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Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2013, Volume 12, Issue 9, pp. 1874 - 1885
Journal Article
CELL DEATH & DISEASE, ISSN 2041-4889, 12/2017, Volume 8, Issue 12, pp. 1 - 13
Multiple target inhibition has gained considerable interest in combating drug resistance in glioblastoma, however, understanding the molecular mechanisms of... 
CELL BIOLOGY | Phosphorylation | Hepatocyte growth factor | Transforming growth factor | Glioblastoma | Extracellular signal-regulated kinase | MAP kinase | AKT protein | Gene expression | Drug resistance | Kinases | 1-Phosphatidylinositol 3-kinase | c-Met protein | Signal transduction | Molecular modelling | Glioma cells | Stem cells | Growth factors | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 10/2011, Volume 13, Issue 10, pp. 1265 - 1271
Journal Article
Cell death & disease, 12/2017, Volume 8, Issue 12, p. 3210
Multiple target inhibition has gained considerable interest in combating drug resistance in glioblastoma, however, understanding the molecular mechanisms of... 
Proto-Oncogene Proteins c-met - metabolism | Receptor, Transforming Growth Factor-beta Type I | Nitriles - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | Pyridazines - pharmacology | Hepatocyte Growth Factor - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Quinolines - pharmacology | Glioblastoma - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Hepatocyte Growth Factor - genetics | Neoplastic Stem Cells - pathology | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Pyrazoles - pharmacology | Butadienes - pharmacology | Pteridines - pharmacology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Pyrimidines - pharmacology | Hepatocyte Growth Factor - metabolism | Proto-Oncogene Proteins c-met - genetics | Phosphatidylinositol 3-Kinases - genetics | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Pyrroles - pharmacology | Transforming Growth Factor beta - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Glioblastoma - pathology | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Receptors, Transforming Growth Factor beta | Protein-Serine-Threonine Kinases - pharmacology | Transforming Growth Factor beta - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2014, Volume 10, Issue 4, pp. 305 - 312
Journal Article
Circulation, ISSN 0009-7322, 03/2001, Volume 103, Issue 9, pp. 1282 - 1288
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 12/2015, Volume 230, Issue 12, pp. 3057 - 3067
The expression of polo-like kinase 1 (Plk1) correlates with malignancy and is thus recognized as a target for cancer therapy. In addition to the development of... 
CANCER-CELLS | REGULATOR | PHYSIOLOGY | DNA-DAMAGE CHECKPOINT | THYMOQUINONE | POLO-LIKE-KINASE-1 | KINASE 1 | CYCLE ARREST | DEPLETION | PROGRESSION | DISCOVERY | CELL BIOLOGY | Apoptosis - drug effects | Humans | Uterine Cervical Neoplasms - pathology | Molecular Targeted Therapy | Cell Cycle Proteins - antagonists & inhibitors | Dose-Response Relationship, Drug | G2 Phase Cell Cycle Checkpoints - drug effects | Time Factors | Adenosine Triphosphate - metabolism | Drug Design | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | Quinones - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Pteridines - pharmacology | Uterine Cervical Neoplasms - enzymology | Cell Cycle Proteins - metabolism | Thiophenes - pharmacology | Benzoquinones - pharmacology | Mitosis - drug effects | Signal Transduction - drug effects | Benzoates - pharmacology | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | HeLa Cells | S Phase Cell Cycle Checkpoints - drug effects | Polo | Tumor proteins | Analysis | Protein binding | Index Medicus
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 10, pp. e77053 - e77053
Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults and there are few effective treatments. GBMs contain cells with molecular and... 
