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humans (233) 233
proto-oncogene proteins c-pim-1 - antagonists & inhibitors (227) 227
index medicus (223) 223
proto-oncogene proteins c-pim-1 - metabolism (164) 164
animals (138) 138
protein kinase inhibitors - pharmacology (138) 138
cell line, tumor (114) 114
mice (94) 94
proto-oncogene proteins c-pim-1 - genetics (76) 76
apoptosis (72) 72
cancer (70) 70
protein kinase inhibitors - chemistry (70) 70
antineoplastic agents - pharmacology (69) 69
chemistry, medicinal (68) 68
oncology (68) 68
phosphorylation (67) 67
male (57) 57
apoptosis - drug effects (55) 55
cell proliferation - drug effects (55) 55
hemic and lymphatic diseases (55) 55
c-myc (53) 53
expression (53) 53
leukemia (51) 51
models, molecular (48) 48
structure-activity relationship (46) 46
activation (43) 43
biochemistry & molecular biology (43) 43
kinases (41) 41
chemistry, organic (40) 40
proto-oncogene proteins c-pim-1 - chemistry (38) 38
protein kinase inhibitors - chemical synthesis (37) 37
cell survival - drug effects (36) 36
growth (35) 35
protein (35) 35
protein-serine-threonine kinases - antagonists & inhibitors (35) 35
signal transduction (35) 35
survival (35) 35
female (34) 34
pim-1 (34) 34
molecular structure (33) 33
article (32) 32
cell biology (32) 32
hematology (31) 31
protein-serine-threonine kinases - metabolism (31) 31
proto-oncogene proteins - antagonists & inhibitors (31) 31
signal transduction - drug effects (31) 31
crystallography, x-ray (30) 30
inhibitors (30) 30
proto-oncogene proteins - metabolism (30) 30
antineoplastic agents - chemistry (29) 29
potent (29) 29
protein binding (27) 27
pyridazines - pharmacology (27) 27
xenograft model antitumor assays (27) 27
imidazoles - pharmacology (26) 26
proteins (26) 26
binding sites (25) 25
protein kinase inhibitors - therapeutic use (25) 25
research (25) 25
discovery (24) 24
neoplasms - drug therapy (24) 24
phosphotransferases (24) 24
analysis (23) 23
binding (23) 23
cell proliferation (23) 23
drug design (23) 23
protein-serine-threonine kinases - genetics (23) 23
proto-oncogene proteins - genetics (23) 23
antineoplastic agents - chemical synthesis (22) 22
antineoplastic agents - therapeutic use (22) 22
drug discovery (22) 22
structural basis (22) 22
acute myeloid-leukemia (21) 21
kinase (21) 21
proliferation (21) 21
prostate cancer (21) 21
protein-kinase (21) 21
transgenic mice (21) 21
dose-response relationship, drug (20) 20
kinase inhibitors (20) 20
leukemia, myeloid, acute - drug therapy (20) 20
phosphorylation - drug effects (20) 20
serine/threonine kinases (20) 20
blotting, western (19) 19
cell cycle (19) 19
gene expression (19) 19
mice, nude (19) 19
pharmacology & pharmacy (19) 19
prostate-cancer cells (19) 19
tumor cells, cultured (19) 19
cell line (18) 18
design (18) 18
genetic aspects (18) 18
in-vitro (18) 18
mice, inbred balb c (18) 18
pim kinases (18) 18
cells (17) 17
mutation (17) 17
pim kinase (17) 17
prostate-cancer (17) 17
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Journal Article
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5214 - 5224
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7677, pp. 534 - 538
The ubiquitin system regulates essential cellular processes in eukaryotes. Ubiquitin is ligated to substrate proteins as monomers or chains and the topology of... 
DEUBIQUITINATING ENZYME | MULTIDISCIPLINARY SCIENCES | LINKED UBIQUITIN | Pyridines - chemistry | Ubiquitin-Specific Peptidase 7 - chemistry | Humans | Ubiquitin - metabolism | Substrate Specificity | Tumor Suppressor Protein p53 - genetics | Aminopyridines - chemistry | Ubiquitin-Specific Peptidase 7 - deficiency | Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-mdm2 - metabolism | Phenols - pharmacology | Binding, Competitive | Indazoles - chemistry | Tumor Suppressor Protein p53 - metabolism | Ubiquitin - chemistry | Models, Molecular | Neoplasms - enzymology | Ubiquitin-Specific Peptidase 7 - antagonists & inhibitors | Ubiquitin-Specific Peptidase 7 - metabolism | Mice, SCID | Tumor Suppressor Protein p53 - deficiency | Neoplasms - drug therapy | Drug Synergism | Indazoles - pharmacology | Animals | Aminopyridines - pharmacology | Cell Line, Tumor | Protein Binding | Phenols - chemistry | Mice | Pyridines - pharmacology | Neoplasms - pathology | Biological research | Physiological aspects | Chemical inhibitors | Research | Ubiquitin-proteasome system | Biology, Experimental | Ubiquitin | Nuclear magnetic resonance--NMR | Toxicity | Hydrogen | p53 Protein | Cytotoxicity | Chains | Kinases | Monomers | Proteins | Depolymerization | Eukaryotes | Ubiquitination | Cell cycle | Reaction kinetics | Catalysis | Crystal structure | Binding | Enzymes | Magnetic resonance | Topology | Substrates | Chemotherapy | Inhibitors | Cell death | Proteasomes | Resonance | Mutation | Kinetics | Cancer | Tumors
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2016, Volume 22, Issue 11, pp. 1303 - 1313
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2014, Volume 20, Issue 7, pp. 1834 - 1845
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2016, Volume 22, Issue 11, pp. 1321 - 1329
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2015, Volume 58, Issue 21, pp. 8373 - 8386
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2013, Volume 85, Issue 5, pp. 629 - 643
Journal Article