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1. Full Text Metabolism of P2 receptor agonists in human airways: Implications for mucociliary clearance and cystic fibrosis
by Picher, Maryse and Burch, Lauranell H and Boucher, Richard C
Journal of Biological Chemistry, ISSN 0021-9258, 05/2004, Volume 279, Issue 19, pp. 20234 - 20241
Extracellular nucleotides are among the most potent mediators of mucociliary clearance (MCC) in human lungs. However, clinical trials revealed that aerosolized... 
TRANSMEMBRANE CONDUCTANCE REGULATOR | INDEPENDENT ATP RELEASE | EXTRACELLULAR ATP | NASAL EPITHELIAL-CELLS | ADENYLATE KINASE | ION-TRANSPORT | VOLUME REGULATION | INTRACELLULAR CALCIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLARIZED EPITHELIA | P2Y RECEPTOR | Up-Regulation | Lung - pathology | Epithelial Cells - metabolism | Adenosine Monophosphate - metabolism | Cystic Fibrosis - metabolism | Humans | Cells, Cultured | Inflammation | Purinergic P2 Receptor Agonists | Chromatography, High Pressure Liquid | Nucleotides - metabolism | RNA, Messenger - metabolism | Cilia - metabolism | Ribonucleases - metabolism | Mucous Membrane - pathology | Time Factors | Adenosine Triphosphate - metabolism | Adenosine - metabolism | Bronchi - metabolism | Adenosine Diphosphate - metabolism
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2. Full Text Minor contribution of ATP P2 receptors to electrically-evoked electrographic seizure activity in hippocampal slices: Evidence from purine biosensors and P2 receptor agonists and antagonists
by Lopatář, Ján and Dale, Nicholas and Frenguelli, Bruno G
Neuropharmacology, ISSN 0028-3908, 2011, Volume 61, Issue 1, pp. 25 - 34
While the position of adenosine as an endogenous anticonvulsant is well established, it is unclear to what extent its precursor, ATP, contributes to seizure... 
Adenosine | Biosensors | ATP | P2Y | P2X | Seizures | TEMPORAL-LOBE EPILEPSY | SYNAPTIC-TRANSMISSION | RELEASE | ASTROCYTES | NEUROSCIENCES | INHIBITION | P2X RECEPTORS | GENE THERAPIES | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | RAT HIPPOCAMPUS | A1 ADENOSINE RECEPTORS | Electric Stimulation - adverse effects | Seizures - prevention & control | Purines - pharmacology | Rats | Male | Purinergic P2 Receptor Antagonists - therapeutic use | Receptors, Purinergic P2 - physiology | Hippocampus - drug effects | Rats, Sprague-Dawley | Seizures - physiopathology | Purinergic P2 Receptor Agonists - therapeutic use | Animals | Seizures - etiology | Purinergic P2 Receptor Antagonists - pharmacology | Biosensing Techniques - methods | Purinergic P2 Receptor Agonists - pharmacology | Purines - therapeutic use | Hippocampus - physiopathology | Organ Culture Techniques | Medical equipment | Alkaloids | Seizures (Medicine) | Physiological apparatus | Adenosine A1 receptors | Brain slice preparation | Antagonists | Electrical stimuli | Purine P2X receptors | Anticonvulsants | Purine P2Y receptors | Sensory neurons | purines | Purine P2 receptors
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3. Full Text Release and interconversion of P2 receptor agonists by human osteoblast-like cells
by Buckley, K.A and Golding, S.L and Rice, J.M and Dillon, J.P and Gallagher, J.A
FASEB Journal, ISSN 0892-6638, 2003, Volume 17, Issue 11, pp. 1401 - 1410
Nucleotides, acting as agonists at P2 receptors, are important extracellular signaling molecules in many tissues. In bone they affect both bone-forming... 
