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Nature Immunology, ISSN 1529-2908, 05/2012, Volume 13, Issue 5, pp. 449 - 456
Intestinal phagocytes transport oral antigens and promote immune tolerance, but their role in innate immune responses remains unclear. Here we found that... 
FLAGELLIN | PATTERN-RECOGNITION | NOD-LIKE RECEPTORS | ACTIVATES CASPASE-1 | MACROPHAGES | INTERLEUKIN-1-BETA | INFLAMMASOME RECEPTORS | INFECTION | NLRP3 INFLAMMASOME | SECRETION | IMMUNOLOGY | Inflammasomes - metabolism | Humans | Receptors, Interleukin-1 - genetics | Salmonella Infections - genetics | Salmonella Infections - immunology | Clonal Anergy | Caspase 1 - metabolism | Monocytes - metabolism | Monocytes - immunology | Intestines - immunology | Host-Pathogen Interactions - immunology | Signal Transduction - immunology | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | Tumor Necrosis Factor-alpha - immunology | Apoptosis Regulatory Proteins - genetics | Pseudomonas - immunology | Toll-Like Receptors - metabolism | Neutrophil Infiltration - immunology | Neutrophils - pathology | Apoptosis Regulatory Proteins - immunology | Flagellin - immunology | Receptors, Interleukin-1 - immunology | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Neutrophils - immunology | Salmonella - genetics | Signal Transduction - genetics | Phagocytes - immunology | Neutrophil Infiltration - genetics | Mice, Knockout | Pseudomonas Infections - immunology | Salmonella - immunology | Animals | Intestines - microbiology | Phagocytes - microbiology | Inflammasomes - immunology | Interleukin-6 - immunology | Interleukin-6 - biosynthesis | Mice | Mice, Inbred BALB C | Tumor Necrosis Factor-alpha - biosynthesis | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
Science, ISSN 0036-8075, 8/2008, Volume 321, Issue 5889, pp. 691 - 696
MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to... 
Receptors | Phenotypes | Transfection | Cytokines | HEK293 cells | Genes | Cell lines | Fibroblasts | Agonists | Reports | Children | MYD88-DEFICIENT MICE | HERPES-SIMPLEX-VIRUS | PROTECTIVE IMMUNITY | MYELOID DIFFERENTIATION FACTOR-88 | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | HUMORAL IMMUNITY | STAPHYLOCOCCUS-AUREUS | AERUGINOSA LUNG INFECTION | HOST RESPONSE | CUTTING EDGE | Humans | Child, Preschool | Male | Mutation, Missense | Bacterial Infections - genetics | Pneumococcal Infections - immunology | Bacterial Infections - immunology | Gene Deletion | Pneumococcal Infections - genetics | Female | Toll-Like Receptors - metabolism | Child | Staphylococcal Infections - genetics | Disease Susceptibility | Cytokines - metabolism | Signal Transduction | Staphylococcal Infections - immunology | Receptors, Interleukin-1 - immunology | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Immunity, Innate | Pseudomonas Infections - genetics | Pseudomonas Infections - immunology | Receptors, Interleukin-1 - metabolism | Animals | Myeloid Differentiation Factor 88 - deficiency | Adolescent | Mice | Myeloid Differentiation Factor 88 - metabolism | Cell Line, Transformed | Genetic aspects | Bacterial infections | Pediatrics | Bacteria | Biomedical research | Genetic disorders | Immunology | Index Medicus | Pneumococcal Infections | Life Sciences | Toll-Like Receptors | Bacterial Infections | Myeloid Differentiation Factor 88 | Bacteriology | Staphylococcal Infections | Microbiology and Parasitology | Pseudomonas Infections | Receptors, Interleukin-1
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 9, pp. e106543 - e106543
NK-lysin is an antimicrobial protein produced by cytotoxic T lymphocytes and natural killer cells. In this study, we examined the biological property of a... 
