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American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 2015, Volume 308, Issue 4, pp. L344 - L357
Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is both a cause and consequence of fibroblast activation.... 
Plasminogen activator inhibitor 1 | Extracellular matrix | Mechanotransduction | Hippo | Idiopathic pulmonary fibrosis | LUNG | DOMAIN | PHYSIOLOGY | mechanotransduction | HIPPO PATHWAY | idiopathic pulmonary fibrosis | TRANSCRIPTIONAL COACTIVATOR | plasminogen activator inhibitor 1 | GROWTH-FACTOR-BETA | MECHANICAL MEMORY | MATRIX STIFFNESS | INHIBITION | RESPIRATORY SYSTEM | DIFFERENTIATION | IDIOPATHIC PULMONARY-FIBROSIS | extracellular matrix | NIH 3T3 Cells | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Pulmonary Fibrosis - genetics | Phosphoproteins - metabolism | Serpin E2 - biosynthesis | Gene Knockdown Techniques | Female | Lung - metabolism | Pulmonary Fibrosis - metabolism | Plasminogen Activator Inhibitor 1 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Mechanotransduction, Cellular - genetics | Fibroblasts - metabolism | Lung - pathology | Pulmonary Fibrosis - pathology | Phosphoproteins - genetics | Fibroblasts - pathology | Plasminogen Activator Inhibitor 1 - biosynthesis | Serpin E2 - genetics | Animals | Transforming Growth Factor beta - genetics | Adaptor Proteins, Signal Transducing - genetics | Mice, Inbred NOD | Mice | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Transforming Growth Factor beta - metabolism | Transcriptional coactivators | Fibroblasts | Genetic aspects | Pulmonary fibrosis | Health aspects | Oncogenes | Bone morphogenetic proteins | Fibrosis | Signal transduction | Pathology | Cellular biology | Protein expression | Biosynthesis | Physiology | Binding sites | Index Medicus | Call for Papers
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2010, Volume 207, Issue 8, pp. 1589 - 1597
Uncontrolled extracellular matrix production by fibroblasts in response to tissue injury contributes to fibrotic diseases, such as idiopathic pulmonary... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | PHOSPHATASE | INJURY | TENSIN HOMOLOG | MECHANISMS | GROWTH-FACTOR | IMMUNOLOGY | MYOFIBROBLAST DIFFERENTIATION | EXPRESSION | CANCER | MICRORNA | Oligonucleotides - genetics | Pulmonary Fibrosis - therapy | Idiopathic Pulmonary Fibrosis - genetics | Gene Expression - drug effects | Gene Expression - genetics | Humans | Actins - metabolism | MicroRNAs - metabolism | Pulmonary Fibrosis - genetics | Idiopathic Pulmonary Fibrosis - metabolism | Actins - genetics | Antisense Elements (Genetics) - therapeutic use | Collagen - genetics | Lung - metabolism | Phosphorylation - drug effects | Smad7 Protein - genetics | Extracellular Matrix Proteins - metabolism | Transforming Growth Factor beta1 - pharmacology | Fibroblasts - metabolism | Smad7 Protein - metabolism | Cell Line | Lung - pathology | Extracellular Matrix Proteins - genetics | Mice, Inbred C57BL | Smad2 Protein - metabolism | Mice, Transgenic | Pulmonary Fibrosis - pathology | Transforming Growth Factor beta1 - genetics | Fibroblasts - pathology | Fibronectins - metabolism | Collagen - metabolism | Animals | Fibroblasts - drug effects | Antisense Elements (Genetics) - genetics | Idiopathic Pulmonary Fibrosis - pathology | Pulmonary Fibrosis - chemically induced | Bleomycin - pharmacology | Fibronectins - genetics | Mice | MicroRNAs - genetics | Index Medicus | Brief Definitive Report
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 02/2015, Volume 21, Issue 2, pp. 150 - 158
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1096 - 1108
Matrix stiffening and myofibroblast resistance to apoptosis are cardinal features of chronic fibrotic diseases involving diverse organ systems. The... 
