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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1440 - 1445
Fibrosis of vital organs is a major public health problem with limited therapeutic options. Mesenchymal cells including microvascular mural cells (pericytes)... 
Receptors | Kidneys | Cytokines | Epithelial cells | Fibrosis | Ligands | Rarefaction | Inflammation | Myofibroblasts | Mesenchymal stem cells | FIBROSIS | CELLS | MULTIDISCIPLINARY SCIENCES | GROWTH-FACTOR | KIDNEY | WNT | PROTEINS | Pericytes - drug effects | Myofibroblasts - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Pericytes - pathology | G1 Phase Cell Cycle Checkpoints | Proto-Oncogene Proteins c-sis - pharmacology | Kidney Diseases - metabolism | Recombinant Proteins - metabolism | Myofibroblasts - pathology | Signal Transduction | Kidney Diseases - pathology | Mice, Inbred C57BL | Pericytes - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Connective Tissue Growth Factor - pharmacology | Mice, Transgenic | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | beta Catenin - metabolism | Transforming Growth Factor beta - pharmacology | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Wnt Signaling Pathway - genetics | Intercellular Signaling Peptides and Proteins - pharmacology | Cell Proliferation - drug effects | Mice | Cell proliferation | Platelet-derived growth factor | Physiological aspects | Fibroblasts | Research | Transforming growth factors | Health aspects | Proteins | Signal transduction | Tissue | Low density lipoprotein receptors | Biochemistry | Kidney diseases | Index Medicus | Biological Sciences
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2015, Volume 17, Issue 8, pp. 994 - 1003
The use of human pluripotent stem cells for in vitro disease modelling and clinical applications requires protocols that convert these cells into relevant... 
DIRECTED DIFFERENTIATION | IN-VIVO | MOUSE | DEFINITIVE ENDODERM | GROWTH-FACTOR | HUMAN BLASTOCYSTS | STROMAL CELLS | WNT | CULTURE | LINES | CELL BIOLOGY | Coculture Techniques | Humans | Endothelial Cells - transplantation | Glycogen Synthase Kinase 3 beta | Cell Lineage - drug effects | Dose-Response Relationship, Drug | Human Umbilical Vein Endothelial Cells - physiology | Transfection | Time Factors | Gene Expression Regulation, Developmental | Transcription, Genetic | Myocytes, Smooth Muscle - drug effects | Proto-Oncogene Proteins c-sis - pharmacology | Myocytes, Smooth Muscle - transplantation | Vascular Endothelial Growth Factor A - pharmacology | Endothelial Cells - physiology | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Biomarkers - metabolism | Cell Line | Induced Pluripotent Stem Cells - enzymology | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Myocytes, Smooth Muscle - enzymology | Induced Pluripotent Stem Cells - transplantation | Myocytes, Smooth Muscle - physiology | Gene Expression Profiling - methods | Muscle, Smooth, Vascular - transplantation | Glycogen Synthase Kinase 3 - metabolism | Mice, SCID | Muscle, Smooth, Vascular - cytology | Metabolomics - methods | Bone Morphogenetic Protein 4 - pharmacology | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Cell Differentiation - drug effects | Mice, Inbred NOD | Protein Kinase Inhibitors - pharmacology | Endothelial Cells - enzymology | Muscle, Smooth, Vascular - enzymology | Neovascularization, Physiologic | Endothelial Cells - drug effects | Usage | Cell research | Growth | Stem cells | Muscle cells | Research | Cell differentiation | Endothelium | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 35, pp. 12847 - 12852
Journal Article
Journal Article
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2011, Volume 55, Issue 6, pp. 1353 - 1360
Journal Article
Gut, ISSN 0017-5749, 12/2014, Volume 63, Issue 12, pp. 1951 - 1959
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0122577 - e0122577
Plasticity of vascular smooth muscle cells (VSMCs) plays a central role in the onset and progression of proliferative vascular diseases. In adult tissue, VSMCs... 
MAMMALIAN TARGET | VASCULAR INJURY | MIGRATION | INDUCED PROLIFERATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | ATHEROSCLEROSIS | SMOOTH-MUSCLE-CELLS | GROWTH-FACTOR | DIFFERENTIATION | EXPRESSION | Male | Dose-Response Relationship, Drug | Time Factors | Actin Cytoskeleton - drug effects | DNA - biosynthesis | Myocytes, Smooth Muscle - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-sis - pharmacology | Myocytes, Smooth Muscle - metabolism | Actin Cytoskeleton - metabolism | Cells, Cultured | Becaplermin | Atorvastatin - pharmacology | Down-Regulation - drug effects | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Blotting, Western | Cell Shape - drug effects | DNA - genetics | Cell Movement - drug effects | Microscopy, Confocal | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Signal Transduction - drug effects | Cytoskeleton - metabolism | Cell Proliferation - drug effects | Cytoskeleton - drug effects | Enzymes | Cellular signal transduction | Platelet-derived growth factor | Muscle proteins | Antilipemic agents | Phosphorylation | Calcium | Smooth muscle | AKT protein | Activation | Proteins | Signal transduction | Calponin | Vascular diseases | Actin | Modulation | Coenzyme A | Inhibition | Secretion | Contractility | Muscles | Phenotypic plasticity | Muscle contraction | Platelet-derived growth factor BB | Signaling | Atorvastatin | Cytoskeleton | Transduction | Reductase | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2011, Volume 6, Issue 12, pp. e28663 - e28663
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e40831 - e40831
The recruitment of mesenchymal stem cells (MSCs) is a vital step in the bone healing process, and hence the functionalization of osteogenic biomaterials with... 
MIGRATION | REPAIR | MULTIDISCIPLINARY SCIENCES | IN-VIVO | BIOLOGY | CONTROLLED-RELEASE | CHEMOKINE | PROTEINS | EXPRESSION | NANOFIBROUS SCAFFOLDS | PDGF-BB | Green Fluorescent Proteins - metabolism | Tissue Engineering - methods | Mitogens - pharmacology | Nanoparticles - chemistry | Humans | Adsorption - drug effects | Fluorescence | Chemotaxis - drug effects | Bone and Bones - drug effects | Tissue Scaffolds - chemistry | Polyesters - pharmacology | Biomimetic Materials - pharmacology | Chemotactic Factors - pharmacology | Mesenchymal Stromal Cells - cytology | Reference Standards | Animals | Time Factors | Cattle | Durapatite - pharmacology | Cell Proliferation - drug effects | Collagen Type I - pharmacology | Proto-Oncogene Proteins c-sis - pharmacology | Cell Migration Assays | Biological products | Platelet-derived growth factor | Adsorption | Tissue engineering | Collagen | Stem cells | Bone morphogenetic proteins | Research | Comparative analysis | Integrins | Chemotactic factors | Collagen (type I) | Mesenchyme | RANTES | Collagens | Electrospinning | Hydroxyapatite | Assaying | Biomaterials | Recruitment | Proteins | Biomedical materials | Bone biomaterials | Cascades | CXCL16 protein | Bone marrow | Biocompatibility | Physiology | Polycaprolactone | Growth factors | Controlled release | Cytokines | Bone morphogenetic protein 2 | Biophysics | Bone healing | Chemotaxis | Adhesion | Platelet-derived growth factor BB | Biological activity | Substrates | Signaling | Sustained release | Bone | Scaffolds | Cell migration | Chemokines | Index Medicus
Journal Article