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The Lancet (British edition), ISSN 0140-6736, 2017, Volume 389, Issue 10082, pp. 1931 - 1940
Summary Chronic obstructive pulmonary disease (COPD) kills more than 3 million people worldwide every year... 
Internal Medicine | INHALED FLUTICASONE FUROATE | LUNG-VOLUME REDUCTION | AIR-FLOW LIMITATION | SMOKING-CESSATION | MEDICINE, GENERAL & INTERNAL | CLINICAL-TRIAL | DOUBLE-BLIND | PHYSICAL-ACTIVITY | RANDOMIZED CONTROLLED-TRIAL | PLACEBO-CONTROLLED TRIAL | RESPIRATORY SOCIETY STATEMENT | Development and progression | Lung diseases, Obstructive | Exercise | Research institutes | Smoking | Comorbidity | Mortality | Germany | Heart | Corticoids | Cooking | Income | Tobacco smoking | Smoke | Biomass | Glucose | Epidemiology | Risk factors | Pollution | Mathematical analysis | Chronic obstructive pulmonary disease | Corticosteroids | Medical treatment | Abnormalities | Indoor environments | Metabolism | Ablation | Asthma | Pathology | Gases | Ventilation | Death | Adults | Cardiovascular diseases | Indoor air pollution | Surgical implants | Destruction | Clinical trials | Congestive heart failure | Occupational exposure | Fuels | Respiratory tract | Bronchitis | Alveoli | Heart diseases | Age | Oxygen | Diabetes mellitus | Lung diseases | Health risks | Particulates | Cigarette smoking | Coronary artery disease | Inhalation | Air flow | Antibiotics | Heating | Air pollution | Low income groups | Outdoor air quality | Drug addiction | Signs and symptoms | Environmental regulations | Physical activity | Tobacco | Obstructive lung disease | Health risk assessment | Alternative fuels
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2016, Volume 138, Issue 1, pp. 16 - 27
Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation affecting predominantly the lung parenchyma and peripheral airways that results in largely irreversible and progressive airflow limitation... 
Allergy and Immunology | cytokine | chemokine | autoantibody | nuclear factor κB | macrophage | Inflammation | neutrophil | oxidative stress | PROGENITOR CELLS | EXHALED BREATH CONDENSATE | nuclear factor kappa B | BRONCHIAL-MUCOSA | INNATE LYMPHOID-CELLS | IMMUNOLOGY | COPD OVERLAP SYNDROME | PERIPHERAL AIRWAYS | ALLERGY | ALVEOLAR MACROPHAGES | GROWTH-FACTOR | SMALL-AIRWAY OBSTRUCTION | Leukocytes - pathology | Pulmonary Disease, Chronic Obstructive - diagnosis | Inflammasomes - metabolism | Cytokines - metabolism | Oxidative Stress | Humans | Risk Factors | Pulmonary Disease, Chronic Obstructive - etiology | Inflammation - etiology | Leukocytes - immunology | Respiratory Mucosa - pathology | Inflammation - metabolism | Phenotype | Animals | Respiratory Mucosa - immunology | Inflammation Mediators - metabolism | Inflammation - diagnosis | Pulmonary Disease, Chronic Obstructive - metabolism | Respiratory Mucosa - metabolism | Leukocytes - metabolism | Autoimmunity | Osteoporosis | Lung diseases, Obstructive | Care and treatment | Autoantibodies | Corticosteroids | Comorbidity | T cells | Medical colleges | Endothelial growth factors | Respiratory agents | Superoxide | Macrophages | Endothelium | Disease | Cytokines | Antimicrobial agents | Lymphocytes | DNA methylation | Biomarkers | Air pollution | Chronic obstructive pulmonary disease | Volatile organic compounds--VOCs | Health risk assessment | Nitrogen dioxide | Metabolic disorders
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 769 - 780
Background Inflammation and oxidative stress play critical roles in patients with chronic obstructive pulmonary disease (COPD... 
