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Circulation, ISSN 0009-7322, 02/2014, Volume 129, Issue 8, pp. 864 - 874
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2013, Volume 19, Issue 1, pp. 74 - 82
Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling associated with obliteration of pulmonary arterioles and formation of plexiform... 
MEDICINE, RESEARCH & EXPERIMENTAL | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL PROLIFERATION | MONOCROTALINE | CELL BIOLOGY | CHRONIC HYPOXIA | SMOOTH-MUSCLE HYPERPLASIA | INFLAMMATION | GROWTH | APJ | RECEPTOR-2 | EXPRESSION | Cell Proliferation | Muscle, Smooth, Vascular - metabolism | Humans | Culture Media, Conditioned - pharmacology | MicroRNAs - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Pulmonary Artery - metabolism | RNA Interference | Fibroblast Growth Factor 2 - metabolism | Myocytes, Smooth Muscle - metabolism | Muscle, Smooth, Vascular - physiology | Apelin | Signal Transduction | Endothelial Cells - metabolism | Down-Regulation | Mice, Inbred C57BL | Cells, Cultured | Fibroblast Growth Factor 2 - biosynthesis | Rats | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Pulmonary Artery - physiopathology | Mice, Knockout | Animals | Mice | MicroRNAs - genetics | RNA, Small Interfering | Vascular Diseases - metabolism | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Receptor, Fibroblast Growth Factor, Type 1 - biosynthesis | Cell Movement | MicroRNA | Peptides | Development and progression | Fibroblast growth factors | Genetic aspects | Health aspects | Pulmonary hypertension | Endothelium | Hypertension | Vein & artery diseases | Pulmonary arteries | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 11/2009, Volume 120, Issue 20, pp. 1951 - 1960
Background-The most important determinant of longevity in pulmonary arterial hypertension is right ventricular (RV) function, but in contrast to experimental... 
Heart failure | Angiogenesis | Microcirculation | Pressure | Pulmonary heart disease | pulmonary heart disease | OVERLOAD | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | angiogenesis | pressure | microcirculation | PROGNOSTIC VALUE | MYOSIN HEAVY-CHAIN | ANTIOXIDANT RESPONSE ELEMENT | TRANSCRIPTION FACTOR NRF2 | VENTRICULAR HYPERTROPHY | CARDIAC-HYPERTROPHY | DISEASE | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HYPERTENSION | HEMATOLOGY | Blood Pressure | Vascular Endothelial Growth Factor A - biosynthesis | Heart Failure - physiopathology | Hypertension, Pulmonary - physiopathology | Male | RNA, Messenger - biosynthesis | Hypertrophy, Right Ventricular - physiopathology | Pulmonary Artery - metabolism | Heme Oxygenase (Decyclizing) - biosynthesis | Hypertrophy, Right Ventricular - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Hypertrophy, Right Ventricular - metabolism | Disease Models, Animal | Gene Expression Regulation | Rats | Heart Failure - metabolism | Hypertension, Pulmonary - metabolism | Pulmonary Artery - physiopathology | Heart Failure - pathology | Rats, Sprague-Dawley | Animals | Fibrosis | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Ventricular Function, Right | Apoptosis | Usage | Animal models in research | Heart ventricle, Left | Physiological aspects | Diagnosis | Pulmonary hypertension | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2007, Volume 104, Issue 4, pp. 1342 - 1347
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2013, Volume 63, pp. 151 - 160
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 01/2012, Volume 46, Issue 1, pp. 14 - 22
Endothelin-1 is a potent vasoactive peptide that occurs in chronically high levels in humans with pulmonary hypertension and in animal models of the disease.... 
