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Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2011, Volume 54, Issue 18, pp. 6342 - 6363
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 2018, Volume 36, Issue 9, pp. 911 - 919
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2010, Volume 363, Issue 18, pp. 1693 - 1703
A small group of patients with non–small-cell lung cancer have genetic lesions that activate anaplastic lymphoma kinase (ALK). Crizotinib, an orally... 
ALK | MEDICINE, GENERAL & INTERNAL | GEFITINIB | EML4-ALK FUSION GENE | 2ND-LINE TREATMENT | PHASE-II | EGFR MUTATIONS | IDENTIFICATION | TUMORS | ACTIVATING MUTATIONS | IMMUNOHISTOCHEMISTRY | Lung Neoplasms - drug therapy | Pyrazoles - therapeutic use | Microtubule-Associated Proteins - genetics | Humans | Middle Aged | Receptors, Growth Factor - antagonists & inhibitors | Lung Neoplasms - pathology | Male | Protein Kinase Inhibitors - adverse effects | Protein-Tyrosine Kinases - genetics | Pyridines - adverse effects | Serine Endopeptidases - genetics | Cell Cycle Proteins - genetics | Adult | Female | Pyrazoles - adverse effects | Pyridines - therapeutic use | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Pyridines - administration & dosage | Administration, Oral | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Kaplan-Meier Estimate | In Situ Hybridization, Fluorescence | Receptor Protein-Tyrosine Kinases | Disease Progression | Protein Kinase Inhibitors - administration & dosage | Pyrazoles - administration & dosage | Oncogene Proteins, Fusion - genetics | Protein Kinase Inhibitors - therapeutic use | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Care and treatment | Lung cancer, Small cell | Genetic aspects | Diagnosis | Health aspects | Phosphotransferases | Lymphomas | Pharmaceutical industry | Lung cancer | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 07/2011, Volume 71, Issue 14, pp. 4758 - 4768
Angiogenesis inhibitors that block VEGF receptor (VEGFR) signaling slow the growth of many types of tumors, but eventually the disease progresses. Multiple... 
BREAST-CANCER | INVASIVE GROWTH | METASTASIS | ONCOLOGY | TYROSINE KINASE | IN-VIVO | THERAPEUTIC TARGET | TUMOR-GROWTH | RENAL-CELL CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | SMALL-MOLECULE INHIBITOR | Proto-Oncogene Proteins c-met - metabolism | Basement Membrane - drug effects | Vascular Endothelial Growth Factor Receptor-3 - biosynthesis | Adenoma, Islet Cell - pathology | Apoptosis - drug effects | Pancreatic Neoplasms - blood supply | Adenoma, Islet Cell - blood supply | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Basement Membrane - pathology | Quinolines - pharmacology | Neovascularization, Pathologic - pathology | Pancreatic Neoplasms - drug therapy | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Adenoma, Islet Cell - drug therapy | Vascular Endothelial Growth Factor Receptor-2 - biosynthesis | Cell Hypoxia - drug effects | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Basement Membrane - metabolism | Animals | Neovascularization, Pathologic - drug therapy | Anilides - pharmacology | Mice | Neovascularization, Pathologic - metabolism | Pyridines - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - antagonists & inhibitors | Index Medicus | RIP-Tag2 mice | receptor tyrosine kinases | VEGF | XL184 (cabozantinib) | c-Met | Angiogenesis inhibitors | XL999 | XL880 (foretinib, GSK1363089)
Journal Article
Cancer Discovery, ISSN 2159-8274, 03/2012, Volume 2, Issue 3, pp. 270 - 287
Journal Article
Cancer Research, ISSN 0008-5472, 12/2010, Volume 70, Issue 24, pp. 10090 - 10100
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2010, Volume 363, Issue 18, pp. 1727 - 1733
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 141, Issue 6, pp. 2218 - 2227.e5
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 24, pp. 9951 - 9956
The tyrosine kinase c-Met promotes the formation and malignant progression of multiple cancers. It is well known that c-Met hyperactivation increases... 
Phenotypes | Cell growth | Hepatocytes | Somatic cells | Induced pluripotent stem cells | Neurons | Stem cells | Glioblastoma | Neural stem cells | Tumors | Cancer stem cell | Oct4 | Sox2 | Klf4 | Hepatocyte growth factor | CANCER-CELLS | MULTIDISCIPLINARY SCIENCES | FACTOR EXPRESSION | PROLIFERATION | TUMORIGENICITY | TUMOR-INITIATING CELLS | P53 | cancer stem cell | PATHWAY | hepatocyte growth factor | IN-VIVO | GROWTH-FACTOR | DIFFERENTIATION | Proto-Oncogene Proteins c-met - metabolism | Homeodomain Proteins - metabolism | Humans | Glycoproteins - metabolism | Peptides - genetics | Immunoblotting | Transplantation, Heterologous | Antigens, CD - genetics | Antigens, CD - metabolism | Cellular Reprogramming | SOXB1 Transcription Factors - metabolism | Neoplasms, Experimental - pathology | Octamer Transcription Factor-3 - genetics | Flow Cytometry | Peptides - metabolism | Glioblastoma - genetics | Neoplastic Stem Cells - metabolism | RNA Interference | SOXB1 Transcription Factors - genetics | Neoplasms, Experimental - genetics | Neoplastic Stem Cells - pathology | Glioblastoma - metabolism | Indoles - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Glycoproteins - genetics | Nanog Homeobox Protein | Signal Transduction | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Sulfonamides - pharmacology | AC133 Antigen | Piperazines - pharmacology | Proto-Oncogene Proteins c-myc - metabolism | Homeodomain Proteins - genetics | Proto-Oncogene Proteins c-met - genetics | Phenotype | Animals | Glioblastoma - pathology | Octamer Transcription Factor-3 - metabolism | Mice | Proto-Oncogene Proteins c-myc - genetics | Neoplasms, Experimental - metabolism | Physiological aspects | Development and progression | Cellular signal transduction | Genetic aspects | Research | Glioblastoma multiforme | Protein kinases | Proteins | Signal transduction | Genotype & phenotype | Kinases | Gene expression | Cancer | Transcription factors | Tumor cells | DNA damage | Embryo cells | Tumorigenicity | neurospheres | Differentiation | Protein-tyrosine kinase | glioblastoma cells | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 500 - 504
Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By... 
COLON-CANCER | OVEREXPRESSION | MELANOMA | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | C-MET | ACQUIRED-RESISTANCE | V600E MUTATION | BRAF | GROWTH-FACTOR | VEMURAFENIB | Proto-Oncogene Proteins c-met - metabolism | Prognosis | Hepatocyte Growth Factor - secretion | Coculture Techniques | Humans | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Tumor Microenvironment - physiology | Molecular Targeted Therapy | Melanoma - genetics | Stromal Cells - drug effects | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Melanoma - metabolism | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Stromal Cells - metabolism | Antineoplastic Combined Chemotherapy Protocols | Melanoma - pathology | Sulfonamides - pharmacology | Hepatocyte Growth Factor - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Stromal Cells - secretion | Signal Transduction - drug effects | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Proteomics | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Mutation | Stromal Cells - cytology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Physiological aspects | Genetic aspects | Research | Gene expression | Drug resistance | Growth factors | Health aspects | Liver cells | Cancer | Cytotoxicity | Epidermal growth factor | FDA approval | Cancer therapies | Tumors | Index Medicus
Journal Article