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Journal Article
Cell, ISSN 0092-8674, 2011, Volume 147, Issue 1, pp. 173 - 184
Journal Article
by Zhang, Bing and Zhang, Bing and Wang, Jing and Wang, Jing and Wang, Xiaojing and Wang, Xiaojing and Zhu, Jing and Zhu, Jing and Liu, Q and Liu, Qi and Shi, Zhiao and Shi, Zhiao and Chambers, Matthew C and Chambers, Matthew C and Zimmerman, Lisa J and Zimmerman, Lisa J and Shaddox, Kent F and Shaddox, Kent F and Kim, Sangtae and Kim, Sangtae and Davies, Sherri R and Davies, Sherri R and Wang, Sean and Wang, Sean and Wang, Pei and Wang, Pei and Kinsinger, Christopher R and Kinsinger, Christopher R and Rivers, Robert C and Rivers, Robert C and Rodriguez, Henry and Rodriguez, Henry and Townsend, R. Reid and Townsend, R Reid and Ellis, Matthew J. C and Ellis, Matthew J C and Carr, Steven A and Carr, Steven A and Tabb, David L and Tabb, David L and Coffey, Robert J and Coffey, Robert J and Slebos, Robbert J C and Slebos, Robbert J. C and Liebler, Daniel C and Liebler, Daniel C and NCI CPTAC, CPTAC and Gillette, Michael A and Klauser, Karl R and Kuhn, Eric and Mani, D.R and Mertins, Philipp and Ketchum, Karen A and Paulovich, Amanda G and Whiteaker, Jeffrey R and Edwards, Nathan J and McGarvey, Peter B and Madhavan, Subha and Chan, Daniel and Pandey, Akhilesh and Shih, Ie-Ming and Zhang, Hui and Zhang, Zhen and Zhu, Heng and Whiteley, Gordon A and Skates, Steven J and White, Forest M and Levine, Douglas A and Boja, Emily S and Hiltke, Tara and Mesri, Mehdi and Shaw, Kenna M and Stein, Stephen E and Fenyo, David and Liu, Tao and McDermott, Jason E and Payne, Samuel H and Rodland, Karin D and Smith, Richard D and Rudnick, Paul and Snyder, Michael and Zhao, Yingming and Chen, Xian and Ransohoff, David F and Hoofnagle, Andrew N and Sanders, Melinda E and Wang, Yue and Ding, Li and NCI CPTAC and the NCI CPTAC
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7518, pp. 382 - 387
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 01/2008, Volume 19, Issue 1, pp. 394 - 404
Podosomes are dynamic actin-rich structures composed of a dense F-actin core surrounded by a cloud of more diffuse F-actin. Src performs one or more unique... 
Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 01/2008, Volume 19, Issue 1, pp. 394 - 404
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 5, pp. 1664 - 1669
Tyrosine kinases present attractive drug targets for specific types of cancers. Gleevec, a well-known therapeutic agent against chronic myelogenous leukemia,... 
Molecules | Thermodynamics | Solvents | Roux | Molecular dynamics | Atoms | Ligands | Chronic myeloid leukemia | Electrostatics | Free energy | Sampling | Alchemical free energy perturbation | CHRONIC MYELOGENOUS LEUKEMIA | BINDING FREE-ENERGY | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | sampling | BCR-ABL | thermodynamics | alchemical free energy perturbation | HISTOGRAM ANALYSIS METHOD | CHRONIC MYELOID-LEUKEMIA | INACTIVE CONFORMATION | RESTRAINING POTENTIALS | MOLECULAR-DYNAMICS SIMULATIONS | C-SRC | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Crystallography, X-Ray | Piperazines - metabolism | Proto-Oncogene Proteins pp60(c-src) - chemistry | Pyrimidines - metabolism | Binding Sites | Binding, Competitive | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Protein Structure, Tertiary | Proto-Oncogene Proteins c-abl - chemistry | Models, Molecular | Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Proto-Oncogene Proteins pp60(c-src) - metabolism | Protein Binding | Proto-Oncogene Proteins c-abl - metabolism | Protein Conformation | Protein Kinase Inhibitors - pharmacology | Benzamides | Protein Kinase Inhibitors - metabolism | Tyrosine | Physiological aspects | Research | Phosphotransferases | Health aspects | Protein binding | Proteins | Kinases | Cancer therapies | Leukemia | Binding sites | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7541, pp. 57 - 62
Journal Article
Science, ISSN 0036-8075, 12/2014, Volume 346, Issue 6216, pp. 1480 - 1486
Targeted cancer therapies have produced substantial clinical responses, but most tumors develop resistance to these drugs. Here, we describe a pharmacogenomic... 
CELL LUNG-CANCER | ALK | KINASE INHIBITION | GEFITINIB | ACTIVATION | CERITINIB | MULTIDISCIPLINARY SCIENCES | CRIZOTINIB | MUTATIONS | CHEMOTHERAPY | BYPASS MECHANISMS | Lung Neoplasms - drug therapy | Sulfones - therapeutic use | Humans | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | MAP Kinase Kinase 1 - genetics | DNA Mutational Analysis | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Tumor Cells, Cultured | Molecular Targeted Therapy - methods | Lung Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | MAP Kinase Kinase 1 - metabolism | Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors | Patient-Specific Modeling | Drug Resistance, Neoplasm - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Mutation | Enzyme Activation - genetics | Drug Screening Assays, Antitumor | Antimitotic agents | Cancer patients | Care and treatment | Lung cancer | Dosage and administration | Genetic aspects | Antineoplastic agents | Drug therapy | Drug resistance | Methods | Cancer | Cell culture | Oncology | Pharmaceutical sciences | Index Medicus | Drugs | Mutations | Therapy | Genetics | Kinases | Patients | Tumors
Journal Article
Journal Article