X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
pteridines - pharmacology (606) 606
animals (597) 597
science & technology (540) 540
life sciences & biomedicine (512) 512
humans (441) 441
pteridines - metabolism (223) 223
rats (204) 204
male (185) 185
mice (175) 175
biochemistry & molecular biology (172) 172
pteridines (167) 167
kinetics (156) 156
biopterin - analogs & derivatives (144) 144
female (144) 144
protein-serine-threonine kinases - antagonists & inhibitors (139) 139
pharmacology & pharmacy (129) 129
cell cycle proteins - antagonists & inhibitors (125) 125
proto-oncogene proteins - antagonists & inhibitors (125) 125
cell line, tumor (121) 121
pteridines - chemistry (111) 111
cell biology (98) 98
pterins (96) 96
oncology (95) 95
protein-serine-threonine kinases - metabolism (91) 91
structure-activity relationship (91) 91
cell cycle proteins - metabolism (87) 87
pteridines - chemical synthesis (87) 87
chemistry (85) 85
proto-oncogene proteins - metabolism (85) 85
oxidation-reduction (76) 76
protein kinase inhibitors - pharmacology (75) 75
mutation (71) 71
research article (71) 71
biopterin - pharmacology (69) 69
dose-response relationship, drug (68) 68
enzyme inhibitors - pharmacology (68) 68
antineoplastic agents - pharmacology (67) 67
biopterin - metabolism (67) 67
cells, cultured (65) 65
apoptosis - drug effects (63) 63
in vitro techniques (61) 61
apoptosis (58) 58
enzymes (58) 58
pteridines - therapeutic use (58) 58
research (58) 58
cell proliferation - drug effects (57) 57
cattle (54) 54
time factors (53) 53
analysis (49) 49
chemistry, medicinal (49) 49
methotrexate - pharmacology (49) 49
molecular structure (49) 49
physical sciences (48) 48
phosphorylation (47) 47
coenzymes (45) 45
folic acid (45) 45
protein-serine-threonine kinases - genetics (45) 45
binding sites (44) 44
cancer (44) 44
microbiology (44) 44
liver - enzymology (43) 43
metalloproteins - metabolism (43) 43
neopterin (43) 43
cell line (42) 42
hydrogen-ion concentration (42) 42
kinases (42) 42
proteins (42) 42
cell cycle (41) 41
cell cycle proteins - genetics (41) 41
biophysics (40) 40
proto-oncogene proteins - genetics (40) 40
tetrahydrobiopterin (39) 39
adult (38) 38
models, molecular (38) 38
mice, nude (37) 37
pteridine (37) 37
anti-bacterial agents - pharmacology (36) 36
tyrosine 3-monooxygenase - metabolism (36) 36
biopterin - biosynthesis (35) 35
cell survival - drug effects (35) 35
escherichia coli - enzymology (35) 35
nitric oxide (35) 35
pteridines - administration & dosage (35) 35
pteridines - biosynthesis (35) 35
chemical phenomena (34) 34
escherichia coli - genetics (34) 34
physiological aspects (34) 34
pyrimidines - pharmacology (33) 33
molecular sequence data (32) 32
tetrahydrofolate dehydrogenase - metabolism (32) 32
xenograft model antitumor assays (32) 32
drugs (31) 31
folic acid antagonists - pharmacology (31) 31
gene expression (31) 31
protein binding (31) 31
escherichia coli - drug effects (30) 30
folic acid - pharmacology (30) 30
molybdenum (30) 30
pteridines - analysis (30) 30
tumor cells, cultured (30) 30
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1132) 1132
Japanese (27) 27
German (22) 22
French (8) 8
Russian (4) 4
Chinese (2) 2
Italian (2) 2
Polish (2) 2
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 10, pp. e77053 - e77053
Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults and there are few effective treatments. GBMs contain cells with molecular and... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Small Molecule Libraries - pharmacology | Glioblastoma - enzymology | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | Glioblastoma - genetics | Swine | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Neoplastic Stem Cells - pathology | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | Drug Screening Assays, Antitumor - methods | Cell Cycle Proteins - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Protein-Serine-Threonine Kinases - genetics | Brain Neoplasms - genetics | Thiophenes - pharmacology | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Tumor Suppressor Protein p53 - deficiency | Blood-Brain Barrier - drug effects | Neural Stem Cells - enzymology | Neural Stem Cells - pathology | Blotting, Western | Blood-Brain Barrier - metabolism | Mice, Knockout | Animals | Cell Cycle Checkpoints - drug effects | Glioblastoma - pathology | Cell Line, Tumor | Benzimidazoles - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Neoplastic Stem Cells - enzymology | Indans - pharmacology | Viral antibodies | Polo | Brain tumors | Stem cells | Antibodies | Tumor proteins | Glioblastoma multiforme | Neuroimaging | Image processing | Polo-like kinase 1 | Laboratories | p53 Protein | Brain cancer | Glioblastoma | Childrens health | Membrane permeability | Stem cell transplantation | Kinases | Cancer therapies | Defects | Allografts | Blood-brain barrier | Clonal deletion | DNA methylation | Polo-like kinase | Cyclin-dependent kinase inhibitors | Pharmaceutical industry | Bioinformatics | Pharmaceutical sciences | Medical research | Antibody microarrays | INK4 protein | Permeability | Gene expression | Medical screening | Endothelial cells | Image analysis | Sensitivity | Brain research | Inhibitors | Neural stem cells | Adults | Mutation | Molecular biology | Human behavior | Tumors | Cancer | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e77390 - e77390
