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Purinergic Signalling, ISSN 1573-9538, 9/2012, Volume 8, Issue 3, pp. 419 - 436
The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors (ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range... 
Clinical trials, nucleosides | Neurosciences | Adenosine receptors | Human Physiology | P2Y receptors | Antagonists | Nucleotides | Biomedicine general | Biomedicine | GPCR structure | Cancer Research | Agonists | Pharmacology/Toxicology | PHYLOGENETIC ANALYSIS | A(2B) ADENOSINE | ANTAGONIST RECOGNITION | SITE-DIRECTED MUTAGENESIS | MUTATIONAL ANALYSIS | NEUROSCIENCES | NUCLEOTIDE RECEPTORS | INTERNATIONAL UNION | SUBTYPE SELECTIVITY | MOLECULAR RECOGNITION | PURINERGIC RECEPTORS | Receptors, G-Protein-Coupled - metabolism | Humans | Purinergic P2Y Receptor Agonists - therapeutic use | Purinergic P1 Receptor Agonists - therapeutic use | Purinergic P1 Receptor Antagonists - pharmacology | Receptors, Purinergic P1 - chemistry | Receptors, Purinergic P2 - chemistry | Drug Design | Receptors, G-Protein-Coupled - drug effects | Purinergic P2Y Receptor Antagonists - therapeutic use | Purinergic P2Y Receptor Antagonists - pharmacology | Purinergic P1 Receptor Agonists - chemistry | Purinergic P1 Receptor Agonists - pharmacology | Purinergic P1 Receptor Antagonists - therapeutic use | Purinergic P2Y Receptor Agonists - chemistry | Clinical Trials as Topic | Receptors, Purinergic P2 - drug effects | Purinergic P2Y Receptor Agonists - pharmacology | Animals | Purinergic P2Y Receptor Antagonists - chemistry | Receptors, Purinergic P2 - metabolism | Ligands | Receptors, Purinergic P1 - metabolism | Receptors, Purinergic P1 - drug effects | Receptors, G-Protein-Coupled - chemistry | Purinergic P1 Receptor Antagonists - chemistry | Glaucoma | Heart | Adenosine | Parkinson's disease | Psoriasis | Cystic fibrosis | Rheumatoid factor | Hepatitis | Alkaloids | Pyrimidines | Heterocyclic compounds | Emissions (Pollution) | Rheumatoid arthritis | Respiratory tract diseases | Eye diseases | G proteins | Diabetes | Ophthalmology | Kidney diseases | Hepatitis C | DNA-ligand interactions | Arrhythmia | Clinical trials | Ionizing radiation | Reperfusion | Ischemia | pyrimidines | Injuries | Movement disorders | Neurodegenerative diseases | Diabetes mellitus | Lung diseases | Pharmacology | Thrombosis | imaging | Stress | Purine P2Y receptors | purines | Hypoxia | Receptor mechanisms | ATP | Cancer | Pharmaceuticals | Original
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 03/2008, Volume 99, Issue 3, pp. 466 - 472
ADP and ATP play a crucial role in platelet activation and their receptors are potential targets for antithrombotic drugs. The ATP-gated cation channel P2X1... 
clopidogrel | prasugrel | AZD6140 | thrombosis | antiplatelet drugs | P2Y12 | cangrelor | Haemostasis | ADP | thienopyridine | P2X1 | P2Y1 | Theme Issue Article | Prasugrel | Cangrelor | P2Y | P2X | Antiplatelet drugs | Clopidogrel | Thienopyridine | Thrombosis | ADENOSINE-DIPHOSPHATE | ANTIPLATELET DRUG | GENE SEQUENCE VARIATIONS | P2Y12 RECEPTOR | PERCUTANEOUS CORONARY INTERVENTION | CLINICAL-EVIDENCE | haemostasis | ANGINA-PECTORIS | PERIPHERAL VASCULAR DISEASE | SHAPE CHANGE | P2Y RECEPTOR | HEMATOLOGY | ACTIVE METABOLITE | Neovascularization, Physiologic - drug effects | Humans | Receptors, Purinergic P2Y1 | Inflammation - blood | Inflammation - metabolism | Inflammation - drug therapy | Adenosine Triphosphate - metabolism | Fibrinolytic Agents - therapeutic use | Receptors, Purinergic P2 - genetics | Receptors, Purinergic P2Y12 | Membrane Proteins - metabolism | Thrombosis - blood | Blood Platelets - drug effects | Atherosclerosis - drug therapy | Purinergic P2 Receptor Antagonists | Atherosclerosis - metabolism | Mice, Knockout | Polymorphism, Genetic | Receptors, Purinergic P2X | Atherosclerosis - blood | Fibrinolytic Agents - pharmacology | Thrombosis - metabolism | Animals | Blood Coagulation - drug effects | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Blood Platelets - metabolism | Receptors, Purinergic P2 - metabolism | Thrombosis - genetics | Mice | Platelet Activation - drug effects | Thrombosis - drug therapy | Adenosine Diphosphate - metabolism
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, p. e19983
Background: After ischemia of the CNS, extracellular adenosine 5'-triphosphate (ATP) can reach high concentrations due to cell damage and subsequent increase... 
EXTRACELLULAR ATP | TUMOR-NECROSIS-FACTOR | MICROGLIAL ACTIVATION | TRANSIENT FOREBRAIN ISCHEMIA | BRAIN-INJURY | IL-1-BETA RELEASE | P2X RECEPTORS | MULTIDISCIPLINARY SCIENCES | CEREBRAL-ARTERY OCCLUSION | PURINERGIC MODULATION | NUCLEUS-ACCUMBENS | Immunohistochemistry | In Situ Nick-End Labeling | Rats, Inbred SHR | Infarction, Middle Cerebral Artery - physiopathology | Pyridoxal Phosphate - pharmacology | Pyridoxal Phosphate - therapeutic use | Recovery of Function - drug effects | Motor Activity - drug effects | Rats | Stroke - complications | Male | Purinergic P2 Receptor Antagonists - therapeutic use | Electroencephalography | Stroke - drug therapy | Stroke - physiopathology | Magnetic Resonance Imaging | Rotarod Performance Test | Animals | Time Factors | Infarction, Middle Cerebral Artery - complications | Purinergic P2 Receptor Antagonists - pharmacology | Cell Death - drug effects | Pyridoxal Phosphate - analogs & derivatives | Hypertension | Permeability | Ischemia | Occlusion | Neurosciences | Nuclear magnetic resonance--NMR | Central nervous system | Membrane permeability | Recovery of function | Confocal microscopy | Nervous system | Confocal | Kinases | Recovery | Proteins | Signal transduction | Receptors | Toxicology | Neurodegeneration | Cerebral blood flow | Rodents | Tumor necrosis factor-TNF | Purine P2 receptors | Degeneration | Inhibition | Stroke | Astrocytes | Inflammation | Pharmacology | Frequencies | Hypoglycemia | Studies | Neurology | Magnetic resonance imaging | Microscopy | Magnetic permeability | Neural networks | ATP | Scanning microscopy | Apoptosis | Veins & arteries | Nuclear magnetic resonance | NMR
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2009, Volume 106, Issue 30, pp. 12489 - 12493
Journal Article