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Cell, ISSN 0092-8674, 2011, Volume 146, Issue 6, pp. 904 - 917
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2015, Volume 58, Issue 7, pp. 3002 - 3024
Journal Article
Oncogene, ISSN 0950-9232, 03/2010, Volume 29, Issue 9, pp. 1394 - 1404
Journal Article
Nature, ISSN 0028-0836, 06/2016, Volume 534, Issue 7607, pp. 341 - 346
Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR-ABL. Direct inhibition of... 
CD34(+) CELLS | INHIBITION | MICROARRAY | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | IMATINIB | TUMOR | COMBINATION | CANCER | EXPRESSION | CHRONIC MYELOID-LEUKEMIA | Antigens, CD34 - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Transcriptome | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Acetamides - pharmacology | Male | Neoplasm Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Imatinib Mesylate - therapeutic use | Acetamides - therapeutic use | Neoplastic Stem Cells - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Imidazolines - therapeutic use | Neoplastic Stem Cells - pathology | Female | Cell Death - drug effects | Hematopoietic Stem Cells - drug effects | Reproducibility of Results | Imatinib Mesylate - pharmacology | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Hematopoietic Stem Cells - metabolism | Tumor Suppressor Protein p53 - deficiency | Proto-Oncogene Proteins c-myc - metabolism | Neoplastic Stem Cells - transplantation | Azepines - therapeutic use | Azepines - pharmacology | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Hematopoietic Stem Cells - cytology | Proto-Oncogene Proteins c-myc - deficiency | Proteomics | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Proto-Oncogene Proteins c-myc - genetics | Fusion Proteins, bcr-abl - metabolism | Molecular targeted therapy | Cancer cells | Stem cells | Development and progression | Genetic aspects | Chronic myeloid leukemia | Tumor proteins | Properties | Health aspects | Methods | Proteins | Transcription factors | Leukemia | Cell cycle | Kinases | Cancer therapies | Apoptosis
Journal Article
International Journal of Biological Sciences, ISSN 1449-2288, 09/2014, Volume 10, Issue 10, pp. 1084 - 1096
Journal Article
Nature communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 323 - 12
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 25, pp. 9157 - 9162
The transcription factor c-MYC is stabilized and activated by phosphorylation at serine 62 (S62) in breast cancer. Protein phosphatase 2A (PP2A) is a critical... 
Tumor cell line | Cell growth | Cell lines | Small interfering RNA | Breast cancer | Breast neoplasms | Heterologous transplantation | Tumors | Cancer | Apoptosis | Breast cancer therapy | Phosphatase activator | TUMOR-SUPPRESSOR PP2A | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | PROTEIN PHOSPHATASE 2A | CIP2A | OVEREXPRESSION | phosphatase activator | CELL-TRANSFORMATION | GENE | breast cancer therapy | MYELOID-LEUKEMIA | DEGRADATION | SUBUNIT | Gene Expression Regulation, Enzymologic - drug effects | Autoantigens - biosynthesis | Histone Chaperones - genetics | Humans | Autoantigens - genetics | Breast Neoplasms - metabolism | Drug Delivery Systems | Gene Knockdown Techniques | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Protein Phosphatase 2 - antagonists & inhibitors | Membrane Proteins - genetics | Enzyme Inhibitors - pharmacology | Protein Phosphatase 2 - genetics | Transcription Factors - biosynthesis | Transcription Factors - genetics | Breast Neoplasms - drug therapy | Proto-Oncogene Proteins c-myc - metabolism | Membrane Proteins - biosynthesis | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Gene Expression Regulation, Enzymologic - genetics | Histone Chaperones - biosynthesis | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-myc - genetics | Physiological aspects | Tumor suppressor genes | Care and treatment | Transcription factors | Genetic aspects | Biological Sciences
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2013, Volume 18, Issue 5, pp. 726 - 739
Journal Article
Experimental Hematology, ISSN 0301-472X, 2011, Volume 39, Issue 8, pp. 817 - 828.e1
Objective The prognosis for diffuse large B-cell lymphomas with concomitant overexpression of c-Myc and Bcl-2 remains dismal; there is an urgent need to... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | GENE | TRANSLOCATIONS | LINE | ABT-737 | LEUKEMIA | INHIBITOR | ESTABLISHMENT | HEMATOLOGY | NON-BURKITTS | EXPRESSION | Translocation, Genetic | Cytarabine - pharmacology | Humans | Gene Expression Regulation, Neoplastic | Lymphoma, Large B-Cell, Diffuse - metabolism | Dose-Response Relationship, Drug | Proto-Oncogene Proteins c-bcl-2 - metabolism | Spectral Karyotyping | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Aniline Compounds - pharmacology | Lymphoma, Large B-Cell, Diffuse - pathology | Etoposide - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-myc - metabolism | Blotting, Western | Drug Synergism | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | MicroRNAs - genetics | Proto-Oncogene Proteins c-myc - genetics | Thiazoles - pharmacology | Chromosomes, Human, Pair 18 - genetics | Lymphoma, Large B-Cell, Diffuse - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Chromosomes, Human, Pair 14 - genetics | Doxorubicin - pharmacology | Care and treatment | Lymphomas | Universities and colleges | Drug therapy | Health aspects | Cancer
Journal Article