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Journal of Experimental Medicine, ISSN 0022-1007, 01/2009, Volume 206, Issue 1, pp. 249 - 258
Psoriasis is a type I interferon-driven T cell-mediated disease characterized by the recruitment of plasmacytoid dendritic cells (pDC) into the skin. The... 
PATHOGENESIS | MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | DERMATITIS | INFLAMMATION | LYMPH-NODES | IN-VIVO | CYTOKINE | IMMUNOLOGY | PRECURSORS | T-CELLS | PROTEASES | CD8-Positive T-Lymphocytes - cytology | Neutrophils - cytology | Membrane Glycoproteins - metabolism | Skin - metabolism | Humans - metabolism | Antigens, CD - metabolism | Chemotaxis, Leukocyte - physiology | Lectins, C-Type - metabolism | Chemotaxis, Leukocyte - drug effects | Psoriasis - pathology | Psoriasis - metabolism | CD8-Positive T-Lymphocytes - metabolism | Receptors, Chemokine - genetics | Neutrophils - metabolism | Antibodies, Monoclonal - immunology | Fibroblasts - metabolism | Tretinoin - pharmacology | Antibodies, Monoclonal - pharmacology | Neutrophils - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Chemokines - genetics | Blotting, Western | Intercellular Adhesion Molecule-1 - metabolism | Calcitriol - pharmacology | Fibroblasts - drug effects | Chemokines - metabolism | Fibroblasts - cytology | Receptors, Immunologic - genetics | Chemokine CXCL10 - metabolism | Dermatitis, Atopic - genetics | Gene Expression - drug effects | Culture Media, Conditioned - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Lectins, C-Type - genetics | Psoriasis - genetics | Adult | Dendritic Cells - metabolism | Skin - pathology | Intercellular Signaling Peptides and Proteins | Receptors, Chemokine - metabolism | Cells, Cultured | Dermatitis, Atopic - pathology | Receptors, Chemokine - immunology | Membrane Glycoproteins - genetics | Chemokine CXCL10 - genetics | CD8-Positive T-Lymphocytes - drug effects | Dendritic Cells - cytology | Dermatitis, Atopic - metabolism | Receptors, Immunologic - metabolism | Index Medicus
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 11/2008, Volume 128, Issue 11, pp. 2625 - 2630
The critical role of IL-17 has recently been reported in a variety of conditions. Since IL-17 deeply participates in the pathogenesis of psoriasis and... 
INTERFERON-GAMMA | CHEMOKINE PRODUCTION | T(H)17 | IL-17 | GENE-EXPRESSION | GROWTH-FACTOR | DIFFERENTIATION | HUMAN KERATINOCYTES | T-LYMPHOCYTES | SKIN INFLAMMATION | DERMATOLOGY | Th1 Cells - pathology | Tumor Necrosis Factor-alpha - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Humans | Middle Aged | Male | Vascular Endothelial Growth Factor A - metabolism | Interleukin-17 - pharmacology | CD4-Positive T-Lymphocytes - pathology | Case-Control Studies | Interleukins - metabolism | Th1 Cells - metabolism | Psoriasis - pathology | Dermatitis, Atopic - etiology | Psoriasis - metabolism | Adult | Female | T-Lymphocytes, Helper-Inducer - pathology | Interleukin-8 - metabolism | Child | Th2 Cells - pathology | Dermis - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | CD4-Positive T-Lymphocytes - metabolism | Dermatitis, Atopic - pathology | Th2 Cells - metabolism | Interleukin-17 - metabolism | Adolescent | Dermis - pathology | Aged | Dermatitis, Atopic - metabolism | Cell Movement | Flow cytometry | Psoriasis | Dermatology | Granulocyte-macrophage colony-stimulating factor | Helper cells | Dermis | Interleukin 22 | Keratinocytes | Lymphocytes T | Interleukin 17 | Atopic dermatitis | CXCL10 protein | Eczema | Peripheral blood | gamma -Interferon | Skin diseases | Internet | Vascular endothelial growth factor | Interleukin 8 | Tumor necrosis factor- alpha | Index Medicus
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 08/2015, Volume 195, Issue 4, pp. 1744 - 1752
Clinical improvement of psoriasis induced by IL-4 treatment has been ascribed to changes in dermal inflammatory cells, such as activation of Th2 cells and... 