Ecto-nucleoside diphosphokinase | Bone | Ecto-NDPK | ADP | ATP | ACTIVATION | OSTEOCLASTS | DIPHOSPHOKINASE | ecto-nucleoside diphosphokinase | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSDUCTION | bone | ecto-NDPK | NUCLEOSIDE DIPHOSPHATE KINASE | IDENTIFICATION | CELL BIOLOGY | NUCLEOTIDES | ENDOTHELIAL-CELLS | BIOLOGY | BONE-CELLS | ATP RELEASE | Nucleoside-Diphosphate Kinase - biosynthesis | Guanosine Triphosphate - pharmacology | Humans | Culture Media, Conditioned - chemistry | Receptors, Purinergic P2Y1 | Adenosine Triphosphate - biosynthesis | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Receptors, Purinergic P2 - biosynthesis | Adenosine Triphosphate - metabolism | Cell Division | Receptors, Purinergic P2 - genetics | Monomeric GTP-Binding Proteins - biosynthesis | Receptors, Purinergic P2Y12 | Nucleoside-Diphosphate Kinase - genetics | Cell Line | Osteoblasts - enzymology | Adenosine Triphosphate - analysis | Osteoblasts - drug effects | Cells, Cultured | Purinergic P2 Receptor Antagonists | Transcription Factors - biosynthesis | Purinergic P2 Receptor Agonists | Monomeric GTP-Binding Proteins - genetics | Transcription Factors - genetics | Membrane Proteins | Cell Membrane - enzymology | NM23 Nucleoside Diphosphate Kinases | Adenosine Diphosphate - metabolism | Osteoblasts - metabolism
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4. Full Text P2 receptor agonists stimulate insulin release from human pancreatic islets
by Fernandez-Alvarez, Josepha and Hillaire-Buys, Dominique and Loubatières-Mariani, Marie-Madeleine and Gomis, Ramon and Petit, Pierre
Pancreas, ISSN 0885-3177, 2001, Volume 22, Issue 1, pp. 69 - 71
Although P2 receptors for adenosine 5'-triphosphate (ATP) and/or adenosine 5'-diphosphate (ADP) have been characterized in mammalian pancreatic beta cells, no... 
Human islets | P2 receptors | Insulin secretion | CELLS | NUCLEOTIDES | PHYSIOLOGY | human islets | ENDOCRINOLOGY & METABOLISM | insulin secretion | SECRETION | ATP | Islets of Langerhans - drug effects | Humans | Middle Aged | Male | Receptors, Purinergic P2Y1 | Glucose - pharmacology | Purinergic P2 Receptor Agonists | Thionucleotides - pharmacology | Adenosine Triphosphate - analogs & derivatives | Adenosine Diphosphate - pharmacology | Receptors, Purinergic P2X | Adenosine Triphosphate - pharmacology | Insulin - metabolism | Islets of Langerhans - metabolism | Radioimmunoassay | Adult | Adenosine Diphosphate - analogs & derivatives | Insulin Secretion
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5. Full Text Purine and pyrimidine receptors
by Burnstock, G
Cellular and Molecular Life Sciences, ISSN 1420-682X, 06/2007, Volume 64, Issue 12, pp. 1471 - 1483
Adenosine 5′-triphosphate (ATP), in addition to its intracellular roles, acts as an extracellular signalling molecule via a rich array of receptors, which have... 
Biochemistry, general | G protein-coupled receptors | heteromultimers | P2X receptor | Biomedicine general | Cell Biology | Life Sciences | Life Sciences, general | gene regulation | P2Y receptor | P1 receptor | Cloned receptors | ion channel receptors | Heteromultimers | Gene regulation | Ion channel receptors | cloned receptors | ATP RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADENOSINE RECEPTOR | HUMAN P2Y RECEPTOR | FUNCTIONAL-CHARACTERIZATION | SENSORY NEURONS | CELL BIOLOGY | NUCLEOTIDE RECEPTORS | PROTEIN-COUPLED RECEPTOR | P2X RECEPTORS | GATED ION CHANNELS | MOLECULAR-CLONING | Purines - metabolism | Humans | Transcriptional Activation | Gene Expression Regulation | Purinergic P2 Receptor Agonists | Pyrimidines - metabolism | Receptors, Purinergic P1 - chemistry | Receptors, Purinergic P2 - chemistry | Animals | Adenosine Triphosphate - metabolism | Receptors, Purinergic P2 - metabolism | Receptors, Purinergic P1 - metabolism | Purinergic P1 Receptor Agonists | Dimerization | Ions | Molecular biology | Cloning | Genomics
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6. Full Text International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
by Maria P. Abbracchio and Geoffrey Burnstock and Jean-Marie Boeynaems and Eric A. Barnard and José L. Boyer and Charles Kennedy and Gillian E. Knight and Marta Fumagalli and Christian Gachet and Kenneth A. Jacobson and Gary A. Weisman
Pharmacological Reviews, ISSN 0031-6997, 09/2006, Volume 58, Issue 3, pp. 281 - 341
There have been many advances in our knowledge about different aspects of P2Y receptor signaling since the last review published by our International Union of... 