Allergy and Immunology | airway hyperresponsiveness | antioxidant | proliferation | MitoQ | inflammation | mitochondria | airway smooth muscle | Ozone | oxidative stress | chronic obstructive pulmonary disease | ASTHMA FEATURES | MECHANISMS | IMMUNOLOGY | FRAGMENTATION | HYPERRESPONSIVENESS | BETA | RESPONSES | ALLERGY | ENERGY-METABOLISM | EXPRESSION | COPD | Respiratory System - pathology | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - pathology | Bronchial Hyperreactivity - genetics | Ubiquinone - pharmacology | Muscle, Smooth - drug effects | Smoking - physiopathology | Organophosphorus Compounds - pharmacology | Myocytes, Smooth Muscle - drug effects | Pneumonia - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Bronchial Hyperreactivity - chemically induced | Signal Transduction | Mitochondria - pathology | Smoking - metabolism | Bronchial Hyperreactivity - pathology | Reactive Oxygen Species - antagonists & inhibitors | Electron Transport Chain Complex Proteins - metabolism | Pulmonary Disease, Chronic Obstructive - chemically induced | Respiratory System - drug effects | Airway Remodeling - genetics | Mice | Oxidative Stress - drug effects | Bronchial Hyperreactivity - drug therapy | Myocytes, Smooth Muscle - pathology | Pneumonia - pathology | Membrane Potential, Mitochondrial - drug effects | Pneumonia - chemically induced | Adult | Female | Pulmonary Disease, Chronic Obstructive - metabolism | Myocytes, Smooth Muscle - metabolism | Ubiquinone - analogs & derivatives | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Muscle, Smooth - metabolism | Animals | Pneumonia - drug therapy | Respiratory System - metabolism | Aged | Muscle, Smooth - pathology | Oxidative stress | Care and treatment | Lung diseases, Obstructive | Inflammation | Pharmaceutical industry | Biomedical research | Disease | Laboratories | Mortality | Colleges & universities | Smooth muscle | Mitochondrial DNA | Metabolism | Defects | Antioxidants | Mitochondria | Hospitals | Biopsy | Chronic obstructive pulmonary disease | Apoptosis | Smoking | NO, Nitric oxide | ΔΨm, Mitochondrial membrane potential | ASM, Airway smooth muscle | NAC, N-acetylcysteine | RL, Lung resistance | BAL, Bronchoalveolar lavage | OCR, Oxygen consumption rate | dTPP, Decyltriphenylphosphonium bromide | AHR, Airway hyperresponsiveness | logPC100, Concentration of acetylcholine that increased lung resistance by 100 | GOLD, Global Initiative for Chronic Obstructive Lung Disease | ATP, Adenosine triphosphate | KC, Keratinocyte-derived cytokine | JC-1, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide | COPD, Chronic obstructive pulmonary disease | ROS, Reactive oxygen species | Mechanisms of Allergy and Clinical Immunology
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2016, Volume 138, Issue 6, pp. 1571 - 1579.e10
Journal Article
Journal Article
Thorax, ISSN 0040-6376, 12/2017, Volume 72, Issue 12, pp. 1074 - 1083
Journal Article
American journal of respiratory and critical care medicine, ISSN 1073-449X, 09/2011, Volume 184, Issue 6, pp. 662 - 671
Journal Article
Clinical and experimental immunology, ISSN 0009-9104, 2014, Volume 176, Issue 3, pp. 461 - 472
Summary Chronic obstructive pulmonary disease (COPD) is characterized by an abnormal innate immune response... 
COPD macrophage | TLR | bacteria | cigarette smoke | immune response | Bacteria | Immune response | Cigarette smoke | NONTYPABLE HAEMOPHILUS-INFLUENZAE | PROTEIN-KINASE | AIRWAY INFLAMMATION | CYTOKINE | IMMUNOLOGY | MURINE | IN-VITRO | INHIBITION | P38 | GENE-EXPRESSION | ALVEOLAR MACROPHAGES | Smoking - adverse effects | Tumor Necrosis Factor-alpha - metabolism | Interleukin-8 - genetics | Humans | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Pulmonary Disease, Chronic Obstructive - etiology | Case-Control Studies | Aged, 80 and over | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-8 - metabolism | Toll-Like Receptors - metabolism | Cytokines - genetics | Macrophages - immunology | Macrophages, Alveolar - immunology | Gene Expression | Macrophages, Alveolar - microbiology | Macrophage Activation - immunology | Gene Expression Regulation | Macrophages - metabolism | Transcription Factor RelA - metabolism | Toll-Like Receptors - genetics | Haemophilus Infections - microbiology | Aged | Enzyme Activation | Haemophilus Infections - immunology | Cytokines - biosynthesis | Lung diseases, Obstructive | Macrophages | Gene expression | Analysis | Smoking | Chronic obstructive pulmonary disease | Cytokines | Rodents | Immune system
Journal Article