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1. Full Text Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
by McDonough, John E and Yuan, Ren and Suzuki, Masaru and Seyednejad, Nazgol and Elliott, W. Mark and Sanchez, Pablo G and Wright, Alexander C and Gefter, Warren B and Litzky, Leslie and Coxson, Harvey O and Paré, Peter D and Sin, Don D and Pierce, Richard A and Woods, Jason C and McWilliams, Annette M and Mayo, John R and Lam, Stephen C and Cooper, Joel D and Hogg, James C
The New England Journal of Medicine, ISSN 0028-4793, 10/2011, Volume 365, Issue 17, pp. 1567 - 1575
Patients with COPD have increased peripheral airway resistance. In this study, increased peripheral airway resistance was strongly associated with a reduction... 
PRESSURE | SITE | MEDICINE, GENERAL & INTERNAL | NUMBER | PHASE IIB TRIAL | SMOKERS | LUNGS | DYSPLASIA | Airway Obstruction - etiology | Lung - pathology | Pulmonary Emphysema - etiology | Humans | Middle Aged | Tomography, X-Ray Computed - methods | Male | Lung - diagnostic imaging | Pulmonary Disease, Chronic Obstructive - physiopathology | Airway Resistance | Pulmonary Disease, Chronic Obstructive - complications | Pulmonary Disease, Chronic Obstructive - pathology | Pulmonary Emphysema - diagnostic imaging | Forced Expiratory Volume | Airway Obstruction - diagnostic imaging | Female | Pulmonary Disease, Chronic Obstructive - diagnostic imaging | Aged | CT imaging | Usage | Lung diseases, Obstructive | Emphysema, Pulmonary | Causes of | Airway obstruction (Medicine) | Diagnosis | Respiratory tract | Gold | Medical research | Computed tomography | Lungs | Syngeneic grafts | Lung diseases | Obstructive lung disease | Lung transplantation | Chronic obstructive pulmonary disease | Emphysema
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2. Full Text Endobronchial Valve Therapy in Patients with Homogeneous Emphysema Results from the IMPACT Study
by Valipour, Arschang and Slebos, Dirk-Jan and Herth, Felix and Darwiche, Kaid and Wagner, Manfred and Ficker, Joachim H and Petermann, Christoph and Hubner, Ralf-Harto and Stanzel, Franz and Eberhard, Ralf and IMPACT Study Team
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 11/2016, Volume 194, Issue 9, pp. 1073 - 1082
Rationale: Endobronchial valves (EBVs) have been successfully used in patients with severe heterogeneous emphysema to improve lung physiology. Limited... 
Homogeneous emphysema | Lobar occlusion | Lung volume reduction | Endobronchial valve | Collateral ventilation | endobronchial valve | COIL TREATMENT | SURGERY | collateral ventilation | lobar occlusion | homogeneous emphysema | ATELECTASIS | TRIAL | OBSTRUCTIVE PULMONARY-DISEASE | RESPIRATORY SYSTEM | PREDICTORS | LUNG-VOLUME-REDUCTION | lung volume reduction | CLINICAL-OUTCOMES | COPD | CRITICAL CARE MEDICINE | Prospective Studies | Prostheses and Implants - adverse effects | Humans | Middle Aged | Pulmonary Emphysema - pathology | Male | Pulmonary Emphysema - surgery | Tomography, X-Ray Computed | Pulmonary Emphysema - diagnostic imaging | Bronchi - surgery | Pneumothorax - etiology | Cross-Over Studies | Forced Expiratory Volume | Pneumonectomy - methods | Female | Bronchi - pathology | Bronchi - diagnostic imaging
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3. Full Text Lung Volumes and Emphysema in Smokers with Interstitial Lung Abnormalities
by Washko, George R and Hunninghake, Gary M and Fernandez, Isis E and Nishino, Mizuki and Okajima, Yuka and Yamashiro, Tsuneo and Ross, James C and Estépar, Raúl San José and Lynch, David A and Brehm, John M and Andriole, Katherine P and Diaz, Alejandro A and Khorasani, Ramin and D'Aco, Katherine and Sciurba, Frank C and Silverman, Edwin K and Hatabu, Hiroto and Rosas, Ivan O and COPDGene Investigators
The New England Journal of Medicine, ISSN 0028-4793, 03/2011, Volume 364, Issue 10, pp. 897 - 906
Smokers with more than a 10-pack-year history of smoking who were part of an ongoing study had CT scans and lung-function tests. Approximately 1 in 12 had... 
