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Journal Article
Hepatology, ISSN 0270-9139, 03/2012, Volume 55, Issue 3, pp. 833 - 845
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1519 - 1528
Genetic mutations that give rise to active mutant forms of Ras are oncogenic and found in several types of tumor. However, such mutations are not clear... 
SIGNAL-TRANSDUCTION | PROTEASE INHIBITOR | MEDICINE, RESEARCH & EXPERIMENTAL | PANCREATIC DUCTAL ADENOCARCINOMA | ACTIVATION | K-RAS | ONCOGENIC KRAS | MOUSE MODEL | IN-VIVO | ACINAR-CELLS | CANCER | Inflammation - chemically induced | Pancreatic Neoplasms - metabolism | Pancreatic Neoplasms - etiology | Humans | Carcinoma, Pancreatic Ductal - metabolism | Sincalide - toxicity | Pancreatitis, Chronic - chemically induced | Proto-Oncogene Proteins p21(ras) - physiology | Gabexate - toxicity | I-kappa B Kinase - physiology | Carcinoma, Pancreatic Ductal - genetics | Cyclooxygenase 2 - biosynthesis | Inflammation - complications | Inflammation - metabolism | Cell Transformation, Neoplastic - genetics | Inflammation Mediators - metabolism | Carcinoma, Pancreatic Ductal - etiology | Gene Expression Regulation, Neoplastic - physiology | I-kappa B Kinase - deficiency | Lipopolysaccharides - toxicity | Cyclooxygenase 2 Inhibitors - pharmacology | Neoplasm Proteins - biosynthesis | Pancreatic Neoplasms - pathology | Ceruletide - toxicity | Enzyme Induction | Cyclooxygenase 2 - physiology | Gabexate - analogs & derivatives | Mice, Transgenic | Pancreatic Neoplasms - genetics | I-kappa B Kinase - genetics | Pancreas - metabolism | Pancreatitis, Chronic - genetics | Carcinoma, Pancreatic Ductal - pathology | Precancerous Conditions - genetics | Proto-Oncogene Proteins p21(ras) - biosynthesis | Gene Knock-In Techniques | Animals | NF-kappa B - physiology | Inflammation - genetics | Mice | Feedback, Physiological - physiology | Precancerous Conditions - chemically induced | Genes, ras | Pancreatitis, Chronic - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2005, Volume 7, Issue 6, pp. 533 - 545
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2011, Volume 121, Issue 10, pp. 4106 - 4117
Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal neoplasms, is characterized by an expanded stroma with marked fibrosis (desmoplasia). We... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | SIGNALING PATHWAYS | IN-VITRO | TGF-BETA | EPITHELIAL-CELLS | K-RAS | CANCER METASTASIS | II RECEPTOR | GROWTH | KAPPA-B | Protein-Serine-Threonine Kinases - deficiency | Receptors, Transforming Growth Factor beta - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Stromal Cells - pathology | Humans | Proto-Oncogene Proteins p21(ras) - physiology | Receptors, Interleukin-8B - antagonists & inhibitors | Tumor Microenvironment - physiology | Carcinoma, Pancreatic Ductal - genetics | Female | Receptors, Interleukin-8B - physiology | Gene Expression | Signal Transduction | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Protein-Serine-Threonine Kinases - genetics | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - therapy | Carcinoma, Pancreatic Ductal - pathology | Mice, Knockout | Animals | Connective Tissue Growth Factor - physiology | Mice, Nude | Chemokines, CXC - physiology | Carcinoma, Pancreatic Ductal - physiopathology | Connective Tissue Growth Factor - genetics | Mice | Pancreatic Neoplasms - physiopathology | Stromal Cells - physiology | Pancreatic Neoplasms - therapy | Receptors, Transforming Growth Factor beta - deficiency | Pancreatic cancer | Physiological aspects | Development and progression | Research | Transforming growth factors | Gene expression | Chemokine receptors | Index Medicus | Abridged Index Medicus
Journal Article
Blood, ISSN 0006-4971, 12/2008, Volume 112, Issue 12, pp. 4646 - 4654
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2013, Volume 23, Issue 2, pp. 143 - 158
The LKB1 (also called STK11) tumor suppressor is mutationally inactivated in ∼20% of non-small cell lung cancers (NSCLC). LKB1 is the major upstream kinase... 
LKB1-AMPK PATHWAY | COMPLEX I | SURVIVAL | RESPIRATORY-CHAIN | METFORMIN | ENERGY STRESS | HOMEOSTASIS | ONCOLOGY | PHOSPHORYLATION | KINASE | AMPK ACTIVATION | CELL BIOLOGY | Lung Neoplasms - drug therapy | AMP-Activated Protein Kinases - metabolism | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins p21(ras) - physiology | Phenformin - therapeutic use | Tumor Suppressor Protein p53 - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Eukaryotic Initiation Factor-2 - metabolism | Real-Time Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - pathology | Hypoglycemic Agents - therapeutic use | Protein-Serine-Threonine Kinases - physiology | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Cells, Cultured | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Animals | Eukaryotic Initiation Factor-2 - genetics | Cell Proliferation - drug effects | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | AMP-Activated Protein Kinases - genetics | Drugs | Care and treatment | Analysis | Physiological aspects | Diabetes | Tumor proteins | Drug therapy | Lung cancer, Non-small cell | Health aspects | Cells | Tumors | Cancer | Index Medicus
Journal Article
Journal Article