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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2018, Volume 115, Issue 11, pp. 2788 - 2793
Chronic obstructive pulmonary disease affects 10% of the worldwide population, and the leading genetic cause is alpha-1 antitrypsin (AAT) deficiency. Due to... 
CRISPR | Mouse model | Alpha-1 antitrypsin | Emphysema | Serpina1 | alpha-1 antitrypsin | LUNG | OFF-TARGET SITES | HUMAN-DISEASE | mouse model | ALPHA-ANTITRYPSIN DEFICIENCY | MULTIDISCIPLINARY SCIENCES | emphysema | INDIVIDUALS | PATTERN | ALPHA-1-ANTITRYPSIN DEFICIENCY | EXPRESSION | OCCUPATIONAL-EXPOSURE | Genetic aspects | Gene expression | Observations | Emphysema, Pulmonary | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2018, Volume 115, Issue 11, p. 2788
Chronic obstructive pulmonary disease affects 10% of the worldwide population, and the leading genetic cause is a-1 antitrypsin (AAT) deficiency. Due to the... 
CRISPR | Animal models | Phenotypes | Lung diseases | Editing | Genomes | Drug development | Population genetics | Genotype & phenotype | Rodents | Obstructive lung disease | Chronic obstructive pulmonary disease | Mice | Elastase | Emphysema | Smoking
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 563 - 570
Mutations in the essential telomerase genes TERT and TR cause familial pulmonary fibrosis; however, in telomerase-null mice, short telomeres predispose to... 
MEDICINE, RESEARCH & EXPERIMENTAL | REVERSE-TRANSCRIPTASE | DISEASE | TETRAHYMENA | RISK | TERMINAL TRANSFERASE | PHENOTYPES | IDIOPATHIC PULMONARY-FIBROSIS | APLASTIC-ANEMIA | COPD | PROCESSIVITY | Chromosome Disorders - epidemiology | Prevalence | Pneumothorax - enzymology | Humans | Middle Aged | Male | Pulmonary Fibrosis - genetics | Pulmonary Fibrosis - epidemiology | Incidence | Telomerase - genetics | Chromosome Disorders - enzymology | Pulmonary Emphysema - genetics | Adult | Female | Registries | Telomerase - metabolism | Telomere - genetics | Chromosome Disorders - pathology | alpha 1-Antitrypsin - genetics | Pneumothorax - epidemiology | Pulmonary Emphysema - pathology | Smoking - genetics | Pulmonary Fibrosis - pathology | Sex Characteristics | Smoking - metabolism | Pneumothorax - pathology | Telomere - pathology | Animals | Smoking - epidemiology | Pulmonary Fibrosis - enzymology | Telomere - enzymology | Sex Factors | Smoking - pathology | Mice | Pneumothorax - genetics | alpha 1-Antitrypsin - metabolism | Mutation | Pulmonary Emphysema - epidemiology | Chromosome Disorders - genetics | Pulmonary Emphysema - enzymology | Smokers | Gene mutations | Emphysema, Pulmonary | Genetic aspects | Telomerase | Identification and classification | Health aspects | Risk factors | Enzymes | Liver diseases | Pulmonary fibrosis | Cloning | Cell division | Chronic obstructive pulmonary disease | Emphysema | Deoxyribonucleic acid--DNA
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2015, Volume 192, Issue 5, pp. 559 - 569
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 44, pp. 18880 - 18885
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 02/2014, Volume 189, Issue 4, pp. 408 - 418
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2012, Volume 122, Issue 6, pp. 2032 - 2045
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2011, Volume 184, Issue 8, pp. 904 - 912
Journal Article