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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2009, Volume 106, Issue 1, pp. 250 - 255
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2015, Volume 185, Issue 12, pp. 3189 - 3201
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2014, Volume 189, Issue 11, pp. 1359 - 1373
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2017, Volume 199, Issue 7, pp. 2323 - 2332
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2005, Volume 172, Issue 8, pp. 987 - 993
Rationale: In cigarette smoking-induced chronic obstructive pulmonary disease, structural and functional derangements are characterized by parenchymal... 
Statin | Emphysema | Pulmonary hypertension | Smoking | ARTERY ENDOTHELIAL-CELLS | pulmonary hypertension | NITRIC-OXIDE SYNTHASE | 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE | PROTEIN-KINASE | NECROSIS-FACTOR-ALPHA | DEPENDENT EMPHYSEMA | emphysema | MATRIX METALLOPROTEINASES | statin | RESPIRATORY SYSTEM | smoking | ADULT MURINE LUNG | SMOOTH-MUSCLE-CELLS | ANTIINFLAMMATORY ROLE | CRITICAL CARE MEDICINE | Smoking - adverse effects | Simvastatin - therapeutic use | Nitric Oxide Synthase - immunology | Pulmonary Emphysema - etiology | Smoking - immunology | Nitric Oxide Synthase - drug effects | Male | Matrix Metalloproteinase 3 - drug effects | Simvastatin - pharmacology | Pulmonary Emphysema - prevention & control | Hypertension, Pulmonary - prevention & control | Matrix Metalloproteinase 3 - immunology | Matrix Metalloproteinase 2 - drug effects | Time Factors | Matrix Metalloproteinase 2 - analysis | Drug Evaluation, Preclinical | Matrix Metalloproteinase 2 - immunology | Disease Models, Animal | Administration, Oral | Risk Factors | Smoking - drug therapy | Rats | Inflammation | Matrix Metalloproteinase 3 - analysis | Pulmonary Artery - drug effects | Rats, Sprague-Dawley | Smoking - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Analysis of Variance | Biopsy | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Smoking - pathology | Chronic Disease | Hypertension, Pulmonary - etiology | Pulmonary Artery - pathology | Pulmonary Artery - immunology
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2010, Volume 185, Issue 1, pp. 688 - 697
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2017, Volume 492, Issue 1, pp. 74 - 81
Journal Article
Molecular Therapy, ISSN 1525-0016, 01/2011, Volume 19, Issue 1, pp. 196 - 203
Journal Article
Respiratory Research, ISSN 1465-9921, 01/2013, Volume 14, Issue 1, pp. 5 - 5
Journal Article
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 01/2016, Volume 54, Issue 1, pp. 91 - 102
Chronic inflammation, oxidative stress, and proteolysis participate primarily in the pathogenesis of chronic obstructive pulmonary disease (COPD)/emphysema.... 
Apolipoprotein a1 | Lipid raft | Emphysema | Apoptosis | Smoking | LUNG | OXIDATIVE STRESS | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AIRWAY INFLAMMATION | apoptosis | MECHANISMS | apolipoprotein A1 | emphysema | CELL BIOLOGY | MATRIX METALLOPROTEINASES | MURINE MODEL | OBSTRUCTIVE PULMONARY-DISEASE | lipid raft | REACTIVE OXYGEN | RESPIRATORY SYSTEM | smoking | A-I | Smoking - adverse effects | Up-Regulation | Pneumonia - physiopathology | Pulmonary Emphysema - etiology | Oxidative Stress | Membrane Microdomains - metabolism | Humans | Pneumonia - prevention & control | Pulmonary Emphysema - metabolism | fas Receptor - metabolism | Pulmonary Emphysema - prevention & control | Case-Control Studies | Apolipoprotein A-I - genetics | Matrix Metalloproteinase 9 - metabolism | Proteolysis | Pulmonary Alveoli - metabolism | Pulmonary Emphysema - genetics | Respiratory Mucosa - physiopathology | Pulmonary Disease, Chronic Obstructive - metabolism | Pulmonary Alveoli - physiopathology | Disease Models, Animal | Pneumonia - genetics | Pulmonary Emphysema - physiopathology | Pneumonia - etiology | Signal Transduction | Matrix Metalloproteinase 2 - metabolism | Smoke - adverse effects | Mice, Transgenic | Apolipoprotein A-I - metabolism | Animals | Cell Line, Tumor | Enzyme Activation | Respiratory Mucosa - metabolism | Pneumonia - metabolism | Oxidative stress | Disease | Lipids | Inflammation | Apolipoproteins | Asthma | Proteins | Studies | Antioxidants | Lungs | Transgenic animals | Rodents | Chronic obstructive pulmonary disease
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 10/2014, Volume 51, Issue 4, pp. 536 - 549
Several studies report that high-density lipoproteins (HDLs) can carry α1-antitrypsin (AAT; an elastase inhibitor). We aimed to determine whether injection of... 
α | Elastase | High-density lipoprotein | antitrypsin | Emphysema | Apolipoprotein A-I - pharmacology | Smoking - adverse effects | Injections, Intravenous | Humans | Pneumonia - prevention & control | Male | Pulmonary Emphysema - metabolism | Pulmonary Emphysema - prevention & control | Pulmonary Emphysema - chemically induced | Lipoproteins, HDL - pharmacology | Dose-Response Relationship, Drug | Matrix Metalloproteinase 9 - metabolism | Time Factors | Pulmonary Alveoli - metabolism | Inflammation Mediators - metabolism | Pneumonia - immunology | Pulmonary Alveoli - drug effects | Drug Therapy, Combination | Neutrophils - metabolism | Macrophages - immunology | Neutrophil Infiltration - drug effects | Disease Models, Animal | Lipoproteins, HDL - administration & dosage | Pneumonia - etiology | Pulmonary Alveoli - pathology | Matrix Metalloproteinase 2 - metabolism | Smoke - adverse effects | Mice, Inbred C57BL | Neutrophils - drug effects | Neutrophils - immunology | Pulmonary Emphysema - pathology | Fibronectins - metabolism | Pulmonary Emphysema - immunology | alpha 1-Antitrypsin - administration & dosage | Macrophages - metabolism | Animals | Pancreatic Elastase | alpha 1-Antitrypsin - pharmacology | Macrophages - drug effects | Apolipoprotein A-I - administration & dosage | Pneumonia - metabolism | Pulmonary Alveoli - immunology
Journal Article