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Journal Article
Cancer Letters, ISSN 0304-3835, 2015, Volume 371, Issue 2, pp. 187 - 193
Highlight • Findings demonstrated a newly synthesized compound, t- CUPM, was a dual small molecule inhibitor of c-Raf and proinflammatory enzyme soluble epoxide hydrolase and had high potential for inhibiting... 
Hematology, Oncology and Palliative Medicine | Pancreatic carcinoma | Growth inhibition | c-Raf | Soluble epoxide hydrolase | C-Raf | Niacinamide - analogs & derivatives | Phosphorylation | Urea - pharmacokinetics | Male | Antineoplastic Agents - administration & dosage | Extracellular Signal-Regulated MAP Kinases - metabolism | Carcinoma, Pancreatic Ductal - genetics | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Mice, Mutant Strains | Urea - analogs & derivatives | Niacinamide - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Phenylurea Compounds - pharmacokinetics | Protein Kinase Inhibitors - pharmacokinetics | Genetic Predisposition to Disease | Administration, Oral | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - enzymology | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | Proto-Oncogene Proteins c-raf - metabolism | Niacinamide - administration & dosage | Carcinoma, Pancreatic Ductal - enzymology | Carcinoma, Pancreatic Ductal - drug therapy | Oxylipins - metabolism | Protein Kinase Inhibitors - administration & dosage | Phenotype | Animals | Phenylurea Compounds - administration & dosage | Signal Transduction - drug effects | Tumor Burden - drug effects | Benzoates - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-raf - antagonists & inhibitors | Epoxide Hydrolases - metabolism | Mutation | Niacinamide - pharmacology | Genes, ras | Epoxide Hydrolases - antagonists & inhibitors | Urea - pharmacology | Benzoates - pharmacokinetics | Index Medicus | growth inhibition
Journal Article
Nature (London), ISSN 1476-4687, 11/2010, Volume 468, Issue 7326, pp. 968 - 972
...(1). Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Allosteric Regulation | Humans | Gene Expression Regulation, Neoplastic | Melanoma - enzymology | Gene Expression Profiling | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Indoles - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Gene Library | Proto-Oncogene Proteins c-raf - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Open Reading Frames - genetics | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein research | Research | Properties | Protein kinases | Cancer cells | Cell lines | Biochemistry | Mutation | Kinases | Genes | Cancer | Index Medicus
Journal Article