X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (65266) 65266
Publication (32) 32
Conference Proceeding (21) 21
Book Chapter (14) 14
Dissertation (3) 3
Book / eBook (1) 1
Magazine Article (1) 1
Newsletter (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (42286) 42286
animals (39262) 39262
proto-oncogene proteins - metabolism (26129) 26129
mice (21696) 21696
biochemistry & molecular biology (17209) 17209
cell biology (16075) 16075
apoptosis (15765) 15765
phosphorylation (14899) 14899
signal transduction (13284) 13284
male (12815) 12815
expression (11591) 11591
female (11366) 11366
cell line, tumor (10664) 10664
proto-oncogene proteins - genetics (10377) 10377
oncology (10335) 10335
proto-oncogene proteins c-bcl-2 - metabolism (10303) 10303
proto-oncogene proteins c-akt - metabolism (9459) 9459
rats (9449) 9449
cell line (8994) 8994
activation (8922) 8922
apoptosis - drug effects (8327) 8327
dna-binding proteins - metabolism (8028) 8028
cells, cultured (7970) 7970
proteins (7653) 7653
cancer (6975) 6975
molecular sequence data (6645) 6645
transfection (6417) 6417
transcription factors - metabolism (6319) 6319
protein binding (6078) 6078
gene expression (5759) 5759
protein-serine-threonine kinases - metabolism (5701) 5701
phosphatidylinositol 3-kinases - metabolism (5507) 5507
research (5444) 5444
signal transduction - drug effects (5358) 5358
mutation (5272) 5272
blotting, western (5114) 5114
protein (5091) 5091
tumor cells, cultured (4788) 4788
amino acid sequence (4745) 4745
proto-oncogene proteins c-akt (4701) 4701
bcl-2-associated x protein - metabolism (4662) 4662
cell proliferation (4534) 4534
cells (4424) 4424
tumor suppressor protein p53 - metabolism (4324) 4324
base sequence (4243) 4243
gene (4161) 4161
immunohistochemistry (4161) 4161
enzyme activation (4100) 4100
nuclear proteins - metabolism (4093) 4093
membrane proteins - metabolism (4056) 4056
rna, messenger - metabolism (4045) 4045
gene expression regulation, neoplastic (3947) 3947
time factors (3917) 3917
research article (3912) 3912
gene-expression (3892) 3892
middle aged (3871) 3871
dna-binding proteins - genetics (3740) 3740
gene expression regulation (3716) 3716
signal transduction - physiology (3713) 3713
multidisciplinary sciences (3697) 3697
binding sites (3643) 3643
analysis (3601) 3601
mice, inbred c57bl (3593) 3593
adult (3505) 3505
neurosciences (3463) 3463
protein-tyrosine kinases - metabolism (3441) 3441
growth (3437) 3437
physiological aspects (3379) 3379
down-regulation (3351) 3351
proto-oncogene proteins c-bcl-2 - genetics (3250) 3250
genetics & heredity (3237) 3237
transcription factors - genetics (3234) 3234
inhibition (3205) 3205
genetic aspects (3185) 3185
cell proliferation - drug effects (3172) 3172
mice, knockout (3157) 3157
cell cycle (3151) 3151
rats, sprague-dawley (3114) 3114
transcription factors (3114) 3114
trans-activators - metabolism (3087) 3087
apoptosis - physiology (3056) 3056
phosphorylation - drug effects (3053) 3053
enzyme inhibitors - pharmacology (3043) 3043
proto-oncogene proteins c-myc - metabolism (3038) 3038
transcription, genetic (3031) 3031
up-regulation (3021) 3021
differentiation (3002) 3002
kinases (3002) 3002
antineoplastic agents - pharmacology (2953) 2953
in-vivo (2949) 2949
akt (2946) 2946
aged (2931) 2931
cell cycle proteins - metabolism (2912) 2912
proliferation (2899) 2899
dose-response relationship, drug (2896) 2896
pathway (2878) 2878
bcl-2 (2864) 2864
carrier proteins - metabolism (2856) 2856
recombinant fusion proteins - metabolism (2839) 2839
promoter regions, genetic (2817) 2817
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (64187) 64187
Chinese (1590) 1590
Japanese (345) 345
Russian (59) 59
French (42) 42
Polish (23) 23
Portuguese (18) 18
German (12) 12
Hungarian (6) 6
Norwegian (6) 6
Spanish (5) 5
Dutch (4) 4
Korean (4) 4
Italian (3) 3
Romanian (2) 2
Croatian (1) 1
Danish (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular cell, ISSN 1097-2765, 2009, Volume 36, Issue 3, pp. 487 - 499
While activation of BAX/BAK by BH3-only molecules (BH3s) is essential for mitochondrial apoptosis, the underlying mechanisms remain unsettled. Here we... 