Emergence of resistance to Tyrosine-Kinase Inhibitors (TKIs), such as imatinib, dasatinib and nilotinib, in Chronic Myelogenous Leukemia (CML) demands new... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Leukemia - pathology | Paclitaxel - pharmacology | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Pteridines | STAT5 Transcription Factor - metabolism | Caspases - metabolism | Benzamides - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Cell Death - drug effects | Phosphorylation - drug effects | Dasatinib | Bortezomib | Leukemia - enzymology | Pyrimidines - pharmacology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Imatinib Mesylate | Piperazines - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacology | Drug Synergism | Mitosis - drug effects | Signal Transduction - drug effects | Models, Biological | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Pyrazines - pharmacology | Fusion Proteins, bcr-abl - metabolism | Boronic Acids - pharmacology | Drug Resistance, Neoplasm - drug effects | Proteins | Tyrosine | Paclitaxel | Phenols | Drug therapy, Combination | Health aspects | Phosphotransferases | BCR protein | Phosphorylation | Polo-like kinase 1 | Leukemia | Multiple myeloma | Clinical trials | Activation | Biochemistry | Kinases | Caspase-3 | Medical schools | Cell cycle | Bone marrow | Fusion protein | Imatinib | Myeloid leukemia | Therapeutic applications | Stat3 protein | Poly(ADP-ribose) polymerase | Caspase | Abl protein | Stat5 protein | Chronic myeloid leukemia | FDA approval | Vincristine | Patients | Proteasome inhibitors | Pathology | Inhibitors | Pharmacy | Ligands | Lyn protein | Combined treatment | Lymphomas | Mutation | Prostate cancer | Apoptosis | Index Medicus
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 392, pp. 71 - 82
Abstract The genomic alterations identified in head and neck squamous cell carcinoma (HNSCC) tumors have not resulted in any changes in clinical care, making... 
Hematology, Oncology and Palliative Medicine | WEE1 | Head neck squamous cell carcinoma | Polo-like kinase 1 | CHK1 | AJUBA | Life Sciences & Biomedicine | Oncology | Science & Technology | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Carcinoma, Squamous Cell - pathology | Humans | G2 Phase Cell Cycle Checkpoints - drug effects | RNA Interference | Smad4 Protein - genetics | Time Factors | Protein-Serine-Threonine Kinases - metabolism | Cell Cycle Proteins - metabolism | Head and Neck Neoplasms - drug therapy | Thiophenes - pharmacology | Genotype | Pyrimidines - pharmacology | Head and Neck Neoplasms - pathology | Checkpoint Kinase 1 - metabolism | Phenotype | Carcinoma, Squamous Cell - drug therapy | Signal Transduction - drug effects | Mice, Nude | Checkpoint Kinase 2 - antagonists & inhibitors | Cell Line, Tumor | Head and Neck Neoplasms - genetics | Mutation | Urea - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Carcinoma, Squamous Cell - genetics | Molecular Targeted Therapy | Cell Cycle Proteins - antagonists & inhibitors | Checkpoint Kinase 2 - metabolism | Dose-Response Relationship, Drug | Squamous Cell Carcinoma of Head and Neck | Transfection | Urea - analogs & derivatives | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Head and Neck Neoplasms - enzymology | Pyrazoles - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Carcinoma, Squamous Cell - enzymology | Pteridines - pharmacology | Checkpoint Kinase 1 - antagonists & inhibitors | Nuclear Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Nuclear Proteins - antagonists & inhibitors | LIM Domain Proteins - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Squamous cell carcinoma | Care and treatment | Genetic aspects | Drug therapy | Analysis | Cancer | Index Medicus
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 2015, Volume 365, Issue 1, pp. 37 - 46
Journal Article
Biochemical journal, ISSN 1470-8728, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | phosphorylation | protein kinase C | kinase-specific inhibitor | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | mitogen-activated protein kinase (MAPK) | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article