TRANSMEMBRANE CONDUCTANCE REGULATOR | PLATELET ADP RECEPTOR | GROWTH-FACTOR RECEPTOR | N-TYPE CA2 | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | RAT SYMPATHETIC NEURONS | VASCULAR ENDOTHELIAL-CELLS | BETA-GAMMA-SUBUNITS | INDUCED ATP RELEASE | HUMAN MAST-CELLS | Cardiovascular Diseases - etiology | Atherosclerosis - drug therapy | Cardiovascular Diseases - drug therapy | Cardiovascular Diseases - prevention & control | Humans | Gene Expression Regulation | Models, Molecular | Purinergic P2 Receptor Antagonists | Receptors, Purinergic P2 - physiology | Ion Channels - physiology | Purinergic P2 Receptor Agonists | Phylogeny | Receptors, Purinergic P2 - classification | Protein Isoforms - physiology | Tissue Distribution | Receptors, Purinergic P2 - therapeutic use | Animals | Models, Biological | Second Messenger Systems - physiology | Atherosclerosis - prevention & control
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7. Full Text Identification of an Ecto-nucleoside Diphosphokinase and Its Contribution to Interconversion of P2 Receptor Agonists
by Eduardo R. Lazarowski and László Homolya and Richard C. Boucher and T. Kendall Harden
Journal of Biological Chemistry, ISSN 0021-9258, 08/1997, Volume 272, Issue 33, pp. 20402 - 20407
The P2Y 4 receptor is selectively activated by UTP. Although addition of neither ATP nor UDP alone increased intracellular Ca 2+ in 1321N1 human astrocytoma... 
GENE | ATP | K CQ BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-METASTASIS | DIPHOSPHATE KINASE | Uridine Triphosphate - metabolism | Adenosine Triphosphate - metabolism | Humans | Nucleoside-Diphosphate Kinase - analysis | Nucleoside-Diphosphate Kinase - physiology | Purinergic P2 Receptor Agonists | Adenosine Diphosphate - metabolism | Tumor Cells, Cultured | Uridine Diphosphate - metabolism
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8. Full Text Purinergic Receptors in Thrombosis and Inflammation
by Hechler, Béatrice and Gachet, Christian
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2015, Volume 35, Issue 11, pp. 2307 - 2315
Under various pathological conditions, including thrombosis and inflammation, extracellular nucleotide levels may increase because of both active release and... 
atherosclerosis | thrombosis | inflammation | nucleotides | platelets | sepsis | ABDOMINAL SEPSIS | ALLERGIC AIRWAY INFLAMMATION | ANTITHROMBOTIC DRUGS | P2 RECEPTORS | PLATELET P2Y RECEPTOR | VASCULAR INFLAMMATION | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | TRANSPLANT ARTERIOSCLEROSIS | P2Y RECEPTOR | HEMATOLOGY | KINASE ACTIVATION | Signal Transduction | Purines - metabolism | Humans | Inflammation Mediators - blood | Purinergic P2 Receptor Antagonists - therapeutic use | Inflammation - blood | Receptors, Purinergic P2 - drug effects | Inflammation - metabolism | Purinergic P2 Receptor Agonists - therapeutic use | Thrombosis - metabolism | Animals | Inflammation - drug therapy | Fibrinolytic Agents - therapeutic use | Receptors, Purinergic P2 - metabolism | Blood Coagulation | Anti-Inflammatory Agents - therapeutic use | Receptors, Purinergic P2X7 - metabolism | Receptors, Purinergic P2Y2 - metabolism | Thrombosis - drug therapy | Thrombosis - blood
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9. Full Text Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
by von Kügelgen, Ivar
Pharmacology and Therapeutics, ISSN 0163-7258, 2006, Volume 110, Issue 3, pp. 415 - 432
Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-cell signalling. P2X-receptors are ligand-gated ion channels, whereas... 