MEDICINE, GENERAL & INTERNAL | PULMONARY-FIBROSIS | DISEASE | REFERENCE VALUES | COPD | Lung Diseases, Interstitial - etiology | Smoking - adverse effects | Spirometry | Lung - pathology | Pulmonary Emphysema - etiology | Lung Diseases, Interstitial - pathology | Humans | Pulmonary Emphysema - pathology | Tomography, X-Ray Computed - methods | Linear Models | Logistic Models | Total Lung Capacity | Lung - diagnostic imaging | Pulmonary Fibrosis - pathology | Pulmonary Disease, Chronic Obstructive - etiology | Pulmonary Disease, Chronic Obstructive - pathology | Pulmonary Emphysema - diagnostic imaging | Lung Diseases, Interstitial - diagnostic imaging | Pulmonary Fibrosis - diagnostic imaging | Smoking - pathology | Pulmonary Disease, Chronic Obstructive - diagnostic imaging | Cohort Studies | CT imaging | Logistic regression | Usage | Care and treatment | Smokers | Emphysema, Pulmonary | Causes of | Diagnosis | Health aspects | Chronic obstructive pulmonary disease | Lungs | Lung diseases | Smoking
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4. Full Text Pulmonary microvascular blood flow in mild chronic obstructive pulmonary disease and emphysema: The MESA COPD study
by Hueper, Katja and Vogel-Claussen, Jens and Parikh, Megha A and Austin, John H.M and Bluemke, David A and Carr, James and Choi, Jiwoong and Goldstein, Thomas A and Gomes, Antoinette S and Hoffman, Eric A and Kawut, Steven M and Lima, Joao and Michos, Erin D and Post, Wendy S and Po, Ming Jack and Prince, Martin R and Liu, Kiang and Rabinowitz, Dan and Skrok, Jan and Smith, Ben M and Watson, Karol and Yin, Youbing and Zambeli-Ljepovic, Alan M and Barr, R. Graham
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2015, Volume 192, Issue 5, pp. 570 - 580
Rationale: Smoking-related microvascular loss causes end-organ damage in the kidneys, heart, and brain. Basic research suggests a similar process in the lungs,... 
Lung emphysema | Pulmonary microvascular blood flow (PMBF) | Chronic obstructive pulmonary disease (COPD) | Gadolinium-enhanced MRI | Small airway disease | VOLUME ANALYSIS | pulmonary microvascular blood flow (PMBF) | LUNG-FUNCTION | ATHEROSCLEROSIS | lung emphysema | CELL APOPTOSIS | REFERENCE VALUES | small airway disease | gadolinium-enhanced MRI | CIRCULATING ENDOTHELIAL MICROPARTICLES | RESPIRATORY SYSTEM | chronic obstructive pulmonary disease (COPD) | QUANTITATIVE ASSESSMENT | CIGARETTE-SMOKE | LEFT-VENTRICULAR MASS | PERFUSION | CRITICAL CARE MEDICINE | Severity of Illness Index | Spirometry | Lung - pathology | Prospective Studies | Humans | Middle Aged | Microvessels - pathology | Pulmonary Emphysema - pathology | Gadolinium | Male | Tomography, X-Ray Computed | Lung - diagnostic imaging | Pulmonary Disease, Chronic Obstructive - pathology | Pulmonary Emphysema - diagnostic imaging | Case-Control Studies | Pulmonary Circulation | Magnetic Resonance Imaging | Smoking - pathology | Female | Pulmonary Disease, Chronic Obstructive - diagnostic imaging | Aged | Lung - blood supply | Perfusion Imaging | Cohort Studies | Original
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5. Full Text A genome-wide association study of emphysema and airway quantitative imaging phenotypes
by Cho, Michael H and Castaldi, Peter J and Hersh, Craig P and Hobbs, Brian D and Barr, R. Graham and Tal-Singer, Ruth and Bakke, Per and Gulsvik, Amund and San José Estépar, Raúl and Van Beek, Edwin J.R and Coxson, Harvey O and Lynch, David A and Washko, George R and Laird, Nan M and Crapo, James D and Beaty, Terri H and Silverman, Edwin K and COPDGene Investigators and NETT Genetics and ECLIPSE and NETT Genetics, ECLIPSE, and COPDGene Investigators
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2015, Volume 192, Issue 5, pp. 559 - 569
Rationale: Chronic obstructive pulmonary disease (COPD) is defined by the presence of airflow limitation on spirometry, yet subjects with COPD can have marked... 
