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humans (965) 965
animals (834) 834
proto-oncogene proteins c-raf - metabolism (614) 614
phosphorylation (430) 430
mice (407) 407
biochemistry & molecular biology (390) 390
signal transduction (357) 357
oncology (346) 346
cell biology (336) 336
enzyme inhibitors - pharmacology (305) 305
proto-oncogene proteins c-raf - antagonists & inhibitors (293) 293
cell line, tumor (258) 258
mitogen-activated protein kinases - metabolism (250) 250
activation (249) 249
rats (245) 245
signal transduction - drug effects (245) 245
cancer (236) 236
apoptosis (213) 213
cell line (208) 208
protein-serine-threonine kinases - metabolism (202) 202
cells, cultured (201) 201
proto-oncogene proteins c-raf - genetics (196) 196
enzyme activation (193) 193
proto-oncogene proteins - metabolism (190) 190
female (189) 189
ras proteins - metabolism (182) 182
mutation (177) 177
expression (173) 173
protein kinase inhibitors - pharmacology (168) 168
male (167) 167
proteins (167) 167
antineoplastic agents - pharmacology (164) 164
map kinase signaling system - drug effects (161) 161
mitogen-activated protein kinase 1 - metabolism (160) 160
map kinase (158) 158
extracellular signal-regulated map kinases - metabolism (155) 155
phosphorylation - drug effects (152) 152
kinases (149) 149
apoptosis - drug effects (145) 145
research (145) 145
proto-oncogene proteins c-raf (143) 143
transfection (140) 140
tumor cells, cultured (139) 139
cell proliferation - drug effects (136) 136
enzyme activation - drug effects (135) 135
proto-oncogene proteins b-raf - antagonists & inhibitors (135) 135
proto-oncogene proteins b-raf - genetics (132) 132
b-raf (127) 127
pathway (125) 125
proto-oncogene proteins c-akt - metabolism (123) 123
signal-transduction (118) 118
mitogen-activated protein kinase kinases - metabolism (117) 117
phosphatidylinositol 3-kinases - metabolism (117) 117
mitogen-activated protein kinase 3 (116) 116
calcium-calmodulin-dependent protein kinases - metabolism (115) 115
ras (115) 115
melanoma (113) 113
mitogen-activated protein kinases - antagonists & inhibitors (112) 112
pharmacology & pharmacy (112) 112
protein-kinase (112) 112
cells (111) 111
growth (110) 110
dose-response relationship, drug (109) 109
blotting, western (107) 107
protein-serine-threonine kinases - antagonists & inhibitors (105) 105
proto-oncogene proteins b-raf - metabolism (105) 105
activated protein-kinase (104) 104
flavonoids - pharmacology (103) 103
article (101) 101
signal transduction - physiology (96) 96
raf-1 (92) 92
inhibition (89) 89
cell division - drug effects (87) 87
proto-oncogene proteins c-raf - physiology (87) 87
kinase (85) 85
mitogen-activated protein kinase kinases - antagonists & inhibitors (85) 85
protein kinases (85) 85
protein binding (83) 83
gene expression (82) 82
protein kinase c - metabolism (82) 82
cell proliferation (81) 81
physiological aspects (81) 81
abridged index medicus (80) 80
in-vitro (80) 80
gene-expression (79) 79
raf (79) 79
in-vivo (78) 78
map kinase signaling system (78) 78
antineoplastic agents - therapeutic use (77) 77
mutations (77) 77
tumors (77) 77
genetic aspects (76) 76
indoles - pharmacology (76) 76
map kinase signaling system - physiology (75) 75
proliferation (75) 75
analysis (74) 74
map kinase kinase 1 (74) 74
multidisciplinary sciences (73) 73
care and treatment (71) 71
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Cancer Research, ISSN 0008-5472, 10/2004, Volume 64, Issue 19, pp. 7099 - 7109
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2010, Volume 16, Issue 7, pp. 793 - 798
Journal Article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 06/2016, Volume 115, pp. 201 - 216
Journal Article
Cancer Research, ISSN 0008-5472, 06/2008, Volume 68, Issue 12, pp. 4853 - 4861
Journal Article
Cellular Signalling, ISSN 0898-6568, 08/2015, Volume 27, Issue 8, pp. 1666 - 1675
The multivariate nature of cancer necessitates multi-targeted therapy, and kinase inhibitors account for a vast majority of approved cancer therapeutics. While... 