Pulmonary artery smooth muscle | Inflammation | Endothelin | Hyaluronic acid | Unfolded protein response | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYALURONAN SYNTHESIS | RATS | ATHEROSCLEROSIS | ENDOPLASMIC-RETICULUM STRESS | PROINFLAMMATORY CYTOKINES | HYPOXIA | hyaluronic acid | CELL BIOLOGY | unfolded protein response | endothelin | inflammation | RESPIRATORY SYSTEM | pulmonary artery smooth muscle | DISEASE | HYPERTENSION | PROGRESSION | Phosphorylation - physiology | Arteritis - pathology | Muscle, Smooth, Vascular - metabolism | Myocytes, Smooth Muscle - pathology | Arteritis - metabolism | Monocytes - metabolism | DNA-Binding Proteins - metabolism | Phosphorylation - genetics | Pulmonary Artery - metabolism | Endothelin A Receptor Antagonists | Myocytes, Smooth Muscle - metabolism | Cytokines - metabolism | Unfolded Protein Response - genetics | Endothelin-1 - genetics | Endothelin-1 - metabolism | Rats | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Signal Transduction - genetics | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Muscle, Smooth, Vascular - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Hyaluronic Acid - metabolism | Receptor, Endothelin A - metabolism | Signal Transduction - physiology | Receptor, Endothelin B - metabolism | Unfolded Protein Response - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2014, Volume 124, Issue 8, pp. 3514 - 3528
Development of the vascular disease pulmonary hypertension (PH) involves disparate molecular pathways that span multiple cell types. MicroRNAs (miRNAs) may... 
SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | HUMAN-DISEASE | ARTERIAL-HYPERTENSION | PPAR-GAMMA | TARGETS | RECEPTOR | SMOOTH-MUSCLE-CELLS | PROLIFERATION | MEDICINE | HYPOXIA | Up-Regulation | Cell Proliferation | Humans | Myocytes, Smooth Muscle - pathology | MicroRNAs - metabolism | Gene Regulatory Networks | PPAR gamma - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Pulmonary Artery - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Computer Simulation | Fibroblast Growth Factor 2 - metabolism | Myocytes, Smooth Muscle - metabolism | STAT3 Transcription Factor - metabolism | Apelin | Disease Models, Animal | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | Hypertension, Pulmonary - genetics | Hypoxia - complications | Systems Theory | Animals | Models, Biological | Octamer Transcription Factor-3 - metabolism | Mice | MicroRNAs - genetics | Endothelial Cells - pathology | Hypertension, Pulmonary - etiology | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | MicroRNA | Physiological aspects | Development and progression | Genetic aspects | Fibroblast growth factors | Research | Pulmonary hypertension | Plasma | Disease | Pulmonary arteries | Pathogenesis | Smooth muscle | Regulation | Intubation | Kinases | Experiments | Index Medicus | Abridged Index Medicus
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 03/2012, Volume 302, Issue 6, pp. L604 - L615
Davies RJ, Holmes AM, Deighton J, Long L, Yang X, Barker L, Walker C, Budd DC, Upton PD, Morrell NW. BMP type II receptor deficiency confers resistance to... 
Nuclear factor-κB | Interleukin | Transforming growth factor-β | Pulmonary hypertension | HYPERTENSION ROLE | PHYSIOLOGY | pulmonary hypertension | BONE MORPHOGENETIC PROTEIN | nuclear factor-kappa B | PROLIFERATION | transforming growth factor-beta | INTERLEUKIN-6 EXPRESSION | GENE | RHO-KINASE ACTIVATION | SIGNALING PATHWAY | RESPIRATORY SYSTEM | INFLAMMATION | MICE | interleukin | NF-KAPPA-B | Interleukin-8 - genetics | RNA, Small Interfering - genetics | Gene Expression | Interleukin-6 - antagonists & inhibitors | Interleukin-6 - genetics | Humans | Transforming Growth Factor beta1 - metabolism | Bone Morphogenetic Protein Receptors, Type II - deficiency | Cells, Cultured | Cell Growth Processes - physiology | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary - genetics | NF-kappa B - metabolism | Hypertension, Pulmonary - metabolism | Interleukin-8 - antagonists & inhibitors | Bone Morphogenetic Protein Receptors, Type II - metabolism | Pulmonary Artery - metabolism | Animals | Transfection - methods | Mice | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Myocytes, Smooth Muscle - metabolism | Smad Proteins - metabolism | Hypertension | Smad protein | Bone morphogenetic protein receptor type II | Cytokines | Transcription | Lung | Transforming growth factor | Antibodies | Smooth muscle | Inflammation | Transforming growth factor- beta 1 | siRNA | Transforming growth factor- beta | Pulmonary artery | Interleukin 6 | NF- Kappa B protein | DNA microarrays | Bone morphogenetic proteins | Mutation | Interleukin 8 | Index Medicus | nuclear factor-κB | transforming growth factor-β
Journal Article
Circulation Research, ISSN 0009-7330, 10/2015, Volume 117, Issue 10, pp. 870 - 883
RATIONALE:The pathogenesis of pulmonary arterial hypertension (PAH) remains unclear. The 4 microRNAs representing the miR-143 and miR-145 stem loops are... 
