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GENOME RESEARCH, ISSN 1088-9051, 05/2001, Volume 11, Issue 5, pp. 731 - 753
Journal Article
Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7290, pp. 927 - 931
Journal Article
Molecular Therapy, ISSN 1525-0016, 05/2017, Volume 25, Issue 5, pp. 1168 - 1186
CRISPR-associated protein 9 (Cas9)-mediated genome editing provides a promising cure for HIV-1/AIDS; however, gene delivery efficiency in vivo remains an... 
genome editing | humanized BLT mice | animal models | viral latency | HIV | AAV | Tg26 mice | gene therapy | Cas9 | gRNA | EFFICIENT DELIVERY | MEDICINE, RESEARCH & EXPERIMENTAL | GENE EDITING TECHNOLOGIES | PACKAGING CAPACITY | LENTIVIRAL VECTORS | ADENOASSOCIATED VIRAL VECTORS | STAPHYLOCOCCUS-AUREUS CAS9 | CRISPR-CAS9 NUCLEASES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CRISPR/CAS9 SYSTEM | GENETICS & HEREDITY | MODULATES PROLIFERATION | NEURAL PRECURSOR CELLS | Oligonucleotides - genetics | Dependovirus - genetics | Endonucleases - genetics | Staphylococcus aureus - enzymology | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | HIV Long Terminal Repeat | pol Gene Products, Human Immunodeficiency Virus - metabolism | Endonucleases - metabolism | gag Gene Products, Human Immunodeficiency Virus - metabolism | HIV Infections - pathology | Proviruses - genetics | Base Sequence | Clustered Regularly Interspaced Short Palindromic Repeats | gag Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - genetics | Disease Models, Animal | Genome, Viral | HIV-1 - metabolism | Dependovirus - metabolism | Genetic Vectors - chemistry | HIV Infections - virology | Bacterial Proteins - genetics | Genetic Vectors - metabolism | Mice, Transgenic | HIV-1 - genetics | Proviruses - metabolism | Staphylococcus aureus - chemistry | Oligonucleotides - metabolism | Animals | CRISPR-Cas Systems | HIV Infections - therapy | Bacterial Proteins - metabolism | Gene Editing - methods | Mice | Genetic Therapy - methods | Neuroimaging | Animal models | Bioluminescence | Intravenous administration | Genes | Liver | Clinical trials | Chronic infection | Infections | Genomes | Thymus | Acquired immune deficiency syndrome--AIDS | Efficiency | Transgenic animals | Human immunodeficiency virus--HIV | Bone marrow | Colon | Deoxyribonucleic acid--DNA | Spleen | CRISPR | Gene transfer | Advisors | Transgenic mice | Ribonucleic acid--RNA | Progenitor cells | Polymerase chain reaction | Studies | Genotyping | Neural stem cells | Index Medicus | Original
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2014, Volume 111, Issue 46, pp. 16532 - 16537
We have developed a screening platform for the isolation of genetic entities involved in metastatic reactivation. Retroviral libraries of cDNAs from fully... 
Dormancy | MicroRNA | Lungs | Libraries | Metastasis | Lesions | Genetic screening | Cells | Tumors | Cancer | SURVIVAL | ACTIVATION | microRNA library screen | MULTIDISCIPLINARY SCIENCES | forward genetic screens | TUMOR | MECHANISMS | shRNA library screen | SHRNA LIBRARIES | DORMANCY | cDNA library screen | BREAST-CANCER CELLS | LUNG-CANCER | metastatic reactivation | IN-VIVO | PROGRESSION | Neoplasm Transplantation | RNA, Small Interfering - genetics | Proviruses - isolation & purification | Genes, Neoplasm | Neoplasm Proteins - physiology | DNA, Complementary - genetics | Gene Expression Regulation, Neoplastic | RNA, Neoplasm - isolation & purification | MicroRNAs - isolation & purification | Lung Neoplasms - secondary | Proviruses - genetics | Retroviridae - genetics | Mammary Neoplasms, Experimental - pathology | Female | Neoplasm Proteins - genetics | Carcinoma - secondary | High-Throughput Screening Assays - methods | Transduction, Genetic | Gene Library | Retroviridae - isolation & purification | Virus Integration | Genetic Vectors - genetics | Genetic Vectors - isolation & purification | Neoplasm Metastasis - genetics | Animals | Neoplasm Metastasis - pathology | Cell Line, Tumor | RNA, Neoplasm - genetics | Mice | Mice, Inbred BALB C | MicroRNAs - genetics | DNA, Neoplasm - genetics | Oncology, Experimental | Genetic research | Genetic aspects | Research | Nucleotide sequencing | Methods | DNA sequencing | Genes | Rodents | Breast cancer | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 11, pp. 3054 - 3059
Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes malignant and inflammatory diseases in ∼10% of infected people. A typical host has... 
