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Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 4, pp. 774 - 789
.... Here we describe an unexpected function for the circadian repressor CRY2 as a component of an FBXL3-containing E3 ligase that recruits T58-phosphorylated c-MYC for ubiquitylation... 
MYC | circadian rhythm | CRY2 | cryptochrome | FBXL3 | circadian clock | ubiquitin | CIRCADIAN CLOCK | CRYPTOCHROME | PROTEIN | UBIQUITIN LIGASE | TUMOR SUPPRESSION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | GENE-EXPRESSION | CANCER-RISK | FACTOR PERIOD 2 | CELL BIOLOGY | Humans | Gene Expression Regulation, Neoplastic | Cryptochromes - genetics | Circadian Clocks - genetics | Lymphoma - mortality | Lymphoma - metabolism | S-Phase Kinase-Associated Proteins - chemistry | Cell Transformation, Neoplastic - genetics | Proteolysis | HEK293 Cells | Cullin Proteins - metabolism | Fibroblasts | Carrier Proteins - chemistry | Lymphoma - pathology | Protein Stability | Cryptochromes - metabolism | Protein Structure, Secondary | Signal Transduction | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Circadian Rhythm - genetics | Lymphoma - genetics | Models, Molecular | S-Phase Kinase-Associated Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Cullin Proteins - chemistry | Cullin Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Survival Analysis | S-Phase Kinase-Associated Proteins - genetics | Cryptochromes - chemistry | Mice | Proto-Oncogene Proteins c-myc - genetics | Cell Transformation, Neoplastic - pathology | Proto-Oncogene Proteins c-myc - chemistry | F-Box Proteins - genetics | Ubiquitin | Physiological aspects | Drug discovery | Research institutes | Ligases | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell and Molecular Biology | Medicinska och farmaceutiska grundvetenskaper | Cell- och molekylärbiologi
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2015, Volume 58, Issue 7, pp. 3002 - 3024
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 52, pp. 18697 - 18702
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2011, Volume 146, Issue 6, pp. 904 - 917
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 534, Issue 7607, pp. 341 - 346
...) and c-MYC regulation. Perturbation of both p53 and c-MYC, and not BCR-ABL itself, leads to synergistic cell kill, differentiation, and near elimination of transplantable human LSCs in mice, while sparing... 
CD34(+) CELLS | INHIBITION | MICROARRAY | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | IMATINIB | TUMOR | COMBINATION | CANCER | EXPRESSION | CHRONIC MYELOID-LEUKEMIA | Antigens, CD34 - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Transcriptome | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Acetamides - pharmacology | Male | Neoplasm Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Imatinib Mesylate - therapeutic use | Acetamides - therapeutic use | Neoplastic Stem Cells - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Imidazolines - therapeutic use | Neoplastic Stem Cells - pathology | Female | Cell Death - drug effects | Hematopoietic Stem Cells - drug effects | Reproducibility of Results | Imatinib Mesylate - pharmacology | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Hematopoietic Stem Cells - metabolism | Tumor Suppressor Protein p53 - deficiency | Proto-Oncogene Proteins c-myc - metabolism | Neoplastic Stem Cells - transplantation | Azepines - therapeutic use | Azepines - pharmacology | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Hematopoietic Stem Cells - cytology | Proto-Oncogene Proteins c-myc - deficiency | Proteomics | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Proto-Oncogene Proteins c-myc - genetics | Fusion Proteins, bcr-abl - metabolism | Molecular targeted therapy | Cancer cells | Stem cells | Development and progression | Genetic aspects | Chronic myeloid leukemia | Tumor proteins | Properties | Health aspects | Methods | Proteins | Transcription factors | Leukemia | Cell cycle | Kinases | Cancer therapies | Apoptosis
Journal Article
Cell metabolism, ISSN 1550-4131, 2013, Volume 18, Issue 5, pp. 726 - 739
Journal Article