Resistance | Lyn | Inhibitors | c-Raf | Retinoic acid | Leukemia | C-Raf | CANCER THERAPEUTICS | TYROSINE KINASE | HL-60 CELLS | CELL-CYCLE ARREST | ACUTE MYELOID-LEUKEMIA | PHOSPHORYLATION SITES | CELL BIOLOGY | INDUCED DIFFERENTIATION | PROMYELOCYTIC LEUKEMIA | ARYL-HYDROCARBON RECEPTOR | SIGNAL-REGULATED KINASE | Leukemia, Promyelocytic, Acute - pathology | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Drug Resistance, Neoplasm | Molecular Targeted Therapy | Time Factors | Leukemia, Promyelocytic, Acute - enzymology | src-Family Kinases - metabolism | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Phosphatidylinositol 3-Kinase - metabolism | Phenols - pharmacology | Tretinoin - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols | Pyrimidines - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | HL-60 Cells | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-raf - antagonists & inhibitors | CD11b Antigen - metabolism | Leukemia, Promyelocytic, Acute - genetics | G1 Phase Cell Cycle Checkpoints - drug effects | Leukemia, Promyelocytic, Acute - drug therapy | Animal genetics | Automobile drivers | Therapeutics | Phosphotransferases | Homeopathy | Materia medica and therapeutics | Tretinoin | Index Medicus
Journal Article
Journal Article
CELL, ISSN 0092-8674, 03/2004, Volume 116, Issue 6, pp. 855 - 867
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2011, Volume 251, Issue 2, pp. 130 - 136
Erlotinib is a potent inhibitor of epidermal growth factor receptor tyrosine kinase and has been demonstrated to treat advanced or metastatic non-small cell... 
c-Raf/ERK | Immunosuppression | Akt | Erlotinib | T cells | C-Raf/ERK | RAF/MEK/ERK | TYROSINE KINASE | P27(KIP1) | GROWTH-FACTOR RECEPTOR | LUNG-CANCER | PHARMACOKINETICS | HEPATITIS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | GEFITINIB IRESSA(R) | TARCEVA(R) | CYCLE | Erlotinib Hydrochloride | T-Lymphocyte Subsets - immunology | Oncogene Protein v-akt - antagonists & inhibitors | Oncogene Protein v-akt - physiology | Cells, Cultured | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Down-Regulation - drug effects | MAP Kinase Signaling System - immunology | Dose-Response Relationship, Drug | Animals | MAP Kinase Signaling System - drug effects | Quinazolines - toxicity | Down-Regulation - immunology | T-Lymphocyte Subsets - drug effects | Protein Kinase Inhibitors - toxicity | Female | Mice | Mice, Inbred BALB C | Proto-Oncogene Proteins c-raf - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - physiology | Tyrosine | Care and treatment | Epidermal growth factor | Immune response | Immunotherapy | Disease susceptibility | Metastasis | Lung cancer, Non-small cell | Mitogens | Cancer | Index Medicus | ANTIBODIES | BODY FLUIDS | CONCANAVALIN A | PHOSPHORYLATION | METASTASES | MITOGENS | LECTINS | ANIMAL CELLS | MEDICINE | 60 APPLIED LIFE SCIENCES | INHIBITION | THERAPY | TYROSINE | IMMUNOSUPPRESSION | IN VITRO | AMINO ACIDS | CHEMICAL REACTIONS | BLOOD CELLS | SOMATIC CELLS | CONNECTIVE TISSUE CELLS | BLOOD | NEOPLASMS | BIOLOGICAL MATERIALS | ORGANIC COMPOUNDS | HYDROXY ACIDS | ORGANIC ACIDS | CELL PROLIFERATION | AGGLUTININS | IN VIVO | CHEMOTHERAPY | GROWTH FACTORS | LAWS | DISEASES | LEUKOCYTES | LYMPHOKINES | CARBOXYLIC ACIDS | HEMAGGLUTININS | REGULATIONS | PROTEINS | MATERIALS | LYMPHOCYTES
Journal Article
Oncogene, ISSN 0950-9232, 01/2009, Volume 28, Issue 1, pp. 85 - 94
Journal Article
Journal Article