CELLS | DEFENSE | CYNOGLOSSUS-SEMILAEVIS | MULTIDISCIPLINARY SCIENCES | ANTIMICROBIAL PEPTIDE | INNATE | FISH | SYNTHETIC PEPTIDE | IDENTIFICATION | EXPRESSION | GRANULYSIN | Antimicrobial Cationic Peptides - immunology | DNA, Bacterial - metabolism | Streptococcal Infections - veterinary | Molecular Sequence Data | Flatfishes - genetics | Vibrio Infections - immunology | Antimicrobial Cationic Peptides - administration & dosage | Host-Pathogen Interactions - immunology | Vibrio - metabolism | Streptococcal Infections - genetics | Fish Proteins - genetics | Bacterial Infections - genetics | Vibrio Infections - genetics | Proteolipids - immunology | Bacterial Infections - immunology | Fish Diseases - immunology | Antimicrobial Cationic Peptides - genetics | Virus Diseases - genetics | Vibrio Infections - veterinary | Amino Acid Sequence | Proteolipids - administration & dosage | Gene Expression | Fish Diseases - microbiology | Proteolipids - genetics | Virus Diseases - immunology | Fish Proteins - immunology | Flatfishes - immunology | Pseudomonas fluorescens | Bacterial Infections - veterinary | Fish Proteins - administration & dosage | Pseudomonas Infections - genetics | Pseudomonas Infections - immunology | Sequence Homology, Amino Acid | Pseudomonas Infections - veterinary | Animals | Fish Diseases - virology | Host-Pathogen Interactions - genetics | Virus Diseases - veterinary | Streptococcal Infections - immunology | Vibrio - pathogenicity | Peptides | DNA | Aquaculture industry | Fishes | Bacteria | Bacterial genetics | Health aspects | Biological properties | Laboratories | Gram-positive bacteria | Cytotoxicity | Amino acids | Lymphocytes T | Infections | Antiinfectives and antibacterials | Degradation | Killer cells | Clonal deletion | E coli | Lymphocytes | Animal tissues | Antimicrobial peptides | Deletion | Fish | Natural killer cells | Deoxyribonucleic acid--DNA | Biodegradation | Pathogens | Immune response | Staphylococcus infections | Marine biology | Antimicrobial agents | Gene expression | Bactericidal activity | Immune systems | In vivo methods and tests | Cytoplasm | Viral infections | Aquaculture | Index Medicus | Deoxyribonucleic acid
Journal Article
PLoS Pathogens, ISSN 1553-7366, 12/2009, Volume 5, Issue 12, pp. e1000703 - e1000703
We sought to define protective mechanisms of immunity to Staphylococcus aureus and Candida albicans bloodstream infections in mice immunized with the... 
RECOMBINANT N-TERMINUS | RISK-FACTORS | SEPTIC RATS | MICROBIOLOGY | IMPROVES SURVIVAL | TUMOR-NECROSIS-FACTOR | CINC MESSENGER-RNA | VIROLOGY | INTERFERON-GAMMA | PSEUDOMONAS-AERUGINOSA | HOST-DEFENSE | CHEMOKINETIC PROPERTIES | PARASITOLOGY | Adaptive Immunity | T-Lymphocyte Subsets - immunology | Interferon-gamma | Adjuvants, Immunologic - pharmacology | Staphylococcal Infections - immunology | Mice, Inbred C57BL | Interleukin-17 - immunology | Vaccines - immunology | Fungal Vaccines - immunology | Adoptive Transfer | Candida albicans - immunology | Th1 Cells - immunology | Candidiasis - prevention & control | Animals | Fungal Proteins - immunology | Aluminum Hydroxide - immunology | Female | Staphylococcal Infections - prevention & control | Staphylococcus aureus - immunology | Mice | Mice, Inbred BALB C | Candidiasis - immunology | Candidiasis | Immune response | Staphylococcus aureus infections | Physiological aspects | Development and progression | Genetic aspects | Research | T cells | Index Medicus | Pathogens | g-Interferon | Helper cells | Adjuvants | Data processing | Inflammation | Leukocytes (neutrophilic) | Lymphocytes T | Vaccines | Immunity | Interleukin 17 | virulence factors | CD4 antigen | Infection | Phagocytes | Aluminum hydroxide | N-Terminus | Public health | Immune system | Microorganisms | Microbiology | Cytokines | Lymphocytes | Staphylococcus infections | Organisms
Journal Article
Immunity, ISSN 1074-7613, 07/2017, Volume 47, Issue 1, pp. 148 - 158.e5
Mucosal sites such as the intestine, oral cavity, nasopharynx, and vagina all have associated commensal flora. The surface of the eye is also a mucosal site,... 