CELLCYCLE | CYTOCHROME-C | PROAPOPTOTIC BAX | OLIGOMERIZES BAK | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM | SUBCELLULAR LOCATION | PROTEINS | BCL-2 FAMILY-MEMBERS | BH3 DOMAIN | CELL-DEATH | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2-Associated X Protein - chemistry | Immunoprecipitation | Apoptosis - drug effects | Protein Multimerization | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Green Fluorescent Proteins - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Bcl-2-Like Protein 11 | Protein Binding - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Green Fluorescent Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Etoposide - pharmacology | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Tunicamycin - pharmacology | Fibroblasts - drug effects | Thapsigargin - pharmacology | Fibroblasts - cytology | Mice | Mutation | Microscopy, Fluorescence | Staurosporine - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Monomers | Apoptosis | Oligomers
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2016, Volume 167, Issue 1, pp. 233 - 247.e17
Journal Article
Nature cell biology, ISSN 1476-4679, 2015, Volume 17, Issue 10, pp. 1270 - 1281
Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to trigger apoptosis, whereas anti-apoptotic BCL-2 members preserve... 
CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | ACTIVATION | CONFORMATIONAL-CHANGE | MEMBERS | PROAPOPTOTIC BAX | BH3 DOMAINS | PUMA | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Cytochromes c - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Embryo, Mammalian - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Mitochondria - genetics | RNA Interference | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Mice, Inbred C57BL | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Intestine, Small - cytology | Embryo, Mammalian - cytology | Models, Biological | Fibroblasts - cytology | Intestine, Small - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Genotype | Genetic aspects | Properties | Cell death | Cellular control mechanisms
Journal Article
Nature cell biology, ISSN 1476-4679, 2012, Volume 14, Issue 3, pp. 311 - 317
Mitotic spindle positioning by cortical pulling forces(1) defines the cell division axis and location(2), which is critical for proper cell division and... 
ACTIVATION | PROTEIN | MECHANISM | KINETOCHORE | IMPORTIN-BETA | MITOTIC SPINDLE | SEGREGATION | ASYMMETRIC CELL-DIVISION | GRADIENT | RAN | CELL BIOLOGY | NIH 3T3 Cells | ran GTP-Binding Protein - genetics | Microtubule-Associated Proteins - genetics | Antigens, Nuclear - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Molecular Sequence Data | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Centrioles - physiology | Spindle Apparatus - metabolism | RNA Interference | Cell Cycle Proteins - genetics | Chromosome Segregation - physiology | Spindle Apparatus - physiology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytoplasmic Dyneins - metabolism | Dyneins - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Cell Cycle Proteins - metabolism | Cytoplasmic Dyneins - genetics | Protein-Serine-Threonine Kinases - genetics | Dynactin Complex | Nuclear Matrix-Associated Proteins - metabolism | Proto-Oncogene Proteins - genetics | ran GTP-Binding Protein - metabolism | Blotting, Western | Animals | Antigens, Nuclear - genetics | Mitosis - physiology | Nuclear Matrix-Associated Proteins - genetics | Models, Biological | Protein Binding | Signal Transduction - physiology | Mice | Centrioles - metabolism | Dyneins - genetics | HeLa Cells | Microscopy, Fluorescence | Spindle (Cell division) | Physiological aspects | Cell division | Research | Chromosomes | Dynein
Journal Article
EMBO reports, ISSN 1469-3178, 2009, Volume 11, Issue 1, pp. 45 - 51
Autophagy is the cellular homeostatic pathway that delivers large cytosolic materials for degradation in the lysosome. Recent evidence indicates that autophagy... 
mitophagy | Nix | LC3 | GABARAP | selective autophagy | Selective autophagy | Mitophagy | APOPTOSIS | PROTEIN | RETICULOCYTE MATURATION | UBIQUITIN | BNIP3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | E3 | CELL-DEATH | CELL BIOLOGY | STRUCTURAL BASIS | DEGRADATION | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Cercopithecus aethiops | Molecular Sequence Data | Substrate Specificity | Autophagy - physiology | Mitochondrial Proteins - genetics | Proto-Oncogene Proteins - chemistry | Mitochondrial Proteins - metabolism | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Membrane Proteins - metabolism | Binding Sites | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Blotting, Western | Amino Acid Motifs | Autophagy-Related Protein 8 Family | Animals | Membrane Proteins - chemistry | Reticulocytes - cytology | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Mice | Receptors, GABA-A - metabolism | COS Cells | Proteins | Mitochondria | Cellular biology | Cytoplasm | Scientific Report
Journal Article
The EMBO journal, ISSN 1460-2075, 2017, Volume 36, Issue 24, pp. 3573 - 3599
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 2005, Volume 17, Issue 3, pp. 393 - 403
Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of its BH3 domain with a groove... 
CYTOCHROME-C | COMPLEX | SURVIVAL FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | BIM | RELEASE | PEPTIDE | CELL-DEATH | FAMILY | MEMBER | CELL BIOLOGY | Humans | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | Genetic Complementation Test | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Carrier Proteins - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Peptide Fragments - genetics | Cell Survival - physiology | Binding, Competitive | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | bcl-X Protein | Peptide Fragments - metabolism | Membrane Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Proto-Oncogene Proteins - genetics | Recombinant Proteins - genetics | Proteins - genetics | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Peptide Fragments - chemistry | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Biosensing Techniques | Ligands | Mice | Apoptosis - physiology | Proteins - chemistry | In Vitro Techniques | Proto-Oncogene Proteins c-bcl-2 - genetics
Journal Article