Prasugrel | MRS2567 | Cangrelor | P2Y receptor | MRS2279 | Subtype-selective antagonists | MRS2179 | Clopidogrel | clopidogrel | PLATELET ADP RECEPTOR | URIDINE NUCLEOTIDE RECEPTOR | prasugrel | DEOXYADENOSINE BISPHOSPHATE DERIVATIVES | cangrelor | HUMAN P2Y RECEPTOR | SITE-DIRECTED MUTAGENESIS | P2 RECEPTORS | PROTEIN-COUPLED RECEPTOR | FUNCTIONAL EXPRESSION | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | subtype-selective antagonists | HUMAN MAST-CELLS | Amino Acid Sequence | Receptors, Purinergic P2 - chemistry | Animals | Signal Transduction | Species Specificity | Humans | Cloning, Molecular | Molecular Sequence Data | Purinergic P2 Receptor Antagonists | Ligands | Receptors, Purinergic P2 - physiology | Purinergic P2 Receptor Agonists | Adenylate cyclase | Coenzymes | RNA | Heterocyclic compounds | Cloning | Angiotensin | Cellulose | Physiological aspects | Nucleosides | Nucleotides | Peptide hormones
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10. Full Text Contrasting effects of P2 receptor agonists on spontaneous contractility of human fallopian tubes with and without acute inflammation
by Ziganshin, Airat U and Vafina, Zukhra R and Fatkullin, Ildar F
Pharmacological Research, ISSN 1043-6618, 2008, Volume 57, Issue 1, pp. 56 - 59
Two groups of women were used to compare effects of P2 receptor agonists on the contractile activity of isolated human fallopian tubes with and without acute... 
Human fallopian tubes | P2 receptor agonists | Inflammation | P2 receptors | Contractility | PURINERGIC NEUROTRANSMISSION | human fallopian tubes | inflammation | contractility | DISEASE | PHARMACOLOGY & PHARMACY | ATP | PATHOPHYSIOLOGY | Acute Disease | Fallopian Tubes - physiology | Humans | Uridine Triphosphate - pharmacology | Receptors, Purinergic P2 - physiology | Purinergic P2 Receptor Agonists | Adenosine Triphosphate - analogs & derivatives | Adenosine Triphosphate - pharmacology | Dose-Response Relationship, Drug | Muscle Contraction - drug effects | Salpingitis - physiopathology | Female | In Vitro Techniques | Fallopian Tubes - drug effects | Analysis
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11. Full Text Evidence for Functional P2X4/P2X7 Heteromeric Receptors
by Chang Guo and Marianela Masin and Omar S. Qureshi and Ruth D. Murrell-Lagnado
Molecular Pharmacology, ISSN 0026-895X, 12/2007, Volume 72, Issue 6, pp. 1447 - 1456
The cytolytic ionotropic ATP receptor P2X 7 has several important roles in immune cell regulation, such as cytokine release, apoptosis, and microbial killing.... 
Adenosine Triphosphate - pharmacology | Receptors, Purinergic P2X7 | Cell Line | Animals | Receptors, Purinergic P2X4 | Humans | Purinergic P2 Receptor Antagonists | Rats | Receptors, Purinergic P2 - physiology | Mice | Purinergic P2 Receptor Agonists | Ivermectin - pharmacology
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12. Full Text Purine and Pyrimidine (P2) Receptors as Drug Targets
by Jacobson, Kenneth A and Jarvis, Michael F and Williams, Michael
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2002, Volume 45, Issue 19, pp. 4057 - 4093
PAROTID ACINAR-CELLS | PLATELET ADP RECEPTOR | GATED ION-CHANNEL | CHEMISTRY, MEDICINAL | NUCLEUS-TRACTUS-SOLITARIUS | RAT VAS-DEFERENS | PROTEIN-COUPLED RECEPTORS | HUMAN P2Y RECEPTOR | RECOMBINANT P2X RECEPTOR | SITE-DIRECTED MUTAGENESIS | DORSAL-ROOT GANGLION | Receptors, Purinergic P2 - chemistry | Uridine Triphosphate - metabolism | Animals | Adenosine Triphosphate - metabolism | Humans | Drug Design | Purinergic P2 Receptor Antagonists | Ligands | Receptors, Purinergic P2 - physiology | Purinergic P2 Receptor Agonists | Pyrimidines - metabolism
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