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1981, ISBN 041215840X, Volume 12., ix, 365
Book
Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 36, pp. 24035 - 24048
The role of endogenous inducers of inflammation is poorly understood. To produce the proinflammatory master cytokine interleukin (IL)-1β, macrophages need... 
GENE | LEUCINE-RICH PROTEOGLYCANS | CASPASE-1 | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | HYALURONAN | IL-1-BETA | SECRETION | ATP | NALP3 INFLAMMASOME | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Index Medicus | Glycobiology and Extracellular Matrices
Journal Article
Blood, ISSN 0006-4971, 11/2010, Volume 116, Issue 18, pp. 3475 - 3484
Engagement of T cells with antigen-presenting cells requires T-cell receptor (TCR) stimulation at the immune synapse. We previously reported that TCR... 
EXTRACELLULAR ATP | OPERATED CA2+ ENTRY | LIPID-RAFTS | P2X RECEPTORS | CALCIUM | STORE | CRAC CHANNELS | IMMUNOLOGICAL SYNAPSE | HEMATOLOGY | PLASMA-MEMBRANE | LYMPHOCYTES | Humans | Calcium - immunology | Connexins - immunology | T-Lymphocytes - ultrastructure | Receptors, Purinergic P2X7 - genetics | Interleukin-2 - immunology | NFATC Transcription Factors - immunology | T-Lymphocytes - metabolism | Neoplasm Proteins - genetics | Calcium Channels - genetics | Receptors, Purinergic P2X7 - immunology | Stromal Interaction Molecule 1 | Gene Expression | Receptors, Purinergic P2X5 - immunology | Immunological Synapses - ultrastructure | Nerve Tissue Proteins - immunology | Jurkat Cells | Lymphocyte Activation | Membrane Proteins - genetics | Receptors, Purinergic P2X4 - immunology | Adenosine Triphosphate - immunology | ORAI1 Protein | Receptors, Purinergic P2X1 - immunology | Connexins - metabolism | Protein Transport | Receptors, Purinergic P2X5 - genetics | Nerve Tissue Proteins - metabolism | Interleukin-2 - genetics | Receptors, Purinergic P2X1 - genetics | T-Lymphocytes - cytology | Immunological Synapses - immunology | T-Lymphocytes - immunology | Receptors, Purinergic P2X4 - genetics | Translocation | Calcium channels | Transcription factors | Immunological synapses | Lymphocytes T | NF-AT protein | Cell surface | Blood | Calcium influx | Purine P2X receptors | T-cell receptor | Cell activation | Interleukin 2 | Antigen-presenting cells | Feedback | Autocrine signalling | Mutation | ATP | Index Medicus | Abridged Index Medicus | Immunobiology
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 04/2012, Volume 121, Issue 2, pp. 287 - 301
Microglial neurotransmitter receptors couple to intracellular superoxide generation 
Microglia express a wide range of neurotransmitter receptors but little is... 
receptors | superoxide | microglia | neurotransmitters | Neurotransmitters | Receptors | Superoxide | Microglia | NADPH OXIDASE | OXIDATIVE STRESS | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FREE-RADICAL PRODUCTION | METABOTROPIC GLUTAMATE RECEPTORS | NEUROSCIENCES | NEUROPATHIC PAIN | GENE-EXPRESSION | ACTIVATED MICROGLIA | SIGNALING CASCADES | CYTOKINE RELEASE | Microglia - metabolism | Chromatography, High Pressure Liquid | Receptors, Glutamate - drug effects | RNA - genetics | RNA - isolation & purification | Flow Cytometry | Microglia - physiology | Neurons - physiology | Superoxides - metabolism | NADPH Oxidases - genetics | NADPH Oxidases - biosynthesis | Real-Time Polymerase Chain Reaction | Receptors, GABA - drug effects | Receptors, Neurotransmitter - antagonists & inhibitors | Isoenzymes - genetics | Cerebellum - metabolism | Cells, Cultured | Rats | Nitroblue Tetrazolium | Rats, Sprague-Dawley | Blotting, Western | Receptors, Purinergic P2 - drug effects | Hydrogen Peroxide - metabolism | Animals | Receptors, Neurotransmitter - agonists | Cerebellum - cytology | GABA Agonists - pharmacology | Mice | Receptors, Neurotransmitter - metabolism | Isoenzymes - biosynthesis | Fluorescent Dyes | Oxidases | GABA | Messenger RNA | RNA | Glutamate | Neurochemistry | Brain | Enzymes | Neurons | Neurodegeneration | Neuroprotection | Intracellular signalling | Glutamic acid receptors | Gene expression | Neuromodulation | NAD(P)H oxidase | Neuronal-glial interactions | Neurotransmitter receptors | gamma -Aminobutyric acid B receptors | Neurotoxicity | Purine P2Y receptors | NOX4 protein | gamma -Aminobutyric acid A receptors | CYBB protein | NADP | Glutamic acid receptors (metabotropic) | Index Medicus
Journal Article
Journal Article
Archiv der Pharmazie, ISSN 0365-6233, 04/2015, Volume 348, Issue 4, pp. 242 - 253
New long‐chain arylpiperazine derivatives of 8‐alkoxy‐purine‐2,6‐dione ( 10–24 ) were synthesized and evaluated for their serotonin (5‐HT 1A , 5‐HT 2A , 5‐HT 6... 