Genetics | Chronic obstructive pulmonary disease | Airway | Emphysema | FLOW OBSTRUCTION | VARIANTS | airway | CELL APOPTOSIS | IDENTIFICATION | emphysema | OBSTRUCTIVE PULMONARY-DISEASE | RISK LOCI | genetics | RESPIRATORY SYSTEM | SMOKERS | ENRICHMENT ANALYSIS | RADIOGRAPHIC EMPHYSEMA | chronic obstructive pulmonary disease | COPD | CRITICAL CARE MEDICINE | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Lung - diagnostic imaging | Tumor Suppressor Proteins - genetics | Pulmonary Emphysema - genetics | Female | Pulmonary Disease, Chronic Obstructive - diagnostic imaging | Receptor for Advanced Glycation End Products - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Serpins - genetics | Pulmonary Emphysema - diagnostic imaging | Nerve Tissue Proteins - genetics | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Phenotype | Image Processing, Computer-Assisted | Iron Regulatory Protein 2 - genetics | Aged | GTPase-Activating Proteins - genetics | Longitudinal Studies | Receptors, Nicotinic - genetics | Cohort Studies | Original
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6. Full Text Images in Anesthesiology: Persistent Pulmonary Interstitial Emphysema
by Jones, Sheri and Kilgallon, Shanique and Schwartz, Alan Jay and Subramanyam, Rajeev
Anesthesiology, ISSN 0003-3022, 10/2018, Volume 129, Issue 4, pp. 808 - 808
ANESTHESIOLOGY | Lung Diseases, Interstitial - diagnostic imaging | Pulmonary Emphysema - surgery | Anesthesia - methods | Lung Diseases, Interstitial - surgery | Pulmonary Emphysema - diagnostic imaging | Humans
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7. Full Text Association of Radiographic Emphysema and Airflow Obstruction with Lung Cancer
by Wilson, David O and Weissfeld, Joel L and Balkan, Arzu and Schragin, Jeffrey G and Fuhrman, Carl R and Fisher, Stephen N and Wilson, Jonathan and Leader, Joseph K and Siegfried, Jill M and Shapiro, Steven D and Sciurba, Frank C
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2008, Volume 178, Issue 7, pp. 738 - 744
Rationale To study the relationship between emphysema and/or airflow obstruction and lung cancer in a high-risk population. Objective We studied lung cancer... 
Emphysema | Lung cancer | Chronic obstructive pulmonary disease | UNITED-STATES | MORTALITY | RISK | TRENDS | emphysema | lung cancer | INDIVIDUALS | RESPIRATORY SYSTEM | INFLAMMATION | VOLUME REDUCTION SURGERY | HEALTH | PULMONARY-DISEASE | chronic obstructive pulmonary disease | CRITICAL CARE MEDICINE | Emphysema - diagnostic imaging | Humans | Middle Aged | Risk Factors | Male | Tomography, X-Ray Computed | Lung Neoplasms - complications | Image Processing, Computer-Assisted | Female | Lung Neoplasms - diagnostic imaging | Pulmonary Disease, Chronic Obstructive - diagnostic imaging | Aged | Odds Ratio | Emphysema - complications | Smoking | F. Lung Cancer and Oncologic Disorders
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8. Full Text Association Between Emphysema-like Lung on Cardiac Computed Tomography and Mortality in Persons Without Airflow Obstruction A Cohort Study
by Oelsner, EC and Hoffman, EA and Folsom, AR and Carr, JJ and Enright, PL and Kawut, SM and Kronmal, R and Lederer, D and Lima, JAC and Lovasi, GS and Shea, S and Barr, RG
ANNALS OF INTERNAL MEDICINE, ISSN 0003-4819, 12/2014, Volume 161, Issue 12, pp. 863 - U54
Background: Low lung function is known to predict mortality in the general population, but the prognostic significance of emphysema on computed tomography (CT)... 