ocular surface disease | γδ T cells | IL-17 | host defense | ocular commensal bacteria | microbiome | mucosal immunity | Pseudomonas aeruginosa - immunology | Humans | Cornea - immunology | Immunity, Mucosal | Corynebacterium - immunology | Receptors, Antigen, T-Cell, gamma-delta - genetics | Candidiasis - microbiology | Corynebacterium Infections - microbiology | Eye Infections - microbiology | Neutrophil Infiltration | Corynebacterium Infections - immunology | Eye Infections - immunology | Neutrophils - microbiology | Candidiasis - immunology | Disease Models, Animal | Cornea - microbiology | Microbiota - immunology | Receptors, Antigen, T-Cell, gamma-delta - metabolism | Mice, Inbred C57BL | Neutrophils - immunology | Interleukin-17 - genetics | Tears - immunology | Candida albicans - immunology | Pseudomonas Infections - microbiology | Mice, Knockout | Pseudomonas Infections - immunology | Host-Pathogen Interactions | Interleukin-17 - metabolism | Animals | T-Lymphocytes - immunology | Mice | Cornea | Commensals | Disease | Mucosa | Interleukin | Homeostasis | Infections | Lymphocytes T | Nasopharynx | Immunity | Recruitment | Eye | Immunology | Lymphocytes | Intestine | Rodents | Bacteria | Immune system | Cytokines | Neutrophils | Vagina | Antimicrobial agents | Interleukin 17 | Studies | Oral cavity | Antibiotics | Flora | Tears | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2011, Volume 186, Issue 11, pp. 6585 - 6596
Biofilms are complex communities of bacteria encased in a matrix composed primarily of polysaccharides, extracellular DNA, and protein. Staphylococcus aureus... 
HUMAN NEUTROPHILS | LIPOTEICHOIC ACID | EXTRACELLULAR DNA | CELL WALL COMPONENTS | HOST-DEFENSE | ARGININE METABOLISM | INNATE IMMUNE-SYSTEM | IMMUNOLOGY | PSEUDOMONAS-AERUGINOSA BIOFILMS | BACTERIAL-DNA | CUTTING EDGE | Toll-Like Receptor 2 - genetics | Catheter-Related Infections - metabolism | Staphylococcus aureus - physiology | Toll-Like Receptor 9 - genetics | Green Fluorescent Proteins - genetics | Host-Pathogen Interactions - immunology | Toll-Like Receptor 9 - immunology | Inflammation - metabolism | Staphylococcal Infections - microbiology | Macrophages - immunology | Cytokines - immunology | Staphylococcal Infections - metabolism | Green Fluorescent Proteins - metabolism | Microscopy, Electron, Scanning | Cytokines - metabolism | Staphylococcal Infections - immunology | Mice, Inbred C57BL | Phagocytosis - immunology | Mice, Transgenic | Inflammation - immunology | Mice, Knockout | Microscopy, Confocal | Macrophages - metabolism | Models, Immunological | Animals | Biofilms | Staphylococcus aureus - ultrastructure | Catheter-Related Infections - microbiology | Catheter-Related Infections - immunology | Toll-Like Receptor 2 - immunology | Staphylococcus aureus - immunology | Mice | Immune Evasion - immunology | Index Medicus | Abridged Index Medicus | S. aureus | alternative activation | Toll-like receptor 2 | biofilm | macrophage | iNOS | arginase-1 | Toll-like receptor 9
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2013, Volume 190, Issue 3, pp. 1276 - 1284
Pseudomonas aeruginosa persists in patients with cystic fibrosis (CF) and drives CF lung disease progression. P. aeruginosa potently activates the innate... 