CYTOCHROME-C | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG FIBROSIS | GRANULATION-TISSUE | LIVER FIBROSIS | RHO-KINASE | LATENT TGF-BETA-1 | MESENCHYMAL TRANSITION | TRANSCRIPTION FACTOR | CELL-DEATH | FIBROBLAST CONTRACTION | Oncogene Proteins, Fusion - metabolism | Apoptosis - drug effects | Myofibroblasts - physiology | Humans | Protein Multimerization | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Extracellular Matrix - metabolism | Molecular Targeted Therapy | rho-Associated Kinases - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Myofibroblasts - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | rho-Associated Kinases - metabolism | Female | Cell Differentiation | Pulmonary Fibrosis - metabolism | Active Transport, Cell Nucleus | Actin Cytoskeleton - metabolism | Down-Regulation | Mice, Inbred C57BL | Trans-Activators | Cells, Cultured | Pulmonary Fibrosis - pathology | DNA-Binding Proteins - genetics | Myofibroblasts - drug effects | Transforming Growth Factor beta1 - physiology | Mechanotransduction, Cellular | Animals | Oncogene Proteins, Fusion - genetics | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | rho GTP-Binding Proteins - metabolism | Pulmonary Fibrosis - chemically induced | Mice | Pulmonary Fibrosis - drug therapy | Proto-Oncogene Proteins c-bcl-2 - genetics | Care and treatment | Pulmonary fibrosis | Fibroblasts | Physiological aspects | Drug targeting | Models | Cellular signal transduction | Research | Mechanoreceptors | Index Medicus | Abridged Index Medicus
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2010, Volume 182, Issue 2, pp. 220 - 229
Journal Article
Clinical Immunology, ISSN 1521-6616, 2010, Volume 137, Issue 1, pp. 89 - 101
Abstract Activated macrophages have been characterized as M1 and M2 according to their inflammatory response pattern. Here we analyzed the M2 marker expression... 
Allergy and Immunology | M2 phenotype | Th2 cytokines | Pulmonary fibrosis | IL-1RA | CCL22 | Sarcoidosis | JAK/STAT pathway | CCL18 | Alveolar macrophages | CCL17 | INTERLEUKIN-1 RECEPTOR ANTAGONIST | CYTOKINE | IMMUNOLOGY | SYSTEMIC-SCLEROSIS | STAT3 ACTIVATION | INTERSTITIAL LUNG-DISEASES | MANNOSE RECEPTOR | GENE-EXPRESSION | TNF-ALPHA RELEASE | GROWTH-FACTOR | UP-REGULATION | Mannose-Binding Lectins - metabolism | Tumor Necrosis Factor-alpha - metabolism | Gene Expression - drug effects | Humans | Middle Aged | STAT Transcription Factors - metabolism | Interleukin 1 Receptor Antagonist Protein - genetics | Male | Monocytes - metabolism | Monocytes - immunology | Sarcoidosis, Pulmonary - diagnosis | Idiopathic Pulmonary Fibrosis - metabolism | Young Adult | Lectins, C-Type - metabolism | Signal Transduction - immunology | Interleukin-4 - pharmacology | Interleukin 1 Receptor Antagonist Protein - metabolism | Scleroderma, Systemic - complications | Aged, 80 and over | Adult | Female | Bronchoalveolar Lavage Fluid - cytology | Pulmonary Fibrosis - metabolism | Interleukin-8 - metabolism | Macrophages, Alveolar - immunology | Pulmonary Fibrosis - etiology | Sarcoidosis, Pulmonary - complications | Cytokines - metabolism | Macrophage Activation - immunology | Scleroderma, Systemic - metabolism | Pulmonary Fibrosis - immunology | Receptors, Cell Surface - metabolism | Idiopathic Pulmonary Fibrosis - immunology | Monocytes - drug effects | Signal Transduction - drug effects | Macrophages, Alveolar - drug effects | Sarcoidosis, Pulmonary - metabolism | Chemokines, CC - genetics | Aged | Macrophages, Alveolar - metabolism | Macrophage Activation - drug effects | Interleukin-10 - pharmacology | Chemokines, CC - metabolism | Respiratory tract diseases | Systemic scleroderma | Transforming growth factors | Macrophages | Scleroderma (Disease) | Index Medicus | Alveoli
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2014, Volume 111, Issue 1, pp. 367 - 372
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2011, Volume 208, Issue 7, pp. 1459 - 1471
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 12/2006, Volume 203, Issue 13, pp. 2895 - 2906
Journal Article