ATOPIC-DERMATITIS | LESIONAL SKIN | ENHANCED EXPRESSION | ORGAN-CULTURE SYSTEM | INCREASED EXPRESSION | GENE-EXPRESSION | TNF-ALPHA | IMMUNOLOGY | AUTOIMMUNE-DISEASE | T-CELLS | HUMAN KERATINOCYTES | GATA3 Transcription Factor - genetics | Leukocytes, Mononuclear - metabolism | Humans | STAT6 Transcription Factor - genetics | Th2 Cells - immunology | Interleukin-1beta - genetics | Interleukin-23 Subunit p19 - metabolism | Interleukin-4 - pharmacology | Psoriasis - genetics | S100 Proteins - genetics | Psoriasis - pathology | Interleukin-1beta - metabolism | Interleukin-23 Subunit p19 - genetics | Inflammation Mediators - metabolism | Psoriasis - metabolism | beta-Defensins - metabolism | Cytokines - genetics | GATA3 Transcription Factor - metabolism | Interleukin-6 - metabolism | Langerhans Cells - drug effects | S100 Calcium Binding Protein A7 | Epidermis - metabolism | beta-Defensins - genetics | Leukocytes, Mononuclear - drug effects | Nerve Growth Factor - metabolism | Psoriasis - drug therapy | Cytokines - metabolism | Interleukin-6 - genetics | Epidermis - drug effects | RNA, Messenger - genetics | Nerve Growth Factor - genetics | S100 Proteins - metabolism | STAT6 Transcription Factor - metabolism | Th2 Cells - metabolism | Gene Expression Regulation - drug effects | Keratinocytes - drug effects | Keratinocytes - metabolism | Langerhans Cells - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 02/2016, Volume 24, Issue 5, pp. 233 - 248
Aims: The immunomodulatory and anti-inflammatory properties of mesenchymal stem cells (MSCs) have been proposed in several autoimmune diseases and successfully... 
Original Research Communication | COLLAGEN-INDUCED ARTHRITIS | ACTIVATED PROTEIN-KINASE | INHIBITION | GENTIAN-VIOLET | P38 | SIGNALING PATHWAY | IMMUNE-RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | VERSUS-HOST-DISEASE | LYMPHOCYTE-PROLIFERATION | RECIPROCAL REGULATION | Janus Kinases | Superoxide Dismutase - genetics | Lymph Nodes - pathology | Reactive Oxygen Species - metabolism | Spleen - immunology | Skin - metabolism | Dendritic Cells - immunology | Humans | Hyperplasia | Psoriasis - etiology | STAT Transcription Factors - metabolism | Dendritic Cells - pathology | NF-kappa B - metabolism | Neutrophil Infiltration | Lymphocyte Activation - immunology | Psoriasis - pathology | T-Lymphocytes - metabolism | Inflammation Mediators - metabolism | Psoriasis - metabolism | T-Lymphocytes - pathology | Spleen - pathology | Dendritic Cells - metabolism | Skin - pathology | Superoxide Dismutase - metabolism | Disease Models, Animal | Psoriasis - therapy | Severity of Illness Index | Gene Expression | Toll-Like Receptor 7 - metabolism | Transduction, Genetic | Cytokines - metabolism | Signal Transduction | Lymph Nodes - metabolism | Mesenchymal Stromal Cells - metabolism | Lymph Nodes - immunology | Animals | Spleen - metabolism | T-Lymphocytes - cytology | Mucolipidoses | T-Lymphocytes - immunology | Mice | Mesenchymal Stem Cell Transplantation | Aminoquinolines - adverse effects | Mitogen-Activated Protein Kinases - metabolism | Care and treatment | Psoriasis | Stem cells | Superoxide dismutase | Influence | Skin | Inflammation | Research | Dermatitis | Cell proliferation | Reactive oxygen species | Animal models | Transcription | Mesenchyme | Imiquimod | Innovations | Effector cells | Stem cell transplantation | Activation | Antioxidants | Receptors | Pathways | Toll-like receptors | Skin diseases | Janus kinase | NF-κB protein | Adenosine | Antiinflammatory agents | Immunomodulation | Feasibility studies | Superoxide | Infiltration | Receptor mechanisms | Autoimmune diseases | Index Medicus | Original Research Communications
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2012, Volume 122, Issue 11, pp. 3965 - 3976
Psoriasis is a chronic inflammatory disorder of the skin affecting approximately 2% of the world's population. Accumulating evidence has revealed that the... 
