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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2013, Volume 110, Issue 18, pp. 7458 - 7463
Although antibiotic resistance represents a public health emergency, the pipeline of new antibiotics is running dry. Repurposing of old drugs for new clinical... 
Bioluminescence | Lungs | Exotoxins | Plasmids | Genes | Virulence | Antivirals | Pseudomonas aeruginosa | Infections | Gene expression | Drug repositioning | Selective optimization of side activities (SOSA) approach | Cystic fibrosis | Antivirulence drug | Iron uptake | ANALYSIS REVEALS | MULTIDISCIPLINARY SCIENCES | antivirulence drug | iron uptake | IRON | TOXICITY | selective optimization of side activities (SOSA) approach | drug repositioning | VIRULENCE | PYOVERDINE SYNTHESIS | PVDS | PATHOGENESIS | GENE | cystic fibrosis | CYSTIC-FIBROSIS | STARVATION SIGMA-FACTOR | Virulence - drug effects | Sigma Factor - metabolism | Transcription, Genetic - drug effects | Genes, Bacterial - genetics | Humans | Male | Antifungal Agents - therapeutic use | Microbial Sensitivity Tests | Pseudomonas aeruginosa - pathogenicity | Virulence - genetics | Antifungal Agents - pharmacology | Fluorouracil - metabolism | Pseudomonas Infections - drug therapy | Mice, Inbred C57BL | Pseudomonas aeruginosa - drug effects | Down-Regulation - drug effects | Pseudomonas Infections - microbiology | Oligopeptides - biosynthesis | Gene Expression Regulation, Bacterial - drug effects | Animals | Pseudomonas aeruginosa - genetics | Flucytosine - therapeutic use | Pseudomonas Infections - pathology | Bacterial Proteins - metabolism | Mice | Flucytosine - pharmacology | Flucytosine | Pseudomonas infections | Control | Dosage and administration | Virulence (Microbiology) | Drug therapy | Biological Sciences
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2013, Volume 9, Issue 3, p. e1003217
Journal Article
Molecular Microbiology, ISSN 0950-382X, 12/2006, Volume 62, Issue 6, pp. 1689 - 1699
Summary MvfR (PqsR), a Pseudomonas aeruginosa LysR‐type transcriptional regulator, plays a critical role in the virulence of this pathogen. MvfR modulates the... 
PATHOGENESIS | CAENORHABDITIS-ELEGANS | VIRULENCE FACTORS | TO-CELL COMMUNICATION | QUORUM-SENSING CIRCUITRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | LYSR FAMILY | FRAGMENT | MICROBIOLOGY | INFECTION | QUINOLONE SIGNAL | Pseudomonas Infections - mortality | Promoter Regions, Genetic - genetics | DNA-Binding Proteins - metabolism | Quinolones - chemistry | Pseudomonas aeruginosa - pathogenicity | Time Factors | Virulence - genetics | Pseudomonas aeruginosa - metabolism | Trans-Activators - genetics | Electrophoretic Mobility Shift Assay | Quinolines - chemistry | Bacterial Proteins - genetics | Quinolones - metabolism | Survival Rate | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Pseudomonas Infections - microbiology | Quinolines - metabolism | Transcription Factors - metabolism | Animals | Pseudomonas aeruginosa - genetics | Protein Binding | Bacterial Proteins - metabolism | Ligands | Protein Conformation | Signal Transduction - physiology | Trans-Activators - metabolism | Mice | Mutation | Gene Expression Regulation, Bacterial | Proteins | Pseudomonas aeruginosa | Quinolines | Promoter Regions, Genetic | Signal Transduction | Trans-Activators | Virulence | Bacterial Proteins | Quinolones | Life Sciences | Human health and pathology | Infectious diseases | Pseudomonas Infections | Transcription Factors | DNA-Binding Proteins
Journal Article
Journal of Infectious Diseases, ISSN 0022-1899, 10/2016, Volume 214, Issue 7, pp. 1105 - 1116
Journal Article
Journal Article
Molecular Microbiology, ISSN 0950-382X, 12/2017, Volume 106, Issue 6, pp. 919 - 937
Summary During environmental adaptation bacteria use small regulatory RNAs (sRNAs) to repress or activate expression of a large fraction of their proteome. We... 
SYSTEM | ACTIVATION | BACTERIA | PROTEIN | OPRD | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | RESISTANCE | MICROBIOLOGY | IDENTIFICATION | PREDICTION | DEACYLASE | Porins - metabolism | RNA, Messenger - metabolism | Type III Secretion Systems - genetics | Host Factor 1 Protein - metabolism | Regulon | Polymyxins - pharmacology | Pseudomonas aeruginosa - pathogenicity | Genes, Regulator - physiology | Trans-Activators - genetics | RNA, Small Untranslated - genetics | Meropenem | Drug Resistance, Bacterial - genetics | RNA, Small Untranslated - metabolism | Carbapenems - metabolism | Porins - genetics | Lipid A - metabolism | Bacterial Proteins - genetics | Pseudomonas aeruginosa - drug effects | Thienamycins - pharmacology | Type III Secretion Systems - metabolism | Pseudomonas aeruginosa - genetics | Bacterial Proteins - metabolism | Trans-Activators - metabolism | Anti-Bacterial Agents - pharmacology | Gene Expression Regulation, Bacterial | Antibiotics | RNA | Analysis | Genetic research | Lipids | Genetic aspects | Genetic transcription | Investigations | Pathogens | Post-transcription | Target recognition | Secretion | Inflammation | Gene expression | Ribonucleic acid--RNA | Lipid A | Pathogenicity | 5' Untranslated Regions | Bacteria | Deacylation | Pseudomonas aeruginosa | In vivo methods and tests | PagL | regulation of T3SS | post-transcriptional regulation | OprD | sRNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 41, pp. 16693 - 16693
Journal Article