Serotonin receptor ligands | Depression | Arylpiperazines | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Receptors, Serotonin - drug effects | Motor Activity - drug effects | Male | Structure-Activity Relationship | Receptors, Dopamine D2 - metabolism | Antidepressive Agents - metabolism | Antipsychotic Agents - chemical synthesis | Serotonin 5-HT2 Receptor Antagonists - chemical synthesis | Serotonin 5-HT1 Receptor Antagonists - chemical synthesis | Serotonin 5-HT1 Receptor Antagonists - metabolism | Biotransformation | Drug Design | Receptors, Dopamine D2 - drug effects | Receptors, Dopamine D2 - chemistry | Behavior, Animal - drug effects | Antidepressive Agents - pharmacology | Molecular Structure | Swimming | Receptor, Serotonin, 5-HT2A - drug effects | Receptor, Serotonin, 5-HT1A - metabolism | Purines - chemical synthesis | Dopamine D2 Receptor Antagonists - chemical synthesis | Purines - metabolism | Purines - pharmacology | Liver - metabolism | Serotonin 5-HT2 Receptor Antagonists - pharmacology | Receptors, Serotonin - metabolism | Serotonin 5-HT2 Receptor Antagonists - metabolism | Receptor, Serotonin, 5-HT1A - drug effects | Animals | Dopamine D2 Receptor Antagonists - metabolism | Antidepressive Agents - chemical synthesis | Dopamine D2 Receptor Antagonists - pharmacology | Protein Binding | Antipsychotic Agents - metabolism | Ligands | Mice | Antipsychotic Agents - pharmacology | Receptor, Serotonin, 5-HT2A - metabolism | Alkaloids | Dopamine | Antipsychotic drugs | Serotonin | Antidepressants | Analysis | Phenols | Index Medicus
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2012, Volume 55, Issue 11, pp. 5311 - 5325
Journal Article
Molecules, ISSN 1420-3049, 07/2017, Volume 22, Issue 7, p. 1220
Nearly 90 years ago, Drury and Szent-Györgyi revealed that adenosine produced profound hypotension and bradycardia, and it affected kidney function in mammals... 
NERVOUS-SYSTEM | CELLS | LIGANDS | A(2A) | CAFFEINE | CHEMISTRY, ORGANIC | ACCUMULATION | DERIVATIVES | CHALLENGES | BRAIN | AGONIST | Animals | Bradycardia - metabolism | Hypotension - metabolism | Receptors, Purinergic P1 - metabolism | Humans | Index Medicus | Batecs cardíacs | Purines | Adenosine | Heart beat | Neural receptor | Receptors neurals | Adenosina | n/a
Journal Article
Blood, ISSN 0006-4971, 09/2011, Volume 118, Issue 13, pp. 3603 - 3612
Journal Article
Glia, ISSN 0894-1491, 04/2014, Volume 62, Issue 4, pp. 592 - 607
ATP is an important regulator of microglia and its effects on microglial cytokine release are currently discussed as important contributors in a variety of... 
antagonists | purine receptors | neuroinflammation | neuroprotection | Neuroprotection | Neuroinflammation | Antagonists | Purine receptors | EXTRACELLULAR ATP | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | FOCAL CEREBRAL-ISCHEMIA | NEUROSCIENCES | P2X7 RECEPTOR | TUMOR-NECROSIS-FACTOR | P2X RECEPTOR | PURINERGIC RECEPTORS | INTERLEUKIN-1-BETA RELEASE | ACTIVATED MICROGLIA | CYTOKINE RELEASE | Tumor Necrosis Factor-alpha - metabolism | Calcium - metabolism | Tumor Necrosis Factor-alpha - genetics | Purinergic P2X Receptor Antagonists - pharmacology | Receptors, Purinergic P2X4 - deficiency | Receptors, Purinergic P2X7 - genetics | Adenosine Triphosphate - pharmacology | Dose-Response Relationship, Drug | Microglia - physiology | Chemokine CCL2 - metabolism | Cell Differentiation - physiology | Interleukin-6 - metabolism | Animals, Newborn | Brain - cytology | Interleukin-6 - genetics | Microglia - drug effects | Mice, Inbred C57BL | Cells, Cultured | Connexins - genetics | Chemokine CCL2 - genetics | Nerve Tissue Proteins - genetics | Purinergic P2X Receptor Agonists - pharmacology | Adenosine Triphosphate - analogs & derivatives | Receptors, Purinergic P2X7 - physiology | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Receptors, Purinergic P2X7 - deficiency | Animals | Cell Differentiation - drug effects | Mice | Index Medicus
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 07/2019, pp. 1 - 17
Purinergic P2 receptors are critical regulators of several functions within the vascular system, including platelet aggregation, vascular inflammation, and... 
CD34 antige