GENERALIZED PUSTULAR PSORIASIS | MEDICINE, RESEARCH & EXPERIMENTAL | INFLAMMATORY SKIN-DISEASE | FAMILY-MEMBERS | MOUSE MODEL | DELTA-T-CELLS | NF-KAPPA-B | AUTOINFLAMMATORY DISEASE | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | CUTTING EDGE | TRANSGENIC MICE | Cell Communication - immunology | Interleukin-1 - genetics | Membrane Glycoproteins - metabolism | Dermatitis - immunology | Dendritic Cells - immunology | Receptors, Interleukin-1 - genetics | Interleukin-17 - immunology | Dendritic Cells - pathology | Interleukins - metabolism | Interleukin-23 - genetics | Interleukins - genetics | Psoriasis - genetics | Interleukin-23 - metabolism | Psoriasis - pathology | Interleukins - immunology | Toll-Like Receptor 7 - immunology | Interleukin-1 - immunology | Psoriasis - metabolism | Membrane Glycoproteins - immunology | Dendritic Cells - metabolism | Psoriasis - immunology | Toll-Like Receptor 7 - genetics | Interleukin-1 - metabolism | Toll-Like Receptor 7 - metabolism | Dermatitis - genetics | Receptors, Interleukin-1 - immunology | Interleukin-17 - genetics | Cell Communication - genetics | Interleukin-23 - immunology | Keratinocytes - immunology | Membrane Glycoproteins - genetics | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Dermatitis - pathology | Interleukin-17 - metabolism | Keratinocytes - pathology | Animals | Keratinocytes - metabolism | Mice | Dermatitis - metabolism | Psoriasis | Interleukins | Keratinocytes | Genetic aspects | Dosage and administration | Diagnosis | Drug therapy | Index Medicus | Abridged Index Medicus | TLR7 protein | Dendritic cells | Mesenchyme | Interleukin 22 | Interleukin 23 | Leukocytes (neutrophilic) | Interleukin 1 receptors | Dermatitis | Inflammatory diseases | Interleukin 17 | Toll-like receptors | Skin
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 03/2017, Volume 101, Issue 3, pp. 775 - 783
Synovial IL‐21 + TNF + CD4 + T cells induce matrix metalloproteinase production by fibroblast‐like synoviocytes in RA patients. Bone and cartilage destruction... 