CANCER-CELLS | SOLID TUMORS | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | HUMAN GLIOMAS | IMAGE-BASED SCREENS | CENTRAL-NERVOUS-SYSTEM | BRAIN-BARRIER MODEL | ADHERENT CULTURE | PHASE-I | TUMOR-INITIATING CELLS | Small Molecule Libraries - pharmacology | Glioblastoma - enzymology | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | Glioblastoma - genetics | Swine | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Neoplastic Stem Cells - pathology | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | Drug Screening Assays, Antitumor - methods | Cell Cycle Proteins - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Protein-Serine-Threonine Kinases - genetics | Brain Neoplasms - genetics | Thiophenes - pharmacology | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Tumor Suppressor Protein p53 - deficiency | Blood-Brain Barrier - drug effects | Neural Stem Cells - enzymology | Neural Stem Cells - pathology | Blotting, Western | Blood-Brain Barrier - metabolism | Mice, Knockout | Animals | Cell Cycle Checkpoints - drug effects | Glioblastoma - pathology | Cell Line, Tumor | Benzimidazoles - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Neoplastic Stem Cells - enzymology | Indans - pharmacology | Viral antibodies | Polo | Brain tumors | Stem cells | Antibodies | Tumor proteins | Glioblastoma multiforme | Neuroimaging | Image processing | Polo-like kinase 1 | Laboratories | p53 Protein | Brain cancer | Glioblastoma | Childrens health | Membrane permeability | Stem cell transplantation | Kinases | Cancer therapies | Defects | Allografts | Blood-brain barrier | Clonal deletion | DNA methylation | Deletion | Polo-like kinase | Cyclin-dependent kinase inhibitors | Pharmaceutical industry | Bioinformatics | Pharmaceutical sciences | Medical research | Antibody microarrays | INK4 protein | Permeability | Gene expression | Medical screening | Endothelial cells | Image analysis | Sensitivity | Brain research | Inhibitors | Neural stem cells | Adults | Mutation | Molecular biology | Human behavior | Tumors | Cancer | Index Medicus
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 392, pp. 71 - 82
Abstract The genomic alterations identified in head and neck squamous cell carcinoma (HNSCC) tumors have not resulted in any changes in clinical care, making... 
Hematology, Oncology and Palliative Medicine | WEE1 | Head neck squamous cell carcinoma | Polo-like kinase 1 | CHK1 | AJUBA | CISPLATIN RESISTANCE | OVARIAN-CANCER | BREAST-CANCER | WEE1 KINASE | POLO-LIKE-KINASE | ONCOLOGY | PLK EXPRESSION | VOLASERTIB BI 6727 | CANCER STATISTICS | PROGNOSTIC-SIGNIFICANCE | PHASE-I | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Carcinoma, Squamous Cell - pathology | Humans | G2 Phase Cell Cycle Checkpoints - drug effects | RNA Interference | Smad4 Protein - genetics | Time Factors | Protein-Serine-Threonine Kinases - metabolism | Cell Cycle Proteins - metabolism | Head and Neck Neoplasms - drug therapy | Thiophenes - pharmacology | Genotype | Pyrimidines - pharmacology | Head and Neck Neoplasms - pathology | Checkpoint Kinase 1 - metabolism | Phenotype | Carcinoma, Squamous Cell - drug therapy | Signal Transduction - drug effects | Mice, Nude | Checkpoint Kinase 2 - antagonists & inhibitors | Cell Line, Tumor | Head and Neck Neoplasms - genetics | Mutation | Urea - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Carcinoma, Squamous Cell - genetics | Molecular Targeted Therapy | Cell Cycle Proteins - antagonists & inhibitors | Checkpoint Kinase 2 - metabolism | Dose-Response Relationship, Drug | Squamous Cell Carcinoma of Head and Neck | Transfection | Urea - analogs & derivatives | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Head and Neck Neoplasms - enzymology | Pyrazoles - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Carcinoma, Squamous Cell - enzymology | Pteridines - pharmacology | Checkpoint Kinase 1 - antagonists & inhibitors | Nuclear Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Nuclear Proteins - antagonists & inhibitors | LIM Domain Proteins - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Squamous cell carcinoma | Care and treatment | Genetic aspects | Drug therapy | Analysis | Cancer | Medical research | DNA damage | Cell division | Roles | Kinases | Gene expression | Proteins | Studies | Cell cycle | Biomarkers | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 04/2015, Volume 204, pp. 20 - 29
Journal Article