Epigenetics | Retrovirus | HTLV-1 | CTCF | Latency | TOPOLOGY | retrovirus | METHYLATION | PROTEIN | INSULATOR | MULTIDISCIPLINARY SCIENCES | latency | TRANSCRIPTION | INFECTIVITY | LOCUS | epigenetics | GENE | IN-VIVO | EXPRESSION | Consensus Sequence | Epigenesis, Genetic | Humans | Retroviridae Proteins - biosynthesis | DNA Methylation | Chromatin Immunoprecipitation | Proviruses - genetics | Histone Code | Transcription, Genetic | Human T-lymphotropic virus 1 - genetics | CD4-Positive T-Lymphocytes - virology | Binding Sites | Repressor Proteins - metabolism | HTLV-I Infections - genetics | Chromatin - ultrastructure | Virus Integration - genetics | Viral Regulatory and Accessory Proteins - genetics | DNA, Viral - metabolism | Basic-Leucine Zipper Transcription Factors - genetics | DNA - metabolism | Transcription Factors - genetics | HTLV-I Infections - virology | Mutagenesis, Insertional - genetics | Retroviridae Proteins - genetics | DNA - genetics | Basic-Leucine Zipper Transcription Factors - biosynthesis | Gene Expression Regulation, Viral | CCCTC-Binding Factor | Protein Binding | DNA, Viral - genetics | Genome, Human | Messenger RNA | Genetic aspects | Host-virus relationships | Observations | Health aspects | HTLV-I (Virus) | Binding sites (Biochemistry) | Chromatin | Lymphocytes | Viruses | Gene expression | Cells | Inflammatory diseases | Deoxyribonucleic acid--DNA | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 08/2014, Volume 514, Issue 7524, pp. 633 - 637
Journal Article
PLoS Pathogens, ISSN 1553-7366, 04/2018, Volume 14, Issue 4, pp. e1007012 - e1007012
The bromodomain protein Brd4 promotes HIV-1 latency by competitively inhibiting P-TEFb-mediated transcription induced by the virus-encoded Tat protein. Brd4 is... 
ACTIVATION | COMPLEX | ACETYLATION | TAT | MICROBIOLOGY | P-TEFB | HISTONE-ACETYLTRANSFERASE | VIROLOGY | ELONGATION | TIP60 | CURE | BROMODOMAIN PROTEIN BRD4 | PARASITOLOGY | HIV-1 - pathogenicity | Virus Latency | Humans | Positive Transcriptional Elongation Factor B - metabolism | Positive Transcriptional Elongation Factor B - genetics | Proviruses - genetics | Transcription, Genetic | Acetylation | CD4-Positive T-Lymphocytes - virology | Lysine Acetyltransferase 5 - genetics | Nuclear Proteins - genetics | Jurkat Cells | tat Gene Products, Human Immunodeficiency Virus - genetics | HIV Infections - genetics | HIV Infections - virology | CD4-Positive T-Lymphocytes - metabolism | Lysine Acetyltransferase 5 - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | HIV-1 - genetics | Transcription Factors - metabolism | Histones - genetics | Gene Expression Regulation, Viral | HIV Infections - drug therapy | Histones - metabolism | tat Gene Products, Human Immunodeficiency Virus - metabolism | Genetic aspects | Research | Genetic transcription | HIV (Viruses) | Analysis | Visualization | Transcription | Funding | Viruses | Lymphocytes T | Kinases | Proteins | Acquired immune deficiency syndrome--AIDS | Coding | Lymphocytes | Human immunodeficiency virus--HIV | Cell cycle | Acetyltransferase | Supervision | Elongation | Pharmaceutical sciences | Therapeutic applications | Proviruses | Latent infection | CD4 antigen | Latency | Tat protein | Lysine | Epigenetics | Molecular biology | Index Medicus | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
FASEB Journal, ISSN 0892-6638, 08/2008, Volume 22, Issue 8, pp. 2936 - 2948
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2010, Volume 397, Issue 1, pp. 144 - 160
Journal Article
PLoS Pathogens, ISSN 1553-7366, 05/2013, Volume 9, Issue 5, pp. e1003338 - e1003338
Journal Article