics | Nuclear Proteins - genetics | Retinoblastoma Binding Proteins - metabolism | DNA Helicases - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Tumor Virus Infections - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Virus Infections - metabolism | Carcinoma, Merkel Cell - genetics | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Merkel cell polyomavirus - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Polyomavirus Infections - pathology | DNA Helicases - metabolism | Nuclear Proteins - antagonists & inhibitors | Polyomavirus Infections - genetics | Carcinoma, Merkel Cell - metabolism | Merkel cell polyomavirus - genetics | Carcinoma, Merkel Cell - virology | Ubiquitin-Protein Ligases - genetics | Cell Cycle Proteins | Carcinoma, Merkel Cell - pathology | Physiological aspects | Care and treatment | Tumor proteins | Oncogenes | Chromatin | MDM2 protein | Carcinoma | p53 Protein | Antigen T (large) | Genes | Xenotransplantation | Viruses | Homology | Activation | Myc protein | Ribonucleic acid--RNA | Gene expression | Gene sequencing | Proteins | Depletion | Inhibitors | Rodents | Xenografts | Skin | Mutation | Cancer | Tumors | Apoptosis | Biological Sciences
Journal Article
Nature chemical biology, ISSN 1552-4469, 2014, Volume 10, Issue 12, pp. 1000 - 1002
Journal Article
Journal Article
Cancer treatment reviews, ISSN 0305-7372, 2014, Volume 40, Issue 10, pp. 1153 - 1160
Journal Article
Journal of hematology and oncology, ISSN 1756-8722, 2017, Volume 10, Issue 1, pp. 133 - 17
.... Indeed, the two proteins act as regulators of P53, a well-known key controller of the cell cycle regulation and cell proliferation that, when altered, plays a direct role on cancer development and progression... 
MDM2 | Pediatric tumors | Clinical studies | Leukemia | MDMX | Pharmacological inhibitor | MULTIPLE-MYELOMA | GENE-MUTATIONS | ACUTE MYELOID-LEUKEMIA | P53 PATHWAY | TP53 MUTATIONS | B-CELL LYMPHOMA | ONCOLOGY | PHASE-I TRIAL | CHRONIC LYMPHOCYTIC-LEUKEMIA | HIGHLY POTENT | HEMATOLOGY | CHROMOSOMAL-ABERRATIONS | Proto-Oncogene Proteins c-mdm2 - genetics | Protein Interaction Maps - drug effects | para-Aminobenzoates - pharmacology | Humans | Spiro Compounds - therapeutic use | Antineoplastic Agents - therapeutic use | Hematologic Neoplasms - pathology | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Imidazolines - therapeutic use | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Child | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Hematologic Neoplasms - metabolism | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Animals | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | para-Aminobenzoates - therapeutic use | Hematologic Neoplasms - drug therapy | Indoles - therapeutic use | Hematologic Neoplasms - genetics | Spiro Compounds - pharmacology | Pediatrics | Medical research | Clinical trials | Medicine, Experimental | Development and progression | Tumor proteins | Cancer | Cell proliferation | MDM2 protein | Animal models | Hematology | Medical innovations | p53 Protein | Genomics | Multiple myeloma | Genomes | Proteins | Side effects | Chemotherapy | Cell cycle | Lymphomas | Mutation | Chromosomes | Regulatory proteins | Tumors
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 353 - 14
Mucosal melanoma is a rare and poorly characterized subtype of human melanoma. Here we perform a cross-species analysis by sequencing tumor-germline pairs from... 
POINT MUTATIONS | CANCER PATIENTS | BREAST-CANCER | MUTATIONAL PROCESSES | ARRAY-CGH | MULTIDISCIPLINARY SCIENCES | COPY NUMBER | TUMOR | OVARIAN-CANCER | MOUSE MODELS | REVEALS | Proto-Oncogene Proteins c-mdm2 - genetics | Cadherins - metabolism | Humans | Carcinogenesis - metabolism | DNA Copy Number Variations | Germ-Line Mutation | Cadherins - genetics | Neoplasm Proteins - genetics | Mouth Neoplasms - genetics | Protein-Serine-Threonine Kinases - metabolism | PTEN Phosphohydrolase - genetics | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Carcinogenesis - genetics | Cell Cycle Proteins - metabolism | Melanoma - pathology | Mucous Membrane - pathology | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Microtubule-Associated Proteins - genetics | Species Specificity | Microtubule-Associated Proteins - metabolism | Gene Expression Regulation, Neoplastic | Mouth Neoplasms - metabolism | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - genetics | Neoplasm Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | Melanoma - genetics | BRCA1 Protein - metabolism | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-mdm2 - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | Neoplasm Recurrence, Local | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | PTEN Phosphohydrolase - metabolism | Mucous Membrane - metabolism | Skin Neoplasms - metabolism | Carcinogenesis - pathology | BRCA1 Protein - genetics | Animals | BRCA2 Protein - metabolism | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - metabolism | Skin Neoplasms - genetics | Dogs | Horses | Mouth Neoplasms - pathology | BRCA2 Protein - genetics | BRCA2 protein | MDM2 protein | BRCA1 protein | Copy number | p53 Protein | Mucosa | Melanoma | Data processing | Breast cancer | Metastases | Heterogeneity | Human performance | Tumorigenesis | Mutation | Comparative analysis | Species | PTEN protein | Tumors
Journal Article
Journal Article
Annual review of biochemistry, ISSN 0066-4154, 6/2016, Volume 85, Issue 1, pp. 375 - 404
Inactivation of the transcription factor p53, through either direct mutation or aberrations in one of its many regulatory pathways, is a hallmark of virtually... 
cancer therapy | signaling pathways | protein evolution | drug design | p53 family | small-molecule stabilizers | Protein evolution | Signaling pathways | Drug design | Small-molecule stabilizers | P53 family | Cancer therapy | DNA-BINDING DOMAIN | TRANSIENT PROTEIN STATES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE ARREST | TUMOR-SUPPRESSOR P53 | CORE-DOMAIN | STRUCTURAL BASIS | SMALL-MOLECULE INHIBITORS | MUTANT P53 | TETRAMERIZATION DOMAIN | TRANSACTIVATION DOMAIN | Neoplasms - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Antineoplastic Agents, Alkylating - chemical synthesis | Humans | Protein Multimerization | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins - chemistry | Molecular Targeted Therapy | Proto-Oncogene Proteins c-mdm2 - chemistry | Tumor Suppressor Protein p53 - genetics | Neoplasms - genetics | Tumor Suppressor Protein p53 - agonists | Drug Design | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Protein Structure, Secondary | Signal Transduction | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | Nuclear Proteins - chemistry | Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Animals | Nuclear Proteins - antagonists & inhibitors | Molecular Docking Simulation | Tumor Suppressor Protein p53 - chemistry | Mutation | Neoplasms - pathology | Transcription factors | Care and treatment | Health aspects | Methods | Cancer
Journal Article