microRNAs | hypertension, pulmonary | endothelium | myocytes, smooth muscle | cell movement | exosomes | MIGRATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MECHANISM | smooth muscle | PHENOTYPE | pulmonary | CANCER | myocytes | MIR-145 | GROWTH | DISEASE | PERIPHERAL VASCULAR DISEASE | CLUSTER | HEMATOLOGY | hypertension | EXPRESSION | Exosomes - metabolism | Vascular Remodeling | Muscle, Smooth, Vascular - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Hypertension, Pulmonary - physiopathology | Male | MicroRNAs - metabolism | Muscle, Smooth, Vascular - physiopathology | Case-Control Studies | Hypertension, Pulmonary - prevention & control | Pulmonary Artery - metabolism | Arterial Pressure | Transfection | Time Factors | Cattle | Female | Binding Sites | Myocytes, Smooth Muscle - metabolism | Promoter Regions, Genetic | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Cell Communication | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Pulmonary Artery - physiopathology | Mice, Knockout | Transcription Factors - metabolism | Muscle, Smooth, Vascular - pathology | Animals | MicroRNAs - genetics | Ventricular Pressure | HeLa Cells | Endothelial Cells - pathology | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Ventricular Function, Right | Cell Movement | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2016, Volume 22, Issue 2, pp. 154 - 162
Although the lung can undergo self-repair after injury, fibrosis in chronically injured or diseased lungs can occur at the expense of regeneration. Here we... 
MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | ANGIOGENESIS | MACROPHAGE REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NOTCH | SIGNALING PROMOTES | CELL BIOLOGY | TO-MESENCHYMAL TRANSITION | ENDOTHELIAL-CELLS | DISEASE | SMOOTH-MUSCLE-CELLS | DIFFERENTIATION | Antibiotics, Antineoplastic - toxicity | Receptors, Notch - metabolism | Humans | Calcium-Binding Proteins - antagonists & inhibitors | Capillaries - drug effects | Hydrochloric Acid - toxicity | Smad3 Protein - metabolism | Pulmonary Circulation - physiology | Intercellular Signaling Peptides and Proteins - metabolism | Pulmonary Artery - metabolism | Receptors, CXCR - metabolism | Serrate-Jagged Proteins | Lung Injury - metabolism | Lung - metabolism | Membrane Proteins - metabolism | Pulmonary Fibrosis - metabolism | Capillaries - metabolism | Endothelial Cells - physiology | Wnt Signaling Pathway | Bleomycin - toxicity | Fibroblasts - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Lung - pathology | Endothelial Cells - metabolism | RNA, Small Interfering - pharmacology | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Pulmonary Artery - drug effects | Lung - physiology | Regeneration - physiology | Macrophages - metabolism | Regeneration - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Smad3 Protein - drug effects | Fibroblasts - drug effects | Lung - drug effects | Fibrosis | Fluorescent Antibody Technique | Macrophages - drug effects | Mice | Pulmonary Circulation - drug effects | Oligopeptides - pharmacology | Receptors, CXCR - agonists | Endothelial Cells - drug effects | Physiological aspects | Regeneration (Biology) | Lung diseases | Blood vessels | Angiogenesis | Pulmonary fibrosis | Cellular biology | Index Medicus
Journal Article