DENSITY | POPULATION | MEDICINE, GENERAL & INTERNAL | CIGARETTE-SMOKING | ATHEROSCLEROSIS MESA | QUANTIFICATION | CALCIUM | NATIONAL-HEALTH | PULMONARY-DISEASE | REFERENCE VALUES | Smoking - adverse effects | Pulmonary Emphysema - complications | Spirometry | Pulmonary Emphysema - physiopathology | Prospective Studies | Pulmonary Ventilation | Humans | Middle Aged | Mortality | Risk Factors | Tomography, X-Ray Computed - methods | Male | Lung - diagnostic imaging | Lung - physiopathology | Pulmonary Emphysema - diagnostic imaging | Heart - diagnostic imaging | Lung Volume Measurements | Aged, 80 and over | Female | Aged | Tomography, X-Ray Computed - instrumentation | CT imaging | Usage | Prognosis | Emphysema, Pulmonary | Research | Diagnosis
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9. Full Text Clinical Features and Outcomes in Combined Pulmonary Fibrosis and Emphysema in Idiopathic Pulmonary Fibrosis
by Ryerson, Christopher J., MD and Hartman, Thomas, MD and Elicker, Brett M., MD and Ley, Brett, MD and Lee, Joyce S., MD and Abbritti, Marta, MD and Jones, Kirk D., MD and King, Talmadge E., MD and Ryu, Jay, MD, FCCP and Collard, Harold R., MD, FCCP
Chest, ISSN 0012-3692, 2013, Volume 144, Issue 1, pp. 234 - 240
Background Combined pulmonary fibrosis and emphysema (CPFE) is increasingly recognized, but its prevalence and prognosis remain unclear. We sought to determine... 
Pulmonary/Respiratory | MORTALITY | SURVIVAL | STANDARDIZATION | RESPIRATORY SYSTEM | VITAL CAPACITY | CRITICAL CARE MEDICINE | Pulmonary Fibrosis - diagnosis | Severity of Illness Index | Emphysema - diagnostic imaging | Prevalence | Prognosis | Comorbidity | Humans | Middle Aged | Idiopathic Pulmonary Fibrosis - diagnostic imaging | Kaplan-Meier Estimate | Proportional Hazards Models | Emphysema - diagnosis | Male | Survival Rate | Tomography, X-Ray Computed | Pulmonary Fibrosis - epidemiology | Idiopathic Pulmonary Fibrosis - epidemiology | Phenotype | Idiopathic Pulmonary Fibrosis - diagnosis | Pulmonary Fibrosis - diagnostic imaging | Female | Aged | Emphysema - epidemiology | Cohort Studies | Cystic fibrosis | Research | Patient outcomes | Emphysema, Pulmonary | Distribution
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10. Full Text Bronchoscopic lung volume reduction with endobronchial valves for patients with heterogeneous emphysema and intact interlobar fissures (the BeLieVeR-HIFi study): a randomised controlled trial
by Davey, Claire, MSc and Zoumot, Zaid, PhD and Jordan, Simon, MD and McNulty, William H, MBBS and Carr, Dennis H, MD and Hind, Matthew D, PhD and Hansell, David M, Prof and Rubens, Michael B, MBBS and Banya, Winston, MSc and Polkey, Michael I, Prof and Shah, Pallav L, MD and Hopkinson, Nicholas S, Dr
Lancet, The, ISSN 0140-6736, 2015, Volume 386, Issue 9998, pp. 1066 - 1073
Summary Background Lung volume reduction surgery improves survival in selected patients with emphysema, and has generated interest in bronchoscopic approaches... 