peripheral blood | autoimmune | inflammation | synovial fluid | Synovial fluid | Autoimmune | Inflammation | Peripheral blood | ACTIVATION | RECEPTOR | CLASSIFICATION | INTERLEUKIN-21 | IMMUNOLOGY | IL-21 | CELL BIOLOGY | B-CELLS | CYTOKINE PRODUCTION | FOLLICULAR-HELPER-CELLS | HEMATOLOGY | EXPRESSION | TH17 CELLS | Tumor Necrosis Factor-alpha - metabolism | Cell Proliferation | RANK Ligand - metabolism | Humans | Synovial Fluid - metabolism | Interferon-gamma - metabolism | Interleukins - metabolism | Peptides, Cyclic - metabolism | CD4-Positive T-Lymphocytes - immunology | Immunoglobulin M - metabolism | Synoviocytes - metabolism | Psoriasis - pathology | T-Lymphocytes, Helper-Inducer - immunology | Proto-Oncogene Proteins c-bcl-6 - metabolism | Interleukin-6 - metabolism | Psoriasis - immunology | Rheumatoid Factor - metabolism | Joints - pathology | Matrix Metalloproteinase 3 - metabolism | Fibroblasts - pathology | T-Box Domain Proteins - metabolism | Arthritis, Rheumatoid - pathology | Interleukin-17 - metabolism | Biopsy | Arthritis, Rheumatoid - immunology | Matrix Metalloproteinase 1 - metabolism | Immunoglobulin M | Destruction | Antibodies | Lymphocytes T | Arthritis | Matrix metalloproteinase | Cartilage | Lymphocytes | Interleukin 21 | Fibroblasts | Metalloproteinase | Interstitial collagenase | Stromelysin 1 | Secretion | Citrulline | Patients | Synoviocytes | CD4 antigen | Rheumatoid factor | Tumor necrosis factor | Rheumatoid arthritis | Health risk assessment | Neutralization | Index Medicus
Journal Article
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 09/2014, Volume 134, Issue 9, pp. 2351 - 2360
Journal Article
Immunity, ISSN 1074-7613, 12/2012, Volume 37, Issue 6, pp. 1050 - 1060
Journal Article
Nature, ISSN 0028-0836, 04/2018, Volume 556, Issue 7702, pp. 501 - 504
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 09/2013, Volume 15, Issue 5, pp. R136 - R136
Introduction: The aim of this study was to characterize interleukin 17 (IL-17) and interleukin 22 (IL-22) producing cells in peripheral blood (PB), skin,... 
RHEUMATOID-ARTHRITIS | MATRIX METALLOPROTEINASES | SYNOVIAL-FLUID | INTERLEUKIN 22 | AUTOIMMUNE ARTHRITIS | PERIPHERAL-BLOOD | PROINFLAMMATORY CYTOKINES | RHEUMATOLOGY | POTENTIAL ROLE | T-CELLS | SKIN INFLAMMATION | Immunohistochemistry | Receptors, CCR6 - immunology | Leukocytes, Mononuclear - metabolism | Receptors, CCR4 - immunology | Skin - metabolism | Humans | Interleukins - cerebrospinal fluid | Middle Aged | Interleukin-17 - immunology | Synovial Membrane - immunology | Synovial Membrane - pathology | Male | CD4-Positive T-Lymphocytes - pathology | CD4-Positive T-Lymphocytes - immunology | Receptors, Interleukin - metabolism | Receptors, CCR4 - metabolism | Arthritis, Psoriatic - pathology | Flow Cytometry | Psoriasis - pathology | Th17 Cells - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Interleukins - immunology | Leukocytes, Mononuclear - immunology | Psoriasis - metabolism | Receptors, CCR6 - metabolism | Adult | Female | T-Lymphocytes, Helper-Inducer - pathology | Arthritis, Psoriatic - metabolism | Skin - pathology | Skin - immunology | Th17 Cells - pathology | Interleukin-17 - blood | Psoriasis - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Interleukins - blood | Receptors, Interleukin - immunology | CD4-Positive T-Lymphocytes - metabolism | Interleukin-17 - cerebrospinal fluid | Synovial Membrane - metabolism | Leukocytes, Mononuclear - pathology | Arthritis, Psoriatic - immunology | Lymphocyte Count | Th17 Cells - immunology | Aged | Interleukins | T cells | Osteoarthritis | Enzyme-linked immunosorbent assay | Psoriatic arthritis | Index Medicus
Journal Article