AIRWAY EPITHELIAL-CELLS | TRANSMEMBRANE CONDUCTANCE REGULATOR | IMMUNE-RESPONSE | TOLL-LIKE RECEPTOR-5 | ANTIINFLAMMATORY TARGET | INFLAMMATION | ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS | MICE | IMMUNOLOGY | TLR5 | LYMPHOCYTES | Pseudomonas aeruginosa - immunology | T-Lymphocyte Subsets - immunology | Flagella - physiology | Lung - microbiology | Pseudomonas Infections - etiology | Pseudomonas aeruginosa - isolation & purification | Humans | Pneumonia, Bacterial - etiology | Culture Media, Conditioned - pharmacology | Male | Flagellin - pharmacology | Young Adult | Pseudomonas aeruginosa - pathogenicity | Immune Tolerance - immunology | Myeloid Cells - immunology | Flagellin - genetics | Adult | Female | Flagella - immunology | Myeloid Cells - drug effects | Receptors, CXCR4 - genetics | Cells, Cultured - immunology | Flagellin - immunology | Pneumonia, Bacterial - microbiology | Disease Susceptibility | Cystic Fibrosis - microbiology | Gene Expression Regulation - immunology | Bacterial Proteins - genetics | Cystic Fibrosis - complications | Immunity, Innate | Pseudomonas Infections - microbiology | Pseudomonas Infections - immunology | Toll-Like Receptor 5 - immunology | Pseudomonas aeruginosa - genetics | Receptors, CXCR4 - biosynthesis | Receptors, CXCR4 - immunology | Up-Regulation - immunology | Adolescent | Th17 Cells - immunology | Pneumonia, Bacterial - immunology | Immune Evasion - immunology | Myelopoiesis - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 06/2014, Volume 40, Issue 6, pp. 896 - 909
Animal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host... 
LIFE-SPAN | IMMUNE-RESPONSE | PATHOGEN INTERACTIONS | CAENORHABDITIS-ELEGANS | DROSOPHILA-MELANOGASTER | AUTOPHAGY GENES | REGULATES AUTOPHAGY | STAPHYLOCOCCUS-AUREUS | IMMUNOLOGY | C. ELEGANS | LYSOSOMAL BIOGENESIS | Pseudomonas aeruginosa - immunology | Caenorhabditis elegans - microbiology | Transcriptional Activation - genetics | Caenorhabditis elegans Proteins - immunology | Salmonella Infections - immunology | Transcriptional Activation - immunology | Autophagy - immunology | Signal Transduction - immunology | RNA Interference | Autophagy - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - immunology | Macrophages - immunology | Enterococcus faecalis - immunology | Basic Helix-Loop-Helix Transcription Factors - genetics | Staphylococcal Infections - immunology | Immunity, Innate | Caenorhabditis elegans - immunology | Pseudomonas Infections - immunology | Animals | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Salmonella enterica - immunology | Basic Helix-Loop-Helix Transcription Factors - immunology | Staphylococcus aureus - immunology | Mice | RNA, Small Interfering | Caenorhabditis elegans Proteins - genetics | Genetic aspects | Genetic transcription | Analysis | Gastrointestinal diseases | Genes | Genomics | Signal transduction | Transcription factors | Nematodes | Staphylococcus infections | Kinases | Mammals | Gene expression | Experiments | Autophagy | Chemokines | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 8, pp. 727 - 737
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2012, Volume 122, Issue 11, pp. 4145 - 4159
Journal Article