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Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 5, pp. 652 - 663
We have investigated the role of individual members of the Raf/Mek/Erk cascade in the onset of oncogene-driven non-small cell lung carcinoma (NSCLC). Ablation... 
C-RAF-1 GENE | APOPTOSIS | TUMOR PROGRESSION | ONCOLOGY | MAP KINASE | GROWTH | ORAL MEK INHIBITOR | PHASE-II | MICE | BRAF | CANCER | CELL BIOLOGY | Fibroblasts - enzymology | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Mitogen-Activated Protein Kinase 1 - deficiency | Lung Neoplasms - pathology | MAP Kinase Kinase 1 - genetics | Transfection | RNA Interference | Time Factors | Cellular Senescence | Mitogen-Activated Protein Kinase 1 - genetics | MAP Kinase Kinase 2 - genetics | Proto-Oncogene Proteins B-raf - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Proto-Oncogene Proteins B-raf - deficiency | Lung Neoplasms - enzymology | MAP Kinase Kinase 2 - deficiency | Mitogen-Activated Protein Kinase 3 - genetics | Proto-Oncogene Proteins c-raf - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Tumor Burden | Proto-Oncogene Proteins c-raf - metabolism | Mice, Knockout | Gene Expression Regulation, Enzymologic | Animals | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Line, Tumor | Mice | Mitogen-Activated Protein Kinase 3 - deficiency | Carcinoma, Non-Small-Cell Lung - enzymology | Genes, ras | Apoptosis | MAP Kinase Kinase 1 - deficiency | Development and progression | Carcinoma | Lung cancer, Non-small cell | Phosphotransferases | Cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 431 - 435
Activating mutations in KRAS and BRAF are found in more than 30% of all human tumours and 40% of melanoma, respectively, thus targeting this pathway could have... 
SELECTIVE INHIBITOR | POTENT | EFFICACY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | C-RAF | HETERODIMERIZATION | B-RAF | PROTEIN-KINASE KINASE | CANCER | Neoplasms - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | ras Proteins - metabolism | Protein Transport - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Benzamides - pharmacology | Cell Membrane - metabolism | raf Kinases - genetics | Cell Membrane - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Pyrazoles - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Indenes - pharmacology | raf Kinases - chemistry | Proto-Oncogene Proteins c-raf - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Ras genes | Growth | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Mitogen-activated protein kinases | Competition | Clinical trials | Enzymes | Kinases | Index Medicus | Proteins | Cellular | Inhibitors | Pathways | Tumours | Signalling | Dimerization
Journal Article
Oncology Reports, ISSN 1021-335X, 8/2013, Volume 30, Issue 2, pp. 877 - 889
Journal Article
Neuron, ISSN 0896-6273, 2002, Volume 35, Issue 1, pp. 65 - 76
Nerve growth factor (NGF) induces dramatic axon growth from responsive embryonic peripheral neurons. However, the roles of the various NGF-triggered signaling... 
SIGNAL-TRANSDUCTION | PROTEIN-KINASE-B | NEURITE OUTGROWTH | PHOSPHATIDYLINOSITOL 3-KINASE | BAX-DEFICIENT MICE | SYMPATHETIC NEURONS | SURVIVAL SIGNALS | NERVE GROWTH | PC12 CELLS | PHOSPHOINOSITIDE 3-KINASE | NEUROSCIENCES | ras Proteins - genetics | Mitogen-Activated Protein Kinase Kinases - genetics | ras Proteins - metabolism | Male | Ganglia, Spinal - cytology | Phosphatidylinositol 3-Kinases - metabolism | MAP Kinase Kinase 1 | Cell Differentiation - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Cell Size - genetics | Receptor, trkC - genetics | Gene Expression - physiology | Female | Fetus | Protein-Serine-Threonine Kinases - metabolism | Neurons, Afferent - cytology | Nerve Growth Factor - metabolism | Proto-Oncogene Proteins c-raf - genetics | Ganglia, Spinal - embryology | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Proto-Oncogene Proteins - deficiency | bcl-2-Associated X Protein | Receptor Protein-Tyrosine Kinases - metabolism | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Proto-Oncogene Proteins c-akt | Animals | Growth Cones - metabolism | Growth Cones - ultrastructure | Receptor Protein-Tyrosine Kinases - genetics | Receptor, trkA - metabolism | Proto-Oncogene Proteins c-raf - deficiency | Receptor, trkA - genetics | Mitogen-Activated Protein Kinases - genetics | Mice | Neurons, Afferent - metabolism | Proto-Oncogene Proteins c-bcl-2 | Receptor, trkC - metabolism | Ganglia, Spinal - metabolism | Mitogen-Activated Protein Kinases - metabolism | Signal transduction | Kinases | Neurons | Rodents | Index Medicus
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 11/2007, Volume 11, Issue 6, pp. 1395 - 1407
Journal Article
Nature Communications, ISSN 2041-1723, 09/2014, Volume 5, Issue 1, pp. 4696 - 4696
Journal Article
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