Internal Medicine | RESPIRATORY QUESTIONNAIRE | SURGERY | MEDICINE, GENERAL & INTERNAL | MULTICENTER | THERAPY | HYPERINFLATION | VALIDATION | MINIMAL IMPORTANT DIFFERENCE | EXERCISE | COPD ASSESSMENT TEST | Pulmonary Emphysema - physiopathology | Double-Blind Method | Forced Expiratory Volume - physiology | Humans | Middle Aged | Bronchoscopy - methods | Prostheses and Implants | Male | Pulmonary Emphysema - surgery | Tomography, X-Ray Computed | Treatment Outcome | Pulmonary Emphysema - diagnostic imaging | Lung Volume Measurements - methods | Exercise Tolerance - physiology | Female | Aged | Prosthesis Implantation - methods | Bronchoscopy | Medicine, Experimental | Medical research | Valves | Care and treatment | Emphysema, Pulmonary | Thoracic surgery | Chronic obstructive pulmonary disease | Lungs | Transplants & implants | Emphysema | Mortality
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11. Full Text Percent Emphysema, Airflow Obstruction, and Impaired Left Ventricular Filling
by Barr, R. Graham and Bluemke, David A and Ahmed, Firas S and Carr, J. Jeffery and Enright, Paul L and Hoffman, Eric A and Jiang, Rui and Kawut, Steven M and Kronmal, Richard A and Lima, João A.C and Shahar, Eyal and Smith, Lewis J and Watson, Karol E
The New England Journal of Medicine, ISSN 0028-4793, 01/2010, Volume 362, Issue 3, pp. 217 - 227
In a population-based study, emphysema was quantified by computed tomography, pulmonary function was assessed by spirometry, and cardiac volumes and function... 
MEDICINE, GENERAL & INTERNAL | CARDIAC CT | RAY CT IMAGES | ATHEROSCLEROSIS MESA | SMOKERS | PULMONARY BLOOD-FLOW | LUNG-DISEASE | CHRONIC COR-PULMONALE | MILD COPD | HYPERTENSION | MYOCARDIAL MASS | Multivariate Analysis | Pulmonary Emphysema - complications | Spirometry | Pulmonary Emphysema - physiopathology | Humans | Middle Aged | Airway Obstruction - physiopathology | Cardiac Output | Ventricular Dysfunction, Left - etiology | Male | Tomography, X-Ray Computed | Pulmonary Emphysema - diagnostic imaging | Ventricular Dysfunction, Left - physiopathology | Forced Expiratory Volume | Stroke Volume | Magnetic Resonance Imaging | Vital Capacity | Airway Obstruction - complications | Smoking - physiopathology | Aged, 80 and over | Female | Aged | CT imaging | Usage | Lung diseases, Obstructive | Research | Risk factors | Heart | Edema | Stroke | Nuclear magnetic resonance--NMR | Medical imaging | Lung diseases | Cardiovascular disease | Population studies | Thorax | Family medical history | Magnetic resonance imaging | Computed tomography | Obstructive lung disease | Population | Hypoxia | Software | Chronic obstructive pulmonary disease | Ventricle | Emphysema | Smoking | Structure-function relationships
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12. Full Text Quantitative Analysis of Pulmonary Emphysema Using Local Binary Patterns
by Srensen, Lauge and Shaker, Saher B and de Bruijne, Marleen
IEEE Transactions on Medical Imaging, ISSN 0278-0062, 02/2010, Volume 29, Issue 2, pp. 559 - 569
We aim at improving quantitative measures of emphysema in computed tomography (CT) images of the lungs. Current standard measures, such as the relative area of... 
Performance evaluation | Area measurement | quantitative computed tomography (CT) | tissue classification | Image texture analysis | Nearest neighbor searches | Histograms | Computed tomography | Lungs | Measurement standards | Current measurement | local binary patterns (LBPs) | Pattern analysis | Emphysema | texture analysis | Quantitative computed tomography (CT) | Texture analysis | Tissue classification | Local binary patterns (LBPs) | TEXTURE CLASSIFICATION | LUNG | DIAGNOSIS | RESOLUTION COMPUTED-TOMOGRAPHY | RECOGNITION | ENGINEERING, BIOMEDICAL | QUANTIFICATION | CT IMAGES | DENSITY MASK | IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY | CLASSIFIERS | ENGINEERING, ELECTRICAL & ELECTRONIC | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | DISEASE COPD | Severity of Illness Index | Humans | Image Interpretation, Computer-Assisted - methods | Tomography, X-Ray Computed - methods | Male | Lung - diagnostic imaging | Pulmonary Emphysema - diagnostic imaging | Pulmonary Emphysema - classification | Normal Distribution | Algorithms | Female | Respiratory Function Tests | Smoking | Usage | Image processing | Emphysema, Pulmonary | Analysis | Tomography | Diagnostic imaging | Research | Diagnosis | Accuracy | Classification | Surface layer | Images | Texture | Pixels
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